News and developments

NEWS AND DEVELOPMENTS

IiT'H EXCHANGE

OF __

VISITS -.-----

OF --

INVESTIGATORS (_------__-----

1i-jHIOLOGICAL ----------

PSYCHIATRY --_-------

Place/Date: S!?&!%!?r_?:

Capri/Naples, Italy, September 27-30, 1985 World Health Organization (WHO) Istituto di Psicologia Medica e Psichiatria, Universita di Napoli, Naples, Italy Instituto Farmacologia e di Neurofarmacologia, di Centro Universita di tlilano, Milan, Italy Farmacognosia,

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1.

Introduction

2 .

Research

Activities

Reviews of Completed Studies Of: of Dexamethasone Suppression Test as a Bilogical Indicator Usage Depressive Illness Lead Centre: Epsom Budapest, Casablanca, Copenhagen, Hasel, Hrussels, Participating Centres: Irvine, Lucknow, Moscow, Munich, Nagasaki, Sapporo, Utrecht Epsom, Comparison of Oral and Intravenous Treatment of Depressive Illness 2.1.2. Lead Centre: Hasel Easel, Bombay, Copenhagen, Lucknow, Moscow, Nayasaki, Participating Centres: Sapporo, Zagreb of Narcotic Antagonist Naloxone on Symptoms of Schizophrenia 2.1..3. Effects - Phase II Lead Centre: Bethesda Bethesda, Lucknow, Moscow, Munich, Sapporo, Utrecht Participating Centres: to Ijiological Studies of Alcohol Dependence Syndrome with Reference 2.1.4. Ethnic Differences Lead Centre: Sapporo Hasel, Bern, Brussels, Participating Centrea: Casablanca, Irvine, Lucknow, Mexico City, Moscow, Quebec City, Sapporo 2.1. 2.1.1.

2.2. 2.2.1

Review of Developments in the Data Collection Phase Since Last Evaluation of Optimal Doses of a Neuroleptic by Measurement Haloperidol Levels -- Phase I Lead Centre: Irvine Participating Centres: Brussels, Casablanca, Irvine, Luclrnow, Munich, Sapporo

.

2.3. 2.9.1.

Meeting of Blood

Moscow,

Reviews of Collaborative Studies in the Preparatory Phase Research in Chronobiology of Affective Disorders - Value of EEG Sleep Abnormalities a~ Hilogical Markers of Depressive Illness Lead Centre: Hrussels Participating Centres: Athens, Brussels, Copenhagen, Irvine, Lucknow, Mexico City, Munich, Milan/Naples, Sapporo, Tokyo, Zagreb 2.3.2. Biological Markers of Violent and Non-Violent Suicidal Behaviour Lead Centre: Brussels Participating Centres: Hasel, Brussels, Copenhagen, Lucknow, Milan/Naples, Utrecht 2.3.3. Validity of Imipramine Platelets Hinding Sites as P Biological Marker of Endogenous Depression Lead Centre: Copenhagen Participating Centres: fAthens, Basel, Brussels, Copenhagen, Irvine, Lucknow,

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xviii

News and developments

Moscow, IL.3. 4 .

Munich, Milan/Naples, F'aris, Tokyo Hole of Hereditary, Clinical and Pharmacokinetic Factors for the t'rediction of Lithium Prophylactic Effect i%r;COW Lead Centre: F'articipating Centres: BrcrsselE;, Lucknow, Moscow, Munich, Milan/Naples, Sapporo 2 . 7;. 5 ~ Acute and f+ophylactic Treatment of Manic Depressive F'atients with Carbamarepine L.ead Centre: 1 r v in e Irvine, Participating Centres: Brussels, Lucknow, Montreal, Moscow, MilarriNaplea, New York, Sapporo, 'roC:yo, Zagreb 2 . ;I.. & . Evaluation o+ Light Therapy as Antidepressant 'Treatment of Depression Lead CelltreE Brussels F'articipating Centr-es: ~~rus~el 5, Lasablanca, Irvine, Lucknow, Montreal, Mt.tni ch , Sapper-o, Zagreb ;i. ‘>_\ . ‘;i~ Evaluation of Haloperidol Decanoate irl the F'revention of Relapse in SctIirophrellic Vatinets - F'hase II Irvine Lead Centre: F:'articipatlng iior-1:

Centr-es:

Ecrussels,

Casablanca,

Irvine,

LIJcknow,

Moscow,

New

2 . 4 .

F'roposals for Joint Collaborative Studies F'harmacother-apy o-f Depr-ession in the Elderly Milan/Naples Lead Centrr: Epsom, Lucknow, F'articipatil,g ...entres. AthenS, 8as;eJ. , Copenhagen, New York, i%.tnicl7, Milan/Naples, Sapporo, i:i .t. y g Mon,tlr e,: 7 Moscow, Zagreb 2 ” ii. . 1,:” Study on Hormonal Nar-ker5 of Substance Use Disorders /L~+c$dCent r-ecs: Utrecht and !kebec (.;ity :.. 4 ~ 2;~ Evoked F'oterltial 'l.o~ogr-aphv and Response to Haloperidol lrv-1rte ILead Centre: 2:" i,. 4 ~ Comparative Study on Amitr-iptyline Blood Levels and EC-1 I..~>adCentre: Laqreb '1.' 4.~ 1 . _”

. Cl-Cher F'roposal5 .ii . II: >.J .I 1. .I yramine Con ruqation Deficit ./ r: ‘ ,; L ” >__I 1.. Iv-jvestigation wj th Concordant

Mexico Tokyo,

::: II 5

in Depression as a 'r'rait-Marker and Discordant Monozygotic .I'wins

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forthcominy .I'he participatrts of: .the meeting were informed about the lraininq Seminarin I~'aychoph"rrnacology for South East FIsian Countries to WHc7 be held in Uhaka, Bangladesh, from October21 to November 2, 1985. -y” '7 ,>. for Standardized Assessment Training Courses will be organized ._I .L” I..L WHO in the WHW collaborative studies on: pa-ticipating investigztors Clinical and F%armacokinetic Factors for the F'rediction -- Role o-f Hereditary, of Lithium F'rophylactic Effect -- F'harmaco-therapy of Depressionin the Elderly. :g . 2

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l'raveLli.nq Seminar on Biological F'Sychiatry and Psychopharmacology It was decided to organize a I’Jth lravelling Seminar on Biological Psychiatry 1986. This from November J .to 6, and F~'sychopharmacology in Ca~.ro, Egypt, Ai n Ukasha at the Department of Psychiatry, will be hosted by Professor A. Shams I.Jnivers:i.%y. 3 _ ‘1. _ 4.

Fellowsjhips

WHO

Scientific

Symposia

News and developments

Review

4.1.

of

Developments

in

xix

1985

Plan of Work for Future Activities 4.2. framework of the possibility of organi i i ng WHO Symposia within the The international meetings (i.e.: the Collegium Internationale forthcoming (CINP) Congress in 1988 and the World Congress of Neuro-Psychopharmacologicum will be e:cplored. Biological F'sychiatry in 1989) E,:change

5.

of

Information

Activities

-- "Hiological Approaches to Mental Health" 5. I.. WHO Newsletter 'The third issue (Vol. 2, No. 1, 1985) of the WHO Newsletter - Biological Approaches to Mental Health -- have appeared in the Journal F'rogress in NeuroF'sychopharmacology and Biological F'sychiatry Vol. 9, No. 3, 1985. participants at the meeting emphasized the importance of the Newsletter 'The network. a channel for disseminating information about activities of the i3S that the actual functioning of the Newsletter is not W.3S also felt It four satisfactory and efforts will be made to bring out three to completely issues per year-. 5.

2.

WHO Expert Series in Biological Psychiatry the already been prepared by the Munich centre 011 manuscripts have Following topics: -.-Treatment with Depot Neuroleptics -- Tat-dive Dyskinesia. suggestions are awaited from members of the editorial board Comments and before submitting them for publication. that the monograph on UST (see 2.1.1.) could come as r7 -third It was suggested volume in these series. Other- topics suggested were: -- Eciological Markers in Psychiatry - Psychiatry and Immunology - Neuroendocrinology in Aging and Dementia - Biological and 'Therapeutical nspects of Anxiety - Nontropic Drugs. The outlines of these subjects should be sent to WHO/HO for consideration and discussion.

Two

6.

General

Issue

of WHO collaborating centres expressed concern abou-t the .-rh e heads limited time allowed for each meeting and discussed ways and means of utilizing resources in collaborative activities. centres' It wc3s agreed that - the duration of future meetings should be five working days - data collection phase could be carried out simultaneously for not more than si): studies - P Lead Centre should not carry out simultaneously more than four studies in the data collection phase. Controversial issues and unresolved problems in psychiatry were also discussed by the heads of the centres. 7.

Ne,:t Meeting

The participants welcomed Professor Exchange of Visits of Investigators Greece, from October 27 to 91, 1986. 8.

List

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Annexes

Annex

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II

- List of - Agenda

Participants

Anne:< Annex

I I I

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Work

Plan

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Stefanis' invitation to hold the 12th in Biological Psychiatry in Athens,

News and developments

xx

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xxi