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Non-invasive potential “carcinoma” of the cervix
167
ABSTRACTS
of fifty. That is, as compared with normal women in this group almost five times as many had a delayed menopause. He refers to recent reports of delayed menopause in cases of adenocarcinoma of the uterus, suggesting the advisability of artificial x-ray termination of unduly prolonged ovarian activity. Thus Olch arrives at the conclusion that an artificial menopause at some arbitrary age between 48 or S6 might possibly be of prophylactic value against the formation of a mammary cancer. HUGO
Stevenson, Charles Summers and Scipiades, “Carcinoma” of the Cervix, Surg. Gynec.
Elemer, Jr.: Obst.
66: 822,
EHRENFEST.
Non-Invasive
Potential
1938.
Cancer is the second most frequent cause of death in the western world; cancer of the uterus is responsible for one-third of the cancer deaths in women; 90 per cent of uterine cancer arises in the portio of the cervix and is thus easily accessible for examination and study. The most favorable statistics from the treatment of cancer when it is limited to the portio of the cervix show a 52 per cent cure, while not more than 20 per cent of all cervical cancers have a fiveyear cure. Schottlaender and Kermauner (1912) and Schiller (1927) have described and called attention to a form of superficial non-invasive cervical “carcinoma.” Schiller considers and treats it as definite carcinoma. The authors present 18 cases for which one of them (C. S. 8.) has proposed the name ‘ ‘non-invasive potential ‘ carcinoma ’ of the cervix. ” In 1 patient (Case 2) the “carcinoma” remained non-invasive for eight years and one month, following which it developed into a clinical carcinoma and finally caused the death of the patient. A second patient (Case 13) died of pernicious anemia three years after the first biopsy examination revealed a non-invasive potential “carcinoma. ” Serial sections of this cervix revealed that invasion had taken place shortly before death. WM.
Emge, Ludwig A.: The Significance West. J. Surg. 47: 107, 1939.
of Estrogenic
Hormones
C. HENSKE.
in Carcinogenesis,
Certain recent studies of mammary cancer in mice suggest that estrogenic hormones may have a more important part in the mechanism of earcinogenesis than heretofore shown for other hormones. In the light of modern research, it is no longer tenable to .speak of cancer as a single disease, or as having a single cause. The Causes vary with the types of cancer, the organs, and the species. Experiments made by Emge with various doses of estrogenie hormones administered exogenously over different periods of time yielded various degrees of hyperplasia in breast tissue, mammary adenofibromas, and in the linings and glands of the genital tract. Doses of inordinate size resulted in cystic mastoplasias and genital metaplasias, but even with huge superstimulation the resultant hyperplasia of any of these tissues never approached a truly malignant state. The author concludes that on the basis of experimental evidence, the relation of estrogenic hormones to cancer is secondary to, and strictly limited by, hereditary factors. It is entirely unlikely that the estrogenic hormones have a broader car&ogenie significance. However, as a matter of caution, it is wise to watch for unusual occurrences in man because of the comparatively short time since the introduction of estrogenic therapy. HUGO
Sorba, M.: 109:
Syphilis
and Cancer of the Cervix, Monatschr.
f. Geburtsh.
EHRENFEST.
u. Gynlk.
73, 1939.
In the differential are made because statistics revealed
diagnosis between syphilis and cancer of the cervix, errors a biopsy is not done and syphilis is not thought of. Sorba’s that among 262 cases of cancer of the uterine cervix, syphilis
ABSTRACTS
of fifty. That is, as compared with normal women in this group almost five times as many had a delayed menopause. He refers to recent reports of delayed menopause in cases of adenocarcinoma of the uterus, suggesting the advisability of artificial x-ray termination of unduly prolonged ovarian activity. Thus Olch arrives at the conclusion that an artificial menopause at some arbitrary age between 48 or S6 might possibly be of prophylactic value against the formation of a mammary cancer. HUGO
Stevenson, Charles Summers and Scipiades, “Carcinoma” of the Cervix, Surg. Gynec.
Elemer, Jr.: Obst.
66: 822,
EHRENFEST.
Non-Invasive
Potential
1938.
Cancer is the second most frequent cause of death in the western world; cancer of the uterus is responsible for one-third of the cancer deaths in women; 90 per cent of uterine cancer arises in the portio of the cervix and is thus easily accessible for examination and study. The most favorable statistics from the treatment of cancer when it is limited to the portio of the cervix show a 52 per cent cure, while not more than 20 per cent of all cervical cancers have a fiveyear cure. Schottlaender and Kermauner (1912) and Schiller (1927) have described and called attention to a form of superficial non-invasive cervical “carcinoma.” Schiller considers and treats it as definite carcinoma. The authors present 18 cases for which one of them (C. S. 8.) has proposed the name ‘ ‘non-invasive potential ‘ carcinoma ’ of the cervix. ” In 1 patient (Case 2) the “carcinoma” remained non-invasive for eight years and one month, following which it developed into a clinical carcinoma and finally caused the death of the patient. A second patient (Case 13) died of pernicious anemia three years after the first biopsy examination revealed a non-invasive potential “carcinoma. ” Serial sections of this cervix revealed that invasion had taken place shortly before death. WM.
Emge, Ludwig A.: The Significance West. J. Surg. 47: 107, 1939.
of Estrogenic
Hormones
C. HENSKE.
in Carcinogenesis,
Certain recent studies of mammary cancer in mice suggest that estrogenic hormones may have a more important part in the mechanism of earcinogenesis than heretofore shown for other hormones. In the light of modern research, it is no longer tenable to .speak of cancer as a single disease, or as having a single cause. The Causes vary with the types of cancer, the organs, and the species. Experiments made by Emge with various doses of estrogenie hormones administered exogenously over different periods of time yielded various degrees of hyperplasia in breast tissue, mammary adenofibromas, and in the linings and glands of the genital tract. Doses of inordinate size resulted in cystic mastoplasias and genital metaplasias, but even with huge superstimulation the resultant hyperplasia of any of these tissues never approached a truly malignant state. The author concludes that on the basis of experimental evidence, the relation of estrogenic hormones to cancer is secondary to, and strictly limited by, hereditary factors. It is entirely unlikely that the estrogenic hormones have a broader car&ogenie significance. However, as a matter of caution, it is wise to watch for unusual occurrences in man because of the comparatively short time since the introduction of estrogenic therapy. HUGO
Sorba, M.: 109:
Syphilis
and Cancer of the Cervix, Monatschr.
f. Geburtsh.
EHRENFEST.
u. Gynlk.
73, 1939.
In the differential are made because statistics revealed
diagnosis between syphilis and cancer of the cervix, errors a biopsy is not done and syphilis is not thought of. Sorba’s that among 262 cases of cancer of the uterine cervix, syphilis