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Nodular leukoplakia and squamous cell carcinoma
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Abstracts
nosis of oral lesions enable appropriate treatment, favoring the prognosis, as observed in our case. The immunohistochemical study was fundamental for the differential diagnosis.
THE IMPORTANCE OF PSYCHOLOGICAL INTERVENTION IN PATIENTS WITH EOSINOPHILIC ULCER Soares GR1, Ferreira LL1, Gonçalves GM1, Bernabé DG1, Soubhia AMP2, Biasoli ER1, Miyahara GI1 - 1FACULDADE DE ODONTOLOGIA DE ARAÇATUBA - UNESP - CENTRO DE ONCOLOGIA BUCAL, 2FACULDADE DE ODONTOLOGIA DE ARAÇATUBA - UNESP - PATOLOGIA E PROPEDÊUTICA CLÍNICA Eosinophilic ulcer of the oral mucosa is characterized by an ulcer with raised and hardened edges, rare, which has a benign course and uncertain pathogenesis. The aim of this work is to present a case of eosinophilic ulcer, emphasizing clinical features. A 33-year-old man attended the Oral Oncology Center complaining of ”sore mouth” that had periods of exacerbation and remission. Oroscopy showed two ulcers, one in the right buccal mucosa region and the other one in the left side of the soft palate, measuring 2cm and 4cm in diameter respectively, covered with necrotic tissue and painful to the touch. Biopsy was performed, and the patient was treated with Decadron in mouthwash form and sent for psychological evaluation. The diagnosis was eosinophilic ulcer. The patient is anxious and has family relationship problems. Therefore, he does not attend regularly in both scheduled appointments, dental and psychological.
EXACERBATION OF CENTRAL GIANT CELL LESION AFTER BIOPSY Momesso GAC1, Machado T1, Furuse CF1, Mattar NJ, Demathé A, Miyahara GI1, Biasoli ER1 - 1UNIVERSIDADE PAULISTA JULIO DE MESQUITA FILHO Patient referred to the Oral Oncology Center - UNESP for evaluation and management of a lesion in the lower jaw. He reported the appearance of this lesion for about six months and involved teeth were getting mobility. Oral exam presented submucosal nodular lesion at region of free and inserted gingival was observed in oroscopy, bulging gingivolabial inferior region, involving the premolars affecting until lower right premolars of the opposite side. Biopsy was performed and the histopathological exam was compatible with central giant cell lesion. Blood were normal for parathyroid function. An interesting fact occurred 15 days after the biopsy, the lesion has exacerbated by increasing in size compared to the examination before the biopsy. The new physical exam showed a protuberant lower lip and the lesion was repelled and externalizing it. The patient was treated as soon as immediately after the pre-operative exams got ready and currently is being monitored. Hubácek M, Dostálová T, Bartonová M, Kozák J, Seydlová M. Giant cell reparative granuloma in the mandible case report and review of the literature. Acta Chir Plast. 2008;50(2):59-63. KABAN, L. B.; TROULIS, M. J.; EBB, D.; AUGUST, M.; HORNICEK, F. J.; DODSON, T. B. Antiangiogenic Therapy with Interferon Alpha for giant cell lesions of the jaws. Journal of Oral Maxillofacial Surgery 2002;60:1103-1111. Bahar Sezer, Banu Koyuncu, Murat Gomel, Tayfun Günbay. The Turkish Journal of Pediatrics 2005; 47:75-81. Injeção intralesional de corticosteróides para o granuloma de células gigantes centrais: Relato de caso e revisão de literatura.
LIPID DROPLETS IN SALIVARY CARCINOMAS: AN IM-
October 2012 MUNOHISTOCHEMICAL STUDY Santos HT1, Montalli VAM2, Mariano FV1, Altemani A2 - 1UNIVERSIDADE ESTADUAL DE CAMPINAS - FACULDADE DE ODONTOLOGIA DE PIRACICABA - DIAGNÓSTICO ORAL - PATOLOGIA, 2UNIVERSIDADE ESTADUAL DE CAMPINAS FACULDADE DE CIÊNCIAS MÉDICAS - ANATOMIA PATOLÓGICA Background/objective: To verify the quantity of cytoplasmic lipid droplets (CLDs) in salivary carcinomas due to its association with tumor aggressiveness. Study design: in 68 salivary carcinomas (17 adenoid-cystic, 12 epithelial-myoepithelial, 11 mucoepidermoid, 10 acinic cell, 6 polymorphic low-grade and 5 salivary duct) the CLDs were stained for adipophilin. The quantity of CLDs in tumor cells was classified as absent (0%-5%), focal (⬎5%-50%) and diffuse (⬎50%). Results and conclusion: 11.7% of the carcinomas presented CLDs in more than 50% of tumor cells as follows: myoepithelial (57%), acinic cell (30%) and epithelial-myoepithelial (8.3%). In 53% of the tumors, CLDs were not detected. In acinic cell carcinomas, the increased number of CLDs was associated with vacuolated appearance of the tumor cells. In salivary carcinomas, CLDs are not a common event and its occurrence is not necessarily associated with high grade carcinomas. In acinic cell carcinomas, the upregulated lipogenesis reflects in the tumor morphology.
NODULAR LEUKOPLAKIA AND SQUAMOUS CELL CARCINOMA Lima HG1, Pagin O2, Del Neri NB2, Lara VS1, Santos PSS2 - 1BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO - DEPARTMENT OF STOMATOLOGY, AREA OF PATHOLOGY, 2BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO - DEPARTMENT OF STOMATOLOGY A 66-year-old man reported that a white lesion on inferior lip was previously biopsied, receiving microscopic diagnosis of chronic stomatitis with lichenoid pattern. Our examination revealed a single, non-removable lesion of many white noduli separated by red areas, involving inferior lip, oral commissure and buccal mucosa. Another incisional biopsy was taken on buccal mucosa and microscopic analysis revealed hyperparakeratotic epithelium with surface papillary and mild cytological changes confined to lower third. There were islands of epithelial cells, suggestive of microinvasion or pseudoepitheliomatous hyperplasia. Associated with clinical aspects and history, the final diagnosis was nodular leukoplakia, with malignant transformation, but this was not microscopically conclusive. A second biopsy in three strategic areas evidenced squamous cell carcinoma. This case highlights the importance of selecting the area for biopsy and the interaction between professionals for final diagnosis; moreover it reports a possible nodular leukoplakia, which progressed to a malignant transformation.
ND:YAG LASER TREATMENT OF ORAL HEMANGIOMAS: A DESCRIPTIVE STUDY Henrique IHM1, Andrade SC1, Carvalho AAT1, Fonseca DDD1, Faria ABS1, Gueiros LAM1, Leão JC1 - 1UFPE - PROGRAMA DE PÓS GRADUAÇÃO EM ODONTOLOGIA The aim of the present study was to describe the treatment of oral hemangiomas using Nd:YAG laser. Ten patients (ranging from 36 to 77 years of age, 2 male and 8 females) diagnosed with
e54
Abstracts
nosis of oral lesions enable appropriate treatment, favoring the prognosis, as observed in our case. The immunohistochemical study was fundamental for the differential diagnosis.
THE IMPORTANCE OF PSYCHOLOGICAL INTERVENTION IN PATIENTS WITH EOSINOPHILIC ULCER Soares GR1, Ferreira LL1, Gonçalves GM1, Bernabé DG1, Soubhia AMP2, Biasoli ER1, Miyahara GI1 - 1FACULDADE DE ODONTOLOGIA DE ARAÇATUBA - UNESP - CENTRO DE ONCOLOGIA BUCAL, 2FACULDADE DE ODONTOLOGIA DE ARAÇATUBA - UNESP - PATOLOGIA E PROPEDÊUTICA CLÍNICA Eosinophilic ulcer of the oral mucosa is characterized by an ulcer with raised and hardened edges, rare, which has a benign course and uncertain pathogenesis. The aim of this work is to present a case of eosinophilic ulcer, emphasizing clinical features. A 33-year-old man attended the Oral Oncology Center complaining of ”sore mouth” that had periods of exacerbation and remission. Oroscopy showed two ulcers, one in the right buccal mucosa region and the other one in the left side of the soft palate, measuring 2cm and 4cm in diameter respectively, covered with necrotic tissue and painful to the touch. Biopsy was performed, and the patient was treated with Decadron in mouthwash form and sent for psychological evaluation. The diagnosis was eosinophilic ulcer. The patient is anxious and has family relationship problems. Therefore, he does not attend regularly in both scheduled appointments, dental and psychological.
EXACERBATION OF CENTRAL GIANT CELL LESION AFTER BIOPSY Momesso GAC1, Machado T1, Furuse CF1, Mattar NJ, Demathé A, Miyahara GI1, Biasoli ER1 - 1UNIVERSIDADE PAULISTA JULIO DE MESQUITA FILHO Patient referred to the Oral Oncology Center - UNESP for evaluation and management of a lesion in the lower jaw. He reported the appearance of this lesion for about six months and involved teeth were getting mobility. Oral exam presented submucosal nodular lesion at region of free and inserted gingival was observed in oroscopy, bulging gingivolabial inferior region, involving the premolars affecting until lower right premolars of the opposite side. Biopsy was performed and the histopathological exam was compatible with central giant cell lesion. Blood were normal for parathyroid function. An interesting fact occurred 15 days after the biopsy, the lesion has exacerbated by increasing in size compared to the examination before the biopsy. The new physical exam showed a protuberant lower lip and the lesion was repelled and externalizing it. The patient was treated as soon as immediately after the pre-operative exams got ready and currently is being monitored. Hubácek M, Dostálová T, Bartonová M, Kozák J, Seydlová M. Giant cell reparative granuloma in the mandible case report and review of the literature. Acta Chir Plast. 2008;50(2):59-63. KABAN, L. B.; TROULIS, M. J.; EBB, D.; AUGUST, M.; HORNICEK, F. J.; DODSON, T. B. Antiangiogenic Therapy with Interferon Alpha for giant cell lesions of the jaws. Journal of Oral Maxillofacial Surgery 2002;60:1103-1111. Bahar Sezer, Banu Koyuncu, Murat Gomel, Tayfun Günbay. The Turkish Journal of Pediatrics 2005; 47:75-81. Injeção intralesional de corticosteróides para o granuloma de células gigantes centrais: Relato de caso e revisão de literatura.
LIPID DROPLETS IN SALIVARY CARCINOMAS: AN IM-
October 2012 MUNOHISTOCHEMICAL STUDY Santos HT1, Montalli VAM2, Mariano FV1, Altemani A2 - 1UNIVERSIDADE ESTADUAL DE CAMPINAS - FACULDADE DE ODONTOLOGIA DE PIRACICABA - DIAGNÓSTICO ORAL - PATOLOGIA, 2UNIVERSIDADE ESTADUAL DE CAMPINAS FACULDADE DE CIÊNCIAS MÉDICAS - ANATOMIA PATOLÓGICA Background/objective: To verify the quantity of cytoplasmic lipid droplets (CLDs) in salivary carcinomas due to its association with tumor aggressiveness. Study design: in 68 salivary carcinomas (17 adenoid-cystic, 12 epithelial-myoepithelial, 11 mucoepidermoid, 10 acinic cell, 6 polymorphic low-grade and 5 salivary duct) the CLDs were stained for adipophilin. The quantity of CLDs in tumor cells was classified as absent (0%-5%), focal (⬎5%-50%) and diffuse (⬎50%). Results and conclusion: 11.7% of the carcinomas presented CLDs in more than 50% of tumor cells as follows: myoepithelial (57%), acinic cell (30%) and epithelial-myoepithelial (8.3%). In 53% of the tumors, CLDs were not detected. In acinic cell carcinomas, the increased number of CLDs was associated with vacuolated appearance of the tumor cells. In salivary carcinomas, CLDs are not a common event and its occurrence is not necessarily associated with high grade carcinomas. In acinic cell carcinomas, the upregulated lipogenesis reflects in the tumor morphology.
NODULAR LEUKOPLAKIA AND SQUAMOUS CELL CARCINOMA Lima HG1, Pagin O2, Del Neri NB2, Lara VS1, Santos PSS2 - 1BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO - DEPARTMENT OF STOMATOLOGY, AREA OF PATHOLOGY, 2BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO - DEPARTMENT OF STOMATOLOGY A 66-year-old man reported that a white lesion on inferior lip was previously biopsied, receiving microscopic diagnosis of chronic stomatitis with lichenoid pattern. Our examination revealed a single, non-removable lesion of many white noduli separated by red areas, involving inferior lip, oral commissure and buccal mucosa. Another incisional biopsy was taken on buccal mucosa and microscopic analysis revealed hyperparakeratotic epithelium with surface papillary and mild cytological changes confined to lower third. There were islands of epithelial cells, suggestive of microinvasion or pseudoepitheliomatous hyperplasia. Associated with clinical aspects and history, the final diagnosis was nodular leukoplakia, with malignant transformation, but this was not microscopically conclusive. A second biopsy in three strategic areas evidenced squamous cell carcinoma. This case highlights the importance of selecting the area for biopsy and the interaction between professionals for final diagnosis; moreover it reports a possible nodular leukoplakia, which progressed to a malignant transformation.
ND:YAG LASER TREATMENT OF ORAL HEMANGIOMAS: A DESCRIPTIVE STUDY Henrique IHM1, Andrade SC1, Carvalho AAT1, Fonseca DDD1, Faria ABS1, Gueiros LAM1, Leão JC1 - 1UFPE - PROGRAMA DE PÓS GRADUAÇÃO EM ODONTOLOGIA The aim of the present study was to describe the treatment of oral hemangiomas using Nd:YAG laser. Ten patients (ranging from 36 to 77 years of age, 2 male and 8 females) diagnosed with