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OP-076 THE RELATIONSHIP BETWEEN MEAN PLATELET VOLUME WITH METABOLIC SYNDROME IN OBESE INDIVIDUALS
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Oral Presentations / International Journal of Cardiology 155S1 (2012) S1–S89
exerts antiatherogenic properties by protecting low-density lipoprotein (LDL)-cholesterol from oxidative modification. The aim of this study was to examine the association between PON activity and aortic stiffness. Methods: A total of 106 patients (mean age 56.8±10.2 years, age range 36–83 years, 64 male and 42 female) underwent transthoracic echocardiography and sphygmomanometer-based brachial blood pressure measurement for aortic stiffness parameters (strain and distensibility). Paraoxonase activity was measured using a spectrophotometric technique. Results: No significant association was found between PON activity and aortic stiffness parameters. For aortic strain, r = 0.025 and p = 0.817, and for aortic distensibility, r = 0.131 and p = 0.230). Conclusions: The study result showed that PON activity is not associated with aortic stiffness parameters. OP-075 THE ASSOCIATION BETWEEN LEFT VENTRICULAR PEAK WALL STRESS AND CIRCADIAN BLOOD PRESSURE PATTERN IN ESSENTIAL HYPERTENSION ¨ O. Turak, A. Isleyen, F. Ucar, ¸ F. Ozcan, E. Sokmen, S. Yilmaz, S. Aydogdu. Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey Objective: Hypertension is associated with increased ventricular wall stress. High wall stress generates cardiac remodeling, leading to cardiovascular adverse outcomes. Failure in decrease in nighttime blood pressure (non-dipper) is associated with higher cardiovascular morbidity and mortality. In this study, we aimed to investigate the relationship between circadian blood pressure variations and left ventricular (LV) peak wall stress in newly diagnosed essential hypertensive patients. Methods: The study consisted of 107 consecutive newly diagnosed essential hypertensive patients. On the basis of the results from 24-hours ambulatory blood pressure monitoring (ABPM), the study subjects were divided into two groups, 52 subjects with nondipper hypertension and 55 subjects with dipper hypertension. Conventional two-dimensional and M-mode echocardiographic measurements were performed after ABPM. LV peak wall stress and LV mass index were calculated according to the previously defined formulas. Results: Non-dipper patients demonstrated higher LV peak wall stress (×103 dynes/cm2 ) compared to the dipper patients (123±63 vs 139±26.2, p < 0.001). LV mass index (g/m2 ) were also significantly higher in non-dippers compared to the dipper group (100.9±21.3 vs 120.7±30.1, p < 0.001). There was a significantly negative correlation between the percentage of nocturnal fall in BP and LV peak wall stress (r = −0.681, p = 0.001) in non-dipper hypertensive cases. In addition, LV peak wall stress was related to the LV mass index (r = 0.601, p = 0.001) in non-dipper cases. Conclusions: LV peak wall stress was found to be increased in nondipper hypertensive patients, which may partly account for the high rates of morbidity and mortality encountered in the patients with non-dipper hypertension. OP-076 THE RELATIONSHIP BETWEEN MEAN PLATELET VOLUME WITH METABOLIC SYNDROME IN OBESE INDIVIDUALS 1 ¨ ¸ Bulur3 , E. Onder , Y. Aslantas2 , A. Kutlucan1 , S. Bulur2 , S. Kir1 , S. I. Ekinozu2 . 1 Deparment of Internal Medicine, Duzce University, Duzce, Turkey; 2 Deparment of Cardiology, Duzce University, Duzce, Turkey; 3 Departments of Physiology, Selcuk University, Konya, Turkey Objective: The metabolic syndrome (MS) is closely associated with atherosclerotic risk factors and increased mortality. Mean platelet volume (MPV) is an indicator of platelet activation which is also shows a close relationship with cardiovascular risk factors, such as diabetes mellitus, hypertension, hypercholesterolemia, obesity, MS. The aim of this study was to investigate the correlates of MS, its
components and MPV adjusted for obesity in a large population study. Methods: A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. 920 obese participants, who had BMI ≥ 30 kg/m2, further evaluated for the presence of MS. 513 [396 females (70.2%)] had MS and the rest 407 subjects [324 females (79.6%)] served as the control group. Results: The BMI, systolic blood pressure, diastolic blood pressure, waist circumference, fasting plasma glucose, visceral fat, total cholesterol, HDL-cholesterol, and triglyceride was higher significantly in MS group (p 0.002 for BMI and p < 0.001 for the others). No significant difference was observed between groups regarding LDL cholesterol, white blood cells, platelet counts, MPV, hematocrit and hemoglobin (p > 0.05 for all). Conclusions: The presence of MS and its components do not constitute a difference in MPV values in obese subjects with a BMI ≥ 30. OP-077 THE EFFECT OF DIFFERENT STATIN TYPES ON ERECTILE DYSFUNCTION IN HYPERCHOLESTEROLEMIC PATIENTS 1 1 ¨ ¨ Yildirimturk1 , S. ¸ Kul1 , K.S. Ozcan , Y. Canga ¸ , Z. Nurkalem1 , O. 1 1 2 1 E. Bozbeyoglu , S. Satilmis , C. Kaya . Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Center, Istanbul, Turkey; 2 Department of Urology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey Objective: Erectile dysfunction (ED) is a common problem which is generally related with atherosclerosis. Hypercholesterolemia is one of the major independent predictors of erectile dysfunction. The aim of this study was to evaluate effect of different statin types on erectile dysfunction in hypercholesterolemic patients. Methods: Ninety male hypercholesterolemic patients (mean age 50.4±7.9 years) who are otherwise healthy were included into the study prospectively. None of patients had any cardiovascular risk factors except hypercholestrolemia. All patients were evaluated with International Index of Erectile Function (IIEF) score and control blood samples were withdrawn. Patients were divided into two different groups. One of the groups have received atorvastatin while the other groups was given rosuvastatin. All patients were followed for 6 months and IIEF score and blood samples were re-evaluated. Results: Patients in Group-1 were received 14.5±6.2 mg of rosuvastatin while patients in Group-2 were given 25.6±11.6 mg of atorvastatin. Patients were in similar ages in both groups. There were also no statistical differences in terms of blood glucose levels, total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and mean IIEF score in both groups at the beginning. After 6 months, TC and LDL levels were lower compared to beginning and there were no statistical difference in both groups. No difference has been observed in HDL levels in Group-1, but HDL levels were slightly increased in Group-2 (p = 0.033). However, the difference in both groups was not statistically significant. There was a significant difference in both groups in terms of TG levels before and after the medications (p < 0.001 in both groups). But TG levels more lower with rosuvastatin therapy (p = 0.037). No IIEF score changes has been observed in Group-1 after the medication however, IIEF score was significantly lower in Group-2 (p = 0.019). There were no difference in IIEF scores between 2 groups after statin therapy. Table 1. Evaluation of IIEF scores in both groups
IIEF score IIEF score
Before After p value
Group 1 (Mean±SD)
Group 2 (Mean±SD)
p value
17.23±6.22 17.14±6.48 0.896
18.96±4.80 17.33±5.30 0.019*
0.143 0.879
Oral Presentations / International Journal of Cardiology 155S1 (2012) S1–S89
exerts antiatherogenic properties by protecting low-density lipoprotein (LDL)-cholesterol from oxidative modification. The aim of this study was to examine the association between PON activity and aortic stiffness. Methods: A total of 106 patients (mean age 56.8±10.2 years, age range 36–83 years, 64 male and 42 female) underwent transthoracic echocardiography and sphygmomanometer-based brachial blood pressure measurement for aortic stiffness parameters (strain and distensibility). Paraoxonase activity was measured using a spectrophotometric technique. Results: No significant association was found between PON activity and aortic stiffness parameters. For aortic strain, r = 0.025 and p = 0.817, and for aortic distensibility, r = 0.131 and p = 0.230). Conclusions: The study result showed that PON activity is not associated with aortic stiffness parameters. OP-075 THE ASSOCIATION BETWEEN LEFT VENTRICULAR PEAK WALL STRESS AND CIRCADIAN BLOOD PRESSURE PATTERN IN ESSENTIAL HYPERTENSION ¨ O. Turak, A. Isleyen, F. Ucar, ¸ F. Ozcan, E. Sokmen, S. Yilmaz, S. Aydogdu. Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey Objective: Hypertension is associated with increased ventricular wall stress. High wall stress generates cardiac remodeling, leading to cardiovascular adverse outcomes. Failure in decrease in nighttime blood pressure (non-dipper) is associated with higher cardiovascular morbidity and mortality. In this study, we aimed to investigate the relationship between circadian blood pressure variations and left ventricular (LV) peak wall stress in newly diagnosed essential hypertensive patients. Methods: The study consisted of 107 consecutive newly diagnosed essential hypertensive patients. On the basis of the results from 24-hours ambulatory blood pressure monitoring (ABPM), the study subjects were divided into two groups, 52 subjects with nondipper hypertension and 55 subjects with dipper hypertension. Conventional two-dimensional and M-mode echocardiographic measurements were performed after ABPM. LV peak wall stress and LV mass index were calculated according to the previously defined formulas. Results: Non-dipper patients demonstrated higher LV peak wall stress (×103 dynes/cm2 ) compared to the dipper patients (123±63 vs 139±26.2, p < 0.001). LV mass index (g/m2 ) were also significantly higher in non-dippers compared to the dipper group (100.9±21.3 vs 120.7±30.1, p < 0.001). There was a significantly negative correlation between the percentage of nocturnal fall in BP and LV peak wall stress (r = −0.681, p = 0.001) in non-dipper hypertensive cases. In addition, LV peak wall stress was related to the LV mass index (r = 0.601, p = 0.001) in non-dipper cases. Conclusions: LV peak wall stress was found to be increased in nondipper hypertensive patients, which may partly account for the high rates of morbidity and mortality encountered in the patients with non-dipper hypertension. OP-076 THE RELATIONSHIP BETWEEN MEAN PLATELET VOLUME WITH METABOLIC SYNDROME IN OBESE INDIVIDUALS 1 ¨ ¸ Bulur3 , E. Onder , Y. Aslantas2 , A. Kutlucan1 , S. Bulur2 , S. Kir1 , S. I. Ekinozu2 . 1 Deparment of Internal Medicine, Duzce University, Duzce, Turkey; 2 Deparment of Cardiology, Duzce University, Duzce, Turkey; 3 Departments of Physiology, Selcuk University, Konya, Turkey Objective: The metabolic syndrome (MS) is closely associated with atherosclerotic risk factors and increased mortality. Mean platelet volume (MPV) is an indicator of platelet activation which is also shows a close relationship with cardiovascular risk factors, such as diabetes mellitus, hypertension, hypercholesterolemia, obesity, MS. The aim of this study was to investigate the correlates of MS, its
components and MPV adjusted for obesity in a large population study. Methods: A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. 920 obese participants, who had BMI ≥ 30 kg/m2, further evaluated for the presence of MS. 513 [396 females (70.2%)] had MS and the rest 407 subjects [324 females (79.6%)] served as the control group. Results: The BMI, systolic blood pressure, diastolic blood pressure, waist circumference, fasting plasma glucose, visceral fat, total cholesterol, HDL-cholesterol, and triglyceride was higher significantly in MS group (p 0.002 for BMI and p < 0.001 for the others). No significant difference was observed between groups regarding LDL cholesterol, white blood cells, platelet counts, MPV, hematocrit and hemoglobin (p > 0.05 for all). Conclusions: The presence of MS and its components do not constitute a difference in MPV values in obese subjects with a BMI ≥ 30. OP-077 THE EFFECT OF DIFFERENT STATIN TYPES ON ERECTILE DYSFUNCTION IN HYPERCHOLESTEROLEMIC PATIENTS 1 1 ¨ ¨ Yildirimturk1 , S. ¸ Kul1 , K.S. Ozcan , Y. Canga ¸ , Z. Nurkalem1 , O. 1 1 2 1 E. Bozbeyoglu , S. Satilmis , C. Kaya . Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Center, Istanbul, Turkey; 2 Department of Urology, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey Objective: Erectile dysfunction (ED) is a common problem which is generally related with atherosclerosis. Hypercholesterolemia is one of the major independent predictors of erectile dysfunction. The aim of this study was to evaluate effect of different statin types on erectile dysfunction in hypercholesterolemic patients. Methods: Ninety male hypercholesterolemic patients (mean age 50.4±7.9 years) who are otherwise healthy were included into the study prospectively. None of patients had any cardiovascular risk factors except hypercholestrolemia. All patients were evaluated with International Index of Erectile Function (IIEF) score and control blood samples were withdrawn. Patients were divided into two different groups. One of the groups have received atorvastatin while the other groups was given rosuvastatin. All patients were followed for 6 months and IIEF score and blood samples were re-evaluated. Results: Patients in Group-1 were received 14.5±6.2 mg of rosuvastatin while patients in Group-2 were given 25.6±11.6 mg of atorvastatin. Patients were in similar ages in both groups. There were also no statistical differences in terms of blood glucose levels, total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and mean IIEF score in both groups at the beginning. After 6 months, TC and LDL levels were lower compared to beginning and there were no statistical difference in both groups. No difference has been observed in HDL levels in Group-1, but HDL levels were slightly increased in Group-2 (p = 0.033). However, the difference in both groups was not statistically significant. There was a significant difference in both groups in terms of TG levels before and after the medications (p < 0.001 in both groups). But TG levels more lower with rosuvastatin therapy (p = 0.037). No IIEF score changes has been observed in Group-1 after the medication however, IIEF score was significantly lower in Group-2 (p = 0.019). There were no difference in IIEF scores between 2 groups after statin therapy. Table 1. Evaluation of IIEF scores in both groups
IIEF score IIEF score
Before After p value
Group 1 (Mean±SD)
Group 2 (Mean±SD)
p value
17.23±6.22 17.14±6.48 0.896
18.96±4.80 17.33±5.30 0.019*
0.143 0.879