Journal of Biochemical and Biophysical Methods, 18 (1989) 85-88 Elsevier
85
BBM 00741 B o o k Reviews
Neuropeptides and their Peptidases Turner, A.J. (ed.) VCH Verlagsgesellschaft, Weinheim, F.R.G.
Drawing on recent work in the neuropeptide field, this book provides a comprehensive survey of the molecular biology, biosynthesis, processing and metabolism of selected neuropeptide systems. It is divided into three sections, going from molecular biology through to the design of therapeutic agents. The first section investigates the gene structures of a number of neuropeptide gene families and considers the oxytocin and vasopressin genes in some detail. It also deals with critical steps in the neuropeptide processing. The second section reviews neurochemistry, pharmacology and physiology of selected neuropeptides, including tackykinins, gastric peptides and atrial natriuretic peptide; studies on neuropeptides and their peptidases in neurological diseases are also included. The final section covers the current knowledge about enzymes implicated in neuropeptide degradation, including data on endopeptidase - 24.11, angiotensin converting enzyme, and the calpains. Finally there is a review of the design and therapeutic applications of selective and potent inhibitors of zinc proteases. All contributors to this volume are internationally recognized and represent well established research groups in the area of neuropeptides. Together they offer an important overview which should attract the advanced student as well as the established workers in the field. Fred Nyberg
Introduction to Biological Membranes, 2nd Edition Mahendra Jain John Wiley & Sons, New York, U.S.A., 1988 (ISBN 0-471-84471-3) 423 pp.