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Optic Nerve Gray Crescent
Ophthalmology Volume 124, Number 7, July 2017 Footnotes and Financial Disclosures Originally received: December 25, 2016. Final revision: March 3, 2017. Accepted: March 3, 2017. Available online: April 13, 2017.
Analysis and interpretation: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra Manuscript no. 2016-1148.
1
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
2
Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Author Contributions: Conception and design: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra
Data collection: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra Obtained funding: none Overall responsibility: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra Abbreviations and Acronyms: FAP ¼ familial amyloid polyneuropathy; logMAR ¼ logarithm of the minimum angle of resolution; TTR ¼ transthyretin. Correspondence: Rohan Chawla, MD, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Room no. S-3, New Delhi, India 110029. E-mail: [email protected].
Pictures & Perspectives Optic Nerve Gray Crescent The optic disc nerve gray crescent is seen as a slate gray crescent within the peripheral portion of the neuroretinal rim. It is most commonly seen in patients of African descent with glaucoma. This pigmented crescent may interfere with adequate assessment of the neuroretinal rim. It has been attributed to Bruch’s membrane extending internally into the peripapillary scleral ring. We document a 24-year-old African man with an optic nerve gray crescent in the right eye (Fig 1, arrows), wherein optical coherence tomography showed a thickened Bruch’s membrane (BM) protruding into the temporal prelaminar tissue of the optic nerve (Fig 1, arrowhead), providing in vivo support of this hypothesis.
GAVIN W. RODDY, MD, PHD MICHAEL C. BRODSKY, MD JOHN J. CHEN, MD, PHD Mayo Clinic, Rochester, Minnesota
Footnotes and Financial Disclosures Supported in part by an unrestricted grant to the Department of Ophthalmology by Research to Prevent Blindness, Inc., New York, NY.
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Analysis and interpretation: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra Manuscript no. 2016-1148.
1
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
2
Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Author Contributions: Conception and design: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra
Data collection: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra Obtained funding: none Overall responsibility: Venkatesh, Selvan, Singh, Gupta, Kashyap, Temkar, Gogia, Tripathy, Chawla, Vohra Abbreviations and Acronyms: FAP ¼ familial amyloid polyneuropathy; logMAR ¼ logarithm of the minimum angle of resolution; TTR ¼ transthyretin. Correspondence: Rohan Chawla, MD, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Room no. S-3, New Delhi, India 110029. E-mail: [email protected].
Pictures & Perspectives Optic Nerve Gray Crescent The optic disc nerve gray crescent is seen as a slate gray crescent within the peripheral portion of the neuroretinal rim. It is most commonly seen in patients of African descent with glaucoma. This pigmented crescent may interfere with adequate assessment of the neuroretinal rim. It has been attributed to Bruch’s membrane extending internally into the peripapillary scleral ring. We document a 24-year-old African man with an optic nerve gray crescent in the right eye (Fig 1, arrows), wherein optical coherence tomography showed a thickened Bruch’s membrane (BM) protruding into the temporal prelaminar tissue of the optic nerve (Fig 1, arrowhead), providing in vivo support of this hypothesis.
GAVIN W. RODDY, MD, PHD MICHAEL C. BRODSKY, MD JOHN J. CHEN, MD, PHD Mayo Clinic, Rochester, Minnesota
Footnotes and Financial Disclosures Supported in part by an unrestricted grant to the Department of Ophthalmology by Research to Prevent Blindness, Inc., New York, NY.
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