New peptone treatment in asthma and other allergies

New peptone treatment in asthma and other allergies

In reply, Dr. Jacqnelin stated that in his experience of the propos& method he had never observed severe reactions, and t,hat he saw no apparent reaso...

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In reply, Dr. Jacqnelin stated that in his experience of the propos& method he had never observed severe reactions, and t,hat he saw no apparent reason why a nasal autoserum therapy should provoke any reaction comparable to one that might be elicited by the introduction of allergens into the mucosa.

eptone Treatment

in Asthma and

ther Allergies.

dnld,

A. G-.:

Lancet 223 : 67, 1932. A new peptone treatment is advocated, i. e.: Witte’s new peptoze used in a 5 per cent solution, intramuscularly, together with a 5 per cent solut,ion of propeptan, preferable wheat propeptan. The author considers that a good many failures in peptone treatnmnt may be due t,o (1) wrong dosage, (2) failure to give a second or a third Care is conrse, (3) the nonproduction of a mild pyrogenic reaction. taken to differentiate between this reaction and so-called ” prorein shock.” The mild pyrogenic reaction may be obtained with serum peptone or a small dose of typhoid vaccine intravenously, after which the peptone treatment may often be continued with great success The making of serum peptone has been described in a previous COK:Imnnication. The author recently has been using the serum of patients (convalescent serum) who after a long course of peptone treatment have recovered apparently good healt,h. For t,he treatment of severe cases, this serum first used plain and then mixed with peptone is reported t,o give good results. A case report is given in which a paCent is injected intravenously (5 C.C. to 40 cc.) for three weeks with convalescent serum. The serum was then incubated with the new peptone (“Peptone Special 30” manufactured by Witte in colla.boration with a German University and devoid of the toxic effects 02 his ordinary pcptone) and injected int,ramuscularly for several weeks, together with wheat peptone. The patient was practically eured of a prolonged. and severe asthma. Satisfactory results have been obtained in other eases. The author also advocates the use of peptone in eases of hay fever and migraine.

iscussion on Specific and Nonspecific

Desensitization

in

eases. Proc. Royal Sot. Med. 25: 1449. 1932. B. H. OGeZ.-Asthma is not to be considered as synonymous with allergy. asthma is a symptom, and a certain proportion of the cases can be shown to depend upon allergy. Treatment may be specific or nonspecific. Specific desensitization can be successful only with one protein at a time ; nonspecific desensitization seems to affect all sensitiza,tion. For nonspecific therapy, various substances have been used : peptone: tuberculin, injections of sulphur, typhoid-paratyphoid WCtine, etc. The results, while undoubtedly beneficial in many cases. ace rarely permanent. Restriction between allergic asthma and other forms of asthma. can