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OA01.05 The Impact of Lung Age on Postoperative Complications in Patients with Lung Cancer Combined with Pulmonary Fibrosis and Emphysema
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death (Figure 1b, right, red curve) because of its linear relation, whereas ppoFEV1 for lung cancer-specific death (Figure 1b, left, black curve). Conclusion: In patients undergoing curative-intent resection of stage I NSCLC, noncancer-specific mortality is a significant competing event, with increasing impact as patient age increases.
Keywords: competing risk, lung resection, Comorbidity, Pulmonary Function
OA01.05 The Impact of Lung Age on Postoperative Complications in Patients with Lung Cancer Combined with Pulmonary Fibrosis and Emphysema Masahito Naito, Yasuto Kondo, Hirotsugu Yamazaki, Hiroyasu Nakashima, Yoshio Matsui, Kazu Shiomi, Yukitoshi Satoh Kitasato University School of Medicine, Sagamiharashi/Japan Background: Postoperative complications after pulmonary resection may cause morbidities such as prolonged hospitalization. Recently, combined pulmonary fibrosis and emphysema (CPFE) have reportedly been linked to a high
Journal of Thoracic Oncology
Vol. 12 No. 1S
risk for postoperative complications following lung cancer surgery. Moreover, some studies have claimed that lung age (LA) is associated with postoperative complications. Here we clarify the relationship between LA and postoperative complications in lung cancer patients with CPFE. Methods: Among a total of 1166 consecutive patients who underwent curative resection for lung cancer from January 2004 to April 2016 at the Kitasato University Hospital, Japan, a dataset of 36 patients with CPFE was retrospectively analyzed. Lungs with CPFE were defined based on preoperative chest computed tomography (CT) findings. LA was determined using the methods advocated by the Japanese Respiratory Society. The difference between “real age” (RA) and LA was calculated as “RALA,” and patients were classified into three groups: group A, RALA > 0 (n ¼ 10); group B, 15 RALA 0 (n ¼ 13); group C, RALA < 15 (n ¼ 13). Results: The average age was 70 (males, 69.1; females, 73.2) years. Thirty two patients were male and four were female. Almost all patients were ex- or current smokers. The average postoperative hospital stay was 16 (range, 7e56) days. There were no significant differences in age, gender, smoking history, and postoperative hospital stay among the three groups. The surgical procedures were lobectomy (n ¼ 29), segmentectomy (n ¼ 2), and wedge resection (n ¼ 5). Histologically, the tumors were squamous cell carcinoma (n ¼ 22), adenocarcinoma (n ¼ 9), and other types (n ¼ 4). Postoperative complications were arrhythmia (4 cases), hypertension (4 cases), air leakage (3 cases), pneumonia (5 cases), hypoxemia (3 cases), and others (5 cases). There were no significant differences in postoperative complications among the groups (p ¼ 0.69). However, cardiovascular complications in group C were significantly higher than those in the other groups (p ¼ 0.008). There were 26 patients with postoperative acute exacerbation, but there were no significant differences among the groups. Conclusion: LA accurately predicted postoperative cardiovascular complications in lung cancer patients with CPFE. Keywords: lung age, postoperative complications, lung cancer, Combined pulmonary fibrosis and emphysema
OA01.06 Early Post-Operative Ambulation after Thoracic Surgery - The WAVE Experience Sandeep Khandhar,1 Christiana Powers,1 Christy Schatz,2 Carolyn Rosner,2 Amit Mahajan,3 Paul Kiernan4 1Thoracic Surgery, Cvtsa, Falls Church/ United States of America, 2Inova Fairfax, Falls Church/VA/ United States of America, 3Thoracic Surgery, Cvtsa, Falls
death (Figure 1b, right, red curve) because of its linear relation, whereas ppoFEV1 for lung cancer-specific death (Figure 1b, left, black curve). Conclusion: In patients undergoing curative-intent resection of stage I NSCLC, noncancer-specific mortality is a significant competing event, with increasing impact as patient age increases.
Keywords: competing risk, lung resection, Comorbidity, Pulmonary Function
OA01.05 The Impact of Lung Age on Postoperative Complications in Patients with Lung Cancer Combined with Pulmonary Fibrosis and Emphysema Masahito Naito, Yasuto Kondo, Hirotsugu Yamazaki, Hiroyasu Nakashima, Yoshio Matsui, Kazu Shiomi, Yukitoshi Satoh Kitasato University School of Medicine, Sagamiharashi/Japan Background: Postoperative complications after pulmonary resection may cause morbidities such as prolonged hospitalization. Recently, combined pulmonary fibrosis and emphysema (CPFE) have reportedly been linked to a high
Journal of Thoracic Oncology
Vol. 12 No. 1S
risk for postoperative complications following lung cancer surgery. Moreover, some studies have claimed that lung age (LA) is associated with postoperative complications. Here we clarify the relationship between LA and postoperative complications in lung cancer patients with CPFE. Methods: Among a total of 1166 consecutive patients who underwent curative resection for lung cancer from January 2004 to April 2016 at the Kitasato University Hospital, Japan, a dataset of 36 patients with CPFE was retrospectively analyzed. Lungs with CPFE were defined based on preoperative chest computed tomography (CT) findings. LA was determined using the methods advocated by the Japanese Respiratory Society. The difference between “real age” (RA) and LA was calculated as “RALA,” and patients were classified into three groups: group A, RALA > 0 (n ¼ 10); group B, 15 RALA 0 (n ¼ 13); group C, RALA < 15 (n ¼ 13). Results: The average age was 70 (males, 69.1; females, 73.2) years. Thirty two patients were male and four were female. Almost all patients were ex- or current smokers. The average postoperative hospital stay was 16 (range, 7e56) days. There were no significant differences in age, gender, smoking history, and postoperative hospital stay among the three groups. The surgical procedures were lobectomy (n ¼ 29), segmentectomy (n ¼ 2), and wedge resection (n ¼ 5). Histologically, the tumors were squamous cell carcinoma (n ¼ 22), adenocarcinoma (n ¼ 9), and other types (n ¼ 4). Postoperative complications were arrhythmia (4 cases), hypertension (4 cases), air leakage (3 cases), pneumonia (5 cases), hypoxemia (3 cases), and others (5 cases). There were no significant differences in postoperative complications among the groups (p ¼ 0.69). However, cardiovascular complications in group C were significantly higher than those in the other groups (p ¼ 0.008). There were 26 patients with postoperative acute exacerbation, but there were no significant differences among the groups. Conclusion: LA accurately predicted postoperative cardiovascular complications in lung cancer patients with CPFE. Keywords: lung age, postoperative complications, lung cancer, Combined pulmonary fibrosis and emphysema
OA01.06 Early Post-Operative Ambulation after Thoracic Surgery - The WAVE Experience Sandeep Khandhar,1 Christiana Powers,1 Christy Schatz,2 Carolyn Rosner,2 Amit Mahajan,3 Paul Kiernan4 1Thoracic Surgery, Cvtsa, Falls Church/ United States of America, 2Inova Fairfax, Falls Church/VA/ United States of America, 3Thoracic Surgery, Cvtsa, Falls