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New diagnostic method for hepatic steatosis using attenuation measurement by ultrasound B mode
Abstracts Hospital das Clinicas - School of Medicine - S~ ao Paulo - Brazil, Sao Paulo, SP, Brazil Endometriosis is characterized by the growth of endometrial tissue outside the uterine cavity. The standard gold diagnosis for endometriosis is the surgery. For surgical planning, the imaging diagnosis is fundamental to obtain complete excision and patient’s treatment. The transvaginal ultrasounds after bowel preparation should be the first line in the diagnosis and endometriosis staging. The hiperechoic uterus serosa must be seen intact. Looking for pelvic adhesions, the ovary often is fixed to the uterus. Vaginal gel before the exam helps to detect small lesions. Intestinal Lesions: perform after bowel preparation, provide the lesions size, wall layers infiltration degree, circumference of bowel involvement and the distance from the anal verge to the inferior lesion margin. Bladder: minimal amount of urine in the bladder to study the vesical wall. The aim of this study is to describe and illustrate radiologic signs, surgery and pathologic correlations of deep endometriosis, from a reference Center, presenting a pre surgical protocol study using ultrasound technique. References: 1. Findings of pelvic endometriosis at transvaginal US, MR imaging, and laparoscopy. Chamie LP, Blasbalg R, Pereira RM, Warmbrand G, Serafini PC. Radiographics. 2011 Jul-Aug;31(4):E77-100. doi: 10.1148/rg.314105193. 2. Transvaginal US after bowel preparation for deeply infiltrating endometriosis: protocol, imaging appearances, and laparoscopic correlation. Chamie LP, Pereira RM, Zanatta A, Serafini PC. Radiographics. 2010 Sep;30(5):1235-49. doi: 10.1148/rg.305095221.
Cardiac subtle dysfunction has already begun in young adults with Prader-Willi syndrome Sayuki Kobayashi,1 Akiko Hayashi,1 Ayako Higashi,1 Syu Inami,2 Jun Tanaka,3 Noriko Kimura,1 Yoshihiko Sakai,1 Isao Taguchi,1 Hiroyuki Toide1 1 Dokkyo Medical University, Saitama Medical Center, Minamikoshigaya, Saitama, Japan, 2 Cardiovascular Medicine, Dokkyo Medical University University Hospital, Kitakobayashi, Mibumachi, Shimotsuga-gun, Tochigi, Japan, 3 Cardiology, Mitsui Memorial Hospital, Kanda-Izumi-cho, Chiyoda-ku, Tokyo, Japan Objective: Prader-Willi syndrome (PWS) is a genetic disorder that affects 1 in 10,000 and 30,000 people. It seems to be associated with a high incidence of sudden death. The purpose of this study is to estimate clinical characteristics and cardiac function by echocardiography in adults with PWS. Methods: Participants were seventeen patients with PWS, without cardiovascular diseases in the past. To estimate cardiac function, left ventricular ejection fraction (LVEF), global longitudinal systolic strain (GLS), the ratio of mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (E/e’ ratio), mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE) were obtained by standard and tissue Doppler echocardiography. Results: In this study, mean age was 27 § 16 years, male were 11 cases and mean body mass index 45.1kg/m2. Hyperlipidemia, diabetes mellitus and hypertension were found in most cases. In cardiac function, mean LVEF showed normal values (61 § 5%), E/e’ was 9 § 2, whereas, GLS was decreased ( 13.7 § 4.8%) and MAPSE showed 12 § 3.0 mm. Mean value of TAPSE showed normal lower limit (17 § 5 mm). Conclusion: It seems that cardiac subtle dysfunction has already begun in patients of PWS in young adults.
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Estimation of echocardiography and biomarkers for the prediction of cardiotoxicity in patients with treated with trastuzumab Jun Tanaka,1 Sayuki Kobayashi,2 Akiko Hayashi,2 Ayako Higashi,2 Shu Inami,3 Yuuri Koshikawa,2 Hiroyuki Toide,2 Noriko Kimura,2 Yoshihiko Sakai,2 Isao Taguchi2 1 Cardiology, Mitsui Memorial Hospital, Kanda-Izumi-cho, Chiyodaku, Tokyo, Japan, 2 Dokkyo Medical University, Saitama Medical Center, Minamikoshigaya, Saitama, Japan, 3 Cardiovascular Medicine, Dokkyo Medical University University Hospital, Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan Publish consent withheld
New diagnostic method for hepatic steatosis using attenuation measurement by ultrasound B mode Yohei Koizumi, Masashi Hirooka, Takaaki Tanaka, Kotarou Sunago, Atsushi Yukimoto, Yuusuke Imai, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa Ehime University Graduate School of Medicine, Toon City, Ehime, Japan Purpose: We have developed a diagnostic technique to evaluate hepatic steatosis using the attenuation coefficient (ATT) on ultrasound B mode. A controlled attenuation parameter (CAP) by vibration-controlled transient elastography (VCTE) has also been used to evaluate hepatic steatosis. As that method uses ultrasound A mode, visualizing the liver in real time is difficult. We planned this clinical study to evaluate the diagnostic advantage of our technique using ATT compared with CAP. Materials and Methods: All participants provided written informed consent, and study protocols were approved by the institutional ethics committee. Liver biopsy had been performed for 94 patients with nonalcoholic fatty liver disease, and at the same time we evaluated ATT and CAP. An M-probe was used for CAP measurement. Data from ATT and CAP were compared with steatosis grade from liver specimens. Results: ATT was measured in all cases. Areas under the receiver operating characteristic curve (AUC-ROCs) for S1 were 0.74 and 0.81 for ATT and CAP, respectively. AUC-ROCs for S2 were 0.80 and 0.85, and for S3 were 0.96 and 0.98, respectively. ATT measurement can evaluate hepatic steatosis compared with histology, offering similar diagnostic strength to CAP measurement. No significant differences between ATT and CAP were observed, but evaluation on ultrasound B mode is convenient and quick, especially for patients with subcutaneous fat thickness 2 cm. Conclusion: New diagnostic techniques using ATT allow similar evaluation of hepatic steatosis to CAP, and evaluation is quicker and more convenient in ultrasound B mode than in ultrasound A mode. Validation trial to diagnose liver tumors by LI-RADS criteria Yohei Koizumi, Masashi Hirooka, Takaaki Tanaka, Kotarou Sunago, Atsushi Yukimoto, Yuusuke Imai, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa Ehime University Graduate School of Medicine, Toon City, Ehime, Japan Background and Aims: LI-RADSÒ was created to standardize the reporting and data collection of CT and MR imaging for hepatocellular carcinoma (HCC). Recently, LI-RADS was gained attention because LI-RADS are consistent with and integrated into the American
Cardiac subtle dysfunction has already begun in young adults with Prader-Willi syndrome Sayuki Kobayashi,1 Akiko Hayashi,1 Ayako Higashi,1 Syu Inami,2 Jun Tanaka,3 Noriko Kimura,1 Yoshihiko Sakai,1 Isao Taguchi,1 Hiroyuki Toide1 1 Dokkyo Medical University, Saitama Medical Center, Minamikoshigaya, Saitama, Japan, 2 Cardiovascular Medicine, Dokkyo Medical University University Hospital, Kitakobayashi, Mibumachi, Shimotsuga-gun, Tochigi, Japan, 3 Cardiology, Mitsui Memorial Hospital, Kanda-Izumi-cho, Chiyoda-ku, Tokyo, Japan Objective: Prader-Willi syndrome (PWS) is a genetic disorder that affects 1 in 10,000 and 30,000 people. It seems to be associated with a high incidence of sudden death. The purpose of this study is to estimate clinical characteristics and cardiac function by echocardiography in adults with PWS. Methods: Participants were seventeen patients with PWS, without cardiovascular diseases in the past. To estimate cardiac function, left ventricular ejection fraction (LVEF), global longitudinal systolic strain (GLS), the ratio of mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (E/e’ ratio), mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE) were obtained by standard and tissue Doppler echocardiography. Results: In this study, mean age was 27 § 16 years, male were 11 cases and mean body mass index 45.1kg/m2. Hyperlipidemia, diabetes mellitus and hypertension were found in most cases. In cardiac function, mean LVEF showed normal values (61 § 5%), E/e’ was 9 § 2, whereas, GLS was decreased ( 13.7 § 4.8%) and MAPSE showed 12 § 3.0 mm. Mean value of TAPSE showed normal lower limit (17 § 5 mm). Conclusion: It seems that cardiac subtle dysfunction has already begun in patients of PWS in young adults.
S101
Estimation of echocardiography and biomarkers for the prediction of cardiotoxicity in patients with treated with trastuzumab Jun Tanaka,1 Sayuki Kobayashi,2 Akiko Hayashi,2 Ayako Higashi,2 Shu Inami,3 Yuuri Koshikawa,2 Hiroyuki Toide,2 Noriko Kimura,2 Yoshihiko Sakai,2 Isao Taguchi2 1 Cardiology, Mitsui Memorial Hospital, Kanda-Izumi-cho, Chiyodaku, Tokyo, Japan, 2 Dokkyo Medical University, Saitama Medical Center, Minamikoshigaya, Saitama, Japan, 3 Cardiovascular Medicine, Dokkyo Medical University University Hospital, Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi, Japan Publish consent withheld
New diagnostic method for hepatic steatosis using attenuation measurement by ultrasound B mode Yohei Koizumi, Masashi Hirooka, Takaaki Tanaka, Kotarou Sunago, Atsushi Yukimoto, Yuusuke Imai, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa Ehime University Graduate School of Medicine, Toon City, Ehime, Japan Purpose: We have developed a diagnostic technique to evaluate hepatic steatosis using the attenuation coefficient (ATT) on ultrasound B mode. A controlled attenuation parameter (CAP) by vibration-controlled transient elastography (VCTE) has also been used to evaluate hepatic steatosis. As that method uses ultrasound A mode, visualizing the liver in real time is difficult. We planned this clinical study to evaluate the diagnostic advantage of our technique using ATT compared with CAP. Materials and Methods: All participants provided written informed consent, and study protocols were approved by the institutional ethics committee. Liver biopsy had been performed for 94 patients with nonalcoholic fatty liver disease, and at the same time we evaluated ATT and CAP. An M-probe was used for CAP measurement. Data from ATT and CAP were compared with steatosis grade from liver specimens. Results: ATT was measured in all cases. Areas under the receiver operating characteristic curve (AUC-ROCs) for S1 were 0.74 and 0.81 for ATT and CAP, respectively. AUC-ROCs for S2 were 0.80 and 0.85, and for S3 were 0.96 and 0.98, respectively. ATT measurement can evaluate hepatic steatosis compared with histology, offering similar diagnostic strength to CAP measurement. No significant differences between ATT and CAP were observed, but evaluation on ultrasound B mode is convenient and quick, especially for patients with subcutaneous fat thickness 2 cm. Conclusion: New diagnostic techniques using ATT allow similar evaluation of hepatic steatosis to CAP, and evaluation is quicker and more convenient in ultrasound B mode than in ultrasound A mode. Validation trial to diagnose liver tumors by LI-RADS criteria Yohei Koizumi, Masashi Hirooka, Takaaki Tanaka, Kotarou Sunago, Atsushi Yukimoto, Yuusuke Imai, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa Ehime University Graduate School of Medicine, Toon City, Ehime, Japan Background and Aims: LI-RADSÒ was created to standardize the reporting and data collection of CT and MR imaging for hepatocellular carcinoma (HCC). Recently, LI-RADS was gained attention because LI-RADS are consistent with and integrated into the American