On The Move: Home-Based Experiences and Educational Milestones in Geriatric Psychiatry Fellowship

2014 AAGP Annual Meeting Abstract: Our multi-site research group (Pittsburgh, St Louis, Toronto) has been in the preliminary stages of testing novelmechanism compounds for treatment-resistant aspects of late-life depression and anxiety disorders. Consistent with NIMH’s recommendations, we are focusing on treatment-resistant dimensions of illness not currently benefiting from existing medication approaches. In this symposium, we will describe efforts to conduct early-phase “learn and confirm” trials using multimodel biomarkers. Our focus is on two existing medications that are serving as prototype molecules for novel-mechanism treatment discovery. The first is buprenorphine, a kappa-opioid antagonist which is being tested as an augmentation treatment for late-life treatment-resistant depression. The second is mifepristone, a glucocorticoid receptor antagonist which is being tested for rescue of cognitive impairment in late-life anxiety disorders. For each agent, we present biomarker-led early phase clinical trials to clarify target engagement, find the optimal dose and patient population, and ultimately test mechanistic proof of concept. We will describe these clinical trial strategies in the larger view of their fit with NIMH and CNS drug development priorities and recommendations, and in the light of our “team science” approach that leverages expertise across multiple sites. Faculty Disclosures: Daniel M. Blumberger Research Support: Brainsway Ltd. - Research support for an investigator Initiated Study Research Support: Tonika/Magventure - Research support for an investigator initiated study Jordan F. Karp Research Support: Pfizer - provided medication supplies for investigator initiated trial Research Support: Reckitt Benckiser - provided medication supplies for investigator initiated trial Eric Lenze Research Support: Lundbeck, Johnson & Johnson, and Roche - no personal income

ON THE MOVE: HOME-BASED EXPERIENCES AND EDUCATIONAL MILESTONES IN GERIATRIC PSYCHIATRY FELLOWSHIP Session 311 Randall Espinoza2; Sandra Swantek3; Susan M. Maixner1 1

University of Michigan Health System, Ann Arbor, MI UCLA, Los Angeles, CA 3 Northwestern University, Chicago, IL 2

Abstract: Home visits are valuable experiences for fellows. This workshop will define and explore the importance of home visits, and the role these visits play in geriatric psychiatry education. In keeping with the educational experience of this rotation, goals, objectives, and milestones in preparation for the Next Accreditation System (NAS) will be suggested, as well as a review of overall geriatric psychiatry milestone formation. Results from a national survey of geriatric psychiatry program directors will highlight the creativity and variety of home-based rotations. Specific fellowship experiences with home visits will be discussed, addressing benefits, challenges and strategies for implementation. Faculty Disclosures: Randall Espinoza Nothing to disclose Susan M. Maixner Nothing to disclose Sandra Swantek Nothing to disclose

S26

Am J Geriatr Psychiatry 22:3, Supplement 1