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Neuroprotective activity of combination of progesterone and curcumin on sub-acute phase changes induced by partial global cerebral ischemia in mice
Abstracts / Journal of the Neurological Sciences 333 (2013) e537–e578
Objective: Our aim was to evaluate the efficacy of the different electrocardiographic (ECG) indexes in detecting left ventricular hypertrophy (LVH, concentric or eccentric) among patients with chronic renal failure under dialysis and carotid ischemic stroke as a prognostic factor. Subjects and method: We assessed 59 dialyzed-patients (median age of 55 +/− 2 years, 30 men) between 2010 and 2012, and followed up for 1 month after the ischemic stroke. The neurological evaluation was performed using the NIHSS scale and brain MRI. For diagnosis of the ECG-LVH, the following indexes were considered: Sokolov N 35 mm, Gubner N 22 mm, Romhilt N 5 points, Cornell N 28 mm in men and N20 mm in women and Lewis N 17 mm. Results: ECHO-LVH was detectable in 70% of all the patients, 29% with concentric hypertrophy (CH) and 22% with eccentric hypertrophy (EH). Considering LV geometry, the Romhilt index also demonstrated superiority in the detection of both CH (SE N 26%) and EH (SE N 36%). All patients presented major hemispheric ischemic stroke syndrome, defined an NIHSS N/= 12 in the territory of the middle cerebral artery (MCA) or internal carotid artery (ICA) and a GCS score b 14. The MRI showed hypersignal T2, lesions primarily in the large MCA territory, in all cases. Conclusions: 30 patients who were dialyzed, and had ECHO-LVH, and Sokolov N 35 mm died in the first 3 weeks after stroke. The dialysis patients with cardiac hypertrophy and ischemic stroke have a greater mortality, due to cardiac disease. Early rehabilitation have poor outcomes in patients. doi:10.1016/j.jns.2013.07.2016
Abstract — WCN 2013 No: 473 Topic: 10 — Neurorehabilitation Aortic plaque thickness and diabetes as a risk predictor for ischemic stroke rehabilitation S.M. Demea, D.C. Jianub, L. Petricac, S. Draganc, N.C. Hreniuca, D.S. Ioncud. aNeurology, Vasile Goldis Western University of Arad, Arad, Romania; bNeurology, Timisoara, Romania; cNephrology, Timisoara, Romania; dVictor Babes University of Medicine and Pharmacy, Timisoara, Romania Background: An increased aortic plaque thickness in diabetic patients with ischemic stroke is demonstrated, but data regarding the value as a prognostic risk factor for the cognitive stroke outcome is limited. Objective: To identify aortic plaque thickness as a risk predictor in patients with diabetes and acute ischemic stroke. Patients and method: We assessed 95 patients, mean age = 69 ± 12 years, (51 male) with first-ever acute stroke confirmed by brain MRI and an initial post-stroke MMSE score N 15 (mean interval between stroke and examination, 6.5 ± 3 days). All present type 2 diabetes mellitus (T2DM), and insulin therapy was initiated during hospitalization. Carotid plaques were classified as simple or complex on the basis of thickness N/= 4 mm, ulceration, or mobility. The NIHSS scale was performed in days 4–7. Results: The mean concentration (HbA(1c)) was 0.9% lower for the patients with intensive treatment. The number of patients with the aortic plaque thickness mean of 3.4 mm (2.3 to 3.6 mm range) was significantly higher (p N 0.047), and the median NIHSS score in patients with thickness N/= 4 mm was 14 (range 3 to 38), and scores differed depending on the arteriographic findings (P b 0.001). The MMSE score at 7 days was 18.6, and 25.6 at 3 months with major difficulties in attention, short-term memory impairment and aphasia. Conclusions: Carotid plaque thickness is a simple and noninvasive marker of subclinical atherosclerosis and it is often associated with acute ischemic stroke in patients with type 2 diabetes. Hyperglycemia
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and MMSE score could not predict deterioration or improvement in cognitive outcome. doi:10.1016/j.jns.2013.07.2017
Abstract — WCN 2013 No: 17 Topic: 10 — Neurorehabilitation Neuroprotective activity of combination of progesterone and curcumin on sub-acute phase changes induced by partial global cerebral ischemia in mice A. Chakrabartia, A. Prakasha, D. Hotaa, U.N. Saikiab. aPharmacology, Post Graduate Institute of Medical Education & Research, Chandigarh, India; bHistopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, India Background: There is need to search for neuroprotective agents in stroke to contain morbidity and mortality. Objective: Progesterone, a neurosteroid and curcumin, a phytophenol were evaluated in combination as neuroprotective agents in a bilateral carotid artery occlusion (BCAO) model in mice. Material and methods: 48 albino Swiss mice were divided into 4 groups: sham operated, DMSO (0.2 ml)- , Progesterone (15 mg/kg)and progesterone (5 mg/kg) + curcumin (100 mg/kg)-treated BCAO groups. BCAO was produced for 10 min with aneurysmal clips.The animals were subjected to behavioral, brain biochemical and histopathological studies on day 15 while drug or vehicle treatment was given for 14 days following BCAO. Drugs were administered intraperitoneally. The protocol was approved by the Institutional Animal Ethics Committee. Results: Compared to the sham group, the BCAO (DMSO treated group) resulted in significant impairment of exploratory behavior (hole-board test) and motor co-ordination (rota rod test) while the seizure susceptibility to kainic acid and anxiety level (elevated plus maze test) were significantly increased; BCAO caused a significant increase in histopathological scores and brain levels of malondialdehyde and TNFalfa; and a significant decrease in the levels for superoxide dimutase, catalase and glutathione peroxidase. Progesterone-alone caused significant reversal of the values for all the parameters as observed for the DMSO treated group following BCAO. The combination of progesterone and curcumin showed a significant synergistic improvement for all the parameters as compared to those observed with DMSO and progesterone-alone treated groups following BCAO. Conclusion: The combination of progesterone and curcumin possesses a translational value as potential synergistic neuroprotective agents in stroke. doi:10.1016/j.jns.2013.07.2018
Abstract — WCN 2013 No: 49 Topic: 10 — Neurorehabilitation Complications of intrathecal baclofen pump: Prevention and cure T. Rizka,b, Y. Awaada. aPediatric Neurology, National Neuroscience Institute, KFMC, Saudi Arabia; bPediatric Neurology, Al-Takhassusi Hospital, Riyadh, Saudi Arabia Increasingly, spasticity is managed with surgically implanted Intrathecal Baclofen pumps. Intrathecal Baclofen pump revision surgery unrelated to programmable pumps during end-of-life is not uncommon, requiring special attention during pre-, intra-, and post-operative management. We aimed to identify and describe complications of
Objective: Our aim was to evaluate the efficacy of the different electrocardiographic (ECG) indexes in detecting left ventricular hypertrophy (LVH, concentric or eccentric) among patients with chronic renal failure under dialysis and carotid ischemic stroke as a prognostic factor. Subjects and method: We assessed 59 dialyzed-patients (median age of 55 +/− 2 years, 30 men) between 2010 and 2012, and followed up for 1 month after the ischemic stroke. The neurological evaluation was performed using the NIHSS scale and brain MRI. For diagnosis of the ECG-LVH, the following indexes were considered: Sokolov N 35 mm, Gubner N 22 mm, Romhilt N 5 points, Cornell N 28 mm in men and N20 mm in women and Lewis N 17 mm. Results: ECHO-LVH was detectable in 70% of all the patients, 29% with concentric hypertrophy (CH) and 22% with eccentric hypertrophy (EH). Considering LV geometry, the Romhilt index also demonstrated superiority in the detection of both CH (SE N 26%) and EH (SE N 36%). All patients presented major hemispheric ischemic stroke syndrome, defined an NIHSS N/= 12 in the territory of the middle cerebral artery (MCA) or internal carotid artery (ICA) and a GCS score b 14. The MRI showed hypersignal T2, lesions primarily in the large MCA territory, in all cases. Conclusions: 30 patients who were dialyzed, and had ECHO-LVH, and Sokolov N 35 mm died in the first 3 weeks after stroke. The dialysis patients with cardiac hypertrophy and ischemic stroke have a greater mortality, due to cardiac disease. Early rehabilitation have poor outcomes in patients. doi:10.1016/j.jns.2013.07.2016
Abstract — WCN 2013 No: 473 Topic: 10 — Neurorehabilitation Aortic plaque thickness and diabetes as a risk predictor for ischemic stroke rehabilitation S.M. Demea, D.C. Jianub, L. Petricac, S. Draganc, N.C. Hreniuca, D.S. Ioncud. aNeurology, Vasile Goldis Western University of Arad, Arad, Romania; bNeurology, Timisoara, Romania; cNephrology, Timisoara, Romania; dVictor Babes University of Medicine and Pharmacy, Timisoara, Romania Background: An increased aortic plaque thickness in diabetic patients with ischemic stroke is demonstrated, but data regarding the value as a prognostic risk factor for the cognitive stroke outcome is limited. Objective: To identify aortic plaque thickness as a risk predictor in patients with diabetes and acute ischemic stroke. Patients and method: We assessed 95 patients, mean age = 69 ± 12 years, (51 male) with first-ever acute stroke confirmed by brain MRI and an initial post-stroke MMSE score N 15 (mean interval between stroke and examination, 6.5 ± 3 days). All present type 2 diabetes mellitus (T2DM), and insulin therapy was initiated during hospitalization. Carotid plaques were classified as simple or complex on the basis of thickness N/= 4 mm, ulceration, or mobility. The NIHSS scale was performed in days 4–7. Results: The mean concentration (HbA(1c)) was 0.9% lower for the patients with intensive treatment. The number of patients with the aortic plaque thickness mean of 3.4 mm (2.3 to 3.6 mm range) was significantly higher (p N 0.047), and the median NIHSS score in patients with thickness N/= 4 mm was 14 (range 3 to 38), and scores differed depending on the arteriographic findings (P b 0.001). The MMSE score at 7 days was 18.6, and 25.6 at 3 months with major difficulties in attention, short-term memory impairment and aphasia. Conclusions: Carotid plaque thickness is a simple and noninvasive marker of subclinical atherosclerosis and it is often associated with acute ischemic stroke in patients with type 2 diabetes. Hyperglycemia
e577
and MMSE score could not predict deterioration or improvement in cognitive outcome. doi:10.1016/j.jns.2013.07.2017
Abstract — WCN 2013 No: 17 Topic: 10 — Neurorehabilitation Neuroprotective activity of combination of progesterone and curcumin on sub-acute phase changes induced by partial global cerebral ischemia in mice A. Chakrabartia, A. Prakasha, D. Hotaa, U.N. Saikiab. aPharmacology, Post Graduate Institute of Medical Education & Research, Chandigarh, India; bHistopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, India Background: There is need to search for neuroprotective agents in stroke to contain morbidity and mortality. Objective: Progesterone, a neurosteroid and curcumin, a phytophenol were evaluated in combination as neuroprotective agents in a bilateral carotid artery occlusion (BCAO) model in mice. Material and methods: 48 albino Swiss mice were divided into 4 groups: sham operated, DMSO (0.2 ml)- , Progesterone (15 mg/kg)and progesterone (5 mg/kg) + curcumin (100 mg/kg)-treated BCAO groups. BCAO was produced for 10 min with aneurysmal clips.The animals were subjected to behavioral, brain biochemical and histopathological studies on day 15 while drug or vehicle treatment was given for 14 days following BCAO. Drugs were administered intraperitoneally. The protocol was approved by the Institutional Animal Ethics Committee. Results: Compared to the sham group, the BCAO (DMSO treated group) resulted in significant impairment of exploratory behavior (hole-board test) and motor co-ordination (rota rod test) while the seizure susceptibility to kainic acid and anxiety level (elevated plus maze test) were significantly increased; BCAO caused a significant increase in histopathological scores and brain levels of malondialdehyde and TNFalfa; and a significant decrease in the levels for superoxide dimutase, catalase and glutathione peroxidase. Progesterone-alone caused significant reversal of the values for all the parameters as observed for the DMSO treated group following BCAO. The combination of progesterone and curcumin showed a significant synergistic improvement for all the parameters as compared to those observed with DMSO and progesterone-alone treated groups following BCAO. Conclusion: The combination of progesterone and curcumin possesses a translational value as potential synergistic neuroprotective agents in stroke. doi:10.1016/j.jns.2013.07.2018
Abstract — WCN 2013 No: 49 Topic: 10 — Neurorehabilitation Complications of intrathecal baclofen pump: Prevention and cure T. Rizka,b, Y. Awaada. aPediatric Neurology, National Neuroscience Institute, KFMC, Saudi Arabia; bPediatric Neurology, Al-Takhassusi Hospital, Riyadh, Saudi Arabia Increasingly, spasticity is managed with surgically implanted Intrathecal Baclofen pumps. Intrathecal Baclofen pump revision surgery unrelated to programmable pumps during end-of-life is not uncommon, requiring special attention during pre-, intra-, and post-operative management. We aimed to identify and describe complications of