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Opiate receptor: autoradiographic localization in rat brain
radioactive tracers, coupled with physiological studies, provided convincing evidence for the authors’ claim. Discrete lesions in dorsolateral funiculus abolished opiate and stimulus-induced analgesia.
Opiate receptor:
autoradiographic
C.B. Pert, M.J. Kuhar (1976) 3729-3733
localization
and S.H. Snyder,
in rat brain
Proc. nat. Acad. Sci. (Wash.),
73
Discovery of endogenous opiates and their receptors in the CNS, through electrophysiolo~cal and pharmacological studies, represents one of the transcendental scientific issues of the seventies, Recently, localization of opiate receptor sites has been directly demonstrated by light microscopy autoradiography: Candice Pert, Kuhar and Snyder have visualized their distribution with radioactive tracers in rat CNS in vivo. Tritiated diprenorphine, an opium antagonist more potent than naloxone, became discretely bound between cells localized in brain and spinal cord. Preferred sites were locus coeruleus, substantia gelatinosa, caudate-putamen, amygdala and periventricular gray matter. From other preliminary studies referred by the authors, it would appear that such receptors are associated with axon terminals rather than with cell bodies.
STOMATOLOGY T~gerninoth~~~~ neurons and nociceptive stimulation
in nucleus caudalis responsive of monkey’s face
D.D. Price, R. Dubner and d.W. Hu, J. Neurophysiol,,
to tactile, thermal,
39 (1976) 939-953
Trigeminothalamic neurons located in trigeminal nucleus caudalis and subjacent lateral reticular formation were studied in anesthetized rhesus monkeys. The analysis yielded 5 classes of neurons distin~ished by their range of responses to mechanical stimuli and by the convergence of different primary afferent fiber populations. Two classes of units responded to lowthreshold mechanical stimuli and received only A/3 afferent input. One class, activated by light touch, but maximally responsive to noxious pinch, received Ap, A6 and C fiber input and usually responded to noxious heat. Two other classes responded only to intense forms of mechanical stimuli and received A6 and sometimes C fiber input. Some responded also to noxious heat. Neurons activated by noxious stimuli were found in the marginal and magnocellular layers of nucleus caudalis and in the subjacent lateral reticular formation, The data support the hypothesis that facial nociceptive input is conveyed centrally by nucleus caudalis trigeminoth~~ic neurons.
Opiate receptor:
autoradiographic
C.B. Pert, M.J. Kuhar (1976) 3729-3733
localization
and S.H. Snyder,
in rat brain
Proc. nat. Acad. Sci. (Wash.),
73
Discovery of endogenous opiates and their receptors in the CNS, through electrophysiolo~cal and pharmacological studies, represents one of the transcendental scientific issues of the seventies, Recently, localization of opiate receptor sites has been directly demonstrated by light microscopy autoradiography: Candice Pert, Kuhar and Snyder have visualized their distribution with radioactive tracers in rat CNS in vivo. Tritiated diprenorphine, an opium antagonist more potent than naloxone, became discretely bound between cells localized in brain and spinal cord. Preferred sites were locus coeruleus, substantia gelatinosa, caudate-putamen, amygdala and periventricular gray matter. From other preliminary studies referred by the authors, it would appear that such receptors are associated with axon terminals rather than with cell bodies.
STOMATOLOGY T~gerninoth~~~~ neurons and nociceptive stimulation
in nucleus caudalis responsive of monkey’s face
D.D. Price, R. Dubner and d.W. Hu, J. Neurophysiol,,
to tactile, thermal,
39 (1976) 939-953
Trigeminothalamic neurons located in trigeminal nucleus caudalis and subjacent lateral reticular formation were studied in anesthetized rhesus monkeys. The analysis yielded 5 classes of neurons distin~ished by their range of responses to mechanical stimuli and by the convergence of different primary afferent fiber populations. Two classes of units responded to lowthreshold mechanical stimuli and received only A/3 afferent input. One class, activated by light touch, but maximally responsive to noxious pinch, received Ap, A6 and C fiber input and usually responded to noxious heat. Two other classes responded only to intense forms of mechanical stimuli and received A6 and sometimes C fiber input. Some responded also to noxious heat. Neurons activated by noxious stimuli were found in the marginal and magnocellular layers of nucleus caudalis and in the subjacent lateral reticular formation, The data support the hypothesis that facial nociceptive input is conveyed centrally by nucleus caudalis trigeminoth~~ic neurons.