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OP-079 The Effect of Septoplasty on Pulmonary Artery Pressure and Right Ventricular Function in Nasal Septum Deviation
MARCH 10e13, 2016
O R A L A B S T R A C T S
presented to the obstetrics and gynecology outpatient clinic for routine prenatal screenings. All study participants underwent 2-D transthoracic echocardiography imaging and LVMI was calculated using the Devereux Formula after measurements of the left ventricle diameter, interventricular septum (IVS), and posterior wall thickness (PWT). Devereux formula defined as 0.80 (1.04 (IVSD þ LVPWd þ LVEDD)3 e LVEDD3þ 0.6 g. Furthermore, pentraxin-3 levels were measured with the enzyme-linked immunosorbent assay method and neutrophil to lymphocyte ratios (NLR) were calculated. Results: The patients with pre-eclampsia were more likely to have higher LVMI than non-preeclamptic pregnants (83.4 9.9 vs. 79.5 9.4 g/m2, p¼ 0.022). However, there was no difference between severe and mild preeclampsia groups in terms of LVMI (84.4 9.4 vs. 82.7 10.2 g/m2, p¼ 0.347). Moreover, there was no correlation between LVMI and some inflammatory markers such as pentraxin-3 (r¼0.109, p¼ 0.201) and NLR (r¼0.126, p¼0.137). Conclusion: LVMI, which is an echocardiographic marker of left ventricular hypertrophy, is related presence of preeclampsia in pregnant women. However, this association does not continue with the severity of preeclampsia. The possible link between raised LVMI and presence of preeclampsia may due to severe chronic inflammation.
- OP-079 The Effect of Septoplasty on Pulmonary Artery Pressure and Right Ventricular Function in Nasal Septum Deviation. Gülay Özkeçeci1, Onder Akçi1, Abdulkadir Bucak2, S¸ahin Ulu2, Zafer Yalım1, Abdullah Ayçiçek2, Ersel Onrat1, Alaettin Avs¸ar1. 1 Department of Cardiology, Afyon Kocatepe University; 2 Department of Otorhinolaryngology, Afyon Kocatepe University. Aim: Nasal septum deviation (NSD) can cause obstruction of the upper airway, which may lead to increased pulmonary artery pressure (PAP) and right ventricle dysfunction. The aim of the present study was to evaluate the effect of septoplasty on right ventricle function and mean PAP of patients with marked NSD. Methods: 25 patients with marked NSD (mean age¼ 31.812.3 years) and 27 healthy volunteers (mean age¼ 34.510.8 years) were enrolled. Echocardiography was performed for all subjects and right ventricle function and mean PAP were evaluated before and three months after septoplasty. Results: Tricuspid annular plane systolic excursion (TAPSE) and tricuspid annulus early diastolic myocardial velocity (E0 ) were significantly Baseline characteristics and echocardiographic findings of study subjects Variables Age, years Gender (F/M) BMI (kg/m2) RVMPI Mean PAP (mmHg) S(cm/sec) E0 (cm/sec) A0 (cm/sec) TAPSE (cm)
Patients with NSD (n¼ 25)
Controls (n¼28)
p
31.8 12.3 3/22 24.9 4.4 0.47 0.11 22.66 10.3 14.3 2.5 13.9 3.3 14.4 5.4 2.42 0.39
34.5 10.8 5/23 26.2 3.2 0.41 0.07 17.72 6.4 15 2.9 16.6 4.6 14.9 4.5 2.76 0.45
0.4 0.4 0.2 0.049* 0.046* 0.7 0.037* 0.7 0.006*
NSD: Nasal septum deviation, F: Female, M: Male, BMI: Body mass index: RVMPI:Right ventricle myocardial performance index, PAP:Pulmonary artery pressure, S: tricuspid annulus systolic myocardial velocity, Eʹ: tricuspid annulus early diastolic myocardial velocity, Aʹ: tricuspid anulus late diastolic myocardial velocity * p<0.05.
lower in patients with NSD than control subjects while right ventricle myocardial performance index (RVMPI) and mean PAB were significantly higher (respectively, p¼ 0.006, 0.037, 0.049, 0.046). When preoperative and postoperative findings were compared, mean PAB decreased whereas TAPSE increased significantly (respectively, p ¼ 0.007, 0.03). Conclusion: The results of the present study demonstrated that mean PAB increased and right ventricle function worsened in patients with NSD. However, mean PAB decreased and right ventricle function tended to recover after septoplasty.
- OP-080 Effects of Levodopa Therapy on Global Left Ventricular Systolic Function in Patients with Parkinson Disease. Osman Bektas¸, Zeki Yüksel Günaydın. Department of Cardiology, Ordu University, Ordu, Turkey. Objectives: Since Levodopa was identified as an efficient therapeutic option in Parkinson Disease (PD), great success has been achieved in the course and treatment of the disease. However, L-dopa-related side effects limit the therapeutic use in some patients. The aim of this study was to evaluate the effects of Ldopa therapy on left ventricular global systolic function via speckle tracking method. Methods: In this study, 55 patients with PD under L-dopa / dopa decarboxylase inhibitor therapy were compared with 30 age and sex matched control subjects. Conventional transthoracic echocardiography was performed in the left lateral position by two experienced operators in accordance with generally accepted guidelines. Left ventricular systolic function was analyzed by speckle tracking method using global longitudinal strain (GLS) and global circumferential strain (GCS) imaging. Results: Adequate echocardiographic imaging for the evaluation of global longitudinal strain and global circumferential strain could be achieved in 55 of the patients. LVEF, GLS and GCS values were found to be similar between the patients with PD under L-dopa therapy and the control group. (62 3.5% vs 61 4%, p <0.05; -19.46 2.3 vs. -19.4 3.2, p <0.05 and -18.60 3.5 vs -18.22 3.2, p<0,05 respectively.) Conclusions: Despite impairment of diastolic function, levodopa therapy has no unfavorable effect on left ventricular systolic function in patients with PD.
- OP-081 Subclinical Left Ventricular Deterioration in Patients with Erectile Dysfunction. Osman Bektas¸, Zeki Yüksel Günaydın. Department of Cardiology, Ordu University, Ordu, Turkey. Objective: The majority of risk factors for coronary artery disease (CAD) are also encountered in patients with erectile dysfunction (ED). We aimed to investigate a possible association between left ventricular contraction dynamics and erectile dysfunction using speckle tracking echocardiography imaging. Methods: A total of 125 patients diagnosed as ED in urology outpatient clinic of our instution were compared with 30 age and sex matched control subjects. Evaluation of erectile dysfunction was performed using a questionnaire consisting of 5 queries, namely International Index of Erectile Function (IIEF-5) in both study and control groups. STE and GLS were assessed using standard two-dimensional grayscale images obtained from two, three and four-chamber apical images while GCS was evaluated using the parasternal shortaxis images in left ventricular basal, mid and apical levels. Results: Longitudinal and circumferencial strain were detected to be higher in the ED group compared to control group. (-17,32,6 vs. -20.8 3.5 p<0.05, -19.34.5 vs. -21.3 3.7 p<0.05 respectively).
S32 The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
O R A L A B S T R A C T S
presented to the obstetrics and gynecology outpatient clinic for routine prenatal screenings. All study participants underwent 2-D transthoracic echocardiography imaging and LVMI was calculated using the Devereux Formula after measurements of the left ventricle diameter, interventricular septum (IVS), and posterior wall thickness (PWT). Devereux formula defined as 0.80 (1.04 (IVSD þ LVPWd þ LVEDD)3 e LVEDD3þ 0.6 g. Furthermore, pentraxin-3 levels were measured with the enzyme-linked immunosorbent assay method and neutrophil to lymphocyte ratios (NLR) were calculated. Results: The patients with pre-eclampsia were more likely to have higher LVMI than non-preeclamptic pregnants (83.4 9.9 vs. 79.5 9.4 g/m2, p¼ 0.022). However, there was no difference between severe and mild preeclampsia groups in terms of LVMI (84.4 9.4 vs. 82.7 10.2 g/m2, p¼ 0.347). Moreover, there was no correlation between LVMI and some inflammatory markers such as pentraxin-3 (r¼0.109, p¼ 0.201) and NLR (r¼0.126, p¼0.137). Conclusion: LVMI, which is an echocardiographic marker of left ventricular hypertrophy, is related presence of preeclampsia in pregnant women. However, this association does not continue with the severity of preeclampsia. The possible link between raised LVMI and presence of preeclampsia may due to severe chronic inflammation.
- OP-079 The Effect of Septoplasty on Pulmonary Artery Pressure and Right Ventricular Function in Nasal Septum Deviation. Gülay Özkeçeci1, Onder Akçi1, Abdulkadir Bucak2, S¸ahin Ulu2, Zafer Yalım1, Abdullah Ayçiçek2, Ersel Onrat1, Alaettin Avs¸ar1. 1 Department of Cardiology, Afyon Kocatepe University; 2 Department of Otorhinolaryngology, Afyon Kocatepe University. Aim: Nasal septum deviation (NSD) can cause obstruction of the upper airway, which may lead to increased pulmonary artery pressure (PAP) and right ventricle dysfunction. The aim of the present study was to evaluate the effect of septoplasty on right ventricle function and mean PAP of patients with marked NSD. Methods: 25 patients with marked NSD (mean age¼ 31.812.3 years) and 27 healthy volunteers (mean age¼ 34.510.8 years) were enrolled. Echocardiography was performed for all subjects and right ventricle function and mean PAP were evaluated before and three months after septoplasty. Results: Tricuspid annular plane systolic excursion (TAPSE) and tricuspid annulus early diastolic myocardial velocity (E0 ) were significantly Baseline characteristics and echocardiographic findings of study subjects Variables Age, years Gender (F/M) BMI (kg/m2) RVMPI Mean PAP (mmHg) S(cm/sec) E0 (cm/sec) A0 (cm/sec) TAPSE (cm)
Patients with NSD (n¼ 25)
Controls (n¼28)
p
31.8 12.3 3/22 24.9 4.4 0.47 0.11 22.66 10.3 14.3 2.5 13.9 3.3 14.4 5.4 2.42 0.39
34.5 10.8 5/23 26.2 3.2 0.41 0.07 17.72 6.4 15 2.9 16.6 4.6 14.9 4.5 2.76 0.45
0.4 0.4 0.2 0.049* 0.046* 0.7 0.037* 0.7 0.006*
NSD: Nasal septum deviation, F: Female, M: Male, BMI: Body mass index: RVMPI:Right ventricle myocardial performance index, PAP:Pulmonary artery pressure, S: tricuspid annulus systolic myocardial velocity, Eʹ: tricuspid annulus early diastolic myocardial velocity, Aʹ: tricuspid anulus late diastolic myocardial velocity * p<0.05.
lower in patients with NSD than control subjects while right ventricle myocardial performance index (RVMPI) and mean PAB were significantly higher (respectively, p¼ 0.006, 0.037, 0.049, 0.046). When preoperative and postoperative findings were compared, mean PAB decreased whereas TAPSE increased significantly (respectively, p ¼ 0.007, 0.03). Conclusion: The results of the present study demonstrated that mean PAB increased and right ventricle function worsened in patients with NSD. However, mean PAB decreased and right ventricle function tended to recover after septoplasty.
- OP-080 Effects of Levodopa Therapy on Global Left Ventricular Systolic Function in Patients with Parkinson Disease. Osman Bektas¸, Zeki Yüksel Günaydın. Department of Cardiology, Ordu University, Ordu, Turkey. Objectives: Since Levodopa was identified as an efficient therapeutic option in Parkinson Disease (PD), great success has been achieved in the course and treatment of the disease. However, L-dopa-related side effects limit the therapeutic use in some patients. The aim of this study was to evaluate the effects of Ldopa therapy on left ventricular global systolic function via speckle tracking method. Methods: In this study, 55 patients with PD under L-dopa / dopa decarboxylase inhibitor therapy were compared with 30 age and sex matched control subjects. Conventional transthoracic echocardiography was performed in the left lateral position by two experienced operators in accordance with generally accepted guidelines. Left ventricular systolic function was analyzed by speckle tracking method using global longitudinal strain (GLS) and global circumferential strain (GCS) imaging. Results: Adequate echocardiographic imaging for the evaluation of global longitudinal strain and global circumferential strain could be achieved in 55 of the patients. LVEF, GLS and GCS values were found to be similar between the patients with PD under L-dopa therapy and the control group. (62 3.5% vs 61 4%, p <0.05; -19.46 2.3 vs. -19.4 3.2, p <0.05 and -18.60 3.5 vs -18.22 3.2, p<0,05 respectively.) Conclusions: Despite impairment of diastolic function, levodopa therapy has no unfavorable effect on left ventricular systolic function in patients with PD.
- OP-081 Subclinical Left Ventricular Deterioration in Patients with Erectile Dysfunction. Osman Bektas¸, Zeki Yüksel Günaydın. Department of Cardiology, Ordu University, Ordu, Turkey. Objective: The majority of risk factors for coronary artery disease (CAD) are also encountered in patients with erectile dysfunction (ED). We aimed to investigate a possible association between left ventricular contraction dynamics and erectile dysfunction using speckle tracking echocardiography imaging. Methods: A total of 125 patients diagnosed as ED in urology outpatient clinic of our instution were compared with 30 age and sex matched control subjects. Evaluation of erectile dysfunction was performed using a questionnaire consisting of 5 queries, namely International Index of Erectile Function (IIEF-5) in both study and control groups. STE and GLS were assessed using standard two-dimensional grayscale images obtained from two, three and four-chamber apical images while GCS was evaluated using the parasternal shortaxis images in left ventricular basal, mid and apical levels. Results: Longitudinal and circumferencial strain were detected to be higher in the ED group compared to control group. (-17,32,6 vs. -20.8 3.5 p<0.05, -19.34.5 vs. -21.3 3.7 p<0.05 respectively).
S32 The American Journal of Cardiologyâ MARCH 10e13, 2016 12th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral