Normal urinary free cortisol and postdexamethasone cortisol in social phobia: comparison to normal volunteers

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Normal urinary free cortisol and postdexamethasone cortisol in social phobia: comparison to normal volunteers Thomas

W Uhde

’ k.

Manuel

E Tancer

h, Cheryl S Gelernter

‘. Bernard

J Vlttone

’

-\bstract

1 lntroductlon Sow4 stress In primates ha been ,wwxlted \\lth xtl\atlon ot the h\poth,ll,lmlc-pltult,~‘ldrendl-J\rs (Sassenrath lY70. SapoM. lY83. 198Y) Thrw obsenatlons led us to e\klmlnt: the h\pothJlamlc-pltult~n-‘ldrrn,ll-,l\ls In p,ltlent\ \\lth soc~l phobia Our hypothesis \\a~that SOCI,II phobic patents. H ho s\prrwnce marksd drLwh In wcIcill Sltuatlon\ In\ol\Ing the possible scrutlrn and/ or evdluatlon b\ others Mould ahlblt hvpsrcortisolemia

IC hlle it IS clr,lr th,lt ‘I \~irlet\ ot strewn such ah ,~ttect~\t: ,lrous,~l (Brwn ,lnd Henlngcl 1Y75) IYXY) can or uncontrollabls nolw (Brewer rwrkrdh Increaw pl,lsm,i cortl\ol Ir\sl< mal controls (Row 1YSO. Stole<. IYtiS). tent to \\hlch the HP.-I-~\I, t1rnt\

Nlth

p‘lthologlcal

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urindrj sure

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total

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prwidr3

glucocorticod

dn integrdtrd production

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