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Nicolau syndrome after glatiramer acetate injection
Med Clin (Barc). 2015;145(12):e41
www.elsevier.es/medicinaclinica
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Nicolau syndrome after glatiramer acetate injection夽 Síndrome de Nicolau tras inyección de acetato de glatirámero Alejandro Lobato-Berezo ∗ , Marcela Martínez-Pérez, Adrián Imbernón-Moya Miguel Ángel Gallego-Valdés Departamento de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain
Fig. 1.
Nicolau syndrome is a rare vascular disease, occurring after injection of a drug, usually intramuscular. We report the case of a 32 year old woman with relapsing-remitting multiple sclerosis treated with intramuscular injections of glatiramer acetate who, after the last injection in abdomen, showed an ill-defined large plate in right hypochondriac region and flank of the mesogastrio, purplish color and infiltrated when touching (Fig. 1). Skin biopsy revealed epidermal changes and leukocytoclastic vasculitis with eosinophil isolated, indicative of toxicoderma plus lobular panniculitis with fat necrosis.
夽 Please cite this article as: Lobato-Berezo A, Martínez-Pérez M, Imbernón-Moya A, Gallego-Valdés MÁ. Síndrome de Nicolau tras inyección de acetato de glatirámero. Med Clin (Barc). 2015;145:e41. ∗ Corresponding author. E-mail address: [email protected] (A. Lobato-Berezo). ˜ S.L.U. All rights reserved. 2387-0206/© 2015 Elsevier Espana,
www.elsevier.es/medicinaclinica
Image of the week
Nicolau syndrome after glatiramer acetate injection夽 Síndrome de Nicolau tras inyección de acetato de glatirámero Alejandro Lobato-Berezo ∗ , Marcela Martínez-Pérez, Adrián Imbernón-Moya Miguel Ángel Gallego-Valdés Departamento de Dermatología, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain
Fig. 1.
Nicolau syndrome is a rare vascular disease, occurring after injection of a drug, usually intramuscular. We report the case of a 32 year old woman with relapsing-remitting multiple sclerosis treated with intramuscular injections of glatiramer acetate who, after the last injection in abdomen, showed an ill-defined large plate in right hypochondriac region and flank of the mesogastrio, purplish color and infiltrated when touching (Fig. 1). Skin biopsy revealed epidermal changes and leukocytoclastic vasculitis with eosinophil isolated, indicative of toxicoderma plus lobular panniculitis with fat necrosis.
夽 Please cite this article as: Lobato-Berezo A, Martínez-Pérez M, Imbernón-Moya A, Gallego-Valdés MÁ. Síndrome de Nicolau tras inyección de acetato de glatirámero. Med Clin (Barc). 2015;145:e41. ∗ Corresponding author. E-mail address: [email protected] (A. Lobato-Berezo). ˜ S.L.U. All rights reserved. 2387-0206/© 2015 Elsevier Espana,