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Neural development and regeneration
hr. 2. Biodttm. Vol. 21, No. 4, p. 453, 1989 Pergsmon Press pk. Printed in Great Britain
BOOK REVIEWS Teratogeap; Chemknls Which Cause Birth DefectsEdited by V. K. MEYERS.472~~. 1988. Elsevier. Amsterdam. SIX.
Cellular and Molecular Basis of Synaptic TmtwdmionEdited by H. ZIMMERMAN. 547~~. 1988. Springer, Berlin. DM 268.
At least 5000 chemicals can have teratogenic m effects and they are listed in this book. In addition details are given of the T of pesticides; the long term effects of T chemicals on the developing brain and behaviour; the safe handling of T chemicals; how to obtain info~ation about the T potential activity of chemicals. The purpose of this book is to make women working with chemicals aware of the potential T danger and how to minimize this T effect.
There is an introduction by Victor Whittaker on the development and present state of our understanding of synaptic transmission. The multi-author paper in the rest of the volume are grouped in topics: (1) structural organixation of the synapse and dynamics of synaptic or~~~tion; (2) presynaptic regulation of transmitter synthesis and release; (3) structure and function of presynaptic ion channels; (4) molecular and functional organization of synaptic vesicles; (5) cotransmitters; cellular location, function and metabolism; and (6) neurotransmitter receptors. The book provides a good picture of the research front in this subject.
The Pharmacology of Lymphocytes: Handbook of Experimental Pharmacology, Vol. U--Edited by M. A. BRAY and J. MORLEY.626~~. 1988. Springer, Berlin. DM 680. Lymphocytes (L) play an important role in the immune response and the development of acquired innate immune deficiency syndrome has focused attention on L physiolo~ and pharmacology. The reviews in this volume are as follows: evolution, ontogeny and physiologic function of L; de noun expression of receptors on T cells; membrane events during L activation; intracellular events during L activation; generation and measurement of antibodies; monoclonal antibodies to L surface molecules on probes for L functions; Interleukin 1 production from various cells and measurement of its multiple biologic activities; production and measurement of Interleukin 2 and Interleukin 3; production and measurement of interferons; factors regulating IgI synthesis; generation, biology and assay of efferent lymphokines; L purification, growth, cloning and functional assays; screening strategies for detecting immunothera~utic agents; selected autacoids as modulators of L function; lipid mediators and L function; thymic hormones and L functions; ~u~orti~osteroids; slow acting antirheumatics; ~y~lophosphamide; lobenzarit (CCA); cyclosporins; muramyl dipeptides; antipurines and purine metabolism; isoprinosine and NPT 15392; bacterial and fungal products; non-steroidal anti-inflammatory drugseffect on L function; and future prospects for drug design of L modulators. This is a very interesting and important volume that will do much to focus attention on the strategies of future research on L.
453
NeuraI Developmentand Regeneratkm-Edited by A. f&RIO, J. R. PEREZ-POLO, J. DEVELLB~~~ B. HABER.711 pp. 1988. Springer, Berlin. DM 388. This publication is based on a satellite symposium of the American Society for Neuroscience and the Intention Society for Neur~he~st~, May 1987. The main sections are (I) growth factors and hormones in development and ageing of neurons and glia. Growth factors and hormones determine the expression of the phenotype properties that characterize the different cell types. This has increased our understanding of the development of different glia oells types and the trophic effects of neurotransmitters. (2) Mechanisms of gene expression. The regulation of expression of myelin proteins and of nerve growth factor receptors has become amenable to direct chemical manipulation at the genome level. (3) Responses of nervous tissue to trauma. Following degeneration of a specific input, the vacated target area is reinnervated by sprouts from adjacent projections. The nature of the chemical signals stim~ating this growth is discussed. (4) Neuronal end~~n~i~une interactions. Nerve growth factor can have a mitogenic effect on some lymphoid cells. Particular attention is given to the innervation of lymphoid organs and the neuroendocrine control of lymphoid function. Lymphokines play a role in glial activation and proliferation. Although neurochemistry has concentrated in the past on metabolism and neurotransmission the 72 papers in this book provide a useful account of the more complex neurochemical problems of the nervous system.
BOOK REVIEWS Teratogeap; Chemknls Which Cause Birth DefectsEdited by V. K. MEYERS.472~~. 1988. Elsevier. Amsterdam. SIX.
Cellular and Molecular Basis of Synaptic TmtwdmionEdited by H. ZIMMERMAN. 547~~. 1988. Springer, Berlin. DM 268.
At least 5000 chemicals can have teratogenic m effects and they are listed in this book. In addition details are given of the T of pesticides; the long term effects of T chemicals on the developing brain and behaviour; the safe handling of T chemicals; how to obtain info~ation about the T potential activity of chemicals. The purpose of this book is to make women working with chemicals aware of the potential T danger and how to minimize this T effect.
There is an introduction by Victor Whittaker on the development and present state of our understanding of synaptic transmission. The multi-author paper in the rest of the volume are grouped in topics: (1) structural organixation of the synapse and dynamics of synaptic or~~~tion; (2) presynaptic regulation of transmitter synthesis and release; (3) structure and function of presynaptic ion channels; (4) molecular and functional organization of synaptic vesicles; (5) cotransmitters; cellular location, function and metabolism; and (6) neurotransmitter receptors. The book provides a good picture of the research front in this subject.
The Pharmacology of Lymphocytes: Handbook of Experimental Pharmacology, Vol. U--Edited by M. A. BRAY and J. MORLEY.626~~. 1988. Springer, Berlin. DM 680. Lymphocytes (L) play an important role in the immune response and the development of acquired innate immune deficiency syndrome has focused attention on L physiolo~ and pharmacology. The reviews in this volume are as follows: evolution, ontogeny and physiologic function of L; de noun expression of receptors on T cells; membrane events during L activation; intracellular events during L activation; generation and measurement of antibodies; monoclonal antibodies to L surface molecules on probes for L functions; Interleukin 1 production from various cells and measurement of its multiple biologic activities; production and measurement of Interleukin 2 and Interleukin 3; production and measurement of interferons; factors regulating IgI synthesis; generation, biology and assay of efferent lymphokines; L purification, growth, cloning and functional assays; screening strategies for detecting immunothera~utic agents; selected autacoids as modulators of L function; lipid mediators and L function; thymic hormones and L functions; ~u~orti~osteroids; slow acting antirheumatics; ~y~lophosphamide; lobenzarit (CCA); cyclosporins; muramyl dipeptides; antipurines and purine metabolism; isoprinosine and NPT 15392; bacterial and fungal products; non-steroidal anti-inflammatory drugseffect on L function; and future prospects for drug design of L modulators. This is a very interesting and important volume that will do much to focus attention on the strategies of future research on L.
453
NeuraI Developmentand Regeneratkm-Edited by A. f&RIO, J. R. PEREZ-POLO, J. DEVELLB~~~ B. HABER.711 pp. 1988. Springer, Berlin. DM 388. This publication is based on a satellite symposium of the American Society for Neuroscience and the Intention Society for Neur~he~st~, May 1987. The main sections are (I) growth factors and hormones in development and ageing of neurons and glia. Growth factors and hormones determine the expression of the phenotype properties that characterize the different cell types. This has increased our understanding of the development of different glia oells types and the trophic effects of neurotransmitters. (2) Mechanisms of gene expression. The regulation of expression of myelin proteins and of nerve growth factor receptors has become amenable to direct chemical manipulation at the genome level. (3) Responses of nervous tissue to trauma. Following degeneration of a specific input, the vacated target area is reinnervated by sprouts from adjacent projections. The nature of the chemical signals stim~ating this growth is discussed. (4) Neuronal end~~n~i~une interactions. Nerve growth factor can have a mitogenic effect on some lymphoid cells. Particular attention is given to the innervation of lymphoid organs and the neuroendocrine control of lymphoid function. Lymphokines play a role in glial activation and proliferation. Although neurochemistry has concentrated in the past on metabolism and neurotransmission the 72 papers in this book provide a useful account of the more complex neurochemical problems of the nervous system.