- Email: [email protected]
Opioids I and II
602
Book Reviews
Many proteins are very easily denatured and care has to be taken in their use. This book provides much of the essential information. It deals with: in vitro characterization; analytical chromatography; internal structure and organization; solution properties; posttranslational processing; fragmentation; peptide sequence determination; electrophoretic technique; production and application of polyclonal and monoclonal antibodies; conformational stability; hydration; recombinant protein technology; storage stabilization, and process purification. Proteins such as interferons, blood factors, hormones, etc. are becoming more available on a commercial scale and this volume will be useful to workers involved in processing such proteins. A Practical Guide to Protein and Peptide Purification for Microsequencing. Second Edition-Edited by P. MATSUDAIRA. 184~~. 1993. Academic Press, San Diego. The first edition was concerned with the question “How can I obtain the N-terminal sequence?’ This second edition is concerned with “How can I obtain useful sequence information?” The topics deal with; obtaining partial sequences from < 500 pmol of protein; enzymic digestion and HPLC peptide isolation; purification by SDS-PAGE; sequence analysis after in situ protease digestion on nitrocellulose; MS characterization; sequences of commonly used preoteases. There is also an updated reference list. RNA Editing; The Alteration of Protein Coding Sequences of RNA-Edited by R. BENNE. 196 pp. 1993. Ellis Horwood, Chichester, U.K. f39.95. The four uridines in mitochondrial transcript for the cytochrome oxidase subunit 2 in Trypanosomes are not encoded in the DNA. The RNAs are edited by massive transcriptional U-insertions and U-deletions. This book deals with RNA editing in mitochondria of: Trypanosomes, Leishmania, and Physarium polycephalum; RNA editing of paramyxovirus P gene mRNA; mammalian apoliporotein B mRNA; RNA in plant organelles; double stranded RNA adenosine deaminase-a potential agent for RNA editing? The editing signals may allow the production of more than one protein by one gene, allow greater compactness, allow the removal of frame shifts, the creation of stop/start codons, and multiple codon changes. The genetic code is very complex and subtle but that is to be expected after about a billion years of development! Asymmetric Synthesis of Natural Products-A. KOSKINEN. 234~~. 1993. Wiley, Chichester, U.K. Paperback f16.95. Most natural products are chiral and many are also asymmetric. This book deals with: chirality, topology and asymmetric compounds; asymmetric synthesis [carbonyl carbon, enolates, olefins]; carbohydrates; amino acids, peptides and proteins; nucleosides, nucleotides and nucleic acids; polyketides; isoprenoids; shikimic acid derivatives; alkaloids. It gives good insight into the nature of the problems in such syntheses and the structural chemistry of many important compounds. The reader will get a much better understanding of the structural relationship of many important drugs and natural products. It also has interesting asides such as “The aroma of sunburnt beer is structurally related to the odor substances of North American skunk and cat’s urine”.
Photosynthesis; Molecular, Physiological and Environmental Processes. Second Edition-D. W. LAWTON. 318 pp. 1993. Longman. Paperback f 19.99. The first edition of this book was published in 1987 and reprinted in 1990. This new edition deals with the major topics; light, the driving force in photosynthesis (P); energy capture in P; the P apparatus; electron and proton transport; synthesis of ATP; chemistry of P; metabolism of P products; C4-P and CAM; molecular biology of P; carbon dioxide supply; P by leaves; plant P production. The information has been brought up to date and the new material includes: the crystalization of the P reaction centre of purple bacteria and high resolution X-ray analysis of the structure resulting in increased understanding of the primary events in P; the X-ray analysis of ribulose biphosphate carboxylase-oxygenase; the genetic mapping of chloroplast DNA and the location of the genes for chloroplast constituents; global climate changes and the increased levels of carbon dioxide in the atmosphere. Protein Phosphorylation; a Practical Approach-Edited by D. G. HARDY. 300 pp. 1993. IRL/Oxford University Press. Hardback $59. Protein phosphorylation (PP) is the major mechanism by which cells respond to extracellular signals such as hormones and growth factors. It is also responsible for the timing of events which must occur at defined stages in the cell cycle such as DNA synthesis and mitosis. PP is catalysed by protein kinases and reversed by protein phosphorylases. This book deals with: PP in intact cells; phosphopeptide mapping and phosphoamino acid analysis on cellulose thin layer plates; analysis of sites phosphorylated in uipo and in u&-o; use of serine/thronine kinase activators and inhibitors to study PP in intact cells; use of PP inhibitors in intact cells; purification of mammalian serine/threonone kinases; purification of tyrosine kinases; identification of cDNAs that encode protein kinases; assay and purification of serine/threonine phosphatases; characterization of tyrosine phosphatases; identification of serine/threonine phosphatase genes in yeast, Drosophila and Man; protein kinase/phosphatase specificity using synthetic peptides. A better understanding of activators and inhibitors of PP systems will provide the basis for new drugs that can be used in cancer therapy. Aspects of Synaptic Transmission; ACh, Sigma Receptors, CCK, Eicosanoids and Neurotoxins-Edited by T. W. STONE. 255 pp. 1993. Taylor & Francis. f45. This is the published proceedings of the second Kelvin Conference. The subjects reviewed are: neuronal muscarinic receptor subtypes; cholinergic pathways in the CNS; cholinergic neurones and memory: nicotinic cholinergic stimulation in animal models of behaviour; sigma receptors [receptors for benzomorphans]; CCK-A and CCK-B in analgesia; CCK receptors; neuronal release of arachidonic acid; presynaptic toxins [TTX, conotoxins, scorpion toxins. anemone toxins, dendrotoxins, bee venom, phospholipase A2, apamin, scyllatoxin]; alpha latrotoxin; spider toxin and glutamate receptors; maitotoxin and calcium homeostasis. Opioids I and II-Edited by A. HERZ. Handbook of Experimental Pharmacology Vol. 104, parts I and II. Opioids I. 815 pp. 1993. Springer, Berlin. DM580. Opioids II 840 pp. 1993. Springer, Berlin. DM580.
Book Reviews In 1957 Vol. 12 of this series was a volume by Otto Schaumann on morphine and morphine derivatives. Since then there has been a tremendous increase in number of research publications and also a great increase in our understanding of the pharmacology of the opioids, mainly due to the identification of the opioid (0) receptors (OR) and the detection of the endogenous ligands. Volume I deals with ORs; cloning of cDNA of OR; 0 binding proteins; 0 bioassay using organ systems; anatomical distribution of OR; OR regulation; multiple OR and presynaptic modulation of neurotransmitter release; ORCr protein interactions; OR coupled 2nd messenger systems; allosteric coupling of OR; chemistry of non-peptide 0; nonpeptide 0 antagonists; endogenous 0 alkaloids; 0 peptide gene expression; POMC gene expression; proenkephalin gene regulation; POMC biosynthesis; biosynthesis of enkephalins; anatomy and function of enkephalins; atypical 0 peptides; 0 peptide processing enzymes; peptidase inactivation of enkephalinsAesign of inhibitors; coexistance of 0 with other neurotransmitters; interrelation of 0, DA, ACh and GABA; ligands for OR; analogs of 0 peptides; ontogeny of 0 system; 0 in the CNS; action of 0 on membrane ion channels. Volume 11 deals with 0 and; brainstem modulation of pain; supraspinal OR in antinoception; spinal action of 0; peripheral mechanisms of 0 analgesia; acupunc-ture and stimulation produced analgesia; multiple OR and chronic pain; gastrointestinal effects of 0; role of endogenous 0 in central cardiovascular regulation; temperature regulation; control of food consumption and taste preference; respiration and vomiting; stress; CNS injury; epilepsy and neuroprotection; immunologic processes; spontaneous animal behavior; learning and memory; pharmacodynamic characteristics of 0 antagonists; neuroendocrine control of reproduction; neurohyophysial system; 0 expression in peripheral tissue; 0 tolerance; 0 tolerance/dependence in isolated organs; 0 abuse assessment in Rhesus monkeys; motivational effects of 0; CSF 0 in pathophysiology; circulating 0 in man; 0 analgesics in clinical pain management; 0 in operative anaesthesia; beta endorphin in human reproduction; 0 in psychiatric disorders; 0 addiction. These two volumes give an excellent account of the frontiers of present day research in opioids. Growth Factors; a Practical Approach-Edited by I. MCKAY and I. LEIGH. 251 pp. 1993. IRL/Oxford University Press. Hardback $48, Paperback $31. There are at least 20 different growth factor (GF) families with a total of as many as 130 individual factors. It is possible that there are a great many more to be discovered. This book gives practical details for: detection and characterization of new GF; detection of polpeptide GF, application of biassay and PCR technology; induction of DNA synthesis and cell division in quiescent cells in response to small peptide GF; gene isolation by differential plaque hydridization; embryological assays for GF; the rule of TGF in bone growth and bone repair; localization of GF mRNA by in situ hybridization; detection of epidermal inhibitory pentapeptide; expression of GF in microbial systems; immunoassay of GF; determination of GF receptor distribution by immunocytochemistry, autoradiography, ligand binding and fluorescence activated cell sorter. Vaccine Design--Edited by F. BROWN, G. DOUGAN, E. M. HOEY, S. J. MARTIN, B. K. TIMA and A. TRUDGETT. 130 pp. 1993. Wiley, Chichester, U.K. f19.50.
603
This book is written for senior undergraduates and postgraduates. It deals with; the history of vaccination; sequence analysis-a starting point for vaccine design; requirements for induction of immunity; prediction of epitopes; peptides as vaccines; vaccines against virus diseases; bacterial vaccines; parasite vaccines; possibilities for future vaccines. A very useful and readable account of the subject.
Principles of Cellular and Molecular Immunology-J. M. AUSTYN and K. J. WOOD. 735 pp. 1993. Oxford University Press. Paperback f25. The literature on immunology increases at a frightening rate and it is very good to have this up to date book. It deals with: the immune system; immune responses; lymphoid tissue; the major histocompatability complex; antigen presenting cells; molecular basis of T cell responses; T cell repertoire; antigen receptors-structure and function; genes and immunoglobulin family; B cells and antibody responses; inflammatory mediators and soluble effector mechanisms; cellular cytotoxicity; idiotypc networks and suppressor pathways; cellular and molecular techniques in Immunology. The information is very clearly presented with good diagrams and tables. The reader will find this a very enjoyable, informative and interesting book.
Cell Surface and Extracellular Glycoconjugates; Structure and Function-Edited by D. R. ROBERTSand R. P. MECHAM. 314 pp. 1993. Academic Press, San Diego. Glycoconjugates (G) such as the selectins have an important role as mediators in lymphocyte recirculation, activation and inflammatory responses. Alterations of G can affect the malignant behaviour of tumor cells. Some hormones and growth factors react with the G on the cell surface receptor. The monosaccharide on the cell surface can be linked to a second sugar to form up to eight positional and anomeric isomers each having distinct chemical and biological properties. This book deals with: the function of N- and O-linked sugar chains of G; pericelluiar proteoglycans; glycosyl phosphatidylinositol linked membrane proteins; glysylation inhibitors; the use of mammalian cell mutants to study the functions of N- and O-linked glycolsylation; glycosphingolipid receptors in inflammation and cancer; G in human choriogonadotropin; G in adehsive cell function.
Bioinorganic Chemistry of Copper-Edited and Z. TYEKLAR. 506 pp. 1993. Chapman f65.
by K. D. KARLIN & Hall, London.
Copper plays a vital biochemical role as an essential metalloenzyme active-site cofactor involved in electron transfer, dioxygen transport, and the reduction of nitrogen oxides. This book deals with copper proteins; blue copper proteins and electron transfer; natural and synthetic regulation of gene expression; copper resistance; copper homeostasis; hemocyanin and copper monooxygenases; copper mediated redox/oxidative pathways; dioxygen binding and oxygenation reactions; copper-nitrogen oxide complexes; copper oxidase.
Protocols for Oligonucleotides and Analogos; Synthesis and PropertiesEdited by S. AGRAWAL. 502 pp. 1993. Humana Press, N. J. Paperback $59.50.
Book Reviews
Many proteins are very easily denatured and care has to be taken in their use. This book provides much of the essential information. It deals with: in vitro characterization; analytical chromatography; internal structure and organization; solution properties; posttranslational processing; fragmentation; peptide sequence determination; electrophoretic technique; production and application of polyclonal and monoclonal antibodies; conformational stability; hydration; recombinant protein technology; storage stabilization, and process purification. Proteins such as interferons, blood factors, hormones, etc. are becoming more available on a commercial scale and this volume will be useful to workers involved in processing such proteins. A Practical Guide to Protein and Peptide Purification for Microsequencing. Second Edition-Edited by P. MATSUDAIRA. 184~~. 1993. Academic Press, San Diego. The first edition was concerned with the question “How can I obtain the N-terminal sequence?’ This second edition is concerned with “How can I obtain useful sequence information?” The topics deal with; obtaining partial sequences from < 500 pmol of protein; enzymic digestion and HPLC peptide isolation; purification by SDS-PAGE; sequence analysis after in situ protease digestion on nitrocellulose; MS characterization; sequences of commonly used preoteases. There is also an updated reference list. RNA Editing; The Alteration of Protein Coding Sequences of RNA-Edited by R. BENNE. 196 pp. 1993. Ellis Horwood, Chichester, U.K. f39.95. The four uridines in mitochondrial transcript for the cytochrome oxidase subunit 2 in Trypanosomes are not encoded in the DNA. The RNAs are edited by massive transcriptional U-insertions and U-deletions. This book deals with RNA editing in mitochondria of: Trypanosomes, Leishmania, and Physarium polycephalum; RNA editing of paramyxovirus P gene mRNA; mammalian apoliporotein B mRNA; RNA in plant organelles; double stranded RNA adenosine deaminase-a potential agent for RNA editing? The editing signals may allow the production of more than one protein by one gene, allow greater compactness, allow the removal of frame shifts, the creation of stop/start codons, and multiple codon changes. The genetic code is very complex and subtle but that is to be expected after about a billion years of development! Asymmetric Synthesis of Natural Products-A. KOSKINEN. 234~~. 1993. Wiley, Chichester, U.K. Paperback f16.95. Most natural products are chiral and many are also asymmetric. This book deals with: chirality, topology and asymmetric compounds; asymmetric synthesis [carbonyl carbon, enolates, olefins]; carbohydrates; amino acids, peptides and proteins; nucleosides, nucleotides and nucleic acids; polyketides; isoprenoids; shikimic acid derivatives; alkaloids. It gives good insight into the nature of the problems in such syntheses and the structural chemistry of many important compounds. The reader will get a much better understanding of the structural relationship of many important drugs and natural products. It also has interesting asides such as “The aroma of sunburnt beer is structurally related to the odor substances of North American skunk and cat’s urine”.
Photosynthesis; Molecular, Physiological and Environmental Processes. Second Edition-D. W. LAWTON. 318 pp. 1993. Longman. Paperback f 19.99. The first edition of this book was published in 1987 and reprinted in 1990. This new edition deals with the major topics; light, the driving force in photosynthesis (P); energy capture in P; the P apparatus; electron and proton transport; synthesis of ATP; chemistry of P; metabolism of P products; C4-P and CAM; molecular biology of P; carbon dioxide supply; P by leaves; plant P production. The information has been brought up to date and the new material includes: the crystalization of the P reaction centre of purple bacteria and high resolution X-ray analysis of the structure resulting in increased understanding of the primary events in P; the X-ray analysis of ribulose biphosphate carboxylase-oxygenase; the genetic mapping of chloroplast DNA and the location of the genes for chloroplast constituents; global climate changes and the increased levels of carbon dioxide in the atmosphere. Protein Phosphorylation; a Practical Approach-Edited by D. G. HARDY. 300 pp. 1993. IRL/Oxford University Press. Hardback $59. Protein phosphorylation (PP) is the major mechanism by which cells respond to extracellular signals such as hormones and growth factors. It is also responsible for the timing of events which must occur at defined stages in the cell cycle such as DNA synthesis and mitosis. PP is catalysed by protein kinases and reversed by protein phosphorylases. This book deals with: PP in intact cells; phosphopeptide mapping and phosphoamino acid analysis on cellulose thin layer plates; analysis of sites phosphorylated in uipo and in u&-o; use of serine/thronine kinase activators and inhibitors to study PP in intact cells; use of PP inhibitors in intact cells; purification of mammalian serine/threonone kinases; purification of tyrosine kinases; identification of cDNAs that encode protein kinases; assay and purification of serine/threonine phosphatases; characterization of tyrosine phosphatases; identification of serine/threonine phosphatase genes in yeast, Drosophila and Man; protein kinase/phosphatase specificity using synthetic peptides. A better understanding of activators and inhibitors of PP systems will provide the basis for new drugs that can be used in cancer therapy. Aspects of Synaptic Transmission; ACh, Sigma Receptors, CCK, Eicosanoids and Neurotoxins-Edited by T. W. STONE. 255 pp. 1993. Taylor & Francis. f45. This is the published proceedings of the second Kelvin Conference. The subjects reviewed are: neuronal muscarinic receptor subtypes; cholinergic pathways in the CNS; cholinergic neurones and memory: nicotinic cholinergic stimulation in animal models of behaviour; sigma receptors [receptors for benzomorphans]; CCK-A and CCK-B in analgesia; CCK receptors; neuronal release of arachidonic acid; presynaptic toxins [TTX, conotoxins, scorpion toxins. anemone toxins, dendrotoxins, bee venom, phospholipase A2, apamin, scyllatoxin]; alpha latrotoxin; spider toxin and glutamate receptors; maitotoxin and calcium homeostasis. Opioids I and II-Edited by A. HERZ. Handbook of Experimental Pharmacology Vol. 104, parts I and II. Opioids I. 815 pp. 1993. Springer, Berlin. DM580. Opioids II 840 pp. 1993. Springer, Berlin. DM580.
Book Reviews In 1957 Vol. 12 of this series was a volume by Otto Schaumann on morphine and morphine derivatives. Since then there has been a tremendous increase in number of research publications and also a great increase in our understanding of the pharmacology of the opioids, mainly due to the identification of the opioid (0) receptors (OR) and the detection of the endogenous ligands. Volume I deals with ORs; cloning of cDNA of OR; 0 binding proteins; 0 bioassay using organ systems; anatomical distribution of OR; OR regulation; multiple OR and presynaptic modulation of neurotransmitter release; ORCr protein interactions; OR coupled 2nd messenger systems; allosteric coupling of OR; chemistry of non-peptide 0; nonpeptide 0 antagonists; endogenous 0 alkaloids; 0 peptide gene expression; POMC gene expression; proenkephalin gene regulation; POMC biosynthesis; biosynthesis of enkephalins; anatomy and function of enkephalins; atypical 0 peptides; 0 peptide processing enzymes; peptidase inactivation of enkephalinsAesign of inhibitors; coexistance of 0 with other neurotransmitters; interrelation of 0, DA, ACh and GABA; ligands for OR; analogs of 0 peptides; ontogeny of 0 system; 0 in the CNS; action of 0 on membrane ion channels. Volume 11 deals with 0 and; brainstem modulation of pain; supraspinal OR in antinoception; spinal action of 0; peripheral mechanisms of 0 analgesia; acupunc-ture and stimulation produced analgesia; multiple OR and chronic pain; gastrointestinal effects of 0; role of endogenous 0 in central cardiovascular regulation; temperature regulation; control of food consumption and taste preference; respiration and vomiting; stress; CNS injury; epilepsy and neuroprotection; immunologic processes; spontaneous animal behavior; learning and memory; pharmacodynamic characteristics of 0 antagonists; neuroendocrine control of reproduction; neurohyophysial system; 0 expression in peripheral tissue; 0 tolerance; 0 tolerance/dependence in isolated organs; 0 abuse assessment in Rhesus monkeys; motivational effects of 0; CSF 0 in pathophysiology; circulating 0 in man; 0 analgesics in clinical pain management; 0 in operative anaesthesia; beta endorphin in human reproduction; 0 in psychiatric disorders; 0 addiction. These two volumes give an excellent account of the frontiers of present day research in opioids. Growth Factors; a Practical Approach-Edited by I. MCKAY and I. LEIGH. 251 pp. 1993. IRL/Oxford University Press. Hardback $48, Paperback $31. There are at least 20 different growth factor (GF) families with a total of as many as 130 individual factors. It is possible that there are a great many more to be discovered. This book gives practical details for: detection and characterization of new GF; detection of polpeptide GF, application of biassay and PCR technology; induction of DNA synthesis and cell division in quiescent cells in response to small peptide GF; gene isolation by differential plaque hydridization; embryological assays for GF; the rule of TGF in bone growth and bone repair; localization of GF mRNA by in situ hybridization; detection of epidermal inhibitory pentapeptide; expression of GF in microbial systems; immunoassay of GF; determination of GF receptor distribution by immunocytochemistry, autoradiography, ligand binding and fluorescence activated cell sorter. Vaccine Design--Edited by F. BROWN, G. DOUGAN, E. M. HOEY, S. J. MARTIN, B. K. TIMA and A. TRUDGETT. 130 pp. 1993. Wiley, Chichester, U.K. f19.50.
603
This book is written for senior undergraduates and postgraduates. It deals with; the history of vaccination; sequence analysis-a starting point for vaccine design; requirements for induction of immunity; prediction of epitopes; peptides as vaccines; vaccines against virus diseases; bacterial vaccines; parasite vaccines; possibilities for future vaccines. A very useful and readable account of the subject.
Principles of Cellular and Molecular Immunology-J. M. AUSTYN and K. J. WOOD. 735 pp. 1993. Oxford University Press. Paperback f25. The literature on immunology increases at a frightening rate and it is very good to have this up to date book. It deals with: the immune system; immune responses; lymphoid tissue; the major histocompatability complex; antigen presenting cells; molecular basis of T cell responses; T cell repertoire; antigen receptors-structure and function; genes and immunoglobulin family; B cells and antibody responses; inflammatory mediators and soluble effector mechanisms; cellular cytotoxicity; idiotypc networks and suppressor pathways; cellular and molecular techniques in Immunology. The information is very clearly presented with good diagrams and tables. The reader will find this a very enjoyable, informative and interesting book.
Cell Surface and Extracellular Glycoconjugates; Structure and Function-Edited by D. R. ROBERTSand R. P. MECHAM. 314 pp. 1993. Academic Press, San Diego. Glycoconjugates (G) such as the selectins have an important role as mediators in lymphocyte recirculation, activation and inflammatory responses. Alterations of G can affect the malignant behaviour of tumor cells. Some hormones and growth factors react with the G on the cell surface receptor. The monosaccharide on the cell surface can be linked to a second sugar to form up to eight positional and anomeric isomers each having distinct chemical and biological properties. This book deals with: the function of N- and O-linked sugar chains of G; pericelluiar proteoglycans; glycosyl phosphatidylinositol linked membrane proteins; glysylation inhibitors; the use of mammalian cell mutants to study the functions of N- and O-linked glycolsylation; glycosphingolipid receptors in inflammation and cancer; G in human choriogonadotropin; G in adehsive cell function.
Bioinorganic Chemistry of Copper-Edited and Z. TYEKLAR. 506 pp. 1993. Chapman f65.
by K. D. KARLIN & Hall, London.
Copper plays a vital biochemical role as an essential metalloenzyme active-site cofactor involved in electron transfer, dioxygen transport, and the reduction of nitrogen oxides. This book deals with copper proteins; blue copper proteins and electron transfer; natural and synthetic regulation of gene expression; copper resistance; copper homeostasis; hemocyanin and copper monooxygenases; copper mediated redox/oxidative pathways; dioxygen binding and oxygenation reactions; copper-nitrogen oxide complexes; copper oxidase.
Protocols for Oligonucleotides and Analogos; Synthesis and PropertiesEdited by S. AGRAWAL. 502 pp. 1993. Humana Press, N. J. Paperback $59.50.