347 Handbook of the Spinal Cord, Vols. 4 & 5. Congenital Disorders and Trauma & Infections and Cancer, edited by R. A. Davidoff. Marcel Dekker, Inc., New York, 1987, 848 pages. $149.75. This 823 page multi-author monograph combines vols. 4 and 5 of the Handbook of the Spinal Cord, and completes the set. It covers, in 20 chapters, trauma, regeneration, spasticity, canal stenosis, tube defects, vascular disorders, tumors, infections, autonomic nervous system derangement, demyelinating processes, Alzheimer's disease, Stiffman syndrome, intoxications, metabolic and deficiency diseases involving the spinal cord. The chapters are clinically oriented, provide sound reviews, are well illustrated, provided with well-selected bibliographies. A rare feature are the most detailed subject and author indexes. Printed on first quality paper the monograph will serve the neurologist and neurosurgeon readily as a reference source, reflecting the state of the art of the mid-eighties. G.W. BRUYN
Neuromethods, SeriesI: Neurochemistry, A.A. Boulton and G.B. Baker (eds.) Neuromethods- 1, GeneralNeurochemical Techniques, by A.A. Boulton and G. B. Baker (eds.), Humana Press, Clifton, New Jersey, 1985. This is the first of a series of 10 volumes in which a comprehensive review is presented of efficient methods, protocols, and recent laboratory techniques available to the modem clinical and experimental neuroscientist. This inaugural volume deals with generally used routine techniques, such as subcellular fractionation, cell/tissue culture, microiontophoresis and microinjection, autoradiography, monoclonal antibodies, neurotransmitter identification, blood-brain barrier transport, and in vivo stimulation. Each one of the chapters has been concisely and lucidly written by experts and is provided with a more than ample and well selected bibliography. Even those not familiar with but contemplating clinical research or laboratory neuroscience, will find the volume a most helpful directory. The book will indubitably find its way to many a desk for ready reference and help. G.W. BRUYN
Neuromethods Series I: Neurochemistry; A.A. Boulton and Glen B. Baker (eds.), Neuromethods - 4, Receptor Binding, by A. A. Boulton, G. B. Baker, P. D. Hrdina (eds.), Humana Press, Clifton, New Jersey, 1986. Not having seen vols. 2 and 3 of this series, the present reviewer finds vol. 4 of this series a most illuminating approach on various types of ligand-reeeptor interaction, computer programs for scatchard analyses, nonlinear and competitive displacement techniques, with reference to the great majority of transmitters opioid/purinergic and neuroleptic drug receptors. General principles of receptor binding assay, the goals of tying the binding data to physiological parameters are recurrent themes in almost every chapter. The methods and techniques for defining the binding properties of the receptors for catecholamine, 5-HT, tryptamine, phenylethylamine, acetylcholine, NMDA (KQ) compounds, GABA, opioids and nonopioids, amphetamine, second messengers, benzodiazepines, etc., are lucidly and concisely dealt with. The reference lists are well-selected and unusually up-to-date. To be unreservedly recommended. G.W. BRUYN