- Email: [email protected]
promethazine, in recreational opioid users
e118
Abstracts / Drug and Alcohol Dependence 171 (2017) e2–e226
and psychiatric disorders. Participants with anxiety disorders were more likely to share needles (AOR: 1.89, 95% CI: 1.17–3.03). Conclusions: Anxiety disorders is associated with needle sharing among cocaine users. Our results suggest a potential role for screening for anxiety disorders as part of preventive interventions to decrease blood-borne viruses’ transmission. Financial support: This work was funded by the Canadian Institute of Health Research grant #207748. Élise Roy holds the Chair in Addiction Research funded by the Charles Lemoyne Hospital Foundation and the University of Sherbrooke Foundation in Québec, Canada. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.327 Health characteristics and sexual risk behaviors among young adult prescription opioid misusers in the club scene: Examining the role of gender Maria A. Levi Minzi ∗ , Mance E. Buttram, Steven P. Kurtz ARSH: Center for Research on Substance Use and Health Disparities, Nova Southeastern University, Miami, FL, United States Aims: Prescription opioids (PO) are the second most popular drug among young adult substance use initiates in the U.S. Few studies have examined the potential negative health consequences of PO misuse among this group. This study sought to document the physical and mental health, and sexual risk behaviors of a sample of PO misusing club drug users; we also aimed to determine the potential association of gender on these health characteristics. Methods: Data were drawn from a behavioral substance use and sexual risk reduction intervention trial with club drug users (n = 498); participants completed baseline comprehensive health and social risk assessments. For this analysis, PO misusers (n = 446) were selected. Results: Mean age of the sample was 25. The majority reported recent good, very good, or excellent physical health (81%). In terms of recent mental health and sex risk, 57% endorsed psychological problems, and 90% reported at least one unprotected vaginal sex act. In bivariate regression models, compared to men, women were more likely to endorse recent: physical pain (p = .015), health problems that kept them from meeting their responsibilities (p = .001), and exhaustion (p = .001). Women had more significant mental health problems: severe mental distress (p = .000), and high levels of trauma (p = .035); women were also more likely to endorse at least one recent unprotected anal sex act (p = .054). Conclusions: Young adult PO misusers in the club scene have mental health problems and engage in risky sex, creating increased susceptibility for STIs. Findings also indicate that female PO misusers were found to be more vulnerable to physical and mental health problems. Further examination of these gender differences is warranted in order to develop interventions to improve the health outcomes among this unique population. Financial support: This research was supported by grant number DA0196048 from the National Institute on Drug Abuse. 324. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.328
No evidence of increased abuse potential of CL-108, a bilayered tablet containing hydrocodone/acetaminophen/promethazine, in recreational opioid users Naama Levy-Cooperman 1,∗ , Megan Shram 1 , Lynn Roy Webster 2 1 2
Altreos Research Partners, Toronto, ON, Canada PRA, Salt Lake City, UT, United States
Aims: CL108 is a novel immediate release (IR) tablet containing 7.5 mg hydrocodone (HYD), 325 mg acetaminophen (APAP) and 12.5 mg rapid-release promethazine (PMZ) under development for treating patients who suffer from moderate to severe pain while preventing opioid induced nausea and vomiting (OINV). The abuse potential of HYD/APAP products is well described, but the potential impact of adding PMZ is unknown. This study evaluated the abuse potential CL108 tablets in nondependent recreational opioid users compared to equivalent doses of HYD/APAP and placebo (PBO). Methods: Following a dose-selection phase, the study utilized a randomized, double-blind, PBO and active-controlled 5-way crossover design. Subjects were recreational opioid users who passed a qualification session to ensure they could distinguish HYD/APAP 30 mg/1300 mg from PBO. Eligible subjects (N = 40) received single doses of CL108 (22.5 mg/975 mg/37.5 mg [low-dose] and 37.5 mg/1625 mg/62.5 mg [high-dose], HYD/APAP (22.5 mg/975 mg and 37.5 mg/1625 mg) and PBO. Subjective measures (e.g., visual analog scales [VAS]) and pupillometry were evaluated for 24 h postdose. Results: Mean peak (Emax ) Drug Liking VAS (primary endpoint) was significantly higher for both doses of HYD/APAP compared to PBO (p ≤ 0.001), confirming study validity. CL108 also showed significantly higher scores on subjective measures and pupillometry compared to PBO. On the majority of subjective measures and pupillometry, comparisons between dose-matched CL108 and HYD/APAP treatments were not statistically different. For both CL108 and HYD/APAP, scores on subjective and objective measures for the high-dose treatments were higher than scores observed for low-dose treatments. All treatments were well tolerated, with most adverse events being mild in severity and consistent with expected side effects. Conclusions: These findings indicate that the addition of PMZ results in no greater abuse potential than the standard HYD/APAP product in the same dosages. Financial support: This study was funded by Charleston Laboratories, Inc. and Daiichi Sankyo. Inc. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.329 Association between working memory, impulsivity and problematic technology use Chris Lewis ∗ , Elizabeth C. Katz Psychology, Towson University, Towson, MD, United States Aims: This study examined whether trait impulsivity and working memory, known predictors of substance use, also influence problematic technology use (i.e., ‘smart’ phone and video game use). It was hypothesized that higher levels of trait impulsivity, combined with working memory deficits, would predict problematic ‘smart’ phone and video game use. Methods: Participants (N = 652) accessed the surveys online through research websites and the research pool at a large midAtlantic university. The survey consisted of the UPPS-P Impulsivity Scale, the Working Memory Questionnaire, The Problematic Use
Abstracts / Drug and Alcohol Dependence 171 (2017) e2–e226
and psychiatric disorders. Participants with anxiety disorders were more likely to share needles (AOR: 1.89, 95% CI: 1.17–3.03). Conclusions: Anxiety disorders is associated with needle sharing among cocaine users. Our results suggest a potential role for screening for anxiety disorders as part of preventive interventions to decrease blood-borne viruses’ transmission. Financial support: This work was funded by the Canadian Institute of Health Research grant #207748. Élise Roy holds the Chair in Addiction Research funded by the Charles Lemoyne Hospital Foundation and the University of Sherbrooke Foundation in Québec, Canada. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.327 Health characteristics and sexual risk behaviors among young adult prescription opioid misusers in the club scene: Examining the role of gender Maria A. Levi Minzi ∗ , Mance E. Buttram, Steven P. Kurtz ARSH: Center for Research on Substance Use and Health Disparities, Nova Southeastern University, Miami, FL, United States Aims: Prescription opioids (PO) are the second most popular drug among young adult substance use initiates in the U.S. Few studies have examined the potential negative health consequences of PO misuse among this group. This study sought to document the physical and mental health, and sexual risk behaviors of a sample of PO misusing club drug users; we also aimed to determine the potential association of gender on these health characteristics. Methods: Data were drawn from a behavioral substance use and sexual risk reduction intervention trial with club drug users (n = 498); participants completed baseline comprehensive health and social risk assessments. For this analysis, PO misusers (n = 446) were selected. Results: Mean age of the sample was 25. The majority reported recent good, very good, or excellent physical health (81%). In terms of recent mental health and sex risk, 57% endorsed psychological problems, and 90% reported at least one unprotected vaginal sex act. In bivariate regression models, compared to men, women were more likely to endorse recent: physical pain (p = .015), health problems that kept them from meeting their responsibilities (p = .001), and exhaustion (p = .001). Women had more significant mental health problems: severe mental distress (p = .000), and high levels of trauma (p = .035); women were also more likely to endorse at least one recent unprotected anal sex act (p = .054). Conclusions: Young adult PO misusers in the club scene have mental health problems and engage in risky sex, creating increased susceptibility for STIs. Findings also indicate that female PO misusers were found to be more vulnerable to physical and mental health problems. Further examination of these gender differences is warranted in order to develop interventions to improve the health outcomes among this unique population. Financial support: This research was supported by grant number DA0196048 from the National Institute on Drug Abuse. 324. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.328
No evidence of increased abuse potential of CL-108, a bilayered tablet containing hydrocodone/acetaminophen/promethazine, in recreational opioid users Naama Levy-Cooperman 1,∗ , Megan Shram 1 , Lynn Roy Webster 2 1 2
Altreos Research Partners, Toronto, ON, Canada PRA, Salt Lake City, UT, United States
Aims: CL108 is a novel immediate release (IR) tablet containing 7.5 mg hydrocodone (HYD), 325 mg acetaminophen (APAP) and 12.5 mg rapid-release promethazine (PMZ) under development for treating patients who suffer from moderate to severe pain while preventing opioid induced nausea and vomiting (OINV). The abuse potential of HYD/APAP products is well described, but the potential impact of adding PMZ is unknown. This study evaluated the abuse potential CL108 tablets in nondependent recreational opioid users compared to equivalent doses of HYD/APAP and placebo (PBO). Methods: Following a dose-selection phase, the study utilized a randomized, double-blind, PBO and active-controlled 5-way crossover design. Subjects were recreational opioid users who passed a qualification session to ensure they could distinguish HYD/APAP 30 mg/1300 mg from PBO. Eligible subjects (N = 40) received single doses of CL108 (22.5 mg/975 mg/37.5 mg [low-dose] and 37.5 mg/1625 mg/62.5 mg [high-dose], HYD/APAP (22.5 mg/975 mg and 37.5 mg/1625 mg) and PBO. Subjective measures (e.g., visual analog scales [VAS]) and pupillometry were evaluated for 24 h postdose. Results: Mean peak (Emax ) Drug Liking VAS (primary endpoint) was significantly higher for both doses of HYD/APAP compared to PBO (p ≤ 0.001), confirming study validity. CL108 also showed significantly higher scores on subjective measures and pupillometry compared to PBO. On the majority of subjective measures and pupillometry, comparisons between dose-matched CL108 and HYD/APAP treatments were not statistically different. For both CL108 and HYD/APAP, scores on subjective and objective measures for the high-dose treatments were higher than scores observed for low-dose treatments. All treatments were well tolerated, with most adverse events being mild in severity and consistent with expected side effects. Conclusions: These findings indicate that the addition of PMZ results in no greater abuse potential than the standard HYD/APAP product in the same dosages. Financial support: This study was funded by Charleston Laboratories, Inc. and Daiichi Sankyo. Inc. http://dx.doi.org/10.1016/j.drugalcdep.2016.08.329 Association between working memory, impulsivity and problematic technology use Chris Lewis ∗ , Elizabeth C. Katz Psychology, Towson University, Towson, MD, United States Aims: This study examined whether trait impulsivity and working memory, known predictors of substance use, also influence problematic technology use (i.e., ‘smart’ phone and video game use). It was hypothesized that higher levels of trait impulsivity, combined with working memory deficits, would predict problematic ‘smart’ phone and video game use. Methods: Participants (N = 652) accessed the surveys online through research websites and the research pool at a large midAtlantic university. The survey consisted of the UPPS-P Impulsivity Scale, the Working Memory Questionnaire, The Problematic Use