- Email: [email protected]
Oncogenes and cell proliferation
9
Oncogenes and cell proliferation Web alert Izabela Makalowska*, Tyra Wolfsberg† and Wojciech Makalowski‡ A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Genetics & Development. Addresses *National Human Genome Research Institute, National Institutes of Health, Building 49, Room 2B75, Bethesda, Maryland 20892-4431, USA; e-mail: [email protected] † National Human Genome Research Institute, National Institutes of Health, Building 9, Room B1E01, Bethesda, Maryland 20892-0960, USA; e-mail: [email protected] ‡ National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, Room 8N-805, Bethesda, Maryland 20894, USA; e-mail: [email protected] Current Opinion in Genetics & Development 2001, 11:9–10
Oncogenes and Tumor Suppressor Genes http://www.ncbi.nlm.nih.gov/CBBresearch/Boguski/Windows 2/CGcancer.html The site presents comprehensive information on oncogenes and tumor suppressor genes selected from “The Oncogene and Tumor Suppressor Gene FactsBook” by Robin Hesketh. Each gene has a link to Gene Symbol, GenBank record, OMIM description, and map location. The Genetics of Cancer http://www.cancergenetics.org/home.htm This site provides information about the genetics of cancer to physicians, nurse practioners, and the general public. It is maintained by the Robert H Lurie Comprehensive Cancer Center of Northwestern University. Cancer Genome Anatomy Project (CGAP) http://www.ncbi.nlm.nih.gov/CGAP/ The goal of CGAP, administered by the National Cancer Institute and other institutes at the National Institutes of Health, is to decipher the molecular anatomy of the cancer cell. It includes five initiatives: the Human Tumor Gene Index and the Mouse Tumor Gene Index identify genes expressed during tumor development, Molecular Profiling demonstrates molecular analysis of human tissue specimens, the Cancer Chromosome Aberration Project characterizes chromosomal alterations associated with malignant transformation, and the Genetic Annotation Index identifies and characterizes cancer polymorphisms. Biomedical Computing, Inc. http://tgdb.biomedcomp.com/ Although a commercial company with the mission “To Provide the Biomedical Research Community with the Informatics Tools They Need”, Biomedical Computing, Inc. offer, among other services, free access to two specialized databases, namely ‘Tumor Gene’ and ‘Breast Cancer Gene’. Both databases are searchable by either gene names or words used in gene description. Genes and Disease: Cancer Subsection http://www.ncbi.nlm.nih.gov/disease/Cancer.html The ‘Genes and Disease’ pages contain information about human genetic diseases for which a gene has been identified
and mapped. For each disease, the site provides a brief description, as well as links to the protein sequence, mapping data, and relevant literature. The cancer subsection deals specifically with 13 human cancers. TumorBoard.com http://www.tumorboard.com/ ‘TumorBoard’ is an online pathology image forum where pathologists can discuss their cases with other specialists. There are >100 certified board members available for consultation. This site contains a big collection of digital pathology images. Each user can contribute images and ask any member for an opinion on the case. Cell Cycle Controlling Pathways http://www.genome.ad.jp/brite/brite.html The ‘Cycle Cell Controlling Pathways’ are a part of the ‘Biomolecular Relations in Information Transmission and Expression’ (BRITE) database. It includes cell-cycle pathways for human, fission yeast, and budding yeast. Each pathway has links to BRITE entries describing proteins taking part in cellcycle control. Yeast Cell Cycle Analysis Project http://genome-www.stanford.edu/cellcycle/ This website — developed by Ron Davis’s lab at Stanford University — presents information about yeast genes the mRNA levels of which are regulated during the cell cycle. This is a complement to the data presented in a paper by Spellman et al. (Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell 1998, 9:3273-3297). Cell Proliferation Society http://odin.mdacc.tmc.edu/cellpro/cell3/ The purpose of this society is to facilitate interaction and communication between clinical practitioners, experimentalists, and theoreticians from diverse backgrounds who share a common interest in cell proliferation to promote basic and clinical research in cell proliferation. The Transcription Regulatory Regions Database http://wwwmgs.bionet.nsc.ru/mgs/dbases/trrd4 The ‘Transcription Regulatory Regions Database’, developed at the Institute of Cytology and Genetics in Novosibirsk, Russia, collects information on the structural and functional organisation of transcription regulatory regions of eukaryotic genes. It contains 905 enrties, which are classified into groups according to species, type of protein coded by the gene and the functional role of the gene including cell-cycle controling genes. The Cell Cycle & Mitosis Tutorial http://www.biology.arizona.edu/cell_bio/tutorials/cell_cycle/main. html This tutorial provides a basic introduction to the cell cycle and the events of mitosis. It is part of ‘The Biology Project’ at the University of Arizona, a web resource that teaches biology to high school and college students.
10
Web alert
The Eukaryotic Cell Cycle and the Genetics of Cancer http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/cellcycle/ cellcycl1.htm This cell cycle and cancer genetics tutorial is part of an intermediate genetics course at North Dakota State University. It provides information about cell cycle, human and retroviral oncogenes, tumor-supressor genes as well as links to cell-cycle and cancer-related web pages.
Cancer Medicine http://intouch.cancernetwork.com/canmed/ This is an online version of the 4th edition of the Cancer Medicine textbook (edited by JF Holland et al.)
Kimball’s Biology Pages http://www.ultranet.com/~jkimball/BiologyPages/ The pages represent an online version of the classic Kimball’s Biology textbook and consists of alphabetized lists of biological terms (the index/glossary) with links to discussions, often illustrated, of a wide range of biological topics. Oncogenes and Tumor Suppressor Genes: the Ying and Yang of Cell Proliferation http://views.vcu.edu/ana/OB/cytology/ This is a slide presentation by Oliver Bogler of Virginia Commonwealth University. He has also posted slide presentations on oncogenes at http://views.vcu.edu/ana/OB/ oncogenes/sld001.htm and p53 at http://views.vcu.edu/ ana/OB/p53/sld001.htm
Oncogenes and cell proliferation Web alert Izabela Makalowska*, Tyra Wolfsberg† and Wojciech Makalowski‡ A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Genetics & Development. Addresses *National Human Genome Research Institute, National Institutes of Health, Building 49, Room 2B75, Bethesda, Maryland 20892-4431, USA; e-mail: [email protected] † National Human Genome Research Institute, National Institutes of Health, Building 9, Room B1E01, Bethesda, Maryland 20892-0960, USA; e-mail: [email protected] ‡ National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, Room 8N-805, Bethesda, Maryland 20894, USA; e-mail: [email protected] Current Opinion in Genetics & Development 2001, 11:9–10
Oncogenes and Tumor Suppressor Genes http://www.ncbi.nlm.nih.gov/CBBresearch/Boguski/Windows 2/CGcancer.html The site presents comprehensive information on oncogenes and tumor suppressor genes selected from “The Oncogene and Tumor Suppressor Gene FactsBook” by Robin Hesketh. Each gene has a link to Gene Symbol, GenBank record, OMIM description, and map location. The Genetics of Cancer http://www.cancergenetics.org/home.htm This site provides information about the genetics of cancer to physicians, nurse practioners, and the general public. It is maintained by the Robert H Lurie Comprehensive Cancer Center of Northwestern University. Cancer Genome Anatomy Project (CGAP) http://www.ncbi.nlm.nih.gov/CGAP/ The goal of CGAP, administered by the National Cancer Institute and other institutes at the National Institutes of Health, is to decipher the molecular anatomy of the cancer cell. It includes five initiatives: the Human Tumor Gene Index and the Mouse Tumor Gene Index identify genes expressed during tumor development, Molecular Profiling demonstrates molecular analysis of human tissue specimens, the Cancer Chromosome Aberration Project characterizes chromosomal alterations associated with malignant transformation, and the Genetic Annotation Index identifies and characterizes cancer polymorphisms. Biomedical Computing, Inc. http://tgdb.biomedcomp.com/ Although a commercial company with the mission “To Provide the Biomedical Research Community with the Informatics Tools They Need”, Biomedical Computing, Inc. offer, among other services, free access to two specialized databases, namely ‘Tumor Gene’ and ‘Breast Cancer Gene’. Both databases are searchable by either gene names or words used in gene description. Genes and Disease: Cancer Subsection http://www.ncbi.nlm.nih.gov/disease/Cancer.html The ‘Genes and Disease’ pages contain information about human genetic diseases for which a gene has been identified
and mapped. For each disease, the site provides a brief description, as well as links to the protein sequence, mapping data, and relevant literature. The cancer subsection deals specifically with 13 human cancers. TumorBoard.com http://www.tumorboard.com/ ‘TumorBoard’ is an online pathology image forum where pathologists can discuss their cases with other specialists. There are >100 certified board members available for consultation. This site contains a big collection of digital pathology images. Each user can contribute images and ask any member for an opinion on the case. Cell Cycle Controlling Pathways http://www.genome.ad.jp/brite/brite.html The ‘Cycle Cell Controlling Pathways’ are a part of the ‘Biomolecular Relations in Information Transmission and Expression’ (BRITE) database. It includes cell-cycle pathways for human, fission yeast, and budding yeast. Each pathway has links to BRITE entries describing proteins taking part in cellcycle control. Yeast Cell Cycle Analysis Project http://genome-www.stanford.edu/cellcycle/ This website — developed by Ron Davis’s lab at Stanford University — presents information about yeast genes the mRNA levels of which are regulated during the cell cycle. This is a complement to the data presented in a paper by Spellman et al. (Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell 1998, 9:3273-3297). Cell Proliferation Society http://odin.mdacc.tmc.edu/cellpro/cell3/ The purpose of this society is to facilitate interaction and communication between clinical practitioners, experimentalists, and theoreticians from diverse backgrounds who share a common interest in cell proliferation to promote basic and clinical research in cell proliferation. The Transcription Regulatory Regions Database http://wwwmgs.bionet.nsc.ru/mgs/dbases/trrd4 The ‘Transcription Regulatory Regions Database’, developed at the Institute of Cytology and Genetics in Novosibirsk, Russia, collects information on the structural and functional organisation of transcription regulatory regions of eukaryotic genes. It contains 905 enrties, which are classified into groups according to species, type of protein coded by the gene and the functional role of the gene including cell-cycle controling genes. The Cell Cycle & Mitosis Tutorial http://www.biology.arizona.edu/cell_bio/tutorials/cell_cycle/main. html This tutorial provides a basic introduction to the cell cycle and the events of mitosis. It is part of ‘The Biology Project’ at the University of Arizona, a web resource that teaches biology to high school and college students.
10
Web alert
The Eukaryotic Cell Cycle and the Genetics of Cancer http://www.ndsu.nodak.edu/instruct/mcclean/plsc431/cellcycle/ cellcycl1.htm This cell cycle and cancer genetics tutorial is part of an intermediate genetics course at North Dakota State University. It provides information about cell cycle, human and retroviral oncogenes, tumor-supressor genes as well as links to cell-cycle and cancer-related web pages.
Cancer Medicine http://intouch.cancernetwork.com/canmed/ This is an online version of the 4th edition of the Cancer Medicine textbook (edited by JF Holland et al.)
Kimball’s Biology Pages http://www.ultranet.com/~jkimball/BiologyPages/ The pages represent an online version of the classic Kimball’s Biology textbook and consists of alphabetized lists of biological terms (the index/glossary) with links to discussions, often illustrated, of a wide range of biological topics. Oncogenes and Tumor Suppressor Genes: the Ying and Yang of Cell Proliferation http://views.vcu.edu/ana/OB/cytology/ This is a slide presentation by Oliver Bogler of Virginia Commonwealth University. He has also posted slide presentations on oncogenes at http://views.vcu.edu/ana/OB/ oncogenes/sld001.htm and p53 at http://views.vcu.edu/ ana/OB/p53/sld001.htm