OP-048 The Relation Between Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured via Carotid Intima-Media Thickness and the SYNTAX Score

MARCH 10e13, 2016

O R A L A B S T R A C T S

Patient demographics, procedural details, postoperative follow-up data, and SF-36 scores were compared between groups. Results: No significant differences in demographic and clinical variables were found between the OSR and EVAR groups. Both groups showed a significant decline in physical health composite scores 30 days after the surgical procedure (P < 0.01 and P < 0.01, respectively) In the postoperative period, the OSR showed a statistically significant decline in three of the four physical health domains (physical function, P < 0.01; role physical, P < 0.01; bodily pain, P < 0.01) while the EVAR group declined in only one physical health domain (bodily pain, P < 0.05). Although both groups were not significantly different from their baseline by 90 days after the surgery in their physical health composite scores or in any of the respective physical health domains, mental recovery was seen earlier than physical recovery in both groups. Conclusion: Our study showed no evidence of more mental deterioration in EVAR group than OSR group. Although patients undergoing EVAR resulted in less physical and emotional decline than OSR at 3 months, patients in both groups may return to near baseline status at 90 days.

- OP-044

Conclusion: A universal policy of endovascular therapy for occluded dialysis access results in reestablishment of function in the majority of patients and will triple functional longevity. Furthermore, while this approach remains procedure-intensive, it carries low morbidity and mortality and preserves future sites of access. In overall, percutaneous techniques are assuming an increasingly important role in the treatment of failed or failing AV fistulae and grafts.

New Horizons in Hypertension and Antihypertensive Therapy Friday, March 11, 2016 09:45 AM w 10:45 AM, Hall 6 (Abstract nos. OP-046 w OP-051)

Midterm Results Following Percutaneous Rotational Thrombectomy for Acute Occlusions of Arteriovenous Access Grafts. Emre Gök1, Mehmet Akif Onalan2, Celalettin Daglı5, Celalettin Karatepe3, Bayer Cinar4, Onur Selcuk Goksel2. 1Karabuk University, Cardiovascular Surgery Department, Karabuk, Turkey; 2Istanbul University, Istanbul Medical Faculty, Cardiovascular Surgery Department, Istanbul, Turkey; 3Mustafa Kemal University, Cardiovascular Surgery Department, Antakya, Turkey; 4 Kemerburgaz University, Cardiovascular Surgery Department, Istanbul, Turkey; 5Antakya State Hospital, Anesthesiology Department, Antakya, Turkey.

- OP-048

Introduction: Percutaneous mechanical thrombectomy has recently gained clinical popularity as a potential alternative to surgical thrombectomy or pharmacological thrombolysis in the setting of an acute thromboembolic vascular occlusion. In this aspect, we reviewed our preliminary results with rotational thrombectomy in the setting of acute dialysis-access graft occlusion of the upper extremity. Patients and Methods: Between March, 2012 to January, 2015, 30 rotational thrombectomies were performed in a total of 22 patients (12 men; the mean age 53.3
24 years) using the Rotarex catheter or Aspirex (Straub Rotarex, Straub Medical, Wangs, Switzerland) following obtaining informed consents for the treatment and the institutional review board approval for the study. Brachio-axillary arteriovenous (AV) PTFE graft occlusion within 3 centimeters distal to the anastomosis site in brachial end upon duplex ultrasound (the mean distance 4
1 cm, range 2-6 centimeters) for less than 7 days underwent thrombectomy using a mechanical rotational catheter. Results: A total of 30 rotational thrombectomies were performed in 22 patients over the two year period. Among the 22 patients, 5 had prior history of surgical thrombectomy from the AV graft. Among the 30 cases of acute occlusion of the AV graft, immediate success with angiographic flow restoration was observed in all patients except for 2 patients (both females, 6%) with de novo occlusion where re-occlusion occurred within 12 hours despite apparent immediate angiographic patency. These latter 2 patients later were deemed for a surgical anastomotic revision. All other patients received a successful hemodialysis within 24 hours of the procedure (93%). During followup of 1 year, 8 patients (26%) experienced re-thrombosis and required reintervention despite the immediate procedural success. The mean duration between the initial presentation with acute AV graft occlusion and the thrombectomy procedure was 27.4
12.4 hours. 19 thrombectomy procedures (63%) were performed within 24 hours upon initial admission. Neither of the two dialysis-only cases was treated in later than 24 hours after initial referral, nor were they in the re-intervention group.

Objective: There is an escalating amount of evidence implying relation between male type baldness and coronary artery disease. We aimed to search the relation between androgenetic alopecia (AGA) and cardiovascular atherosclerosis measured via carotid intima-media thickness (CIMT) and the SYNTAX score. Methods: Of 451 subjects, 116 subjects with an indication for coronary angiography were eligible and prospectively enrolled into the study. AGA was classified according to the Hamilton baldness scale (for males) and Ludwig scale (for females). Laboratory examination for fasting lipid profile, glucose, thyroid stimulating hormone, creatinine, and whole blood count was carried out. Exclusion criteria were as follows: patients with acute coronary syndrome, previously diagnosed coronary, cerebral, and peripheral arterial disease, chronic kidney disease, congestive heart failure, left ventricular ejection fraction (LVEF) of <50%, thyroid, pituitary, and adrenal disorders, current or previous usage of medication for alopecia, and use of drugs such as androgen, anti-androgen, weight loss or insulin sensitizing drugs and glucocorticoids within the last 3 months. Subjects were separated into three groups according to degree of their baldness scale as follows: Group 1¼mild, Group 2¼moderate and Group 3¼severe AGA. The SYNTAX score and CIMT were measured for each subject accordingly. Analyses of male and female subjects were carried out separately. Results: Group 1, 2, and 3 of the male patients included 12, 34, and 15 subjects respectively while group 1, 2, and 3 of the female patients consisted of 29, 14, and 12 subjects respectively. Frequency of major cardiovascular risk factors and laboratory findings of the subjects between the groups were similar for both male and female subjects. Likewise, average age, height, weight, and BMI of groups of were statistically similar for both males and females (Table 1). For male subjects; group 3 had significantly higher SYNTAX score compared to group 1 (<0.001) and group 2 (<0.01). Similarly for female subjects, group 3 had significantly higher SYNTAX score

The Relation Between Androgenetic Alopecia and Cardiovascular Atherosclerosis Measured via Carotid Intima-Media Thickness and the SYNTAX Score. Hüseyin Ede1, Emine Çölgeçen2, Mustafa Fatih Erkoç3, Ali Rıza Erbay1. 1Department of Cardiology, Bozok University School of Medicine, Yozgat, Turkey; 2Department of Dermatology, Bozok University School of Medicine, Yozgat, Turkey; 3Department of Radiology, Bozok University School of Medicine, Yozgat, Turkey.

S18 The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral

MARCH 10e13, 2016 Clinical, echocardiographic data, and the SYNTAX scores of the subjects. Analyses were performed for male and females separately

Age (year) Group 1 Group 2 Group 3 BMI (kg/m2) Group 1 Group 2 Group 3 Left atrium diameter (mm) Group 1 Group 2 Group 3 Glucose (mg/dl) Group 1 Group 2 Group 3 Creatinine (mg/dl) Group 1 Group 2 Group 3 Total cholesterol (mg/dl) Group 1 Group 2 Group 3 Triglyceride (mg/dl) Group 1 Group 2 Group 3 HDL (mg/dl) Group 1 Group 2 Group 3 LDL (mg/dl) Group 1 Group 2 Group 3 LVEF (%) Group 1 Group 2 Group 3 The SYNTAX score Group 1 Group 2 Group 3 CIMT value (mm) Group 1 Group 2 Group 3 Number of subjects with CIMT >1 mm (%) Group 1 Group 2 Group 3

Males (n¼61) p value

Females (n¼55) p value

55
8 58
6 0.432 59
5

55
8 59
3 0.168 60
3

28.5
1.2 27.1
3.0 0.261 28.9
2.6

27.2
2.5 24.9
0.5 0.210 27.2
1.6

37
3 38
2 0.351 38
2

36
4 42
4 0.377 38
2

99
7 100
11 0.997 101
16

97
14 104
13 0.371 101
16

1.05
0.24 0.91
0.10 0.576 0.91
0.09

0.90
0.13 0.90
0.19 0.571 0.98
0.18

186
44 194
48 0.796 177
42

207
31 214
27 0.751 215
33

175
84 192
85 0.731 226
96

200
57 225
57 0.372 198
59

39
10 39
6 0.244 34
4

41
2 40
2 0.087 39
3

116
34 126
43 0.958 120
44

131
21 134
20 0.719 137
21

61
2 60
4 0.632 59
3

62
5 58
13 0.924 62
6

1.5
2.8 9.8
6.7 <0.001 17.3
9.8

0.4
1.7 6.4
3.2 <0.001 17.2
8.0

0.60
0.18 0.64
0.19 0.94
0.21 <0.001 1.07
0.11 <0.001 1.10
0.20 1.33
0.11

0 (0) 11 (32) <0.05 8 (53)

1 (3) 8 (57) <0.001 12 (100)

AGA:Androgenetic Alopecia; BMI: Body mass index; LVEF: Left ventricular ejection fraction; CIMT: Carotid intima media thickness; Group 1: Mild AGA; Group 2: Moderate AGA; Group 3: Severe AGA compared to group 1 (p<0.001) and group 2 (p<0.001). Among both male and female subjects, CIMT of group 3 were significantly higher than that of other groups. The SYNTAX score was significantly

correlated with CIMT value both in male (r¼0.894 p<0.001) and female subjects (r¼0.840 p<0.001). Conclusions: AGA may be a simple phenotypical indicator for cardiovascular atherosclerosis since we found that patients with higher stage of AGA had significantly higher SYNTAX score and CIMT value among both gender.

- OP-049 A Novel Marker for Asymptomatic Organ Damage in the Patients with Hypertension: MIR-21. Erkan Yıldırım1, _ 1, Ugur Aksu2, Kamuran Kalkan1, Emrah Ipek 1 Selami Demirelli , Emrah Ermis¸1, Mustafa Öztürk1, Hikmet Hamur3. 1Department of Cardiology, Erzurum Region Training and Research Hospital, Erzurum, Turkey; 2 Department of Cardiology, Kars State Hospital, Kars, Turkey; 3Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey. Objectives: Hypertension (HT) is a modifiable risk factor for cardiovascular, cerebrovascular, and renal disease. To be aware of asymptomatic organ damage (AOD) in hypertensive patients is important for HT management.We aimed to define the relation of plasma micro RNA21 (miR-21), oxidized LDL (oxLDL) and the lectin-like oxLDL receptor (LOX-1) levels with the parameters those reflect AOD such as carotid intima media thickness (CIMT) in hypertensive patients compared to healthy controls. Moreover; to detect the relative increased levels of plasma miR-21 in patients with HT with respect to AOD. Methods: The study population consisted of two groups: 32 hypertensive and 32 healthy controls were included. Firstly we compared these two groups. Then to signalize the relation of plasma miR-21 with HT; hypertensive patients were divided into two groups according to AOD as with AOD and without AOD. Results: miR-21 levels was correlated with the clinical systolic and diastolic blood pressure, microalbuminuria (MAU), LOX-1, CRP and CIMT. Sixteen patients with HT had AOD. CIMT, miR-21 and CRP levels were significantly higher in patients with AOD. Conclusions: We found increased levels of LOX-1 and oxLDL in patients with HT as shown in other studies. In the absence of decreased eGFR with the presence of mild MAU, the increased plasma miR-21 expression in patients with increased CIMT, lead us to think that in hypertensive patients, miRNA can take some role in the early stages of atherosclerotic process. Our study showed that miR-21 measured in plasma could be utilized as a novel marker to indicate asymptomatic organ damage in hypertensive patients.

- OP-050 Increased Serum Ykl-40 Level is Associated with the Presence and Severity of Metabolic Syndrome. Mehmet Kadri Akboga1, Ridvan Yalcin2, Asife Sahinarslan2, Canan Yilmaz Demirtas3, Hatice Pasaoglu3, Adnan Abaci2. 1 Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology; 2Gazi University Medical Faculty, Department of Cardiology; 3Gazi University Medical Faculty, Department of Medical Biochemistry. Objective: Metabolic syndrome (MS) is defined by a cluster of interdependent physiological, biochemical and clinical risk factors and linked to a state of chronic low grade inflammation. YKL-40 is known as an inflammatory glycoprotein which is secreted by various cell lines during inflammation. Thus, we aimed to assess the association of serum YKL-40 levels with the presence and severity of MS. Methods: In this prospective cross-sectional study, a total 186 consecutive patients [n¼122 MS present and n¼64 MS absent] were enrolled. MS was defined according to NCEP-ATP III criteria. Serum

The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral

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O R A L A B S T R A C T S