Novel GM-CSF gene polymorphisms and atopic dermatitis

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Novel GM-CSF gene polymorphisms and atopic dermatitis Although there is no doubt that T lymphocytes are important mediators of inflammation in atopic dermatitis and other atopic diseases, research focusing on genes directly controlling T-cell activity has not led to major advances in our understanding of the strong genetic predisposition to these diseases. Inasmuch as the specialist antigen-presenting dendritic cell is the primary trigger of all immune responses, Rafatpanah et al (p 593) speculated that genetic factors controlling the maturation and

function of this cell type might be important in the development of atopic dermatitis. In their article, they examine functional gene polymorphisms in IL-1β and TNF-α, as well as novel polymorphisms in the GM-CSF gene in 227 children with moderate to severe atopic dermatitis. They find a strong correlation between the GM-CSF –677 genotype and the frequency and severity of the disease. Focusing on genetic factors that control dendritic cell activity and thus the priming of immune responses in atopic dermatitis appears to provide a better understanding of the pathogenesis of this disorder and might lead to novel treatment strategies.

Selected articles are indicated in the Table of Contents by EC

Page 468 September 2003

J ALLERGY CLIN IMMUNOL