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Neurocytology: Fine structure of neurons, nerve processes, ami neuroglial cells
Nwronal~ Schiiden durch Epilepsien: Summlung psychiutrischer und neurologischer Einzeldurstellungrn, by J. Peiffer, 1993, Georg Thieme Verlag, Stuttgart-New York, 128 pages, DM80.00. The question whether epilepsy induces neuronal damage is an old and controversial one, with great clinical and theoretical importance. This problem may be studied in several ways. Clinical, neurophysiological and neuropsychological data may be related to results from functional and structural neuroimaging techniques and from neurochemical and neuropathological studies of material from epilepsy surgery. In the presented retrospective monograph clinical and neuropathological studies are presented concerning 174 brain autopsies. As a consequence of this approach the population studied does not represent the distribution of epileptic disorders in the general population. Data concerning seizure frequency are missing in about 50% of the population. Tonic-clonic seizures are over-represented (55%) whereas temporal lobe seizures are found in only 6% of the study population. Two age groups are over-represented: young children and adults from 36 45 years. The author tries to reconstruct the epileptic process while performing
Ncuroc~~~tology: Fine structure of’ neurons, nerve processrs, and neuroglitrl cells, by Ennio Pannese, 1993, G. Thieme Verlag, Stuttgart, 264 pages, DM 130.00, ISBN 3 13 781801 X. For those of us neurologists. neuropathologists and neuroanatomists who were brought up during the period of calloidin-embedding, and staining methods such as Nissl, Holzer, Golgi-COX, PTAH, Bodian, Holmes. methenamine-Hg, Nauta-Gygax, etc., but had to relinquish the grip, when the full-flight of freeze-fractures, horseradish-tracing, autoradiography, immuneand chemocytology, and scanning EM flooded the domain, this up-to-date monograph is a blessing. The types of neurons. the fine structure of the neuronal perikaryon,
microscopic studies on brain slices using classical staining techniques and to determine whether the neuropathological abnormality represents the cause or the result of the seizure disorder. He compares his investigations to those of an archeologist who tries to reconstruct a classical temple from a few scattered remains. Recent studies, however. point to the discrepancies between epileptogenic lesion and cpileptogenie pacemaker zone (Liiders). Peiffer’s scope is a more simple one. He considers the presence of a tumour as a correlate of an epileptic focus. In conclusion, due to the retrospective approach chosen and the neuropathological technique used this monograph rephrases many well known problems without solving any of them. This monograph can be recommended to those who prefer classical neuropathology in relation to clinical data to a modern multidisciplinary approach involving neurophysiology, neuropsychology and functional and structural neuroimaging.
A.C. van Huffelen, MD Department of Neurology Academic Hospital Utrecht Utrecht. The Netherlands
nucleus and nucleolus, dendrites, axon and membrane, of the \ynapses and telodendrion, of the satellite and Schwann cells, the myelinated nerve fibres, the cells of ependyma and choroid plexus, of the astrocyte. oligodendrocyte and microglia, are synthetically presented in lucid text and eloquent illustrations. Only the ultrastructure of paraganglionic cells is not dealt with in a similar way. though the blood ves\els arc. The lay-out and format of the book are pleasant. the quahty of the product is high and the price most reasonable. Prof. emer. Dr. G.W. Bruyn, MD Dept. Neurology Academic Hospital Leiden. The Netherlands
Ncuroc~~~tology: Fine structure of’ neurons, nerve processrs, and neuroglitrl cells, by Ennio Pannese, 1993, G. Thieme Verlag, Stuttgart, 264 pages, DM 130.00, ISBN 3 13 781801 X. For those of us neurologists. neuropathologists and neuroanatomists who were brought up during the period of calloidin-embedding, and staining methods such as Nissl, Holzer, Golgi-COX, PTAH, Bodian, Holmes. methenamine-Hg, Nauta-Gygax, etc., but had to relinquish the grip, when the full-flight of freeze-fractures, horseradish-tracing, autoradiography, immuneand chemocytology, and scanning EM flooded the domain, this up-to-date monograph is a blessing. The types of neurons. the fine structure of the neuronal perikaryon,
microscopic studies on brain slices using classical staining techniques and to determine whether the neuropathological abnormality represents the cause or the result of the seizure disorder. He compares his investigations to those of an archeologist who tries to reconstruct a classical temple from a few scattered remains. Recent studies, however. point to the discrepancies between epileptogenic lesion and cpileptogenie pacemaker zone (Liiders). Peiffer’s scope is a more simple one. He considers the presence of a tumour as a correlate of an epileptic focus. In conclusion, due to the retrospective approach chosen and the neuropathological technique used this monograph rephrases many well known problems without solving any of them. This monograph can be recommended to those who prefer classical neuropathology in relation to clinical data to a modern multidisciplinary approach involving neurophysiology, neuropsychology and functional and structural neuroimaging.
A.C. van Huffelen, MD Department of Neurology Academic Hospital Utrecht Utrecht. The Netherlands
nucleus and nucleolus, dendrites, axon and membrane, of the \ynapses and telodendrion, of the satellite and Schwann cells, the myelinated nerve fibres, the cells of ependyma and choroid plexus, of the astrocyte. oligodendrocyte and microglia, are synthetically presented in lucid text and eloquent illustrations. Only the ultrastructure of paraganglionic cells is not dealt with in a similar way. though the blood ves\els arc. The lay-out and format of the book are pleasant. the quahty of the product is high and the price most reasonable. Prof. emer. Dr. G.W. Bruyn, MD Dept. Neurology Academic Hospital Leiden. The Netherlands