Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global ischemia

Neuroscience Letters, 156 (1993) 121 © Elsevier Scientific Publishers Ireland Ltd. All rights reserved 0304-3940/93/$ 06.00

121

ERRATUM

Takakura, S., Sogabe, K., Satoh, H., Mori, J., Fujiwara, T., Totsuka, Z., Tokuma, Y. and Kohsaka, M, Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride, Neuroscience Letters, 141 (1992) 199 202. In Table I on page 200, there is an error in one of the references to the footnotes. The correct table has been printed below.

TABLE I E F F E C T S O F NILVADIPINE A N D N I C A R D I P I N E ON F R E E FATTY A C I D L I B E R A T I O N IN T H E I S C H E M I C RAT B R A I N For details of treatment see text. The results are expressed as nmol free acids/g brain and as mean + S.E.M. All FFA levels in control were significantly higher than those of non-ischemia (P < 0.01. Student's t-test). Statistical analysis in ischemic group was performed with D u n n e t t ' s type multiple comparisons. Nonischemia

Palmitic acid Stearicacid Oleicacid Arachidonic acid Docosahexaenoicacid

76 + 24+ 43+ 0+ 6+

10 5 7 0 6

Control

259 + 14++ 2 0 6 + 4 ++ 166+ 6 +÷ 375 +_ 8 ++ 83-+ 6 ++

Nilvadipine (~g/kg) 1

l0

266 _+ 14 203_+ 8 168+ 9 366 + 10 77+ 4

226 + 203_+ 150+ 348 + 79+

Nicardipine (flg/kg)

9 4 4 10 3

100

10

219 _+ 11 202_+ 7 1 4 9 _+ 4 335 + 9** 6 2 + 4**

246 + 199+ 163+ 370 + 73_+

+÷P < 0.01 and **P < 0.01, statistically significant compared with non-ischemia and control, respectively, n -- 6-9.

100 14 4 4 10 4

221 _+ 5 202+8 156+3 354 + 7 83+2