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O54. Survival and patterns of relapse in patients with oral tongue cancer
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74
Oral abstracts / Oral Oncology Supplement 3 (2009) 56–122
O52. Squamous cell carcinoma of the buccal mucosa: The prognostic importance of site F. Bekiroglu *, R.J. Shaw, D. Lowe, S.N. Rogers
Objectives: The effect of the site of oral cancer on outcome is not clear. Recent series have found that buccal cancers have relatively poor prognosis compared with other sites. It has been suggested that this may be due to more aggressive tumour behaviour. Method: We have examined 482 consecutive oral cancers surgically treated in a single institution and report the presentation, treatment and outcome of buccal tumours in comparison with other oral sites and with reference to other known prognostic variables. Results: Results showed that there were no significant differences between buccal and other oral cancers in patient demographics, clinical presentation or pathological staging. There was exception that buccal tumours infrequently had pT1 stage (16%) compared with other sites (29%, p = 0.03). Despite a higher rate (p = 0.04) of frankly involved margins, the 5 year disease specific survival was 70% for buccal carcinoma compared with 75% for other sites (p = 0.34). Conclusion: We conclude that site had little influence on prognosis. The poor outcome of buccal cancers reported in other series had not been replicated in our series.
Methods: Between 1999 and 2007, 50 patients with SCC of the oral tongue were treated at the University of Colorado Denver. Thirty-eight of 50 patients had newly diagnosed SCC of the oral tongue, with 13 stages I–II and 25 stages III–IV disease. Twelve patients were treated for locally recurrent SCC. Forty-nine patients were treated with initial surgery and one patient with definitive chemoradiation. Adjuvant radiation or chemoradiation was administered in 42 patients after surgery. Seven patients with stages I–II disease did not receive adjuvant therapy. Actuarial locoregional control (LRC), freedom from distant relapse and survival were determined using the Kaplan–Meier method and comparisons made using the Log rank test. Results: Median follow-up was 29 months (range 4–95 months) for living patients. Two-year LRC and freedom from distant relapse was 58% and 83%, respectively. Locoregional control was particularly low among patients with stages I–II disease, in whom 2-year LRC was only 35%. Median and 2-year survival for all patients was 42 months and 65%, respectively. Two-year survival for patients with stages I–II oral tongue cancer was 77% versus 52% for patients with stages III–IV disease (p = 0.04). Conclusion: Patients with SCC of the oral tongue have high rates of locoregional relapse and poor survival, particularly among those with stages I–II disease. Patients with stages I–II oral tongue cancer may benefit from adjuvant combined modality therapy.
doi:10.1016/j.oos.2009.06.137
doi:10.1016/j.oos.2009.06.139
O53. Squamous cell carcinoma of the floor of mouth: Outcomes and prognostic indicators J. Lea *, D. Goldstein, M. Yehuda, R. Moukarbel, R. Gilbert, D. Brown
O55. Outcomes in patients with tongue cancer treated at the Princess Margaret from 1994 to 2004 D. Goldstein *, G. Bachar, J. Lea, J. White, R.W. Gilbert, D.H. Brown
Princess Margaret Hospital, Canada University of Toronto, Canada
Princess Margaret Hospital, Canada University of Toronto, Canada
Objective: To review treatment outcomes and prognostic indicators of survival in floor of the mouth carcinoma. Design: A 10-year retrospective chart review (1994–2004) identified 142 patients with previously untreated squamous cell carcinoma of the floor of the mouth treated with curative intent. Descriptive statistics, Kaplan–Meier estimates and the log rank test were used to determine statistical significance. Results: The overall 5 year survival rate was 68%. Five-year cause specific survival was 80%. Death due to floor of the mouth disease was 14%. Failure occurred in 24 patients (17%). Regional failure was most common at 12%, followed by local (9%) and distant failure (2%). Second primary cancers occurred in 18%. Male gender, advanced pathologic TN stage, extracapsular spread, and tumour thickness >5 mm were statistically significant prognostic indicators of reduced 5-year survival. Conclusions: Over the last decade there has been a trend toward more aggressive management of the neck and improved local, regional and distant failure rates.
Objective: To review treatment outcomes in patients with squamous cell carcinoma of the oral tongue. Methods: A 10-year retrospective chart review (1994–2004) identified 282 patients with previously untreated squamous cell carcinoma of the oral tongue treated with curative intent at the Princess Maragret Hospital. Descriptive statistics, Kaplan–Meier estimates and the log rank test were used to determine statistical significance. Results: Two hundred and sixty-eight (95%) patients were treated with primary surgery, 70 of which (26%) underwent post-operative adjuvant therapy. The median follow-up time was 4.54 years. The overall 5 year survival rate was 62% (95% CI 55%, 68%). The 5year disease-free survival was 47% (95% CI: 41%, 54%). Both advanced pathologic T stage and N Stage were significantly associated with survival. The local and regional control rates were 79% and 69.5%, respectively. Conclusions: Surgical treatment of SCC of the tongue base is highly effective in achieving local disease control and disease-free survival for early lesions.
University Hospital Aintree, Liverpool, United Kingdom
doi:10.1016/j.oos.2009.06.138 doi:10.1016/j.oos.2009.06.140 O54. Survival and patterns of relapse in patients with oral tongue cancer K. Rusthoven, D. Raben, J. Song, M. Kane, T. Altoos, C. Chen * University of Colorado Denver, United States Introduction: To evaluate the survival and patterns of relapse for patients with squamous cell carcinoma (SCC) of the oral tongue
O56. Tumor–host histopathologic variables of stromal myofibroblasts and risk score are significantly associated with recurrent disease in tongue cancer A. Dobriyan *, M. Vered, Y.P. Talmi, L. Bedrin, S. Teicher, R. Yahalom Sheba Medical Center, Israel Tel Aviv University, Israel
74
Oral abstracts / Oral Oncology Supplement 3 (2009) 56–122
O52. Squamous cell carcinoma of the buccal mucosa: The prognostic importance of site F. Bekiroglu *, R.J. Shaw, D. Lowe, S.N. Rogers
Objectives: The effect of the site of oral cancer on outcome is not clear. Recent series have found that buccal cancers have relatively poor prognosis compared with other sites. It has been suggested that this may be due to more aggressive tumour behaviour. Method: We have examined 482 consecutive oral cancers surgically treated in a single institution and report the presentation, treatment and outcome of buccal tumours in comparison with other oral sites and with reference to other known prognostic variables. Results: Results showed that there were no significant differences between buccal and other oral cancers in patient demographics, clinical presentation or pathological staging. There was exception that buccal tumours infrequently had pT1 stage (16%) compared with other sites (29%, p = 0.03). Despite a higher rate (p = 0.04) of frankly involved margins, the 5 year disease specific survival was 70% for buccal carcinoma compared with 75% for other sites (p = 0.34). Conclusion: We conclude that site had little influence on prognosis. The poor outcome of buccal cancers reported in other series had not been replicated in our series.
Methods: Between 1999 and 2007, 50 patients with SCC of the oral tongue were treated at the University of Colorado Denver. Thirty-eight of 50 patients had newly diagnosed SCC of the oral tongue, with 13 stages I–II and 25 stages III–IV disease. Twelve patients were treated for locally recurrent SCC. Forty-nine patients were treated with initial surgery and one patient with definitive chemoradiation. Adjuvant radiation or chemoradiation was administered in 42 patients after surgery. Seven patients with stages I–II disease did not receive adjuvant therapy. Actuarial locoregional control (LRC), freedom from distant relapse and survival were determined using the Kaplan–Meier method and comparisons made using the Log rank test. Results: Median follow-up was 29 months (range 4–95 months) for living patients. Two-year LRC and freedom from distant relapse was 58% and 83%, respectively. Locoregional control was particularly low among patients with stages I–II disease, in whom 2-year LRC was only 35%. Median and 2-year survival for all patients was 42 months and 65%, respectively. Two-year survival for patients with stages I–II oral tongue cancer was 77% versus 52% for patients with stages III–IV disease (p = 0.04). Conclusion: Patients with SCC of the oral tongue have high rates of locoregional relapse and poor survival, particularly among those with stages I–II disease. Patients with stages I–II oral tongue cancer may benefit from adjuvant combined modality therapy.
doi:10.1016/j.oos.2009.06.137
doi:10.1016/j.oos.2009.06.139
O53. Squamous cell carcinoma of the floor of mouth: Outcomes and prognostic indicators J. Lea *, D. Goldstein, M. Yehuda, R. Moukarbel, R. Gilbert, D. Brown
O55. Outcomes in patients with tongue cancer treated at the Princess Margaret from 1994 to 2004 D. Goldstein *, G. Bachar, J. Lea, J. White, R.W. Gilbert, D.H. Brown
Princess Margaret Hospital, Canada University of Toronto, Canada
Princess Margaret Hospital, Canada University of Toronto, Canada
Objective: To review treatment outcomes and prognostic indicators of survival in floor of the mouth carcinoma. Design: A 10-year retrospective chart review (1994–2004) identified 142 patients with previously untreated squamous cell carcinoma of the floor of the mouth treated with curative intent. Descriptive statistics, Kaplan–Meier estimates and the log rank test were used to determine statistical significance. Results: The overall 5 year survival rate was 68%. Five-year cause specific survival was 80%. Death due to floor of the mouth disease was 14%. Failure occurred in 24 patients (17%). Regional failure was most common at 12%, followed by local (9%) and distant failure (2%). Second primary cancers occurred in 18%. Male gender, advanced pathologic TN stage, extracapsular spread, and tumour thickness >5 mm were statistically significant prognostic indicators of reduced 5-year survival. Conclusions: Over the last decade there has been a trend toward more aggressive management of the neck and improved local, regional and distant failure rates.
Objective: To review treatment outcomes in patients with squamous cell carcinoma of the oral tongue. Methods: A 10-year retrospective chart review (1994–2004) identified 282 patients with previously untreated squamous cell carcinoma of the oral tongue treated with curative intent at the Princess Maragret Hospital. Descriptive statistics, Kaplan–Meier estimates and the log rank test were used to determine statistical significance. Results: Two hundred and sixty-eight (95%) patients were treated with primary surgery, 70 of which (26%) underwent post-operative adjuvant therapy. The median follow-up time was 4.54 years. The overall 5 year survival rate was 62% (95% CI 55%, 68%). The 5year disease-free survival was 47% (95% CI: 41%, 54%). Both advanced pathologic T stage and N Stage were significantly associated with survival. The local and regional control rates were 79% and 69.5%, respectively. Conclusions: Surgical treatment of SCC of the tongue base is highly effective in achieving local disease control and disease-free survival for early lesions.
University Hospital Aintree, Liverpool, United Kingdom
doi:10.1016/j.oos.2009.06.138 doi:10.1016/j.oos.2009.06.140 O54. Survival and patterns of relapse in patients with oral tongue cancer K. Rusthoven, D. Raben, J. Song, M. Kane, T. Altoos, C. Chen * University of Colorado Denver, United States Introduction: To evaluate the survival and patterns of relapse for patients with squamous cell carcinoma (SCC) of the oral tongue
O56. Tumor–host histopathologic variables of stromal myofibroblasts and risk score are significantly associated with recurrent disease in tongue cancer A. Dobriyan *, M. Vered, Y.P. Talmi, L. Bedrin, S. Teicher, R. Yahalom Sheba Medical Center, Israel Tel Aviv University, Israel