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On the question of the identity of animal hair allergy (horse, cat and dog hair allergen)
Skin tests were matle revealing the paticlrt sensitive to a variety of substances. lTpon active immwization with howc (lust wntl rye tlic patient became free from asthlrla and ha?- fvrc~-. It is not considered that liver Hlld liver t’XtrilC!t call br the Valises of asthma but it is suggested tllat they IllaT cawe otl~er allergic manifestations, ant1 tllrrefore they lllny h iIStlllll~~pf?lli~.
On the Question of the Identity of Animal Hair Allergy and Dog Hair Allergen). Storm Tan Leellweil, I\‘. : Innilit~~tsfor,scl~.
II. rxper.
(Horse, Cat Ztwlir.
f. ln-
Thr1~~1). 68 : 427, 7 MO.
It was observctl that patients who pave a positive YclilctiOll to olle animal hair alleiyen nsnally KiiVt’ a positive reaction to othcar animal hair i~lle~@?llS. This observation led to cqwriments t,o tliscover whether or not the animal hair allergens were identical or at l(‘ilSt wnititilltbtl a conirnon factor. Kxtracts wew matle of lioiw. cat, am1 (log dander. TllCSC cXtl’CiCtS \VeYP IlSPtl to tC?st 36 i~llillli~l hailscilsitive patients. 1tcw11ts
sllowc~tl
:
l’liwe reslllts shon~ed that the primary skin reaction wl-llicli was elicited in hypersensitive patients through the allergens of horsr. cat and dog dander, was not, dependent upon a common factor in these allcrgfws, and there is no identity among them. It was further observed that a desensitieat,ion of a certain area of’ the skin through repeated injections of a given animal hair allergen often gave rise to a desensitization of the area to other animal hair a Ilc~pens. Experiment,s with animal hair allergen were carried out. to discover whether this desensitization might be attribnt,ed to a common 111 18 cases of animal hair allergy, desensitifactor in t,hese allergens. zation to a givwi animal allergen 7vas acconiplisl~rd on 31 separate areas of skin. After the reaction became negative sensitivity to nne Of
the
othcl~
two
allrrgens
c-110w11.
\vaS
tested.
“00
‘1‘llIc
lit~slllts
01.’
AI,I.M<(;\
ilftt~l. iitl arc’s of skill Iliitl bt~rll tltwirsitiztvl \\,itll I\-llivh clitdttvl il StlYlllg ptisitiyta lY~il~:titlll t’l~olll tilt, jiwtit~iit, tllcb Wilrtitbll to tltllc~1’ illlilllill hair alltll’pt~IH \viiS gl’c~kltl>* tliniiiiislit-‘tl 01’ tlisiil)l~~~ili.t~tl. III tltow t*aws. tlo\vt~vt~r, wllcw tlie tiripiiial illltLl’~:.(Lll IlStVl ftll’ tlt~st~llsitiziltitl1l lliltl C;lliPtl ftll’tll Olll)il \Vt’illi l’t’S~~tlllSt’ iii tllcl pilti(bllt. ttltl twt~tioii to tlltk tlttlt~t~ illli~lli~l Ilair iIllt~l~~t~llS \vilS oIlI>\\.t~akt~lltYl nlltl l’il lxt~I>-, if C\‘PI’. tlis;tlili’~;i1,c,tl. This fact \VilS wiirsitltm~tl snfficirirt t~vitleilw ilgilillst ttlcl ttttbol~)tllilt tllt’ it~~~tllll~~ilIl~ill~ tlrsr~ilsitiaatioii iuiglit htb tlllth to illI!~0111111011 t’itctol~ ?~lllt)l~~ tilt’ ilIlt’l’~C’llS. 1 t ?iJ’l)t’il 1’s. l’ilttlt’l’ tllilt tilt’ skill Ilt~tdtllllChS (‘1. IlilllStt’tl ttll*t)ll~ll I’t’l)t‘iltt’tl illlt’l’~t’ll IY~ilt~titltlS. This t~XttilllSti~lll is Ilot tlllt~ to ii tlt~pwt~iwtitiir iii ttltl l’t~itt+ti\-tb t*ilp>~t~itJT 01 ttlti c~iipill~ll~it~s fol. ~10lst:lls SlltJll ilS Iiistauiin iltltl urorl)tiiiit~. ‘I’llt’W il;lVt~ tlit~ir 11tlI’lIlilI I~K’tJt~t. ill1
slro\\rtl
.101’1~5.\1,
illlilll~l
tlrat
hair
~lllcl~~rll
Passive Local Sensitization
in Atopic
Individuals.
\\‘alzt~r.
11.. illIt
J1:slwrinrcllts \vtlrt’ Illltlt~dalct~tl to tc’st ttlti vt)lnllar;lti~t~ c+wpavity of ttlt> ;rtti]iit~ ;rlltl ttlth 1101’311WIilltlivitlllitl to ilt’t’t’l)t 1IilSsiTt~ ltlt’ill wtrsitiz;ititjii. .\ttipit* alltl iiorlllill srlh,jtv*ts \vt’rt’ st~iisitimtl \vitt: iltOllit~ ht~t’lllll ill ii I’itllpt’ of tlili~titnis tltltt~riiiiiltvl II)- Iiwvioris titriition 011 Iltrl’lllill Sliills. St~\c~Il tl:lp ;Ifttlt, ttiis st~llsitiaiitioll. tlltb sitths \Vt’l’t’ tt’httlcl \\,itli il (lillitioil 01’ ttlcl iltO~)t’ll 1’01, \\.IIit*ll tlits S~~I’IIIII 1iwt1 ii, tliti t~slwriiiit~ttts t~tllltilillt~tl rtwgitls. (‘otltlY~l4 \vt’t’t’ Ilstvl. St~VPlXI ;itupit. Yt’f’il \Vt’I’t’ 1lSt~tl. Sllt.11 ilS I~illlllit S~‘1’11111, .\St*ill’iS l,irliilii’ic~oitlt~s ilirtl tinrotti~~ pt~ll~~ii. lil?SiVtx IO~ilI wiihitixiil ioii ii1 ttlilt SOllIt /jilt it>tits \\.I10 fililt~tl to i1Vt’(‘[ll ttlt, tl’illlSftLt’ \vittl 0111’ St~l’lllll tlitl ;tc*c’t’llt it \vitli illlotll~~t~. Iillt I’t’pilt’ClIt’SS Of ttltl lliltlll’t’ Of ttlt’ St’1’11111 IIStLtI. I’tsSllltS StlO\~l~tl tldiiiitt~l~tllill attjliic* ilttlivitllliils tlitl IlOt ilt’c’t’l’t IOCilI IlilSsiVt~ sriisitiaittioii \\.itti ttlct Sillllt’ t’t’~lllill.it~~, Ot’ t0 tilt’ hilltlt’ tlt’~l’t’ta, ils Iltll~lllill ilitlivitliials. III votk t~liwioll. it \VilS coiisitlt~wtl iii ttltl iiitt~rprc~. tilti Of tilt, I~t~SllltS 01 tlltx illlht)l~~lfit~ll ~Itlt’llt~ltlt~llt~lI ii1 ;rttjpit* srltl,j~‘c*ts.
The Mechanism Iiwll\vt~ll,
of Desensitization
I\‘. :
Ztsclrr.
of the Allergic
f’. Irll~~~nl~itiitsl’ol.s~ll.
II.
Skin. t’xlwt*.
Storlll
‘l’Ilt~1*i~~~,
\.;I11 69:
1.
I !):I().
I~rft~wtlct~ lllltlt~t~
t’tLl’tilill
animal
Ilair
Of
st>nsitiyity
pt%tPtl pr11s.
Sliill
is
to il liwvitiiis ;irticltl iti \vtiicli il \\‘ilX stto\\~ll ttlitl c~tiiitlitioils. IOt~~II tlt’sc,iisitiz;ttitiii Of il Sliill ilt’t’il jritti 0Tlt’ t’Xtl’ilVt IlSlli~II~ Iiriirgs iLlltltlt il IOSS OI’ ilt It’ilSt il tliltiiiiutioil to OtllVt illlilltill tlilir PXtl*ilVtS. ‘1’litb possiliilit>tllfail sriglltittlt’
itsttlt’. tll;lt Eslirriilitwts ill’t’ilS
\Vt’l’t’
tilt,
Sillllt’ T\.PI’t
tltwiisitizt3l
IlOltl
Itligtlt
cVill’l’i?tl illltl
(:llt ttlt~ll
tl’llt’ 1l~ltlll
ftll’
0ttlC.t
SPYt’llttvJll
iiijwtt~tl
witli
~l’tl~l~lS ~)t~rSolls. illltlttl~~t~
Of
illl?l’-
St>vt‘llt>. itlltigt~ll.
On the Question of the Identity of Animal Hair Allergy and Dog Hair Allergen). Storm Tan Leellweil, I\‘. : Innilit~~tsfor,scl~.
II. rxper.
(Horse, Cat Ztwlir.
f. ln-
Thr1~~1). 68 : 427, 7 MO.
It was observctl that patients who pave a positive YclilctiOll to olle animal hair alleiyen nsnally KiiVt’ a positive reaction to othcar animal hair i~lle~@?llS. This observation led to cqwriments t,o tliscover whether or not the animal hair allergens were identical or at l(‘ilSt wnititilltbtl a conirnon factor. Kxtracts wew matle of lioiw. cat, am1 (log dander. TllCSC cXtl’CiCtS \VeYP IlSPtl to tC?st 36 i~llillli~l hailscilsitive patients. 1tcw11ts
sllowc~tl
:
l’liwe reslllts shon~ed that the primary skin reaction wl-llicli was elicited in hypersensitive patients through the allergens of horsr. cat and dog dander, was not, dependent upon a common factor in these allcrgfws, and there is no identity among them. It was further observed that a desensitieat,ion of a certain area of’ the skin through repeated injections of a given animal hair allergen often gave rise to a desensitization of the area to other animal hair a Ilc~pens. Experiment,s with animal hair allergen were carried out. to discover whether this desensitization might be attribnt,ed to a common 111 18 cases of animal hair allergy, desensitifactor in t,hese allergens. zation to a givwi animal allergen 7vas acconiplisl~rd on 31 separate areas of skin. After the reaction became negative sensitivity to nne Of
the
othcl~
two
allrrgens
c-110w11.
\vaS
tested.
“00
‘1‘llIc
lit~slllts
01.’
AI,I.M<(;\
ilftt~l. iitl arc’s of skill Iliitl bt~rll tltwirsitiztvl \\,itll I\-llivh clitdttvl il StlYlllg ptisitiyta lY~il~:titlll t’l~olll tilt, jiwtit~iit, tllcb Wilrtitbll to tltllc~1’ illlilllill hair alltll’pt~IH \viiS gl’c~kltl>* tliniiiiislit-‘tl 01’ tlisiil)l~~~ili.t~tl. III tltow t*aws. tlo\vt~vt~r, wllcw tlie tiripiiial illltLl’~:.(Lll IlStVl ftll’ tlt~st~llsitiziltitl1l lliltl C;lliPtl ftll’tll Olll)il \Vt’illi l’t’S~~tlllSt’ iii tllcl pilti(bllt. ttltl twt~tioii to tlltk tlttlt~t~ illli~lli~l Ilair iIllt~l~~t~llS \vilS oIlI>\\.t~akt~lltYl nlltl l’il lxt~I>-, if C\‘PI’. tlis;tlili’~;i1,c,tl. This fact \VilS wiirsitltm~tl snfficirirt t~vitleilw ilgilillst ttlcl ttttbol~)tllilt tllt’ it~~~tllll~~ilIl~ill~ tlrsr~ilsitiaatioii iuiglit htb tlllth to illI!~0111111011 t’itctol~ ?~lllt)l~~ tilt’ ilIlt’l’~C’llS. 1 t ?iJ’l)t’il 1’s. l’ilttlt’l’ tllilt tilt’ skill Ilt~tdtllllChS (‘1. IlilllStt’tl ttll*t)ll~ll I’t’l)t‘iltt’tl illlt’l’~t’ll IY~ilt~titltlS. This t~XttilllSti~lll is Ilot tlllt~ to ii tlt~pwt~iwtitiir iii ttltl l’t~itt+ti\-tb t*ilp>~t~itJT 01 ttlti c~iipill~ll~it~s fol. ~10lst:lls SlltJll ilS Iiistauiin iltltl urorl)tiiiit~. ‘I’llt’W il;lVt~ tlit~ir 11tlI’lIlilI I~K’tJt~t. ill1
slro\\rtl
.101’1~5.\1,
illlilll~l
tlrat
hair
~lllcl~~rll
Passive Local Sensitization
in Atopic
Individuals.
\\‘alzt~r.
11.. illIt
J1:slwrinrcllts \vtlrt’ Illltlt~dalct~tl to tc’st ttlti vt)lnllar;lti~t~ c+wpavity of ttlt> ;rtti]iit~ ;rlltl ttlth 1101’311WIilltlivitlllitl to ilt’t’t’l)t 1IilSsiTt~ ltlt’ill wtrsitiz;ititjii. .\ttipit* alltl iiorlllill srlh,jtv*ts \vt’rt’ st~iisitimtl \vitt: iltOllit~ ht~t’lllll ill ii I’itllpt’ of tlili~titnis tltltt~riiiiiltvl II)- Iiwvioris titriition 011 Iltrl’lllill Sliills. St~\c~Il tl:lp ;Ifttlt, ttiis st~llsitiaiitioll. tlltb sitths \Vt’l’t’ tt’httlcl \\,itli il (lillitioil 01’ ttlcl iltO~)t’ll 1’01, \\.IIit*ll tlits S~~I’IIIII 1iwt1 ii, tliti t~slwriiiit~ttts t~tllltilillt~tl rtwgitls. (‘otltlY~l4 \vt’t’t’ Ilstvl. St~VPlXI ;itupit. Yt’f’il \Vt’I’t’ 1lSt~tl. Sllt.11 ilS I~illlllit S~‘1’11111, .\St*ill’iS l,irliilii’ic~oitlt~s ilirtl tinrotti~~ pt~ll~~ii. l
The Mechanism Iiwll\vt~ll,
of Desensitization
I\‘. :
Ztsclrr.
of the Allergic
f’. Irll~~~nl~itiitsl’ol.s~ll.
II.
Skin. t’xlwt*.
Storlll
‘l’Ilt~1*i~~~,
\.;I11 69:
1.
I !):I().
I~rft~wtlct~ lllltlt~t~
t’tLl’tilill
animal
Ilair
Of
st>nsitiyity
pt%tPtl pr11s.
Sliill
is
to il liwvitiiis ;irticltl iti \vtiicli il \\‘ilX stto\\~ll ttlitl c~tiiitlitioils. IOt~~II tlt’sc,iisitiz;ttitiii Of il Sliill ilt’t’il jritti 0Tlt’ t’Xtl’ilVt IlSlli~II~ Iiriirgs iLlltltlt il IOSS OI’ ilt It’ilSt il tliltiiiiutioil to OtllVt illlilltill tlilir PXtl*ilVtS. ‘1’litb possiliilit>tllfail sriglltittlt’
itsttlt’. tll;lt Eslirriilitwts ill’t’ilS
\Vt’l’t’
tilt,
Sillllt’ T\.PI’t
tltwiisitizt3l
IlOltl
Itligtlt
cVill’l’i?tl illltl
(:llt ttlt~ll
tl’llt’ 1l~ltlll
ftll’
0ttlC.t
SPYt’llttvJll
iiijwtt~tl
witli
~l’tl~l~lS ~)t~rSolls. illltlttl~~t~
Of
illl?l’-
St>vt‘llt>. itlltigt~ll.