- Email: [email protected]
Neural mechanisms of hyperalgesia
“Of particular
interest” -
in the opinion of neurobiologists. Papers “of particular
interest” selected, from the previous
in the section on Sensory
Functional
organization
maps and mechanisms
Systems
in the August
of the auditory
cortex:
selected by Christoph
E.
Schreiner RIQUIMAR~UXH, GAIONI SJ, SUGA N: Cortical Computational Maps Control Auditory Perception. Science 1991, 251:565-568. An important study that links the content of functionally defined representational cortical maps to deficits in perception after chemical inactivation of a map. WALLACEMN, KITZES LM, JONESEG: Intrinsic
Interlaminar and Intralaminar Connections and their Relationship to the Tonotopic Map in Cat Primary Auditory Cortex. Exp Brain Res 1991, 86:527-544. This detailed analysis of interlaminar and intralaminar connections supports the notion of a patchy or fractured anatomical and, potentially, functional organization in the isofrequency domain of the primary auditory cortical field. KOUILIER EM, SIMM GM, VILLA AEP, DE RIBAUPIERREY, IIE RIBAIJPIERRE F: Auditory Corticocortical Intercon-
nections in the Cat: Evidence For Parallel and Hierarchical Arrangement of the Auditory Cortical Areas. Exp Brain Res 1991, 86:483-505. A scheme for hierarchical and parallel processing streams is deduced from the cortico-cortical interconnections of five major fields of cat auditory cortex.
year’s literature,
1992 issue of Current
by the authors Opinion
of reviews
in Neurobiology.
one of the first direct demonstrations volvement of parietal and temporal visual functions.
of differential in cortex in different
LYNCH JJ, SILVEIRALCL, PERRY VH, MERIGANWH: Visual Effects of Damage to P Ganglion Cells in Macaques. Visual Neurosci 1992, 8~575-583. A careful behavioral assessment of visual capabilities after the parvocellular pathway has been inactivated. Among the results is the finding that the magnocellular pathway can mediate shape discrimination.
Neural
mechanisms
of hyperalgesia
selected
by Donald A. Simone MEYER RA, DAVIS KD, COHEN RH, TREEDER-D, CAMPBELL
JN: Mechanically Insensitive Atferents (MIAs) in Cutaneous Nerves of Monkey. Brain Res 1991, 561:252-261. Cutaneous afferents that did not respond to mechanical stimulation, but that were excited by intradermal injection of inflammatory mediators into the receptive field, were found in monkey. A portion became sensitized to mechanical stimulation. Further research is needed to determine the role of these chemical receptors in pain and hyperalgesia associated with inflammation. NOGCCIII K, KOWAISKI K, TRAUB R, SOLOIIKINA, LAD~OIA MJ, RIJDA MA: Dynorphin Expression and Fos-Like
Functional
visual streams
Immunoreactivity Following Inflammation Induced Hyperalgesia are Colocalized in Spinal Cord Neurons.
selected by John H.R.
Maunsell CORBEI~‘A M, MIEZIN FM, DOBMEYER S, SHIXMAN GL, PETERSENSE: Selective and Divided Attention Dur-
ing Visual Discrimination of Shape, Color, and Speed: Functional Anatomy by Positron Emission Tomography. .J Neurosci 1991, 11:2383-2402. This report shows that attending to different dimensions of a visual stimulus preferentially activates different regions in human extrastriate visual cortex. Because the same visual stimuli are used in all tests, these experi ments provide some of the best evidence that different regions in human visual cortex contribute to different visual functions. ZEKI S, WATSON JDG, LUECK CJ, FRISTON KJ, KENNAKII C, FKACKOWIAKRSJ: A Direct Demonstration of Func-
tional
Specialization
in
Human
Visual
Cortex.
J
Neurosci 1991, 11:641649. In this study positron emission tomography is used to record the cortical activity of human subjects viewing either a colored or a moving stimulus. The results provide
500
Mol Brain Res 1991, 10:227-233. This study demonstrates that during peripheral inflammation, approximately 80 % of spinal neurons exhibiting in creased levels of dynorphin mFWA or the peptide also exhibit increased levels of Fos-related proteins. Suggests that activation of Fos and related proteins may be involved in regulating dynorphin gene expression in spinal neurons. HEIDEN JLK, NAHIN RI, TFLUJURJ, DIJBNERR: Effects of
Spinal Kappa-Opioid Receptor Agonists on the Responsiveness of Nociceptive Superficial Dorsal Horn Neurons. Pain 1991, 44:187-193. Application of x-opioid receptor agonists to the rat spinal cord produced an expansion of receptive fields and in creased responses to mechanical and/or thermal stimuli, These data suggest that one function of the increased levels of spinal dynorphin during inflammation may be to contribute to enhanced excitability of dorsal horn neurons.
0
1992 Current
Biology
interest” -
in the opinion of neurobiologists. Papers “of particular
interest” selected, from the previous
in the section on Sensory
Functional
organization
maps and mechanisms
Systems
in the August
of the auditory
cortex:
selected by Christoph
E.
Schreiner RIQUIMAR~UXH, GAIONI SJ, SUGA N: Cortical Computational Maps Control Auditory Perception. Science 1991, 251:565-568. An important study that links the content of functionally defined representational cortical maps to deficits in perception after chemical inactivation of a map. WALLACEMN, KITZES LM, JONESEG: Intrinsic
Interlaminar and Intralaminar Connections and their Relationship to the Tonotopic Map in Cat Primary Auditory Cortex. Exp Brain Res 1991, 86:527-544. This detailed analysis of interlaminar and intralaminar connections supports the notion of a patchy or fractured anatomical and, potentially, functional organization in the isofrequency domain of the primary auditory cortical field. KOUILIER EM, SIMM GM, VILLA AEP, DE RIBAUPIERREY, IIE RIBAIJPIERRE F: Auditory Corticocortical Intercon-
nections in the Cat: Evidence For Parallel and Hierarchical Arrangement of the Auditory Cortical Areas. Exp Brain Res 1991, 86:483-505. A scheme for hierarchical and parallel processing streams is deduced from the cortico-cortical interconnections of five major fields of cat auditory cortex.
year’s literature,
1992 issue of Current
by the authors Opinion
of reviews
in Neurobiology.
one of the first direct demonstrations volvement of parietal and temporal visual functions.
of differential in cortex in different
LYNCH JJ, SILVEIRALCL, PERRY VH, MERIGANWH: Visual Effects of Damage to P Ganglion Cells in Macaques. Visual Neurosci 1992, 8~575-583. A careful behavioral assessment of visual capabilities after the parvocellular pathway has been inactivated. Among the results is the finding that the magnocellular pathway can mediate shape discrimination.
Neural
mechanisms
of hyperalgesia
selected
by Donald A. Simone MEYER RA, DAVIS KD, COHEN RH, TREEDER-D, CAMPBELL
JN: Mechanically Insensitive Atferents (MIAs) in Cutaneous Nerves of Monkey. Brain Res 1991, 561:252-261. Cutaneous afferents that did not respond to mechanical stimulation, but that were excited by intradermal injection of inflammatory mediators into the receptive field, were found in monkey. A portion became sensitized to mechanical stimulation. Further research is needed to determine the role of these chemical receptors in pain and hyperalgesia associated with inflammation. NOGCCIII K, KOWAISKI K, TRAUB R, SOLOIIKINA, LAD~OIA MJ, RIJDA MA: Dynorphin Expression and Fos-Like
Functional
visual streams
Immunoreactivity Following Inflammation Induced Hyperalgesia are Colocalized in Spinal Cord Neurons.
selected by John H.R.
Maunsell CORBEI~‘A M, MIEZIN FM, DOBMEYER S, SHIXMAN GL, PETERSENSE: Selective and Divided Attention Dur-
ing Visual Discrimination of Shape, Color, and Speed: Functional Anatomy by Positron Emission Tomography. .J Neurosci 1991, 11:2383-2402. This report shows that attending to different dimensions of a visual stimulus preferentially activates different regions in human extrastriate visual cortex. Because the same visual stimuli are used in all tests, these experi ments provide some of the best evidence that different regions in human visual cortex contribute to different visual functions. ZEKI S, WATSON JDG, LUECK CJ, FRISTON KJ, KENNAKII C, FKACKOWIAKRSJ: A Direct Demonstration of Func-
tional
Specialization
in
Human
Visual
Cortex.
J
Neurosci 1991, 11:641649. In this study positron emission tomography is used to record the cortical activity of human subjects viewing either a colored or a moving stimulus. The results provide
500
Mol Brain Res 1991, 10:227-233. This study demonstrates that during peripheral inflammation, approximately 80 % of spinal neurons exhibiting in creased levels of dynorphin mFWA or the peptide also exhibit increased levels of Fos-related proteins. Suggests that activation of Fos and related proteins may be involved in regulating dynorphin gene expression in spinal neurons. HEIDEN JLK, NAHIN RI, TFLUJURJ, DIJBNERR: Effects of
Spinal Kappa-Opioid Receptor Agonists on the Responsiveness of Nociceptive Superficial Dorsal Horn Neurons. Pain 1991, 44:187-193. Application of x-opioid receptor agonists to the rat spinal cord produced an expansion of receptive fields and in creased responses to mechanical and/or thermal stimuli, These data suggest that one function of the increased levels of spinal dynorphin during inflammation may be to contribute to enhanced excitability of dorsal horn neurons.
0
1992 Current
Biology