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OP-330 Plasma Gelsolin as Biomarker of Acute Rheumatic Carditis
MARCH 13e16, 2014 LAVI ¼[p/6 x (LAmax x LAshort x LAlong)]/m2.Additionally several indices were calculated: left ventricle mass (LVM), left ventricle mass index (LVMI), left ventricle systolic and diastolic diameters. Results: Results shown a significant decreased of left atrial ejction force in BD in comparison to the control group (p<0.05). LV mass index also augmented (p<0.001). Instead, E/É not significantly changed in BD patients in comparison with healthy controls. LAVI raised in BD patients. Clinical characteristics and baseline echocardiographic measurements of the study population and control group are listed in Table. Conclusions: The results of this study suggest, that left atrial functions are impaired in Behcet disease’s patients. A routine, thorough evaluation of atrial size and function may assist in the early detection of subclinical disease, provide useful adjunctive information.
Biomarkers in Coronary Artery Diseases: From Bench to Bedside Sunday, March 16, 2014 10:30 AM w 12:00 PM, Hall 6 (Abstract nos. OP-329 w OP-336) - OP-329 Thymoquinone Prevent End Organs from Abdominal Aorta Ischemia/Reperfusion Injury in Rat Model. M.S. Aydın1, A. Kocarslan1, S. Kocarslan2, A. Kucuk3, I. Eser4, H. Sezen5, E. Buyukfırat6, A. Hazar1. 1Department of Cardiovascular Surgery, Harran University, Sanliurfa, Turkey; 2Department of Pathology, Harran University, Sanliurfa, Turkey; 3Department of Anesthesiology and Reanimation, Harran University, Sanliurfa, Turkey; 4Department of Thoracicr Surgery, Harran University, Sanliurfa, Turkey; 5 Department of Biochemistry, Harran University, Sanliurfa, Turkey; 6 Department of Anesthesiology and Reanimation, Balıklıgol State Hospital, Sanlıurfa, Turkey.
Background: Previous studies have demonstrated that Thymoquinone (TQ) has protective effects against ischemia reperfusion injury on various organs though its protective effects on end organ (lung, kidney, heart) against ischemia reperfusion injury remain to be astablished. We aimed to determine whether TQ prevents abdominal aorta ischemiareperfusion injury in rats. Materials-Methods: Thirty rats were divided into three groups as sham (group 1), control (group 2), and TQ-treatment group (group 3). All rats underwent abdominal aorta ischemia for 45min followed by a 120min period of reperfusion. Rats were intraperitoneally infused only 0.9% saline solutions in group 2. Rats in the group 3 received TQ (0.2 mL/kg) intraperitoneally, before ischemia and before reperfusion. Total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI) in blood serum were measured and lung, kidney and heart tissue histopathology was evaluated with light microscope. Results: TOS and OSI activity in blood samples were higher in the control group than in the sham and thymoquinone group, and the differences were statistically significant (p < 0.01 for TOS and OSI). Histological tissue damage was milder in the TQ treatment group than in the control group. Conclusion: Our results suggest that TQ treatment protected the rat’s end organ against abdominal aorta ischemia- reperfusion injury.
- OP-330 Plasma Gelsolin as Biomarker of Acute Rheumatic Carditis. M. Argun1, A. Baykan1, F. Narin2, A. Ozyurt1, O. Pamukcu1, F. Elmalı3, K. Uzum1, N. Narin1. 1Department of Pediatric Cardiology, Erciyes University, Kayseri, Turkey; 2Department of Biochemistry, Erciyes University, Kayseri, Turkey; 3Department of Biostatistics and Bioinformatics, Erciyes University, Kayseri, Turkey. Objective: Acute rheumatic fever is an autoimmune inflammatory and multisystemic disease secondary to pharyngitis caused by group A streptococcus. In developing countries, acute rheumatic fever is the most common cause of acquired heart disease. Gelsolin is a calcium dependent, multifunctional actin regulatory protein circulating in plasma of healthy. Correlation between blood gelsolin levels and inflammatory conditions suggests the potential benefit of gelsolin as a prognostic marker. The aim of the present study was to appraise the association of gelsolin and acute rheumatic carditis in childhood. Material-Methods: Plasma gelsolin were measured in patients (n¼37) with acute rheumatic carditis and compared with age- and gender-matched healthy controls (n¼24). Erythrocyte sedimentation rates, C-reactive protein, anti-streptolysin O were examined in every patient group. All patients underwent echocardiography. Results: The gelsolin levels of children with acute rheumatic carditis were significantly higher than those of the control group (197 218 versus 322 255 mg/L, P¼0,039). There was significant correlation between gelsolin levels and the degree of mitral regurgitation (p¼0,030), left ventricular end-diastolic diameter (p¼0,017), left ventricular end-systolic diameter (p¼0,028) at diagnosis. Conclusions: The plasma isoform of gelsolin is decreased in patients with acute rheumatic carditis compared with healthy controls. Gelsolin can be used as a biochemical marker in the acute rheumatic carditis.
- OP-331 Association between Serum Pentraxin Levels and Coronary Artery Plaque Morphology in Patients with Unstable Angina Pectoris. _ Canbolat3, Y.E. Döventas¸1, S. Sarı1, A. Arat Özkan2, S. Yigit1, I.P. M. Koldas¸1, C. Bostan2, T. Gürmen2. 1Department of Biochemistry, Haseki Training and Research Hospital, Istanbul, Turkey; 2Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey; 3Kagithane State Hospital, Istanbul, Turkey. The American Journal of Cardiologyâ MARCH 13e16, 2014 10th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
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Biomarkers in Coronary Artery Diseases: From Bench to Bedside Sunday, March 16, 2014 10:30 AM w 12:00 PM, Hall 6 (Abstract nos. OP-329 w OP-336) - OP-329 Thymoquinone Prevent End Organs from Abdominal Aorta Ischemia/Reperfusion Injury in Rat Model. M.S. Aydın1, A. Kocarslan1, S. Kocarslan2, A. Kucuk3, I. Eser4, H. Sezen5, E. Buyukfırat6, A. Hazar1. 1Department of Cardiovascular Surgery, Harran University, Sanliurfa, Turkey; 2Department of Pathology, Harran University, Sanliurfa, Turkey; 3Department of Anesthesiology and Reanimation, Harran University, Sanliurfa, Turkey; 4Department of Thoracicr Surgery, Harran University, Sanliurfa, Turkey; 5 Department of Biochemistry, Harran University, Sanliurfa, Turkey; 6 Department of Anesthesiology and Reanimation, Balıklıgol State Hospital, Sanlıurfa, Turkey.
Background: Previous studies have demonstrated that Thymoquinone (TQ) has protective effects against ischemia reperfusion injury on various organs though its protective effects on end organ (lung, kidney, heart) against ischemia reperfusion injury remain to be astablished. We aimed to determine whether TQ prevents abdominal aorta ischemiareperfusion injury in rats. Materials-Methods: Thirty rats were divided into three groups as sham (group 1), control (group 2), and TQ-treatment group (group 3). All rats underwent abdominal aorta ischemia for 45min followed by a 120min period of reperfusion. Rats were intraperitoneally infused only 0.9% saline solutions in group 2. Rats in the group 3 received TQ (0.2 mL/kg) intraperitoneally, before ischemia and before reperfusion. Total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI) in blood serum were measured and lung, kidney and heart tissue histopathology was evaluated with light microscope. Results: TOS and OSI activity in blood samples were higher in the control group than in the sham and thymoquinone group, and the differences were statistically significant (p < 0.01 for TOS and OSI). Histological tissue damage was milder in the TQ treatment group than in the control group. Conclusion: Our results suggest that TQ treatment protected the rat’s end organ against abdominal aorta ischemia- reperfusion injury.
- OP-330 Plasma Gelsolin as Biomarker of Acute Rheumatic Carditis. M. Argun1, A. Baykan1, F. Narin2, A. Ozyurt1, O. Pamukcu1, F. Elmalı3, K. Uzum1, N. Narin1. 1Department of Pediatric Cardiology, Erciyes University, Kayseri, Turkey; 2Department of Biochemistry, Erciyes University, Kayseri, Turkey; 3Department of Biostatistics and Bioinformatics, Erciyes University, Kayseri, Turkey. Objective: Acute rheumatic fever is an autoimmune inflammatory and multisystemic disease secondary to pharyngitis caused by group A streptococcus. In developing countries, acute rheumatic fever is the most common cause of acquired heart disease. Gelsolin is a calcium dependent, multifunctional actin regulatory protein circulating in plasma of healthy. Correlation between blood gelsolin levels and inflammatory conditions suggests the potential benefit of gelsolin as a prognostic marker. The aim of the present study was to appraise the association of gelsolin and acute rheumatic carditis in childhood. Material-Methods: Plasma gelsolin were measured in patients (n¼37) with acute rheumatic carditis and compared with age- and gender-matched healthy controls (n¼24). Erythrocyte sedimentation rates, C-reactive protein, anti-streptolysin O were examined in every patient group. All patients underwent echocardiography. Results: The gelsolin levels of children with acute rheumatic carditis were significantly higher than those of the control group (197 218 versus 322 255 mg/L, P¼0,039). There was significant correlation between gelsolin levels and the degree of mitral regurgitation (p¼0,030), left ventricular end-diastolic diameter (p¼0,017), left ventricular end-systolic diameter (p¼0,028) at diagnosis. Conclusions: The plasma isoform of gelsolin is decreased in patients with acute rheumatic carditis compared with healthy controls. Gelsolin can be used as a biochemical marker in the acute rheumatic carditis.
- OP-331 Association between Serum Pentraxin Levels and Coronary Artery Plaque Morphology in Patients with Unstable Angina Pectoris. _ Canbolat3, Y.E. Döventas¸1, S. Sarı1, A. Arat Özkan2, S. Yigit1, I.P. M. Koldas¸1, C. Bostan2, T. Gürmen2. 1Department of Biochemistry, Haseki Training and Research Hospital, Istanbul, Turkey; 2Department of Cardiology, Istanbul University Cardiology Institute, Istanbul, Turkey; 3Kagithane State Hospital, Istanbul, Turkey. The American Journal of Cardiologyâ MARCH 13e16, 2014 10th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral
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