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On the appearance of vasodilator substances in the blood
:i’is
ABSTRACTS
Karasek, F., and Poupa, 0.: Modification by Hormones of the Opposite Sex. Compt.
of the Vascular rend,
Effect of Adrenalin
8oc. de l&l.
126:
118, 1937.
Using the same method the authors show that sex hormones of the opposite sex (testosterone in females, folliculin in males) gives rise to a decrease rather than an increase in sensitivity of the lingual artery of the frog to adrenalin. STERT,E.
Fleisch, A.: 239:
345,
Concerning
a Vasodilator
in Erythrocytes.
Arch. t’. d. ges. Ph>-siol.
1937.
Hemolyzed red blood cell corpuscles obtained from the rabbit, dog, ox, and cat were found to have a marked effect upon increasing blood flow and lowering pressure in cats and rabbits. The author believes that a ferment present in the blood destroys the substance because in two hours the effect is more than half gone and because preserving the blood at 0” C., or with hydrocyanic acid l/10,00(1 and heating prevents destruction of the substance. The substance is not soluble in ether, chloroform, or acetone, but is readily soluble in water. Prom bio10gi~ tests of its action upon various types of smooth muscle, he concludes that thrx substance is not acetylcholine, histamine, adenosin, or adenvfic ar*id.
Fleisch, A., and Weger, P.: On the Appearance of Vasodilator Blood. Arch. f. d. ges. Physiol. 239: 354, 1937.
Substances in the
Using the two hind legs of a dog-one as “donor,” in the circulation of which a Stromuhr and a cannula for removing samples of venous blood were placed, the other as “recipient, ” furnished wit.h a pressure perfusion apparatus-venous samples of blood from one leg could readily be perfused through the other under various circumstances I . Increase in flow through the perfused leg was taken as evidence of a vasodilator substance in the venous blood of the other leg. The authors found that under normal resting conditions almost no vasodilator substance was present in the venous blood but that after muscular work (electrical stimulation of the muscles of the donor leg) and with insuficient circulation large amounts could be shown to be present. STEEIX.
A., and Weger, P.: Vasodilatory Products. Sreh. f. d. ges. Physiol. 239:
Fleisch,
Action
of Phosphorrelated
Metabolic
362, 1937.
The hind legs of dogs were perfused in the manner described in the previous paper with blood to which was added numerous phosphoric acid compounds, ant1 their effect compared with histamine and acetylc.holine. Adenosin triphosphoric acid was found to be the most powerful vasodilator of all the phosphoric acids used, being active in 100 times greater dilution than the nearest competitor, mus” cle adenylic acid. The authors conclude, although the reasons are not quite clear. that the sum of the actions, all the intermediate products of metabolism, ncetylcholine, adenosintriphosphorie acid, histamine, constitute an adequate stimulus for the vasodilatation which follows exercise. &ITCRl,E.
Bager, A., and Wezler, Ii.: Calculation of Total Peripheral Man. Arch. f. exper. Path. u. Pharmakol. 186: 43? 1937. The important
calculations as degree
Arterial
Resistance in
are based upon the conception that arterial elastieity is as of contraction of arterioles in forming peripheral resistance.
ABSTRACTS
Karasek, F., and Poupa, 0.: Modification by Hormones of the Opposite Sex. Compt.
of the Vascular rend,
Effect of Adrenalin
8oc. de l&l.
126:
118, 1937.
Using the same method the authors show that sex hormones of the opposite sex (testosterone in females, folliculin in males) gives rise to a decrease rather than an increase in sensitivity of the lingual artery of the frog to adrenalin. STERT,E.
Fleisch, A.: 239:
345,
Concerning
a Vasodilator
in Erythrocytes.
Arch. t’. d. ges. Ph>-siol.
1937.
Hemolyzed red blood cell corpuscles obtained from the rabbit, dog, ox, and cat were found to have a marked effect upon increasing blood flow and lowering pressure in cats and rabbits. The author believes that a ferment present in the blood destroys the substance because in two hours the effect is more than half gone and because preserving the blood at 0” C., or with hydrocyanic acid l/10,00(1 and heating prevents destruction of the substance. The substance is not soluble in ether, chloroform, or acetone, but is readily soluble in water. Prom bio10gi~ tests of its action upon various types of smooth muscle, he concludes that thrx substance is not acetylcholine, histamine, adenosin, or adenvfic ar*id.
Fleisch, A., and Weger, P.: On the Appearance of Vasodilator Blood. Arch. f. d. ges. Physiol. 239: 354, 1937.
Substances in the
Using the two hind legs of a dog-one as “donor,” in the circulation of which a Stromuhr and a cannula for removing samples of venous blood were placed, the other as “recipient, ” furnished wit.h a pressure perfusion apparatus-venous samples of blood from one leg could readily be perfused through the other under various circumstances I . Increase in flow through the perfused leg was taken as evidence of a vasodilator substance in the venous blood of the other leg. The authors found that under normal resting conditions almost no vasodilator substance was present in the venous blood but that after muscular work (electrical stimulation of the muscles of the donor leg) and with insuficient circulation large amounts could be shown to be present. STEEIX.
A., and Weger, P.: Vasodilatory Products. Sreh. f. d. ges. Physiol. 239:
Fleisch,
Action
of Phosphorrelated
Metabolic
362, 1937.
The hind legs of dogs were perfused in the manner described in the previous paper with blood to which was added numerous phosphoric acid compounds, ant1 their effect compared with histamine and acetylc.holine. Adenosin triphosphoric acid was found to be the most powerful vasodilator of all the phosphoric acids used, being active in 100 times greater dilution than the nearest competitor, mus” cle adenylic acid. The authors conclude, although the reasons are not quite clear. that the sum of the actions, all the intermediate products of metabolism, ncetylcholine, adenosintriphosphorie acid, histamine, constitute an adequate stimulus for the vasodilatation which follows exercise. &ITCRl,E.
Bager, A., and Wezler, Ii.: Calculation of Total Peripheral Man. Arch. f. exper. Path. u. Pharmakol. 186: 43? 1937. The important
calculations as degree
Arterial
Resistance in
are based upon the conception that arterial elastieity is as of contraction of arterioles in forming peripheral resistance.