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New Cardiovascular Drugs 1986
BOOK REVIEWS
New Cardiovascular Drugs 1986. Edited by Alexander Scriabine. Raven Press: New York. 1986.xi + 274 pp. 16 x 24 cm. ISBN 0-88167-209-2. $65.00. This book is the fourth of a series New Drugs Annual: Cardiovascular Drugs, and is composed of 14 chapters, 13 of which are monographs on new drugs. The final chapter is a brief, though provocative commentary on the role of advisory committees in the drug approval process with some suggestions on increasing the effectiveness of these groups. As in earlier editions of this series, the reviewed drugs are classified according to major therapeutic uses which vary from volume to volume. In this particular instance, the uses include antihypertensive drugs (terazosin, carteolol), cardiac stimulants (alfedrine, enoximone, imazodan), antiarrhythmics (cibenzoline, asocainol, mexiletine), antithrombotics (nafazatrom, soluctidil) and cardioprotectives (iloprost, OKY-1581,magnesium asparate hydrochloride). The information presented covers pharmacology (and electrophysiology where appropriate), toxicology, metabolism, pharmacokinetics, and clinical studies. In many instances a discussion of the mechanism of action of the drug is included in the chapter. The review of the pharmacology of the agents is quite comprehensive with a n adequate number of figures and graphs in each chapter depicting various dose response characteristics. It is always of interest to see the pharmacological data which led to the identification of each of these agents as clinical candidates. This is especially true of those compounds with more contemporary cardiovascular actions such as the “cardioprotectives”; in this case newer approaches to establish efficacy are described. The metabolism of these agents, when known, is often presented in terms of chemical structures or metabolic pathway schemes, a valued feature of these volumes. Other strong points of the text are the timeliness of cited references, detailed subject index, and the generous use of tables, figures, headings, and subheadings throughout the chapters. The content of the chapters follows a logical progression of test information ending with the available clinical results, therapeutic uses, and potential side effects. Many chapters finish with a summary or conclusion section. Within many of the chapters of this volume and earlier members of this series, a section headed “Chemistry” is included. However, in this section, one usually finds only the name, physical properties, and physical constants of the titled compound, a n incongruity that might be addressed in future editions. This volume should be a valuable source of information for preclinical and clinical investigators involved with the development of new cardiovascular drugs. The inclusion of the chapter on magnesium aspartate hydrochloride provides a bit of frosting to the cake. The magnesium ion has been receiving increasing attention because of its role in catalysis and modulation of cellular function. This timely account of the cardiovascular pharmacology of the magnesium ion and the therapeutic activity of this agent makes this presentation an appealing finish to the monograph chapters. Robert J. Chorvat Department of Medicinal Chemistry Cardiovascular Diseases Research G. D. Searle and Company Skokie, IL 60077 420 [Journal of Pharmaceutical Sciences Vol. 76, No. 5,May 1987
Practice of High Performance Llquld Chromatography. Edited by H. Engelhardt. Springer-Verlag: Secaucus, NJ. 1986.xii +461 pp. 25 x 17 cm. ISBN 3-540-1 2589-2.$79.00. This book contains 15 chapters, 189 figures and 79 tables and is devoted to applications, equipment and quantitative analysis by liquid chromatography. The following topics are discussed in this monograph: “Liquid Chromatography Equipment”, “Quantitative Analysis in HPLC”, “Preparative Applications of HPLC”, “Column Switching”, “Sample Pretreatment and Cleanup”, “Liquidliquid Chromatography”, “Ion Pair Liquid Chromatography”, “Applications of HPLC in Inorganic Chemistry”, “HPLC in Forensic Chemistry”, “Applications of HPLC to the Separation of Lipids”, “Applications of HPLC to the Separation of Metabolites of Nucleic Acids in Physiological Fluids”, “Applications of HPLC to the Analysis of Natural and Synthetic Pharmaceutially Important Drugs”, “Application of HPLC for Analysis of Psychotropic Drugs in Body Fluids”, “HPLC of Amino Acids and Proteins”, “HPLC in the Separation of Coal and Oil Products”. Overall the book is well written and contains contributions by many recognized scientists. Unfortunately, over 50 percent of the monograph is devoted to applications. In addition many of the topics covered in the first seven chapters may be found in many previously published texts devoted to liquid chromatography. From a liquid chromatographic user’s viewpoint, the chapter devoted to quantitative analysis is the most useful. This chapter should be appealing to both the novice and experienced chromatographer. Nevertheless, each of the chapters contains timely references and updates the reader on advances in a particular field. This treatise on liquid chromatography should be welcomed by biomedical researchers. The authoritative work by each contributor is a definitive asset to the monograph. The book should find use as a reference work for individuals interested in the final eight topics listed above. Lawrence A. Pachla Warner LambertParke Davis Pharmaceutical Research Ann Arbor, MI 48105
Clarke’s lsolatlon and Identification of Drugs. Second edition. Edited by A. C. Moffatt. Pharmaceutical Press: London. 1986. 1248 pp. 24.6 x 18.9cm. ISBN 0-85369-166-5.
f88.00. The first edition of “Clarke” appeared as two volumes published in 1969 and 1975 and quickly established itself as both a practical manual and standard reference work in the area of drug isolation and identification. The second edition has been completely revised and expanded and is now published as a single volume under the overall editorial direction of Dr. Tony Moffatt, a pharmacist and pharmaceutical scientist by training who is now the Assistant Director of the Home Office Forensic Science Laboratory in the United Kingdom. Moffatt and his editorial collaborators are to be congratulated on putting together a comprehensive text
New Cardiovascular Drugs 1986. Edited by Alexander Scriabine. Raven Press: New York. 1986.xi + 274 pp. 16 x 24 cm. ISBN 0-88167-209-2. $65.00. This book is the fourth of a series New Drugs Annual: Cardiovascular Drugs, and is composed of 14 chapters, 13 of which are monographs on new drugs. The final chapter is a brief, though provocative commentary on the role of advisory committees in the drug approval process with some suggestions on increasing the effectiveness of these groups. As in earlier editions of this series, the reviewed drugs are classified according to major therapeutic uses which vary from volume to volume. In this particular instance, the uses include antihypertensive drugs (terazosin, carteolol), cardiac stimulants (alfedrine, enoximone, imazodan), antiarrhythmics (cibenzoline, asocainol, mexiletine), antithrombotics (nafazatrom, soluctidil) and cardioprotectives (iloprost, OKY-1581,magnesium asparate hydrochloride). The information presented covers pharmacology (and electrophysiology where appropriate), toxicology, metabolism, pharmacokinetics, and clinical studies. In many instances a discussion of the mechanism of action of the drug is included in the chapter. The review of the pharmacology of the agents is quite comprehensive with a n adequate number of figures and graphs in each chapter depicting various dose response characteristics. It is always of interest to see the pharmacological data which led to the identification of each of these agents as clinical candidates. This is especially true of those compounds with more contemporary cardiovascular actions such as the “cardioprotectives”; in this case newer approaches to establish efficacy are described. The metabolism of these agents, when known, is often presented in terms of chemical structures or metabolic pathway schemes, a valued feature of these volumes. Other strong points of the text are the timeliness of cited references, detailed subject index, and the generous use of tables, figures, headings, and subheadings throughout the chapters. The content of the chapters follows a logical progression of test information ending with the available clinical results, therapeutic uses, and potential side effects. Many chapters finish with a summary or conclusion section. Within many of the chapters of this volume and earlier members of this series, a section headed “Chemistry” is included. However, in this section, one usually finds only the name, physical properties, and physical constants of the titled compound, a n incongruity that might be addressed in future editions. This volume should be a valuable source of information for preclinical and clinical investigators involved with the development of new cardiovascular drugs. The inclusion of the chapter on magnesium aspartate hydrochloride provides a bit of frosting to the cake. The magnesium ion has been receiving increasing attention because of its role in catalysis and modulation of cellular function. This timely account of the cardiovascular pharmacology of the magnesium ion and the therapeutic activity of this agent makes this presentation an appealing finish to the monograph chapters. Robert J. Chorvat Department of Medicinal Chemistry Cardiovascular Diseases Research G. D. Searle and Company Skokie, IL 60077 420 [Journal of Pharmaceutical Sciences Vol. 76, No. 5,May 1987
Practice of High Performance Llquld Chromatography. Edited by H. Engelhardt. Springer-Verlag: Secaucus, NJ. 1986.xii +461 pp. 25 x 17 cm. ISBN 3-540-1 2589-2.$79.00. This book contains 15 chapters, 189 figures and 79 tables and is devoted to applications, equipment and quantitative analysis by liquid chromatography. The following topics are discussed in this monograph: “Liquid Chromatography Equipment”, “Quantitative Analysis in HPLC”, “Preparative Applications of HPLC”, “Column Switching”, “Sample Pretreatment and Cleanup”, “Liquidliquid Chromatography”, “Ion Pair Liquid Chromatography”, “Applications of HPLC in Inorganic Chemistry”, “HPLC in Forensic Chemistry”, “Applications of HPLC to the Separation of Lipids”, “Applications of HPLC to the Separation of Metabolites of Nucleic Acids in Physiological Fluids”, “Applications of HPLC to the Analysis of Natural and Synthetic Pharmaceutially Important Drugs”, “Application of HPLC for Analysis of Psychotropic Drugs in Body Fluids”, “HPLC of Amino Acids and Proteins”, “HPLC in the Separation of Coal and Oil Products”. Overall the book is well written and contains contributions by many recognized scientists. Unfortunately, over 50 percent of the monograph is devoted to applications. In addition many of the topics covered in the first seven chapters may be found in many previously published texts devoted to liquid chromatography. From a liquid chromatographic user’s viewpoint, the chapter devoted to quantitative analysis is the most useful. This chapter should be appealing to both the novice and experienced chromatographer. Nevertheless, each of the chapters contains timely references and updates the reader on advances in a particular field. This treatise on liquid chromatography should be welcomed by biomedical researchers. The authoritative work by each contributor is a definitive asset to the monograph. The book should find use as a reference work for individuals interested in the final eight topics listed above. Lawrence A. Pachla Warner LambertParke Davis Pharmaceutical Research Ann Arbor, MI 48105
Clarke’s lsolatlon and Identification of Drugs. Second edition. Edited by A. C. Moffatt. Pharmaceutical Press: London. 1986. 1248 pp. 24.6 x 18.9cm. ISBN 0-85369-166-5.
f88.00. The first edition of “Clarke” appeared as two volumes published in 1969 and 1975 and quickly established itself as both a practical manual and standard reference work in the area of drug isolation and identification. The second edition has been completely revised and expanded and is now published as a single volume under the overall editorial direction of Dr. Tony Moffatt, a pharmacist and pharmaceutical scientist by training who is now the Assistant Director of the Home Office Forensic Science Laboratory in the United Kingdom. Moffatt and his editorial collaborators are to be congratulated on putting together a comprehensive text