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Nucleolar organizer regions in lining epithelium adjacent to squamous cell carcinoma of human oral mucosa
Copyright 9 Munksgaard 1995
Int. ,L Oral MaxilloJac. Surg. 1995; 24:450 Printed in Denmark. All rights reserved
InternationalJournal of
Oral& MaxillofacialSurgery ISSN 0901-5027
Abstracts from international literature Nucleolar organizer regions in lining epithelium adjacent to squamous cell carcinoma of human oral mucosa A. E. Schwint, T. M. Savino, H. E. Lanfranchi, E. Marschoff, R. L. Cabrini, M. E. Itoiz Cancer 1994: 73:2674-9
The value of silver staining of nucleolar organizer regioifs (AgNOR) as a diagnostic aid has been reported for several neoplastic entities. Previous studies have proved the value of the morphometric evaluation of A g N O R in the detection of incipient cellular alterations. A morphometric analysis of AgNORs was performed in oral mucosa epithelium adjacent to squamous cell carcinoma compared with normal mucosa epithelium and the carcinomatous parenchyma. Highly statistically significant differences in all five AgNOR-related parameters assessed were found between normal mucosa and mucosa adjacent to cancer. Conversely, the corresponding nuclear parameters failed to exhibit significant differences. The parameter AgNOR contour index plotted for individual cases affords a cutoff value that could prove useful in identifying epithelia at early stages of transformation. AgNOR evidenced significant variations in epithelium adjacent
to oral squamous cell carcinoma, which did n o t exhibit morphologic signs of atypia. According to this study, AgN,OR would be a quantitative, discriminative aid, easy to monitor in a pathology laboratory, in detecting incipient cellular alterations. These findings contribute to the issue of early diagnosis and to the knowledge of tumoral growth. H. TIDEMAN
Trends and differentials in mortality from cancers of the oral cavity and pharynx in the United States, 1973-1987 H. Goldberg, S. A. Lockwood, S. W. Wyatt, L. S. Crossett Cancer 1994: 74:565-72
This analysis consisted of an examination of trends and differentials in mortality rate from cancers of the oral cavity and pharynx in the USA for a recent 15-year period. The authors have used national cause-of-death data for the USA and intercensal population estimates to examine the mortality rate from oral and pharyngeal cancers between 1973 and 1987 and to study differentials according to sex, race, and region of residence. The overall mortality
rate from these cancers decreased by 19% during the 15-year period, with most of the decline occurring after 1979. The mortality rate was much higher for men than for women and for blacks than for whites throughout the interval. Despite the o~,erall decline, mortality rates increased among blacks, especially among black men. The mortality rate was highest in the South Atlantic, New England, and Middle Atlantic states and lowest in the Mountain states. The disparity between male and female mortality rates from oral and pharyngeal cancer stems mainly from differences in the likelihood of developing these cancers, whereas the differences between blacks and whites appears to arise more from differences in survival rates than in incidence. Different age patterns of mortality rates for blacks and whites exist, in which the mortality rate among whites, but not among blacks, rises continuously with age. An unexplained finding was that mortality rates were reported to have fallen in recent years, whereas incidence and survival rates have remained almost unchanged. This apparent inconsistency may have resulted from declines in the incidence of oral and pharyngeal cancers that have been masked by improved detection. H. TIDEMAN
Int. ,L Oral MaxilloJac. Surg. 1995; 24:450 Printed in Denmark. All rights reserved
InternationalJournal of
Oral& MaxillofacialSurgery ISSN 0901-5027
Abstracts from international literature Nucleolar organizer regions in lining epithelium adjacent to squamous cell carcinoma of human oral mucosa A. E. Schwint, T. M. Savino, H. E. Lanfranchi, E. Marschoff, R. L. Cabrini, M. E. Itoiz Cancer 1994: 73:2674-9
The value of silver staining of nucleolar organizer regioifs (AgNOR) as a diagnostic aid has been reported for several neoplastic entities. Previous studies have proved the value of the morphometric evaluation of A g N O R in the detection of incipient cellular alterations. A morphometric analysis of AgNORs was performed in oral mucosa epithelium adjacent to squamous cell carcinoma compared with normal mucosa epithelium and the carcinomatous parenchyma. Highly statistically significant differences in all five AgNOR-related parameters assessed were found between normal mucosa and mucosa adjacent to cancer. Conversely, the corresponding nuclear parameters failed to exhibit significant differences. The parameter AgNOR contour index plotted for individual cases affords a cutoff value that could prove useful in identifying epithelia at early stages of transformation. AgNOR evidenced significant variations in epithelium adjacent
to oral squamous cell carcinoma, which did n o t exhibit morphologic signs of atypia. According to this study, AgN,OR would be a quantitative, discriminative aid, easy to monitor in a pathology laboratory, in detecting incipient cellular alterations. These findings contribute to the issue of early diagnosis and to the knowledge of tumoral growth. H. TIDEMAN
Trends and differentials in mortality from cancers of the oral cavity and pharynx in the United States, 1973-1987 H. Goldberg, S. A. Lockwood, S. W. Wyatt, L. S. Crossett Cancer 1994: 74:565-72
This analysis consisted of an examination of trends and differentials in mortality rate from cancers of the oral cavity and pharynx in the USA for a recent 15-year period. The authors have used national cause-of-death data for the USA and intercensal population estimates to examine the mortality rate from oral and pharyngeal cancers between 1973 and 1987 and to study differentials according to sex, race, and region of residence. The overall mortality
rate from these cancers decreased by 19% during the 15-year period, with most of the decline occurring after 1979. The mortality rate was much higher for men than for women and for blacks than for whites throughout the interval. Despite the o~,erall decline, mortality rates increased among blacks, especially among black men. The mortality rate was highest in the South Atlantic, New England, and Middle Atlantic states and lowest in the Mountain states. The disparity between male and female mortality rates from oral and pharyngeal cancer stems mainly from differences in the likelihood of developing these cancers, whereas the differences between blacks and whites appears to arise more from differences in survival rates than in incidence. Different age patterns of mortality rates for blacks and whites exist, in which the mortality rate among whites, but not among blacks, rises continuously with age. An unexplained finding was that mortality rates were reported to have fallen in recent years, whereas incidence and survival rates have remained almost unchanged. This apparent inconsistency may have resulted from declines in the incidence of oral and pharyngeal cancers that have been masked by improved detection. H. TIDEMAN