- Email: [email protected]
OP-112 [AJC » Percutaneous coronary interventions] Associations Between Important Coronary Artery Disease and Aneurysm and Ectasia
MARCH 23e26, 2017
O R A L A B S T R A C T S
level was found to be significantly greater in the CAD group, when compared to the control group (p¼0.005). While we found a weak positive correlation between the angiographic severity of CAD (i.e. Gensini score) and serum ApoE levels (r¼0.005), this correlation was not statistically significant. Conclusion: Our findings suggest that serum ApoE levels are significantly greater in individuals with atherosclerotic CAD when compared to those without, yet there is no significant correlation between serum ApoE levels and the angiographic severity of CAD. Our findings need to be verified in larger scale studies. Keywords: Apolipoprotein E, coronary artery disease, Gensini score
- OP-111 [AJC » Chronic stable angina pectoris] Serum Levels of Adiponectin Are Not Related to Angiographic Presence or Severity of Atherosclerotic Coronary Artery Disease. Aycan Fahri Erkan1, Neslihan Çoban2, Berkay Ekici1, Özge Kurmus¸1, Sezen Ba glan Uzunget1, Ays¸em Kaya3, Evin Ademoglu4, Celal Kervancıo glu1. 1Department of Cardiology, Medical Faculty, Ufuk University, Ankara, Turkey; 2Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey; 3Division of Biochemistry, Institute of Cardiology, Istanbul University, Istanbul, Turkey; 4 Department of Biochemistry, Medical Faculty, Istanbul University, Istanbul, Turkey. Background and Aim: Adiponectin, an adipocyte derived protein, may play important roles in metabolic and vascular diseases, owing to its robust links with insulin sensitivity and obesity. Studies concerning the association of adiponectin to atherosclerotic coronary artery disease (CAD) have yielded conflicting results; While some have suggested a cardioprotective role for adiponectin, others have not demonstrated any association between adiponectin levels and CAD. We aimed to elucidate whether adiponectin levels are related to angiographic presence and severity of CAD. Methods: We measured serum levels of adiponectin in 271 consecutive patients who had undergone invasive coronary angiography due to chest discomfort and myocardial ischemia documented with a non-invasive stress test. Individuals with a normal coronary angiogram constituted the control group (n:42), whereas patients with coronary atherosclerosis constituted the CAD group (n:229). The
Adiponectin Levels According to Groups. While adiponectin levels are numerically higher in the CAD group, the difference between groups is not statistically significant.
angiographic severity of CAD was evaluated using the Gensini score. Serum adiponectin level was measured utilizing an immuno-turbidimetric assay. Results: Mean serum adiponectin level was 6.884.21mg/mL and 8.086.56 mg/mL in the control and the CAD groups, respectively. While mean serum adiponectin level is numerically greater in the CAD group, this difference was not statistically significant (p¼0.722). While we found a weak negative correlation between the angiographic severity of CAD (i.e. Gensini score) and serum adiponectin levels (r¼ -0.094), this correlation was not statistically significant, either. Conclusion: Despite the significant roles of adiponectin in metabolic and inflammatory pathways, our findings suggest that serum adiponectin levels are not significantly different between controls and angiographically proven CAD cases, and that there is no significant correlation between serum adiponectin levels and angiographic severity of CAD. Our findings need to be verified in larger scale studies. Keywords: adiponectin, coronary artery disease, Gensini score
- OP-112 [AJC » Percutaneous coronary interventions] Associations Between Important Coronary Artery Disease and Aneurysm and Ectasia. Cengiz Ovalı1, Hüseyin Ugur Yazıcı2. 1Department of Cardiovascular Surgery, Medical School of Eskis¸ehir Osmangazi University, Eskis¸ehir, Turkey; 2Department of Cardiology, Medical School of Eskis¸ehir Osmangazi University, Eskis¸ehir, Turkey. Aim: In the present study we aim to investigate the frequency and contribution of coronary artery aneurysm/ectasia in addition to their correlation with coronary artery disease (CAD). Material and Methods: We retrospectively evaluated the coronary angiography records of 6500 adult patients. Coronary artery ectasia was identified as a diffuse dilatation of coronary arteries with a diameter of 1.5 times larger than of its normal contiguous segment. Coronary artery aneurysm was identified as localized coronary artery dilatation exceeding twice the diameter of normal adjacent segments. As to significant CAD, it was defined as the existence of angiographic coronary stenosis of >50% of the luminal diameter in no less than one of the epicardial coronary arteries. Also, the frequencies and features of the coronary artery aneurysm/ectasia among the cases with and without CAD were compared. Results: We found coronary artery aneurysm (CAA) and ectasia (CAE) in 6.6% of the significant CAD (þ), and 6.1% of the patients with significant CAD (-) (p¼0.2). The percentage of coronary artery aneurysms was significantly higher in CAD (þ) patients than in CAD (-) patients (0.8% vs. 0.4%, p¼0.015). The percentage of coronary artery ectasia showed no variation between CAD (þ) patients and CAD (-) patients (5.8% vs. 5.7%, p¼0.47). The frequency of spotting aneurysm on a single coronary artery was higher than discerning aneurysm on two or three coronary arteries. The incidence of aneurysm on the coronary arteries with CAD (þ) was most common on the LAD artery (0.3%). As for with CAD (-), it was predominant on the Cx arteries (0.2%). Then again, the frequency of ectasia present on the coronary arteries was the maximum on the RCA in both groups. The main results have been summarized in table. Conclusion: Presence of CAA and CAE cases are often encountered in those who have coronary artery disease. CAA and CAE should not be considered as simple dilations of vessels. Further studies are needed to determine prognostic important for those diagnosed as having CAA and CAE. Keywords: Coronary Artery Disease, Aneurysm, Ectasia
e34 The American Journal of Cardiologyâ MARCH 23e26, 2017 13th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
MARCH 23e26, 2017 Frequencies of coronary artery aneurysm and ectasia according to the presence of coronary artery disease
Aneurysm (n, %) Ectasia (n, %) Aneurysm and Ectasia (n, %)
Total (n¼6500)
CAD (þ) (n¼4227)
CAD (-) (n¼2273)
P value
43 (0.7) 375 (5.8) 418 (6.4)
35 (0.8) 245 (5.8) 280 (6.6)
8 (0.4) 130 (5.7) 138 (6.1)
0.015 0.47 0.2
Positive/Negative Predictive Values Variables
- OP-113 [AJC » Acute Coronary Syndromes]
Objective: Coronary artery disease is the most common cause of death all over the world and in our country. Indeed it is one of the chronic diseases which has high prevalance andimportant cause of morbidity. Nevertheless there is not any cost-effective, feasible and simple test which can predict disease before it causes mortality and morbidity. The aim of this study was to investigate the relationship of coronary artery disease and its severity with serum sclerostin levels. Methods: 39 coronary artery disease patients documanted by angiography and 40 patients as a control group whose angiografy result was normal coronary arters were included in our study. Patient’s Gensini and SYNTAX scores was calculated angiographicly. Serum sclerostin levels and coronary artery disease’s severity was compared. Results: Patients with coronary artery disease had significantly higher sclerostin levels than controls (p<0.001). Serum sclerostin concentrations were moderately correlated with Gensini score (r¼0.068, p¼0.675), there were weak correlations between SYNTAX score and sclerostin concentrations (r¼0.622, p<0.05). By 10% disease prevelance sclerostin’s positive predictive value was 27.8%, negative predictive value was 94.86%, it was almost close to HDL’s negative predictive value. Sclerostin’s specificity was found 82.5% and its sensitivity was found 60%. Conclusion: Plasma sclerostin concentrations were significantly elevated in coronart artery disease patients compared with patients with normol coronary artery controls. Concentrations seemed to be associated with the risk score which calculated severity of coronary artery
Coronary artery disease relation with sclerostin. Coronary artery disease relation between HDL, sclerostin, creatinine, GFR, glucose and LDL variables.
Positive Predictive Value (%)
Negative Predictive Value (%)
10 20 30 40 50
27.08 45.52 58.89 69.03 76.97
94.86 89.13 82.72 75.47 67.22
Sclerostin (pg/mL)
HDL (mg/dL)
“Sclerostin” a Novel Marker for Predicting Severity and Degree of Coronary Artery Disease. Meltem Özaydin1, Muhammed Bora Demirçelik2. 1Department of Cardiology, Ataturk Chest Medicine and Thoracic Surgery Teaching Hospital, Ankara, Turkey; 2Department of Cardiology, Hopa State Hospital, Artvin, Turkey.
Disease Prevalence (%)
Disease Prevalence (%) 10 20 30 40 50
Positive Predictive Value (%) 17.35 32.07 44.74 55.74 65.38
Negative Predictive Value (%) 95.93 91.29 85.95 79.72 72.38
Positive/Negative Predictive Values for different disease prevalence scenerios Roc curve analysis results Variables
AUC
Std. Err.
HDL (mg/dL) Sclerostin (mg/dL) Creatinine (mg/dL) GFR (mL/dk/1,73 m2) Glucose (mg/dL) LDL (mg/dL)
0.64 0.77 0.70 0.63 0.68 0.59
0.07 0.05 0.06 0.06 0.06 0.065
95% CI 0.52 0.66 0.58 0.51 0.56 0.48
to to to to to to
0.74 0.86 0.80 0.74 0.78 0.70
p value 0.03 <0.01 <0.01 0.03 <0.01 0.16
Roc curve analysis results of select variables related to coranary artery disease disease SYNTAX score moderately and with Gensini score weakly the severity of the coronary artery disease. Keywords: Sclerostin, Coronary Artery Disease, Gensini Score, SYNTAX Score
- OP-114 [AJC » Preventive cardiology] Erectile Dysfunction Severity and SYNTAX Score in Coronary Artery Disease. Kenan Abdurrahman Kara1, Mustafa Bilal Tuna2, Tansu Gudelci4, Ömer Burak Argun2, Egemen Duygu3, Murat S¸ener5. 1Medicana Hospital Çamlıca, 2 _ Üsküdar, Istanbul; Acıbadem Maslak hospital, Maslak, 3 istanbul; Acıbadem Intenational hospital, yes¸ilköy istanbul; 4 Acıbadem Atakent Hospital, Halkalı, istanbul; 5Biruni _ University, Florya-Bakırköy, Istanbul. Introduction: Erectile dysfunction (ED) can be an early manifestation of coronary artery disease (CAD). The SYNTAX score (SS) is used in grading CAD complexity by evaluating lesions on angiography. The present study aimed to investigate the relationship between ED severity and SS in patients with CAD who underwent coronary angiography. Materials and Methods: Male patients undergoing coronary angiography due to coronary artery stenosis were included. Angiograms of the patients were scored into three groups regarding the SS: low (SS 22), intermediate (SS between 23-32), and high (SS 33). Erectile performances were evaluated by the International Index of Erectile Function (IIEF). The patients were divided into 4 groups regarding IIEF scores: severe (IIEF: 0-10), moderate ED (IIEF: 11-16), mild (IIEF: 17-25), and no (IIEF: 26-30). Patients’ data regarding age, body mass index, smoking, diabetes, hypertension, and blood lipid profiles were recorded. Results: Of 58 patients, 13 (22.4%) were in the low SS, 29 (50.0%) were in the moderate SS, and 16 (27.6%) were in the high SS group.
The American Journal of Cardiologyâ MARCH 23e26, 2017 13th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
e35
O R A L A B S T R A C T S
O R A L A B S T R A C T S
level was found to be significantly greater in the CAD group, when compared to the control group (p¼0.005). While we found a weak positive correlation between the angiographic severity of CAD (i.e. Gensini score) and serum ApoE levels (r¼0.005), this correlation was not statistically significant. Conclusion: Our findings suggest that serum ApoE levels are significantly greater in individuals with atherosclerotic CAD when compared to those without, yet there is no significant correlation between serum ApoE levels and the angiographic severity of CAD. Our findings need to be verified in larger scale studies. Keywords: Apolipoprotein E, coronary artery disease, Gensini score
- OP-111 [AJC » Chronic stable angina pectoris] Serum Levels of Adiponectin Are Not Related to Angiographic Presence or Severity of Atherosclerotic Coronary Artery Disease. Aycan Fahri Erkan1, Neslihan Çoban2, Berkay Ekici1, Özge Kurmus¸1, Sezen Ba glan Uzunget1, Ays¸em Kaya3, Evin Ademoglu4, Celal Kervancıo glu1. 1Department of Cardiology, Medical Faculty, Ufuk University, Ankara, Turkey; 2Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey; 3Division of Biochemistry, Institute of Cardiology, Istanbul University, Istanbul, Turkey; 4 Department of Biochemistry, Medical Faculty, Istanbul University, Istanbul, Turkey. Background and Aim: Adiponectin, an adipocyte derived protein, may play important roles in metabolic and vascular diseases, owing to its robust links with insulin sensitivity and obesity. Studies concerning the association of adiponectin to atherosclerotic coronary artery disease (CAD) have yielded conflicting results; While some have suggested a cardioprotective role for adiponectin, others have not demonstrated any association between adiponectin levels and CAD. We aimed to elucidate whether adiponectin levels are related to angiographic presence and severity of CAD. Methods: We measured serum levels of adiponectin in 271 consecutive patients who had undergone invasive coronary angiography due to chest discomfort and myocardial ischemia documented with a non-invasive stress test. Individuals with a normal coronary angiogram constituted the control group (n:42), whereas patients with coronary atherosclerosis constituted the CAD group (n:229). The
Adiponectin Levels According to Groups. While adiponectin levels are numerically higher in the CAD group, the difference between groups is not statistically significant.
angiographic severity of CAD was evaluated using the Gensini score. Serum adiponectin level was measured utilizing an immuno-turbidimetric assay. Results: Mean serum adiponectin level was 6.884.21mg/mL and 8.086.56 mg/mL in the control and the CAD groups, respectively. While mean serum adiponectin level is numerically greater in the CAD group, this difference was not statistically significant (p¼0.722). While we found a weak negative correlation between the angiographic severity of CAD (i.e. Gensini score) and serum adiponectin levels (r¼ -0.094), this correlation was not statistically significant, either. Conclusion: Despite the significant roles of adiponectin in metabolic and inflammatory pathways, our findings suggest that serum adiponectin levels are not significantly different between controls and angiographically proven CAD cases, and that there is no significant correlation between serum adiponectin levels and angiographic severity of CAD. Our findings need to be verified in larger scale studies. Keywords: adiponectin, coronary artery disease, Gensini score
- OP-112 [AJC » Percutaneous coronary interventions] Associations Between Important Coronary Artery Disease and Aneurysm and Ectasia. Cengiz Ovalı1, Hüseyin Ugur Yazıcı2. 1Department of Cardiovascular Surgery, Medical School of Eskis¸ehir Osmangazi University, Eskis¸ehir, Turkey; 2Department of Cardiology, Medical School of Eskis¸ehir Osmangazi University, Eskis¸ehir, Turkey. Aim: In the present study we aim to investigate the frequency and contribution of coronary artery aneurysm/ectasia in addition to their correlation with coronary artery disease (CAD). Material and Methods: We retrospectively evaluated the coronary angiography records of 6500 adult patients. Coronary artery ectasia was identified as a diffuse dilatation of coronary arteries with a diameter of 1.5 times larger than of its normal contiguous segment. Coronary artery aneurysm was identified as localized coronary artery dilatation exceeding twice the diameter of normal adjacent segments. As to significant CAD, it was defined as the existence of angiographic coronary stenosis of >50% of the luminal diameter in no less than one of the epicardial coronary arteries. Also, the frequencies and features of the coronary artery aneurysm/ectasia among the cases with and without CAD were compared. Results: We found coronary artery aneurysm (CAA) and ectasia (CAE) in 6.6% of the significant CAD (þ), and 6.1% of the patients with significant CAD (-) (p¼0.2). The percentage of coronary artery aneurysms was significantly higher in CAD (þ) patients than in CAD (-) patients (0.8% vs. 0.4%, p¼0.015). The percentage of coronary artery ectasia showed no variation between CAD (þ) patients and CAD (-) patients (5.8% vs. 5.7%, p¼0.47). The frequency of spotting aneurysm on a single coronary artery was higher than discerning aneurysm on two or three coronary arteries. The incidence of aneurysm on the coronary arteries with CAD (þ) was most common on the LAD artery (0.3%). As for with CAD (-), it was predominant on the Cx arteries (0.2%). Then again, the frequency of ectasia present on the coronary arteries was the maximum on the RCA in both groups. The main results have been summarized in table. Conclusion: Presence of CAA and CAE cases are often encountered in those who have coronary artery disease. CAA and CAE should not be considered as simple dilations of vessels. Further studies are needed to determine prognostic important for those diagnosed as having CAA and CAE. Keywords: Coronary Artery Disease, Aneurysm, Ectasia
e34 The American Journal of Cardiologyâ MARCH 23e26, 2017 13th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
MARCH 23e26, 2017 Frequencies of coronary artery aneurysm and ectasia according to the presence of coronary artery disease
Aneurysm (n, %) Ectasia (n, %) Aneurysm and Ectasia (n, %)
Total (n¼6500)
CAD (þ) (n¼4227)
CAD (-) (n¼2273)
P value
43 (0.7) 375 (5.8) 418 (6.4)
35 (0.8) 245 (5.8) 280 (6.6)
8 (0.4) 130 (5.7) 138 (6.1)
0.015 0.47 0.2
Positive/Negative Predictive Values Variables
- OP-113 [AJC » Acute Coronary Syndromes]
Objective: Coronary artery disease is the most common cause of death all over the world and in our country. Indeed it is one of the chronic diseases which has high prevalance andimportant cause of morbidity. Nevertheless there is not any cost-effective, feasible and simple test which can predict disease before it causes mortality and morbidity. The aim of this study was to investigate the relationship of coronary artery disease and its severity with serum sclerostin levels. Methods: 39 coronary artery disease patients documanted by angiography and 40 patients as a control group whose angiografy result was normal coronary arters were included in our study. Patient’s Gensini and SYNTAX scores was calculated angiographicly. Serum sclerostin levels and coronary artery disease’s severity was compared. Results: Patients with coronary artery disease had significantly higher sclerostin levels than controls (p<0.001). Serum sclerostin concentrations were moderately correlated with Gensini score (r¼0.068, p¼0.675), there were weak correlations between SYNTAX score and sclerostin concentrations (r¼0.622, p<0.05). By 10% disease prevelance sclerostin’s positive predictive value was 27.8%, negative predictive value was 94.86%, it was almost close to HDL’s negative predictive value. Sclerostin’s specificity was found 82.5% and its sensitivity was found 60%. Conclusion: Plasma sclerostin concentrations were significantly elevated in coronart artery disease patients compared with patients with normol coronary artery controls. Concentrations seemed to be associated with the risk score which calculated severity of coronary artery
Coronary artery disease relation with sclerostin. Coronary artery disease relation between HDL, sclerostin, creatinine, GFR, glucose and LDL variables.
Positive Predictive Value (%)
Negative Predictive Value (%)
10 20 30 40 50
27.08 45.52 58.89 69.03 76.97
94.86 89.13 82.72 75.47 67.22
Sclerostin (pg/mL)
HDL (mg/dL)
“Sclerostin” a Novel Marker for Predicting Severity and Degree of Coronary Artery Disease. Meltem Özaydin1, Muhammed Bora Demirçelik2. 1Department of Cardiology, Ataturk Chest Medicine and Thoracic Surgery Teaching Hospital, Ankara, Turkey; 2Department of Cardiology, Hopa State Hospital, Artvin, Turkey.
Disease Prevalence (%)
Disease Prevalence (%) 10 20 30 40 50
Positive Predictive Value (%) 17.35 32.07 44.74 55.74 65.38
Negative Predictive Value (%) 95.93 91.29 85.95 79.72 72.38
Positive/Negative Predictive Values for different disease prevalence scenerios Roc curve analysis results Variables
AUC
Std. Err.
HDL (mg/dL) Sclerostin (mg/dL) Creatinine (mg/dL) GFR (mL/dk/1,73 m2) Glucose (mg/dL) LDL (mg/dL)
0.64 0.77 0.70 0.63 0.68 0.59
0.07 0.05 0.06 0.06 0.06 0.065
95% CI 0.52 0.66 0.58 0.51 0.56 0.48
to to to to to to
0.74 0.86 0.80 0.74 0.78 0.70
p value 0.03 <0.01 <0.01 0.03 <0.01 0.16
Roc curve analysis results of select variables related to coranary artery disease disease SYNTAX score moderately and with Gensini score weakly the severity of the coronary artery disease. Keywords: Sclerostin, Coronary Artery Disease, Gensini Score, SYNTAX Score
- OP-114 [AJC » Preventive cardiology] Erectile Dysfunction Severity and SYNTAX Score in Coronary Artery Disease. Kenan Abdurrahman Kara1, Mustafa Bilal Tuna2, Tansu Gudelci4, Ömer Burak Argun2, Egemen Duygu3, Murat S¸ener5. 1Medicana Hospital Çamlıca, 2 _ Üsküdar, Istanbul; Acıbadem Maslak hospital, Maslak, 3 istanbul; Acıbadem Intenational hospital, yes¸ilköy istanbul; 4 Acıbadem Atakent Hospital, Halkalı, istanbul; 5Biruni _ University, Florya-Bakırköy, Istanbul. Introduction: Erectile dysfunction (ED) can be an early manifestation of coronary artery disease (CAD). The SYNTAX score (SS) is used in grading CAD complexity by evaluating lesions on angiography. The present study aimed to investigate the relationship between ED severity and SS in patients with CAD who underwent coronary angiography. Materials and Methods: Male patients undergoing coronary angiography due to coronary artery stenosis were included. Angiograms of the patients were scored into three groups regarding the SS: low (SS 22), intermediate (SS between 23-32), and high (SS 33). Erectile performances were evaluated by the International Index of Erectile Function (IIEF). The patients were divided into 4 groups regarding IIEF scores: severe (IIEF: 0-10), moderate ED (IIEF: 11-16), mild (IIEF: 17-25), and no (IIEF: 26-30). Patients’ data regarding age, body mass index, smoking, diabetes, hypertension, and blood lipid profiles were recorded. Results: Of 58 patients, 13 (22.4%) were in the low SS, 29 (50.0%) were in the moderate SS, and 16 (27.6%) were in the high SS group.
The American Journal of Cardiologyâ MARCH 23e26, 2017 13th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
e35
O R A L A B S T R A C T S