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OP-080 [AJC » Chronic heart failure] Relation of Levels of Soluble ST2 with Clinic and Prognosis in Heart Failure Patients
MARCH 23e26, 2017 1 month but did not have a role on arterial patency after 1 month. Only smoking (odds:4.8, p¼0.01) associated with patency at 6 months. Conclusions: Preprocedural NLR was an independent risk factor for infrapopliteal arterial patency at short-term. It may be used as a risk factor for subsequent amputation or recurrent interventions. Keywords: Neutrophil to lymphocyte ratio, Infrapopliteal arterial patency, Percutaneous transluminal angioplasty.
Molecular and Genetic Basis of Cardiovascular Diseases
- OP-081 [AJC » Acute heart failure] Serum Presepsin Levels in Patients with Decompensated Heart Failure. Fatma Nihan Turhan Caglar1, Nilgun Isiksacan2, Ismail Biyik3, Hakan Sahin1, Dilay Karakozak1, Fahrettin Katkat4, Ibrahim Faruk Akturk1. 1 Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 2 Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 3 Department of Cardiology, Usak Universty Education and Research Hospital, Usak, Turkey; 4Department of Cardiology, Bagcilar Education and Research Hospital, Istanbul, Turkey.
- OP-080 [AJC » Chronic heart failure] Relation of Levels of Soluble ST2 with Clinic and Prognosis in Heart Failure Patients. Hakan Günes¸1, _ Gül2, Handan Günes¸3. Abdullah Zararsız2, Ibrahim 1 Department of Cardiology Sutcu Imam University, Kahramanmaras, Turkey; 2Department of Cardiology, Cumhuriyet University, Sivas, Turkey; 3Department of Physiology, Cumhuriyet University, Sivas, Turkey. Background and Aim: Prevalance of heart failure (HF) is increasing due to more aging of society and prolongation of life span of patient with heart disease related with modern treatment approaches. Despite improvements in treatment approaches, mortality rates are still high in HF patients due to problems in compliance of patients to drug tratment, problems in choosing the appropriate treatment dose and associated comorbid conditions. Soluble ST2 is high than other biomarker in predicting the course of disease in patients with HF in studies. In this study, levels of soluble ST2 were examined in relationship with clinical and echocardiographic parameters. Methods: The study included 55 patients (41 males, 14 females). Patients were evaluated by clinical findings and underwent
mortality and Levels of Soluble ST2 (Roc analysis) â
The American Journal of Cardiology
echocardiography. Blood samples were taken for Routine blood tests and soluble ST2. Results and Conclusion: Soluble ST2 levels was associated with endpoints such NHYA functional class (p:0,001), left ventricular ejection fraction (LV EF) (p:0,001), left ventricular end-diastolic diameter (LV EDD) (p:0,007), left atrial (LA) size (p:0,001), pulmonary artery pressure (PAP) (p:0,023), rate of admission to the hospital (p:0,008) and death (p:0,001). (Figure 1). Keywords: soluble ST2, heart failure, death
Objective: Acute decompansated heart failure (HF) represents a major public health burden, and it is understood that HF is not simply a mechanical failure of the heart pump but inflammatory mediators play a crucial role in the development of HF. Possible targets involve pro- and anti-inflammatory cytokines and their receptors, endotoxins, adhesion molecules, nitric oxide and nitric oxide synthase, reactive oxygen species, and different types of leucocytes. Recently, the soluble CD14 subtype; presepsin (PSP) has been suggested as a reliable marker for systemic inflammation which have not been studied in HF setting. Our aim in this study was to evaluate serum PSP levels in patients who were admitted to coronary care unit with HF. Methods: 50 patients with confirmed acute decompansated HF (27 (54%) male, 23 (46%) female) and 51 controls without HF (20 (39,2%) male, 31 (60,8%) female) were included in our study. Besides routine clinical and laboratory data, brain natriuretic peptide (BNP) and PSP levels were measured in peripheral venous blood samples of all the participants. Results: PSP levels were significantly higher in patients with HF than controls (1107,981001,15 vs 540,47526,9 pg/ml, p¼0.001). Cut-off value for PSP was 442 pg/ml to detect HF with 76%, sensitivity, 62.7% specificity, 66.7% positive predictive value and 72.7% negative predictive value (CI: 0,975-1,000). The HF diagnostic accuracy of PSP was not superior to that of BNP (AUC: 0.99 vs 0.74). Conclusion: PSP levels are significantly elevated in patients with HF compared to controls. PSP may be a new marker for HF. Keywords: decompansated heart failure, presepsin, inflammation
Figure 1. PSP levels in patient and control groups th
MARCH 23e26, 2017 13 INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
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Molecular and Genetic Basis of Cardiovascular Diseases
- OP-081 [AJC » Acute heart failure] Serum Presepsin Levels in Patients with Decompensated Heart Failure. Fatma Nihan Turhan Caglar1, Nilgun Isiksacan2, Ismail Biyik3, Hakan Sahin1, Dilay Karakozak1, Fahrettin Katkat4, Ibrahim Faruk Akturk1. 1 Department of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 2 Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 3 Department of Cardiology, Usak Universty Education and Research Hospital, Usak, Turkey; 4Department of Cardiology, Bagcilar Education and Research Hospital, Istanbul, Turkey.
- OP-080 [AJC » Chronic heart failure] Relation of Levels of Soluble ST2 with Clinic and Prognosis in Heart Failure Patients. Hakan Günes¸1, _ Gül2, Handan Günes¸3. Abdullah Zararsız2, Ibrahim 1 Department of Cardiology Sutcu Imam University, Kahramanmaras, Turkey; 2Department of Cardiology, Cumhuriyet University, Sivas, Turkey; 3Department of Physiology, Cumhuriyet University, Sivas, Turkey. Background and Aim: Prevalance of heart failure (HF) is increasing due to more aging of society and prolongation of life span of patient with heart disease related with modern treatment approaches. Despite improvements in treatment approaches, mortality rates are still high in HF patients due to problems in compliance of patients to drug tratment, problems in choosing the appropriate treatment dose and associated comorbid conditions. Soluble ST2 is high than other biomarker in predicting the course of disease in patients with HF in studies. In this study, levels of soluble ST2 were examined in relationship with clinical and echocardiographic parameters. Methods: The study included 55 patients (41 males, 14 females). Patients were evaluated by clinical findings and underwent
mortality and Levels of Soluble ST2 (Roc analysis) â
The American Journal of Cardiology
echocardiography. Blood samples were taken for Routine blood tests and soluble ST2. Results and Conclusion: Soluble ST2 levels was associated with endpoints such NHYA functional class (p:0,001), left ventricular ejection fraction (LV EF) (p:0,001), left ventricular end-diastolic diameter (LV EDD) (p:0,007), left atrial (LA) size (p:0,001), pulmonary artery pressure (PAP) (p:0,023), rate of admission to the hospital (p:0,008) and death (p:0,001). (Figure 1). Keywords: soluble ST2, heart failure, death
Objective: Acute decompansated heart failure (HF) represents a major public health burden, and it is understood that HF is not simply a mechanical failure of the heart pump but inflammatory mediators play a crucial role in the development of HF. Possible targets involve pro- and anti-inflammatory cytokines and their receptors, endotoxins, adhesion molecules, nitric oxide and nitric oxide synthase, reactive oxygen species, and different types of leucocytes. Recently, the soluble CD14 subtype; presepsin (PSP) has been suggested as a reliable marker for systemic inflammation which have not been studied in HF setting. Our aim in this study was to evaluate serum PSP levels in patients who were admitted to coronary care unit with HF. Methods: 50 patients with confirmed acute decompansated HF (27 (54%) male, 23 (46%) female) and 51 controls without HF (20 (39,2%) male, 31 (60,8%) female) were included in our study. Besides routine clinical and laboratory data, brain natriuretic peptide (BNP) and PSP levels were measured in peripheral venous blood samples of all the participants. Results: PSP levels were significantly higher in patients with HF than controls (1107,981001,15 vs 540,47526,9 pg/ml, p¼0.001). Cut-off value for PSP was 442 pg/ml to detect HF with 76%, sensitivity, 62.7% specificity, 66.7% positive predictive value and 72.7% negative predictive value (CI: 0,975-1,000). The HF diagnostic accuracy of PSP was not superior to that of BNP (AUC: 0.99 vs 0.74). Conclusion: PSP levels are significantly elevated in patients with HF compared to controls. PSP may be a new marker for HF. Keywords: decompansated heart failure, presepsin, inflammation
Figure 1. PSP levels in patient and control groups th
MARCH 23e26, 2017 13 INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
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O R A L A B S T R A C T S