- Email: [email protected]
New and Nonofficial Remedies
JOURNAL OF
N
'~:Q~
AMERICAN PHARMACEUTICAL ASSOCIATION
ew and ". onofficial Remedies
Admitted under new policy of A.M .A. Courtpil on Pharmacy and Chernistry. "
CHLORQUINALDOL- Sterosan (Geigy)5,7 - Dichloro - 8 - hydroxyquinaldine- Exhibits the keratoplastic, antibacterial and antifungal properties shared by other externally applied oxy quinoline derivatives. Its mild antiseptic action may be useful in topical treatment of minor cutaneous bacterial and mycotic infections . Chlorquinaldol is applied topically twice daily as a 3- 5% ointment or cream. CROTAMITON- Eurax (Geigy)- N-Ethylo-crotonotoluide- A sarcopticide useful in the treatment of scabies 10% topical ointment applied to the skin by gentle massage over the entire body (except the head). A secopd application is made 24 hours later, apd, if necessary, a third. A cleansing bath should be taken 48 hours after the last application.
as
CYCLIZINE HYDROCHLORIDE- Marezine Hel (Burroughs Wellcome)-I -Diphenylmethyl-4-methylpiperazine Hel- An antihistamine compound useful in the prevention and relief of motion sickness, in the control of vertigo, nausea and vomiting. Administered orally, 50 mg. one-half hour before departure and 50 mg. three times daily before meals. Half the adult dosage for children 6 to 10 years, and one-fourth the adult dosage for those under 6 years of age. CYCLIZINE LACTATE- Marezine Lactate (Burroughs Wellcome)- Same systemic actions as the HCI salt of cyc1izine. S~itable for intramuscular injection, the lactate is administered in a solution containing 50 mg. per cc. in the same dosage as the orally administered h y drochloride. LENTE INSULIN- Lente Iletin- A sterile aqueous buffered su spension of insulin modified b y addition of zinc chloride. Not more than 1 unit of insulin per cc. is in solution, approximately 70 % is crystalline, and the remainder is amorphous . Each cc. contains 40 or 80 U.S.P. units of insulin. The zinc content in the insulin is sufficiently high to make the mixture r elativ ely insoluble at the pH of blood. Lente insulin ca n be u sed interchangeably with modified protamine zinc insulin, isophane (NPH) insulin. Lente insulin is administered by deep subcutaneous injection. Suspensions
80
of lente insulin should be refrigerated but should not be exposed to freezing or high temperatures. A vial in which the precipitated suspension has clumped or deposited on the vial wall should not be used. (Lilly) MECLIZINE HYDROCHLORIDE- Bonamine HCI (Pfizer)- I-(p-Chlorobenzhydryl) -4(m-methylbenzyl) piperazine HCI-An antihistaminic ,agent which depresses the central rlervous sY$tem and exhibits a pronounced act!'ion against motion sickness. The dose is 2550 mg. once daily taken about one hour prior to travel. Half dose for children. SODIUM RADIO-CHROMATE (Cr 51)Na2Cr5104- The radioactive chromium (Cr51) has a half-life of 26.5 days. It disintegrates primarily by K capture, with transmutation to vanadium and emission of x-rays. The presence of a gamma ray of 0.32 mev energy in the radiation emitted by er 51 makes sodium radio-chromate (Cr 51) useful as a biological tracer for determination of circulating red cell volume, studies of red cell survival time, and alone or in conjunction with Cr 51 CIa for determination of whole blood volume (red cell mass and plasma volume) . Sodium radio-chromate (Cr 51) is used in the form of a solution suitable for intravenous injection that first is mixed with a sample of 40 or 50 cc. of whole blood withdrawn from the patient or from a compatible donor. The dose is based upon the amount necessary to tag 80 to 90% of the erythrocytes in the sample of whole blood and ranges from 75 to 125 JLc(microcuries) with conventional techniques. Doses as low as 10 to 15 J.1.C have been used with special techniques for determinations of whole blood volume. A,fter it is mixed with the appropriate dose, the s~\tJ,1ple should be allowed to stand for 15 to 60 miriutes to achieve adequate tagging. After appropriate reduction or removal of the unbound . portion of the isotope, the treated sample 'or separated suspension of erythrocytes is then injfcted and allowed to mix with the circulating b~ood before samples are withdrawn for counting. As the- tagged cells are very stable, repe ~,t doses are seldom indicated. In ,conditions Sl1ch as severe hemolytic anemia where red blood cell survival studies may be indicated before, during, and after treatment, and where repeat doses are necessary because of rapid destruction of red blood cells, the number of repeat doses should be kept at a minimum and' the total dosage should not exceed 390 J.1.C in the body at anyone time.
Vol. XVII, No.2
PRACTICAL PHARMACY EDITION
PRESCRIPTION DEPT. SPECIALTIES A page of high-profit items worth stocking at all times ••• •• ••• •• ••
ACHROMYCIN N asal S usp ension Combination of tetracycline , phenylephrine, and hydrocortisone. Attacks germs, reduces soreness, relieves congestion-in colds , hay fever, etc. Handy 15 cc. squeeze bottle.
GEVRABON* ACHROMYCIN*
Geriatric Vitamin -M ineral Sup plement
Tetracycline Tablets Today's foremost antibiotic in a form preferred by many doctors and their patients. Potencies of 50, 100, and 250 mg.
A well -balanced formula comprising 16 vitamins and minerals, specially prepared for fol ks past forty . Deli ghtfu I wine flavor. An outstanding aTe product! Bottles of 16 oz. and 1 gallon.
STRESSCAPS* S tress Formula V itamin Cap sules The formula authorities recommend for people suffering unusual stress and strain. A fine product with a broad potential market in your area . Suggest it with confidence. 30's, 100's, SOD's and CENTURY-PAK* bulk packaging.
ARTANE* Tridihexethy l I odide A new Lederle product for ulcer relief with fewer side effects. Tablets of 25 mg. Also available with added phenobarbital , 15 mg. Either form in 100's and I ,OOO's.
T rihexyphenidyl Lederle's reliable antispasm.odic for treatment of Parkinsonism. Well tolerated , does not lose effectiveness when given over long periods. Tablets, 2 and 5 mg., in 100's and 1,000's. Elixir, 2 mg. per 4 cc., in bottles of 16 oz. and 1 gallon.
~":~~~L,~,.~~BORATORIES
AMERICAN ~COMPANY.
PATHllON*
DIVISION
lEDERPlEX* : • : • : : •
Vitamin B Comp lex Liquid All B vitamins, including B12 and Folic Acid. Pleasant flavor does not lose appeal during long usage. An easy dose , for children or adults. Bottles of 4, 8, and 12 oz., and 1 gallon.
PEARL RIVER, NEW YORK . .
81
N
'~:Q~
AMERICAN PHARMACEUTICAL ASSOCIATION
ew and ". onofficial Remedies
Admitted under new policy of A.M .A. Courtpil on Pharmacy and Chernistry. "
CHLORQUINALDOL- Sterosan (Geigy)5,7 - Dichloro - 8 - hydroxyquinaldine- Exhibits the keratoplastic, antibacterial and antifungal properties shared by other externally applied oxy quinoline derivatives. Its mild antiseptic action may be useful in topical treatment of minor cutaneous bacterial and mycotic infections . Chlorquinaldol is applied topically twice daily as a 3- 5% ointment or cream. CROTAMITON- Eurax (Geigy)- N-Ethylo-crotonotoluide- A sarcopticide useful in the treatment of scabies 10% topical ointment applied to the skin by gentle massage over the entire body (except the head). A secopd application is made 24 hours later, apd, if necessary, a third. A cleansing bath should be taken 48 hours after the last application.
as
CYCLIZINE HYDROCHLORIDE- Marezine Hel (Burroughs Wellcome)-I -Diphenylmethyl-4-methylpiperazine Hel- An antihistamine compound useful in the prevention and relief of motion sickness, in the control of vertigo, nausea and vomiting. Administered orally, 50 mg. one-half hour before departure and 50 mg. three times daily before meals. Half the adult dosage for children 6 to 10 years, and one-fourth the adult dosage for those under 6 years of age. CYCLIZINE LACTATE- Marezine Lactate (Burroughs Wellcome)- Same systemic actions as the HCI salt of cyc1izine. S~itable for intramuscular injection, the lactate is administered in a solution containing 50 mg. per cc. in the same dosage as the orally administered h y drochloride. LENTE INSULIN- Lente Iletin- A sterile aqueous buffered su spension of insulin modified b y addition of zinc chloride. Not more than 1 unit of insulin per cc. is in solution, approximately 70 % is crystalline, and the remainder is amorphous . Each cc. contains 40 or 80 U.S.P. units of insulin. The zinc content in the insulin is sufficiently high to make the mixture r elativ ely insoluble at the pH of blood. Lente insulin ca n be u sed interchangeably with modified protamine zinc insulin, isophane (NPH) insulin. Lente insulin is administered by deep subcutaneous injection. Suspensions
80
of lente insulin should be refrigerated but should not be exposed to freezing or high temperatures. A vial in which the precipitated suspension has clumped or deposited on the vial wall should not be used. (Lilly) MECLIZINE HYDROCHLORIDE- Bonamine HCI (Pfizer)- I-(p-Chlorobenzhydryl) -4(m-methylbenzyl) piperazine HCI-An antihistaminic ,agent which depresses the central rlervous sY$tem and exhibits a pronounced act!'ion against motion sickness. The dose is 2550 mg. once daily taken about one hour prior to travel. Half dose for children. SODIUM RADIO-CHROMATE (Cr 51)Na2Cr5104- The radioactive chromium (Cr51) has a half-life of 26.5 days. It disintegrates primarily by K capture, with transmutation to vanadium and emission of x-rays. The presence of a gamma ray of 0.32 mev energy in the radiation emitted by er 51 makes sodium radio-chromate (Cr 51) useful as a biological tracer for determination of circulating red cell volume, studies of red cell survival time, and alone or in conjunction with Cr 51 CIa for determination of whole blood volume (red cell mass and plasma volume) . Sodium radio-chromate (Cr 51) is used in the form of a solution suitable for intravenous injection that first is mixed with a sample of 40 or 50 cc. of whole blood withdrawn from the patient or from a compatible donor. The dose is based upon the amount necessary to tag 80 to 90% of the erythrocytes in the sample of whole blood and ranges from 75 to 125 JLc(microcuries) with conventional techniques. Doses as low as 10 to 15 J.1.C have been used with special techniques for determinations of whole blood volume. A,fter it is mixed with the appropriate dose, the s~\tJ,1ple should be allowed to stand for 15 to 60 miriutes to achieve adequate tagging. After appropriate reduction or removal of the unbound . portion of the isotope, the treated sample 'or separated suspension of erythrocytes is then injfcted and allowed to mix with the circulating b~ood before samples are withdrawn for counting. As the- tagged cells are very stable, repe ~,t doses are seldom indicated. In ,conditions Sl1ch as severe hemolytic anemia where red blood cell survival studies may be indicated before, during, and after treatment, and where repeat doses are necessary because of rapid destruction of red blood cells, the number of repeat doses should be kept at a minimum and' the total dosage should not exceed 390 J.1.C in the body at anyone time.
Vol. XVII, No.2
PRACTICAL PHARMACY EDITION
PRESCRIPTION DEPT. SPECIALTIES A page of high-profit items worth stocking at all times ••• •• ••• •• ••
ACHROMYCIN N asal S usp ension Combination of tetracycline , phenylephrine, and hydrocortisone. Attacks germs, reduces soreness, relieves congestion-in colds , hay fever, etc. Handy 15 cc. squeeze bottle.
GEVRABON* ACHROMYCIN*
Geriatric Vitamin -M ineral Sup plement
Tetracycline Tablets Today's foremost antibiotic in a form preferred by many doctors and their patients. Potencies of 50, 100, and 250 mg.
A well -balanced formula comprising 16 vitamins and minerals, specially prepared for fol ks past forty . Deli ghtfu I wine flavor. An outstanding aTe product! Bottles of 16 oz. and 1 gallon.
STRESSCAPS* S tress Formula V itamin Cap sules The formula authorities recommend for people suffering unusual stress and strain. A fine product with a broad potential market in your area . Suggest it with confidence. 30's, 100's, SOD's and CENTURY-PAK* bulk packaging.
ARTANE* Tridihexethy l I odide A new Lederle product for ulcer relief with fewer side effects. Tablets of 25 mg. Also available with added phenobarbital , 15 mg. Either form in 100's and I ,OOO's.
T rihexyphenidyl Lederle's reliable antispasm.odic for treatment of Parkinsonism. Well tolerated , does not lose effectiveness when given over long periods. Tablets, 2 and 5 mg., in 100's and 1,000's. Elixir, 2 mg. per 4 cc., in bottles of 16 oz. and 1 gallon.
~":~~~L,~,.~~BORATORIES
AMERICAN ~COMPANY.
PATHllON*
DIVISION
lEDERPlEX* : • : • : : •
Vitamin B Comp lex Liquid All B vitamins, including B12 and Folic Acid. Pleasant flavor does not lose appeal during long usage. An easy dose , for children or adults. Bottles of 4, 8, and 12 oz., and 1 gallon.
PEARL RIVER, NEW YORK . .
81