Nephrology Crossword: Antihypertensive agents

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Nephrology Crossword: Antihypertensive agents Manish Saha1 and Kenar D. Jhaveri2 1

Division of Nephrology, University of Alabama, Birmingham, Alabama, USA; and 2Division of Nephrology, Hofstra Northwell School of Medicine, Great Neck, New York, USA Correspondence: Kenar D. Jhaveri, Division of Nephrology, Hofstra Northwell School of Medicine, 100 Community Drive, Floor 2, Great Neck, New York 11021, USA. E-mail: [email protected] Kidney International (2016) 90, 1137–1138; http://dx.doi.org/10.1016/j.kint.2016.05.021 by Elsevier Inc. All rights reserved.

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Copyright ª 2016, International Society of Nephrology. Published

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ACROSS 3. A major side effect of large doses of furosemide 6. Metolazone in the serum is bound to albumin and this cell (abbr.) 7. This antihypertensive medication has a uricosuric effect 8. Amiloride is excreted into the tubule through organic-______ pathways 10. This electrolyte abnormality needs to be corrected before initiation of acetazolamide 11. More than 95% of metolazone is eliminated from the body in ______ hours 13. Spironolactone can alter the clearance of this antiarrhythmic

DOWN 1. Its action on the ENaC results in sodium retention; a possible mechanism for edema in nephrotic syndrome 2. This diuretic doesn’t need to be secreted into tubules to provide its effect 3. This antihypertensive agent can cause kidney injury by causing vasoconstriction, interstitial nephritis, and crystal formation 4. This loop diuretic has more predictable pharmacokinetics than furosemide 5. This hypertension trial (acronym) showed that chlorthalidone may improve cardiovascular outcomes 8. Short-term tolerance of diuretics is called ______ 9. Alternative diuretic in patients with sulfa anaphylaxis 10. Compound of this metal was a potent diuretic prior to the use of thiazides and loop diuretics (abbr.) 12. Below this level of serum albumin (g/dl), combined infusion of albumin and a loop diuretic may enhance diuresis in nephrotic syndrome DISCLOSURE

All the authors declared no competing interests.

Kidney International (2016) 90, 1137–1138

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M Saha and KD Jhaveri: Antihypertensive agents

Nephrology Crossword Answers: Antihypertensive agents 1

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Kidney International (2016) 90, 1137–1138