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Observations on ligature of the patent ductus arteriosus
536
AMERICAN
HEART
JOURNAL
survival time is not prolonged. Coramine increases skeletal muscle tone, but doe8 not favorably influence the course of events. The correction of acidosis by the administration of sodium bicarbonate with the initial transfusion does not alter the deteriorating trend of advanced hemorrhagic shock. Sodium succinate is of no benefit in the therapy of advanced hemorrhagic shock. Tuamine, given when the initial transfusion i8 failing, causes a transitory rise in blood pressure but the effect is brief. Survival t.ime is not prolonged. L ‘ Potassium phosphate” intracisternally did not alter the deteriorating trend of hemorrhagic shock and at the same time produced undesirable cerebral excitatory phenomena. It is the authors’ view that advanced 8hock constitutes a state of progressive deterioration which is not amenable to the types of therapy now available, probably because fundamental biochemical changes have developed as a result of prolonged deficiency of capillary flow. These changes may result from injury predominantly involving one vital organ, such as the liver, or from widespread cellular damage. A7JTfIORS.
Goldberg, M., and Fine, J.: Traumatic Shock, XI. Intestinal Shock, J. Clin. Investigation 24: 445, 1945.
Absorption
in Hemorrhagic
In hemorrhagic shock, the small intestine is progressively deficient in its After transfusion, whether effective or capacity for water and isotonic glucose. improvement in this function may be observed, but full recovery is not observed time interval of these experiments. The absorption of phy8iologic saline is not clearly affected by the institution rhagic shock until the advanced stage of shock is reached.
Hunter, 731,
J. B.:
Observations
on Ligature
of the Patent
Ductus Arteriosus.
Brit.’
absorptive not, some within the of hemorAUTHORS. M.
J. 1:
1945.
Fourteen cases are reported in which ligation of a patent ductus arteriosus has been performed. Twelve case8 were uncomplicated by infection, and in only two was endocarditis present, In ten cases the patients were female and the ages varied between 5 and 31 years. In the noncomplicated cases, the patients were all slightly stunted in growth, and the majority were breathless on exertion, but only one showed any signs of cyanosis. It is too soon is now taking up to see what the ultimate fate of these cases may be. One of the children tap dancing a8 a profession; the young male was accepted by the Service. The others have lost their breathlessness on exertion, and the earlier ones that have been recently reviewed MCCULLOCH. have improved in general health and physique.
Got&hall, R. Y., Laurent, D., DeKruif, P., Simpson, W. M., Kendell, II. W., and Rqse, D. The Effect of Arti&ially Introduced Fever on Humoral Antibodies and on L.: Histamine Intoxication in the Guinea Pig. J. Lab. 6 Clin. Med. 30: 563, 1945. An no effect
artificminduced upon the humoral
fever temperature of 42.2” C. maintained precipitin titer of guinea pigs immunized
for thirty minutes has against horse serum.
The antiprotein titer of sensitized guinea pigs is not significantly altered by a fever temperature of 42.2” C. maintained for sixty minute8 when the serum is titrated by a modified Prausnitz-Kiistner reaction. A
fever
temperature
of
42.2”
C. maintained
for
thirty
minutes
suppresses
histamine
shock. In vitro tests with surviving normal intestine exposed to histamine indicate that there is less contraction at 43.3”, 45”, or 46” C. than at 38.8” or 39” C. Response of sensitized intestine to the specific antigen (ovalbumin) is also decreased by temperature8 of 43.3’, 45”, or 46’ C. The immediate type of reaction in the guinea pig’s skin is suppressed perature of 42.2’ C. maintained for sixty minutes when the locally sensitized with the specific antigen during hyperpyrexia.
by a fever temtissue is injected AUTHORS.
AMERICAN
HEART
JOURNAL
survival time is not prolonged. Coramine increases skeletal muscle tone, but doe8 not favorably influence the course of events. The correction of acidosis by the administration of sodium bicarbonate with the initial transfusion does not alter the deteriorating trend of advanced hemorrhagic shock. Sodium succinate is of no benefit in the therapy of advanced hemorrhagic shock. Tuamine, given when the initial transfusion i8 failing, causes a transitory rise in blood pressure but the effect is brief. Survival t.ime is not prolonged. L ‘ Potassium phosphate” intracisternally did not alter the deteriorating trend of hemorrhagic shock and at the same time produced undesirable cerebral excitatory phenomena. It is the authors’ view that advanced 8hock constitutes a state of progressive deterioration which is not amenable to the types of therapy now available, probably because fundamental biochemical changes have developed as a result of prolonged deficiency of capillary flow. These changes may result from injury predominantly involving one vital organ, such as the liver, or from widespread cellular damage. A7JTfIORS.
Goldberg, M., and Fine, J.: Traumatic Shock, XI. Intestinal Shock, J. Clin. Investigation 24: 445, 1945.
Absorption
in Hemorrhagic
In hemorrhagic shock, the small intestine is progressively deficient in its After transfusion, whether effective or capacity for water and isotonic glucose. improvement in this function may be observed, but full recovery is not observed time interval of these experiments. The absorption of phy8iologic saline is not clearly affected by the institution rhagic shock until the advanced stage of shock is reached.
Hunter, 731,
J. B.:
Observations
on Ligature
of the Patent
Ductus Arteriosus.
Brit.’
absorptive not, some within the of hemorAUTHORS. M.
J. 1:
1945.
Fourteen cases are reported in which ligation of a patent ductus arteriosus has been performed. Twelve case8 were uncomplicated by infection, and in only two was endocarditis present, In ten cases the patients were female and the ages varied between 5 and 31 years. In the noncomplicated cases, the patients were all slightly stunted in growth, and the majority were breathless on exertion, but only one showed any signs of cyanosis. It is too soon is now taking up to see what the ultimate fate of these cases may be. One of the children tap dancing a8 a profession; the young male was accepted by the Service. The others have lost their breathlessness on exertion, and the earlier ones that have been recently reviewed MCCULLOCH. have improved in general health and physique.
Got&hall, R. Y., Laurent, D., DeKruif, P., Simpson, W. M., Kendell, II. W., and Rqse, D. The Effect of Arti&ially Introduced Fever on Humoral Antibodies and on L.: Histamine Intoxication in the Guinea Pig. J. Lab. 6 Clin. Med. 30: 563, 1945. An no effect
artificminduced upon the humoral
fever temperature of 42.2” C. maintained precipitin titer of guinea pigs immunized
for thirty minutes has against horse serum.
The antiprotein titer of sensitized guinea pigs is not significantly altered by a fever temperature of 42.2” C. maintained for sixty minute8 when the serum is titrated by a modified Prausnitz-Kiistner reaction. A
fever
temperature
of
42.2”
C. maintained
for
thirty
minutes
suppresses
histamine
shock. In vitro tests with surviving normal intestine exposed to histamine indicate that there is less contraction at 43.3”, 45”, or 46” C. than at 38.8” or 39” C. Response of sensitized intestine to the specific antigen (ovalbumin) is also decreased by temperature8 of 43.3’, 45”, or 46’ C. The immediate type of reaction in the guinea pig’s skin is suppressed perature of 42.2’ C. maintained for sixty minutes when the locally sensitized with the specific antigen during hyperpyrexia.
by a fever temtissue is injected AUTHORS.