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OP-073 THE ASSOCIATION BETWEEN PARAOXONASE ACTIVITY AND NOCTURNAL BLOOD PRESSURE PROFILE
Oral Presentations / International Journal of Cardiology 155S1 (2012) S1–S89
performed in 3 groups including the healthy control group to calculate aortic elastic properties (aortic strain, distensibility, aortic stiffness index). Serum endothelin-1 levels were measured by ELISA method from the blood samples obtained from all 3 groups. Results: There was a significant correlation between serum endothelin-1 levels and aortic elastic properties of all volunteers in this study (p = 0.004). When the relationship between blood pressure levels and aortic elastic properties were assessed; aortic elastic properties of uncontrolled hypertensive group were significantly different from not only healthy control group but also controlled hypertensive group (p < 0.01) (Table 1). Although endothelin-1 levels were different in 3 groups, but this result was not statistically significant (p = 0.101). Conclusions: The significant relationship was found between aortic elastic properties and endothelin-1 levels of all volunteers included in this study. When the relationship between BP levels and aortic elastic properties were assessed; the difference between all 3 groups regarding aortic elastic properties might indicate that aortic stiffness was related to high blood pressure levels and blood pressure regulation by antihypertensive drugs could improve the aortic stiffness. These results make us to think that in daily practice; measurement aortic elastic properties in hypertensive patients might give an idea of blood pressure level regulation. Table 1. The relationship between aortic elastic properties and study groups Controlled Hypertension Group (n = 56)
Uncontrolled Hypertension Group (n = 47)
Control Group (n = 49)
Aortic strain (%)
7.24±3.97
11.02±5.73
16.2±4.73
Aortic Distensibility (cm2 /dyne) Aortic Stiffness index
2.52±1.65 8.92±4.69
4.66±2.62 5.31±2.75
7.58±2.90 3.04±0.83
OP-072 ASSESSMENT OF SERUM INFLAMMATION MARKERS AT YOUNG PREHYPERTENSIVE PATIENTS 1 2 U.C. ¸ Yuksel1 , T. Celik ¸ , A. Iyisoy1 , M. Celik ¸ , B. Bugan3 , S. Firtina4 , 1 Y. Gokoglan1 , K. Karabacak5 , E. Yalcinkaya ¸ , E. Yildirim1 . 1 GATA Ankara Department of Cardiology, Ankara, Turkey; 2 Van Military Hospital Division of Cardiology, Van, Turkey; 3 Malatya Military Hospital Division of Cardiology, Malatya, Turkey; 4 Erzincan Military Hospital Division of Cardiology, Erzincan, Turkey; 5 Erzurum Military Hospital Division of Cardiovascular Surgery, Erzurum, Turkey Objective: Prehypertension is a recently described class of hypertension in which patient’s arteriel blood pressure is between the values of 120/80 mmHg and 140/90 mmHg. Hypertension is known to be a cause of systemic inflammation. Aim of this study is to investigate whether there is a systemic inflammation or not at the prehypertensive patients without any cardiovasculary disease. Methods: Study involved a total of 31 newly diagnosed prehypertensive patient (20 male, mean age = 34±6) and 31 healthy volunteers (21 male, mean age = 32±5). Blood pressure measurement is done from the right arm after 10 minutes of resting period. An avarage of 3 different measurement taken for analysis. Whole blood count, fasting gluse, total cholesterol, trigliseride, HDL cholesterol, LDL choleserol, hs-CRP, insulin resistance (with homa technique; HOMA-IR) measurements performed to all individuals from the blood samples. Results: there were no diference for the baseline clinical characteristics between two groups besides blood pressure values (Table 1). Biochemical results are summarized in Table 2. White blood cell count (11.69±0.80 vs 8.60±0.12 (×109 /l); p < 0.001) and hs-CRP (170.44±81.94 vs 84.26±34.64 (mg/dl); p < 0.001) values were higher in prehypertensive group. Other laboratory parameters were similar for both groups. Conclusions: The results showed us that inflammation also accompanies to prehypertension as in hypertension. Prehypertension is known to be a risk for developing hypertension and other cardiovascular diseases. Increased systemic inflmmation
S13
may have a role at the pathophsiologic mechanisms of increased cardiovascular disease risk. Table 1. Basic clinical features
Age (years) Sex (M), n (%) BMI (kg/m2 ) BSA (m2 ) SBP (mmHg) (median) DBP (mmHg) (median) Mean BP (mmHg) (median) Heart Rate (beats/min)
Prehypertension (n = 31)
Control (n = 31)
p
34±6 20 (64.5) 25.77±3.08 1.84±0.14 131.93±5.11 82.25±5.60 98.81±4.51 73±12
32±5 21 (67.7) 25.82±1.59 1.81±0.10 108.22±9.62 66.61±6.63 80.48±6.47 71±9
0.16 0.78 0.62 0.47 <0.001 <0.001 <0.001 0.27
BMI, Body Mass Index; BSA, Body Surface Area; TG, Triglyceride; HDL, High density lipoprotein; LDL, Low density lipoprotein; BP, Blood Pressure; SBP, Systolic Blood Pressure; DKB, Diastolic Blood Pressure.
Table 2. Biochemical analysis
Total cholesterol (mg/dl) TG (mg/dl) (median) HDL cholesterol (mg/dl) LDL cholesterol (mg/dl) Serum glucose (mg/dl) Serum insulin (pU/mL) HOMA-IR WBC (×109 /1) hs-CRP (pg/d1) (median)
Prehypertension (n = 31)
Control (n = 31)
P
200.41±44.39 144.96±82.33 (123) 44.45±11.74 126.97±40.12 97.30±7.85 10.44±2.68 2.52±0.69
206.61±41.34 124.58±48.58 (115) 45.54±10.07 137.14±42.85 94.03±6.90 8.94±3.28 2.09±1.26
0.57 0.54 0.97 0.32 0.08 0.16 0.10
11.69±0.80 170.44±81.94 (162)
8.60±0.12 84.26±34.64 (78)
<0.001 <0.001
TG, Triglyceride; HDL, High density lipoprotein; LDL, Low density lipoprotein; WBC, White Blood Cell; HOMAIR, Homeostasis Model Insulin Resistance.
OP-073 THE ASSOCIATION BETWEEN PARAOXONASE ACTIVITY AND NOCTURNAL BLOOD PRESSURE PROFILE T. Durmaz1 , T. Keles1 , H. Ayhan2 , E. Bilen2 , N.A. Bayram2 , M. Akcay2 , E. Bozkurt1 . 1 Department of Cardiology, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey; 2 Department of Cardiology, Ataturk Education and Research Hospital, Ankara, Turkey Objective: Abnormal nocturnal blood pressure profile has been linked to microvascular function and autonomic dysfunction. Paraoxonase (PON) is a high-density lipoprotein (HDL)-bound enzyme that exerts antiatherogenic properties by protecting lowdensity lipoprotein (LDL)-cholesterol from oxidative modification. The aim of this study was to examine the association between PON activity and nocturnal blood pressure profile. Methods: A total of 109 patients (mean age 57.1±10.4 years, age range 36–87 years, 67 male and 42 female) underwent 24-h ambulatory blood pressure monitoring. Dippers and non-dippers were determined. Paraoxonase activity was measured using a spectrophotometric technique. Results: No significant difference was found between patients with dipper (n = 49) and non-dipper (n = 60) nocturnal blood pressure profile regarding PON activity (203.0±119.8 U/l vs. 193.8±131.2 U/l, or 1.001, 95%CI 0.997–1.004, p = 0.732). Conclusions: This study showed that PON activity is not associated with nocturnal blood pressure profile. OP-074 THE ASSOCIATION BETWEEN PARAOXONASE ACTIVITY AND AORTIC STIFFNESS PARAMETERS T. Durmaz1 , T. Keles1 , H. Ayhan2 , N. Cay3 , E. Bilen2 , N.A. Bayram2 , M. Akcay2 , E. Bozkurt1 . 1 Department of Cardiology, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey; 2 Department of Cardiology, Ataturk Education and Research Hospital, Ankara, Turkey; 3 Department of Radiology, Ataturk Education and Research Hospital, Ankara, Turkey Objective: An association between aortic stiffness and atherosclerosis has been previously demonstrated. Paraoxonase (PON) is a high-density lipoprotein (HDL)-bound enzyme that
performed in 3 groups including the healthy control group to calculate aortic elastic properties (aortic strain, distensibility, aortic stiffness index). Serum endothelin-1 levels were measured by ELISA method from the blood samples obtained from all 3 groups. Results: There was a significant correlation between serum endothelin-1 levels and aortic elastic properties of all volunteers in this study (p = 0.004). When the relationship between blood pressure levels and aortic elastic properties were assessed; aortic elastic properties of uncontrolled hypertensive group were significantly different from not only healthy control group but also controlled hypertensive group (p < 0.01) (Table 1). Although endothelin-1 levels were different in 3 groups, but this result was not statistically significant (p = 0.101). Conclusions: The significant relationship was found between aortic elastic properties and endothelin-1 levels of all volunteers included in this study. When the relationship between BP levels and aortic elastic properties were assessed; the difference between all 3 groups regarding aortic elastic properties might indicate that aortic stiffness was related to high blood pressure levels and blood pressure regulation by antihypertensive drugs could improve the aortic stiffness. These results make us to think that in daily practice; measurement aortic elastic properties in hypertensive patients might give an idea of blood pressure level regulation. Table 1. The relationship between aortic elastic properties and study groups Controlled Hypertension Group (n = 56)
Uncontrolled Hypertension Group (n = 47)
Control Group (n = 49)
Aortic strain (%)
7.24±3.97
11.02±5.73
16.2±4.73
Aortic Distensibility (cm2 /dyne) Aortic Stiffness index
2.52±1.65 8.92±4.69
4.66±2.62 5.31±2.75
7.58±2.90 3.04±0.83
OP-072 ASSESSMENT OF SERUM INFLAMMATION MARKERS AT YOUNG PREHYPERTENSIVE PATIENTS 1 2 U.C. ¸ Yuksel1 , T. Celik ¸ , A. Iyisoy1 , M. Celik ¸ , B. Bugan3 , S. Firtina4 , 1 Y. Gokoglan1 , K. Karabacak5 , E. Yalcinkaya ¸ , E. Yildirim1 . 1 GATA Ankara Department of Cardiology, Ankara, Turkey; 2 Van Military Hospital Division of Cardiology, Van, Turkey; 3 Malatya Military Hospital Division of Cardiology, Malatya, Turkey; 4 Erzincan Military Hospital Division of Cardiology, Erzincan, Turkey; 5 Erzurum Military Hospital Division of Cardiovascular Surgery, Erzurum, Turkey Objective: Prehypertension is a recently described class of hypertension in which patient’s arteriel blood pressure is between the values of 120/80 mmHg and 140/90 mmHg. Hypertension is known to be a cause of systemic inflammation. Aim of this study is to investigate whether there is a systemic inflammation or not at the prehypertensive patients without any cardiovasculary disease. Methods: Study involved a total of 31 newly diagnosed prehypertensive patient (20 male, mean age = 34±6) and 31 healthy volunteers (21 male, mean age = 32±5). Blood pressure measurement is done from the right arm after 10 minutes of resting period. An avarage of 3 different measurement taken for analysis. Whole blood count, fasting gluse, total cholesterol, trigliseride, HDL cholesterol, LDL choleserol, hs-CRP, insulin resistance (with homa technique; HOMA-IR) measurements performed to all individuals from the blood samples. Results: there were no diference for the baseline clinical characteristics between two groups besides blood pressure values (Table 1). Biochemical results are summarized in Table 2. White blood cell count (11.69±0.80 vs 8.60±0.12 (×109 /l); p < 0.001) and hs-CRP (170.44±81.94 vs 84.26±34.64 (mg/dl); p < 0.001) values were higher in prehypertensive group. Other laboratory parameters were similar for both groups. Conclusions: The results showed us that inflammation also accompanies to prehypertension as in hypertension. Prehypertension is known to be a risk for developing hypertension and other cardiovascular diseases. Increased systemic inflmmation
S13
may have a role at the pathophsiologic mechanisms of increased cardiovascular disease risk. Table 1. Basic clinical features
Age (years) Sex (M), n (%) BMI (kg/m2 ) BSA (m2 ) SBP (mmHg) (median) DBP (mmHg) (median) Mean BP (mmHg) (median) Heart Rate (beats/min)
Prehypertension (n = 31)
Control (n = 31)
p
34±6 20 (64.5) 25.77±3.08 1.84±0.14 131.93±5.11 82.25±5.60 98.81±4.51 73±12
32±5 21 (67.7) 25.82±1.59 1.81±0.10 108.22±9.62 66.61±6.63 80.48±6.47 71±9
0.16 0.78 0.62 0.47 <0.001 <0.001 <0.001 0.27
BMI, Body Mass Index; BSA, Body Surface Area; TG, Triglyceride; HDL, High density lipoprotein; LDL, Low density lipoprotein; BP, Blood Pressure; SBP, Systolic Blood Pressure; DKB, Diastolic Blood Pressure.
Table 2. Biochemical analysis
Total cholesterol (mg/dl) TG (mg/dl) (median) HDL cholesterol (mg/dl) LDL cholesterol (mg/dl) Serum glucose (mg/dl) Serum insulin (pU/mL) HOMA-IR WBC (×109 /1) hs-CRP (pg/d1) (median)
Prehypertension (n = 31)
Control (n = 31)
P
200.41±44.39 144.96±82.33 (123) 44.45±11.74 126.97±40.12 97.30±7.85 10.44±2.68 2.52±0.69
206.61±41.34 124.58±48.58 (115) 45.54±10.07 137.14±42.85 94.03±6.90 8.94±3.28 2.09±1.26
0.57 0.54 0.97 0.32 0.08 0.16 0.10
11.69±0.80 170.44±81.94 (162)
8.60±0.12 84.26±34.64 (78)
<0.001 <0.001
TG, Triglyceride; HDL, High density lipoprotein; LDL, Low density lipoprotein; WBC, White Blood Cell; HOMAIR, Homeostasis Model Insulin Resistance.
OP-073 THE ASSOCIATION BETWEEN PARAOXONASE ACTIVITY AND NOCTURNAL BLOOD PRESSURE PROFILE T. Durmaz1 , T. Keles1 , H. Ayhan2 , E. Bilen2 , N.A. Bayram2 , M. Akcay2 , E. Bozkurt1 . 1 Department of Cardiology, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey; 2 Department of Cardiology, Ataturk Education and Research Hospital, Ankara, Turkey Objective: Abnormal nocturnal blood pressure profile has been linked to microvascular function and autonomic dysfunction. Paraoxonase (PON) is a high-density lipoprotein (HDL)-bound enzyme that exerts antiatherogenic properties by protecting lowdensity lipoprotein (LDL)-cholesterol from oxidative modification. The aim of this study was to examine the association between PON activity and nocturnal blood pressure profile. Methods: A total of 109 patients (mean age 57.1±10.4 years, age range 36–87 years, 67 male and 42 female) underwent 24-h ambulatory blood pressure monitoring. Dippers and non-dippers were determined. Paraoxonase activity was measured using a spectrophotometric technique. Results: No significant difference was found between patients with dipper (n = 49) and non-dipper (n = 60) nocturnal blood pressure profile regarding PON activity (203.0±119.8 U/l vs. 193.8±131.2 U/l, or 1.001, 95%CI 0.997–1.004, p = 0.732). Conclusions: This study showed that PON activity is not associated with nocturnal blood pressure profile. OP-074 THE ASSOCIATION BETWEEN PARAOXONASE ACTIVITY AND AORTIC STIFFNESS PARAMETERS T. Durmaz1 , T. Keles1 , H. Ayhan2 , N. Cay3 , E. Bilen2 , N.A. Bayram2 , M. Akcay2 , E. Bozkurt1 . 1 Department of Cardiology, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey; 2 Department of Cardiology, Ataturk Education and Research Hospital, Ankara, Turkey; 3 Department of Radiology, Ataturk Education and Research Hospital, Ankara, Turkey Objective: An association between aortic stiffness and atherosclerosis has been previously demonstrated. Paraoxonase (PON) is a high-density lipoprotein (HDL)-bound enzyme that