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NMR imaging of normal and abnormal anatomy using a 3000 G permanent magnet imaging system
230
Magnetic Resonance Imaging 0 Volume 1, Number 3, 1982
and after lithium therapy (900 mg per day for ten days) measuring serum lithium levels at therapeutic range (0.5 to 1.4 mEq/liter), the T, values, obtained from the same areas of the brain, were near normal levels (208 f 8.0 msec). One patient with a prelithium level within normal range was proved to have cyclothymic disorder and not bipolar affective disorder. Two patients did not complete the study and they do not have T, postlithium values. This study shows, for the first time in medical literature, a statistically significant difference (p = 0.01) in the behavior of hydrogen protonS in bipolar affective disorders.
Normal and Abnormal Anatomy of Head and Neck on 3000 G Magnet
William Hanffee. UCLA, California Scans were performed on the Fonar 3000 G magnet to include normal and some pathological cases. The normal anatomical details are compared to anatomical sections with particular reference being given to the larynx and neck structures. Factors used in optimizing clinical information will also be discussed.
Applications of Nuclear Magnetic Resonance Scanning to Monitoring Patient Progress: Case Study Reports
Elaine K. Keeler, Ph.D. and Stanley
Weiss, M.D.
FONAR Corporation, 110 Marcus Drive, Melville, New York I1 747, National Institutes of Health, Bethesda, Maryland
The application of nuclear magnetic resonance scanning for the purpose of following both malignant and nonmalignant disease will be discussed using case studies. The response of inflammatory carcinoma of the breast to a regimen of experimental chemotherapy has been monitored for 10 months using NMR scanning. Changes in tumor size, proton density levels within the lesion and T, values have been observed over this period and correlate well with traditional techniques for monitoring progress. The capability for monitoring changes in diseases without the use of invasive techniques or ionizing radiation is an important benefit of NMR scanning. Benign lesions, such as cysts and hematomas have been detected and followed over periods of time without the risk of additional exposure to radiation. A postsurgical hematoma was identified and followed through healing. These innovative uses of NMR effectively demonstrate its use as a safe method for patient monitoring during recovery or therapy.
NMR Imaging of Normal and Abnormal Anatomy Using a 3000 G Permanent Magnet Imaging System
Anthony Giambalvo, Joel Stutman, S. David Smith, Moshe Avnet, Terry Morrone, and Raymond Damadian. FONAR Corporation, 110 Marcus Drive, Melville, New York 11747
NMR images were obtained on a number of adult subjects using a FONAR QED Beta 3000 permanent magnet whole body imaging system. Images were obtained at pulse sequence repetition periods ranging from 0.5 to 1.5 set either using a spin-echo (90°-1 80°) RF pulse sequence or an inversion recovery (1 80°~--90~-180~) RF pulse sequence. The 90°-1800 interpulse spacing is 28 msec in both cases and for inversion recovery scans, 7 = 350 msec. Overall, spin-echo images show excellent spatial resolution, and inversion recovery images show enhanced soft tissue contrast as related to tissue-specific differences in T, relaxation times. This is particularly evident in cases where scans of the same anatomical cross-section were performed using both RF pulse sequences. The images to be presented exhibit highly resolved anatomical detail. For example, in the head, grey/white matter discrimination is very good, and structures such as optic nerve, aqueduct of Sylvius, semicircular canals and carotid arteries are clearly visible; in views of the spine, there is delineation of vertebra and intervertebral discs; and images taken of extremities reveal precise detail of muscular and skeletal anatomy. Clinical cases showing abnormal anatomy will also be presented. Proton Density Images and In Vivo Measurements of Relaxation Time in the Human Brains. Comparison of TI Values in Healthy Volunteer and Cerebrovascular Disease
M. Furuse, K. Saso, Y. Moteki, S. Inao, H. Asai, S. Izawa, and A. Kasai. Department of Neurosurgery, Neurology & Radiology, Nakatsugawa Municipal General Hospital, Nakatsugawa, 508, Japan
Proton density images and changes in relaxation time were studied in the human brains of both healthy and pathologic situations using dual modes FONAR QED 80 alpha system. Applying the procedure of anatomy mode by reconstruction technique, distribution of proton density was imaged under the conditions of approximately 400 G in static magnetic field strength. This image was directed, as well as to observe the attitude of proton density distribution, to determine the exact location of measuring points on spin-lattice relaxation time, T,. The values of T, were measured by means of the chemistry mode of magnetic focusing technique.
Magnetic Resonance Imaging 0 Volume 1, Number 3, 1982
and after lithium therapy (900 mg per day for ten days) measuring serum lithium levels at therapeutic range (0.5 to 1.4 mEq/liter), the T, values, obtained from the same areas of the brain, were near normal levels (208 f 8.0 msec). One patient with a prelithium level within normal range was proved to have cyclothymic disorder and not bipolar affective disorder. Two patients did not complete the study and they do not have T, postlithium values. This study shows, for the first time in medical literature, a statistically significant difference (p = 0.01) in the behavior of hydrogen protonS in bipolar affective disorders.
Normal and Abnormal Anatomy of Head and Neck on 3000 G Magnet
William Hanffee. UCLA, California Scans were performed on the Fonar 3000 G magnet to include normal and some pathological cases. The normal anatomical details are compared to anatomical sections with particular reference being given to the larynx and neck structures. Factors used in optimizing clinical information will also be discussed.
Applications of Nuclear Magnetic Resonance Scanning to Monitoring Patient Progress: Case Study Reports
Elaine K. Keeler, Ph.D. and Stanley
Weiss, M.D.
FONAR Corporation, 110 Marcus Drive, Melville, New York I1 747, National Institutes of Health, Bethesda, Maryland
The application of nuclear magnetic resonance scanning for the purpose of following both malignant and nonmalignant disease will be discussed using case studies. The response of inflammatory carcinoma of the breast to a regimen of experimental chemotherapy has been monitored for 10 months using NMR scanning. Changes in tumor size, proton density levels within the lesion and T, values have been observed over this period and correlate well with traditional techniques for monitoring progress. The capability for monitoring changes in diseases without the use of invasive techniques or ionizing radiation is an important benefit of NMR scanning. Benign lesions, such as cysts and hematomas have been detected and followed over periods of time without the risk of additional exposure to radiation. A postsurgical hematoma was identified and followed through healing. These innovative uses of NMR effectively demonstrate its use as a safe method for patient monitoring during recovery or therapy.
NMR Imaging of Normal and Abnormal Anatomy Using a 3000 G Permanent Magnet Imaging System
Anthony Giambalvo, Joel Stutman, S. David Smith, Moshe Avnet, Terry Morrone, and Raymond Damadian. FONAR Corporation, 110 Marcus Drive, Melville, New York 11747
NMR images were obtained on a number of adult subjects using a FONAR QED Beta 3000 permanent magnet whole body imaging system. Images were obtained at pulse sequence repetition periods ranging from 0.5 to 1.5 set either using a spin-echo (90°-1 80°) RF pulse sequence or an inversion recovery (1 80°~--90~-180~) RF pulse sequence. The 90°-1800 interpulse spacing is 28 msec in both cases and for inversion recovery scans, 7 = 350 msec. Overall, spin-echo images show excellent spatial resolution, and inversion recovery images show enhanced soft tissue contrast as related to tissue-specific differences in T, relaxation times. This is particularly evident in cases where scans of the same anatomical cross-section were performed using both RF pulse sequences. The images to be presented exhibit highly resolved anatomical detail. For example, in the head, grey/white matter discrimination is very good, and structures such as optic nerve, aqueduct of Sylvius, semicircular canals and carotid arteries are clearly visible; in views of the spine, there is delineation of vertebra and intervertebral discs; and images taken of extremities reveal precise detail of muscular and skeletal anatomy. Clinical cases showing abnormal anatomy will also be presented. Proton Density Images and In Vivo Measurements of Relaxation Time in the Human Brains. Comparison of TI Values in Healthy Volunteer and Cerebrovascular Disease
M. Furuse, K. Saso, Y. Moteki, S. Inao, H. Asai, S. Izawa, and A. Kasai. Department of Neurosurgery, Neurology & Radiology, Nakatsugawa Municipal General Hospital, Nakatsugawa, 508, Japan
Proton density images and changes in relaxation time were studied in the human brains of both healthy and pathologic situations using dual modes FONAR QED 80 alpha system. Applying the procedure of anatomy mode by reconstruction technique, distribution of proton density was imaged under the conditions of approximately 400 G in static magnetic field strength. This image was directed, as well as to observe the attitude of proton density distribution, to determine the exact location of measuring points on spin-lattice relaxation time, T,. The values of T, were measured by means of the chemistry mode of magnetic focusing technique.