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OR040: The Association of Nutritional Status with Brain Atrophy and Cerebrovascular Lesions on Mri in a Cohort of Geriatric Outpatients
S16 children avoiding milk. We investigated the impact of a dairyfree diet on the final stature of IgE-mediated Cow Milk Allergy (IgE-CMA) young adults. These patients, by definition, are unable to consume even minor amounts of dairy foods, since infancy. Methods: Anthropometric data was measured in 49 IgE-CMA patients (20.3±3.4 years old, 19 males) and 36 healthy subjects (control group, 22.5±4.2 years old, 15 males). All of them were at least 2 years post pubertal, as classified by Tanner’s Stage 5. Age- and gender-specific SDSs and percentiles were determined according to Centers for Disease Control and Prevention growth charts. Nutrient intake assessment was based on 24 hour dietary recall and presented as percent of dietary reference values (DRI’s). Individuals with conditions or treatments affecting bone metabolism or growth, were excluded. Results: Height (cm) and height-SDS were significantly reduced in CMA subjects when compared to controls (164.1±8.0 vs 168.5±7.8, p = 0.01; 0.61±0.9 vs 0.04±0.7, p = 0.002). An abnormal distribution of height-for-age was noted in the CMA group, as compared to the controls (47% vs 17% were categorized as less than the 25th percentile, and 18% vs 3% were categorized as less than the 10th percentile). In addition, height-SDS in CMA patients was significantly lower than their predicted height (mid-parental target height, MPH) (p < 0.0001). Dheight-MPH in CMA patients and controls were 4.0±5.2 and 0.62±5.2 cm, respectively, p = 0.007. The incidence of subjects consuming less than 67% of the DRI was greater in the CMA group, as compared to controls. Conclusion: Individuals with CMA are at risk for not reaching their growth potential. Growth monitoring and appropriate dietary intervention may avoid nutritional deficiencies and growth retardation in these patients. Disclosure of Interest: None declared
OR039 VITAMIN D DURING PREGNANCY AND POSTPARTUM A LONGITUDINAL STUDY A. Lundqvist1 , J. Hultdin2 , H. Stenlund3 , I. Johansson4 , H. Sandstr¨ om1 . 1 Family Medicine, Department of Public Health and Clinical Medicine, 2 Department of Medical Biosciences, Clinical Chemistry, 3 Epidemiology and Global Health, Department of Public Health and Clinical Medicine, 4 Department of Odontology, School of Dentistry, Cariology, Ume˚ a, Sweden Rationale: Low levels of vitamin D may have negative impact on both mother and child’s health. Cross-sectional studies suggest that vitamin D levels tend to be low in pregnant women but there are few longitudinal studies. The aim of this study is to study vitamin D status and the prevalence of low vitamin levels in a longitudinal study during pregnancy and postpartum. Methods: The Pregnancy and Nutritional cohort study follows 226 women from early pregnancy to post-partum. The women were consecutively recruited from five antenatal clinics in primary care in between September 2006 and March 2009 in northern Sweden (latitude 630 ). We collected diet data with a self-reported validated food frequency questionnaire with 66 food items/food aggregates, supplement use and blood sampling at gestational week 12, 21, 35 and- 12 respective
Oral communications 29 weeks after birth. 25(OH)D in plasma was analysed using; Liquid chromatography-tandem mass spectrometry technique. Statistical analysis included descriptive, comparative statistics and multivariate mixed model analysis. Results: Concentrations of 25(OH)D showed a slightly increasing trend over time, peaking in late pregnancy and then declining after birth. Mean dietary intake of vitamin D was 5.1 mg/day. Mean concentrations of 25(OH)D was 57.7 nmol/L (SD 21.1), 62.3% had serum concentrations 50 nmol/L, 37.7% <50 nmol/L, from early pregnancy to 29 weeks after birth. Multivariate analysis showed that gestational week, season, dietary intake of vitamin D and multivitamin supplementation were significantly related to 25(OH)D concentrations. Conclusion: 25(OH)D peaked in late pregnancy in our longitudinal cohort. It is relatively common to find low 25(OH)D during pregnancy, especially during winter time, raising concern about potential health risks for both mother and child. Finding (and treating) these women is an important task for antenatal care. Disclosure of Interest: None declared
Geriatrics OR040 THE ASSOCIATION OF NUTRITIONAL STATUS WITH BRAIN ATROPHY AND CEREBROVASCULAR LESIONS ON MRI IN A COHORT OF GERIATRIC OUTPATIENTS M.A. de van der Schueren1 , S. Lonterman-Monasch2 , M.A. Chung3 , W.M. van der Flier4 , A.B. Maier5 , M.M. Muller3 . 1 Nutrition and Dietetics, VU University Medical Center, Amsterdam, 2 Haga Hospital, the Hage, 3 Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 4 Alzheimer Center, 5 Gerontology and Geriatrics, VU University Medical Center, Amsterdam, Netherlands Rationale: Little information exists on the relation between malnutrition and brain atrophy and cerebrovascular lesions. Methods: In 359 geriatric outpatients nutritional status was assessed by MNA and by vitamin B1, B6, B12, and folic acid levels. White Matter Hyperintensities (WMHs), Global Cortical brain Atrophy (GCA) or Medial Temporal lobe Atrophy (MTA) on MRI were quantified using visual rating scales. Cognitive functioning was assessed by neuropsycological examination (n = 192) or by MMSE. Logistic regression analyses were performed to associate MNA categories and micronutrients (per SD decrease or absolute deficiency) with severe WHMs, GCA and MTA. All analyses were adjusted for age, sex, education, comorbidities, alcohol use and smoking and MNA scores were additionally adjusted for vitamin B levels. Analyses were repeated after stratification for cognitive status (healthy n = 94, unhealthy n = 265). Results: Mean age was 80 (SD 7) years, 13% were malnourished, and 55% were at risk of malnutrition. Vitamin deficiencies were observed in 5% (B1), 1.7% (B6), 8.1% (B12), and 1.9% (folic acid). Malnutrition and risk of malnutrition were associated with an increased risk of having severe WHMs, ORs (95% CI) 2.15 (1.10 4.22) and 2.98 (1.25 7.09). Results held after additional adjustment for B-vitamin status. Stratification
Geriatrics for cognitive status showed similar results in cognitively (un)healthy patients. Lower vit B1 and vit B12 levels were associated with increased risk of WMHs [OR per SD decrease vit B1 1.49 (1.08 2.08), OR for absolute vit B12 deficiency 2.55 (1.04 6.26)]. Conclusion: Malnutrition and vit B1 and B12 deficiencies were associated with increased risk of WMHs, independent of each other and of cognitive status. Underlying mechanisms need to be further clarified and it also needs to be studied whether these findings are modifiable by nutritional interventions. Disclosure of Interest: None declared
OR041 LEUKOCYTE TELOMERE LENGTH IS ASSOCIATED WITH LEAN MASS: DATA FROM THE BERLIN AGING STUDY-II (BASE-II) A. Meyer1 , B. Salewsky2 , E. Steinhagen-Thiessen1 , K. Norman1 , I. Demuth1,2 . 1 Research Group on Geriatrics, 2 Institute of Medical and Human Genetics, Charit´ e-Universit¨ atsmedizin Berlin, Berlin, Germany Rationale: Age-related loss of muscle mass is an increasing problem in in our aging society, affecting physical ability. Telomere length has been recognized as a marker of biological age on the population level. Here we evaluated the rarely examined relationship between lean mass and relative leukocyte telomere length (rLTL) in 1,398 participants of the Berlin Aging Study II (mean age 68.2±3.7 years, 49.6% men). Methods: The determination of rLTL was carried out by real time PCR. Lean mass was estimated by dual X-ray absorptiometry and examined as leg lean mass (LLM), appendicular lean mass (ALM), and ALM corrected for body mass index (ALMBMI ). Results: Highly significant correlations (p < 0.001) of rLTL and ALM (r = 0.248), ALMBMI (r = 0.254), and LLM (r = 0.263) were found. Associations remained significant in linear models adjusted for age, gender, BMI, low-grade inflammation, life style factors and morbidities: ALM (b = 0.844, p = 0.009), ALMBMI (b = 0.032, p = 0.011), and LLM (b = 0.967, p < 0.001). Shorter rLTL, advanced age, being female, sedentary lifestyle and elevated CRP level were associated with lower lean mass. Conclusion: Short telomeres were associated with low lean mass. Our results indicate that rLTL may be a risk factor for loss of lean mass. To confirm the association between telomere attrition and loss of LLM and ALMBMI , which are highly relevant for physical ability, further research should examine this subject in a longitudinal context. Disclosure of Interest: None declared
OR042 EFFECTS OF CITRULLINE (CIT) ORAL SUPPLEMENTATION DURING 21 DAYS ON BODY COMPOSITION IN MALNOURISHED ELDERLY PATIENTS O. Bouillanne1,2 , J.-C. Melchior2,3 , C. Faure2 , F. CanouïPoitrine4,5 , M. Paul6 , Y. Boirie7,8,9 , B. D´ erick10 , D. Chevenne11 , C. Forasassi12 , E. Guery E4,5,13 , S. Herbaud14 , P. Le Corvoisier15 , N. Neveux2,16 , V. Nivet Antoine2,17 , A. Astier6 , A. RaynaudSimon2,18 , E. Valiente19 , S. Walrand7,8 , L. Cynober2,16 , C. Aussel2,20 . 1 D´ epartement de G´ erontologie, Assistance Publique Hˆ opitaux de Paris (AP-HP), Hˆ opitaux Universitaires (HU) Henri-Mondor, Hˆ opital Emile-Roux, Limeil-Br´ evannes, 2 EA 4466, Laboratoire de Biologie de la Nutrition, Facult´ e
S17 des Sciences Pharmaceutiques et Biologiques, Universit´ e Paris-Descartes, Paris, 3 Unit´ e de Nutrition clinique-TCA, APHP, Hˆ opitaux Universitaires (HU) Paris-Ile-de-France-Ouest, Hˆ opital Raymond-Poincar´ e, Garches, 4 EA 4393, CEpiA (Clinical Epidemiology and Ageing), Facult´ e de M´ edecine, Universit´ e Paris-Est, 5 Service de Sant´ e Publique, 6 D´ epartement de Pharmacie, AP-HP, Hˆ opital Henri-Mondor, Cr´ eteil, 7 UMR 1019, Unit´ e de Nutrition Humaine, INRA, CRNH Auvergne, 8 Unit´ e de Nutrition Humaine, Universit´ e d’Auvergne, 9 D´ epartement de Nutrition Clinique, Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, 10 D´ epartement de G´ erontologie, AP-HP, GH Henri-Mondor, Hˆ opital Joffre-Dupuytren, Draveil, 11 D´ epartement de Biochimie et d’Hormonologie, AP-HP, Hˆ opital Robert Debr´ e, 12 D´ epartement de G´ erontologie, AP-HP, HU Est-Parisien, Hˆ opital Rothschild, Paris, 13 Unit´ e de Recherche Clinique, AP-HP, Hˆ opital Henri-Mondor, 14 D´ epartement de G´ erontologie, AP-HP, GH Henri-Mondor, Hˆ opital Albert-Chenevier, 15 Centre d’Investigation Clinique 006, INSERM, Cr´ eteil, 16 D´ epartement de Biochimie, AP-HP, HU Paris-Centre, 17 D´ epartement de Biochimie, AP-HP, HU Paris-Ouest, Hˆ opital Georges Pompidou, 18 D´ epartement de G´ erontologie, AP-HP, HU ParisNord-Val-de-Seine, Hˆ opital Bichat, Paris, 19 D´ epartement de Radiologie, AP-HP, GH Henri-Mondor, Hˆ opital Emile-Roux, Limeil-Br´ evannes, 20 Unit´ e de Nutrition, D´ epartement de Pharmacie, AP-HP, Hˆ opital Henri-Mondor, Cr´ eteil, France Rationale: Aging is associated with a gradual loss of skeletal muscle mass and function which can be accelerated by malnutrition. It has been shown that Cit has the property to stimulate muscle protein synthesis and to decrease fat mass in aged rats. We therefore hypothesized that in malnourished elderly people in whom muscle anabolism is diminished, Cit could stimulate muscle protein synthesis and increase muscle mass. Methods: This prospective randomized multicenter study enrolled 29 elderly malnourished patients in inpatient rehabilitation units. All were given an oral dose of 10 g of Cit or an equimolair mixture of 6 non-essential amino acids (NEAAs), as isonitrogenous placebo, for 21 days. The patients were evaluated at D1 and D21 for body composition: whole body lean mass (LM), appendicular skeletal muscle mass (ASMM), fat mass (FM) (X-ray absorptiometry). Results: 24 patients completed the study. Changes in body composition in the whole population (WP) and in women (W) are given in the table. LM and ASMM were significantly increased at D21 as compared with D1 in the Cit group and FM was significantly decreased in the Cit group in women. ASMM mass and FM changes were significantly different between the 2 groups in women. Women
Whole population NEAA, n = 13
Cit, n = 11
NEAA, n = 10
Cit, n = 8
LM (%) 1.72 [ 0.07; 3.94] 2.33 [0.26; 12.06]a 1.63 [ 0.07; 3.94] 5.52 [0.57; 12.67]a ASMM (%) 1.42 [ 1.07; 6.30] 5.40 [1.76; 11.32]a 2.10 [ 0.60; 6.20] 9.60 [5.40; 15.60]a,b 3.52 [ 3.27; 5.60] 8.82 FM (%) 2.01 [ 3.27; 5.60] 4.73 [ 12.35; 1.47] [ 14.62; 4.46]a,c Values are median; quartiles [Q1; Q3] of the relative percent change (D21 D1)/D1. a p < 0.05 signed-rank Wilcoxon test for paired samples (D21 vs D1). b p = 0.03, c p < 0.01 Wilcoxon test for unpaired samples (Cit vs NEAA).
OR039 VITAMIN D DURING PREGNANCY AND POSTPARTUM A LONGITUDINAL STUDY A. Lundqvist1 , J. Hultdin2 , H. Stenlund3 , I. Johansson4 , H. Sandstr¨ om1 . 1 Family Medicine, Department of Public Health and Clinical Medicine, 2 Department of Medical Biosciences, Clinical Chemistry, 3 Epidemiology and Global Health, Department of Public Health and Clinical Medicine, 4 Department of Odontology, School of Dentistry, Cariology, Ume˚ a, Sweden Rationale: Low levels of vitamin D may have negative impact on both mother and child’s health. Cross-sectional studies suggest that vitamin D levels tend to be low in pregnant women but there are few longitudinal studies. The aim of this study is to study vitamin D status and the prevalence of low vitamin levels in a longitudinal study during pregnancy and postpartum. Methods: The Pregnancy and Nutritional cohort study follows 226 women from early pregnancy to post-partum. The women were consecutively recruited from five antenatal clinics in primary care in between September 2006 and March 2009 in northern Sweden (latitude 630 ). We collected diet data with a self-reported validated food frequency questionnaire with 66 food items/food aggregates, supplement use and blood sampling at gestational week 12, 21, 35 and- 12 respective
Oral communications 29 weeks after birth. 25(OH)D in plasma was analysed using; Liquid chromatography-tandem mass spectrometry technique. Statistical analysis included descriptive, comparative statistics and multivariate mixed model analysis. Results: Concentrations of 25(OH)D showed a slightly increasing trend over time, peaking in late pregnancy and then declining after birth. Mean dietary intake of vitamin D was 5.1 mg/day. Mean concentrations of 25(OH)D was 57.7 nmol/L (SD 21.1), 62.3% had serum concentrations 50 nmol/L, 37.7% <50 nmol/L, from early pregnancy to 29 weeks after birth. Multivariate analysis showed that gestational week, season, dietary intake of vitamin D and multivitamin supplementation were significantly related to 25(OH)D concentrations. Conclusion: 25(OH)D peaked in late pregnancy in our longitudinal cohort. It is relatively common to find low 25(OH)D during pregnancy, especially during winter time, raising concern about potential health risks for both mother and child. Finding (and treating) these women is an important task for antenatal care. Disclosure of Interest: None declared
Geriatrics OR040 THE ASSOCIATION OF NUTRITIONAL STATUS WITH BRAIN ATROPHY AND CEREBROVASCULAR LESIONS ON MRI IN A COHORT OF GERIATRIC OUTPATIENTS M.A. de van der Schueren1 , S. Lonterman-Monasch2 , M.A. Chung3 , W.M. van der Flier4 , A.B. Maier5 , M.M. Muller3 . 1 Nutrition and Dietetics, VU University Medical Center, Amsterdam, 2 Haga Hospital, the Hage, 3 Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 4 Alzheimer Center, 5 Gerontology and Geriatrics, VU University Medical Center, Amsterdam, Netherlands Rationale: Little information exists on the relation between malnutrition and brain atrophy and cerebrovascular lesions. Methods: In 359 geriatric outpatients nutritional status was assessed by MNA and by vitamin B1, B6, B12, and folic acid levels. White Matter Hyperintensities (WMHs), Global Cortical brain Atrophy (GCA) or Medial Temporal lobe Atrophy (MTA) on MRI were quantified using visual rating scales. Cognitive functioning was assessed by neuropsycological examination (n = 192) or by MMSE. Logistic regression analyses were performed to associate MNA categories and micronutrients (per SD decrease or absolute deficiency) with severe WHMs, GCA and MTA. All analyses were adjusted for age, sex, education, comorbidities, alcohol use and smoking and MNA scores were additionally adjusted for vitamin B levels. Analyses were repeated after stratification for cognitive status (healthy n = 94, unhealthy n = 265). Results: Mean age was 80 (SD 7) years, 13% were malnourished, and 55% were at risk of malnutrition. Vitamin deficiencies were observed in 5% (B1), 1.7% (B6), 8.1% (B12), and 1.9% (folic acid). Malnutrition and risk of malnutrition were associated with an increased risk of having severe WHMs, ORs (95% CI) 2.15 (1.10 4.22) and 2.98 (1.25 7.09). Results held after additional adjustment for B-vitamin status. Stratification
Geriatrics for cognitive status showed similar results in cognitively (un)healthy patients. Lower vit B1 and vit B12 levels were associated with increased risk of WMHs [OR per SD decrease vit B1 1.49 (1.08 2.08), OR for absolute vit B12 deficiency 2.55 (1.04 6.26)]. Conclusion: Malnutrition and vit B1 and B12 deficiencies were associated with increased risk of WMHs, independent of each other and of cognitive status. Underlying mechanisms need to be further clarified and it also needs to be studied whether these findings are modifiable by nutritional interventions. Disclosure of Interest: None declared
OR041 LEUKOCYTE TELOMERE LENGTH IS ASSOCIATED WITH LEAN MASS: DATA FROM THE BERLIN AGING STUDY-II (BASE-II) A. Meyer1 , B. Salewsky2 , E. Steinhagen-Thiessen1 , K. Norman1 , I. Demuth1,2 . 1 Research Group on Geriatrics, 2 Institute of Medical and Human Genetics, Charit´ e-Universit¨ atsmedizin Berlin, Berlin, Germany Rationale: Age-related loss of muscle mass is an increasing problem in in our aging society, affecting physical ability. Telomere length has been recognized as a marker of biological age on the population level. Here we evaluated the rarely examined relationship between lean mass and relative leukocyte telomere length (rLTL) in 1,398 participants of the Berlin Aging Study II (mean age 68.2±3.7 years, 49.6% men). Methods: The determination of rLTL was carried out by real time PCR. Lean mass was estimated by dual X-ray absorptiometry and examined as leg lean mass (LLM), appendicular lean mass (ALM), and ALM corrected for body mass index (ALMBMI ). Results: Highly significant correlations (p < 0.001) of rLTL and ALM (r = 0.248), ALMBMI (r = 0.254), and LLM (r = 0.263) were found. Associations remained significant in linear models adjusted for age, gender, BMI, low-grade inflammation, life style factors and morbidities: ALM (b = 0.844, p = 0.009), ALMBMI (b = 0.032, p = 0.011), and LLM (b = 0.967, p < 0.001). Shorter rLTL, advanced age, being female, sedentary lifestyle and elevated CRP level were associated with lower lean mass. Conclusion: Short telomeres were associated with low lean mass. Our results indicate that rLTL may be a risk factor for loss of lean mass. To confirm the association between telomere attrition and loss of LLM and ALMBMI , which are highly relevant for physical ability, further research should examine this subject in a longitudinal context. Disclosure of Interest: None declared
OR042 EFFECTS OF CITRULLINE (CIT) ORAL SUPPLEMENTATION DURING 21 DAYS ON BODY COMPOSITION IN MALNOURISHED ELDERLY PATIENTS O. Bouillanne1,2 , J.-C. Melchior2,3 , C. Faure2 , F. CanouïPoitrine4,5 , M. Paul6 , Y. Boirie7,8,9 , B. D´ erick10 , D. Chevenne11 , C. Forasassi12 , E. Guery E4,5,13 , S. Herbaud14 , P. Le Corvoisier15 , N. Neveux2,16 , V. Nivet Antoine2,17 , A. Astier6 , A. RaynaudSimon2,18 , E. Valiente19 , S. Walrand7,8 , L. Cynober2,16 , C. Aussel2,20 . 1 D´ epartement de G´ erontologie, Assistance Publique Hˆ opitaux de Paris (AP-HP), Hˆ opitaux Universitaires (HU) Henri-Mondor, Hˆ opital Emile-Roux, Limeil-Br´ evannes, 2 EA 4466, Laboratoire de Biologie de la Nutrition, Facult´ e
S17 des Sciences Pharmaceutiques et Biologiques, Universit´ e Paris-Descartes, Paris, 3 Unit´ e de Nutrition clinique-TCA, APHP, Hˆ opitaux Universitaires (HU) Paris-Ile-de-France-Ouest, Hˆ opital Raymond-Poincar´ e, Garches, 4 EA 4393, CEpiA (Clinical Epidemiology and Ageing), Facult´ e de M´ edecine, Universit´ e Paris-Est, 5 Service de Sant´ e Publique, 6 D´ epartement de Pharmacie, AP-HP, Hˆ opital Henri-Mondor, Cr´ eteil, 7 UMR 1019, Unit´ e de Nutrition Humaine, INRA, CRNH Auvergne, 8 Unit´ e de Nutrition Humaine, Universit´ e d’Auvergne, 9 D´ epartement de Nutrition Clinique, Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, 10 D´ epartement de G´ erontologie, AP-HP, GH Henri-Mondor, Hˆ opital Joffre-Dupuytren, Draveil, 11 D´ epartement de Biochimie et d’Hormonologie, AP-HP, Hˆ opital Robert Debr´ e, 12 D´ epartement de G´ erontologie, AP-HP, HU Est-Parisien, Hˆ opital Rothschild, Paris, 13 Unit´ e de Recherche Clinique, AP-HP, Hˆ opital Henri-Mondor, 14 D´ epartement de G´ erontologie, AP-HP, GH Henri-Mondor, Hˆ opital Albert-Chenevier, 15 Centre d’Investigation Clinique 006, INSERM, Cr´ eteil, 16 D´ epartement de Biochimie, AP-HP, HU Paris-Centre, 17 D´ epartement de Biochimie, AP-HP, HU Paris-Ouest, Hˆ opital Georges Pompidou, 18 D´ epartement de G´ erontologie, AP-HP, HU ParisNord-Val-de-Seine, Hˆ opital Bichat, Paris, 19 D´ epartement de Radiologie, AP-HP, GH Henri-Mondor, Hˆ opital Emile-Roux, Limeil-Br´ evannes, 20 Unit´ e de Nutrition, D´ epartement de Pharmacie, AP-HP, Hˆ opital Henri-Mondor, Cr´ eteil, France Rationale: Aging is associated with a gradual loss of skeletal muscle mass and function which can be accelerated by malnutrition. It has been shown that Cit has the property to stimulate muscle protein synthesis and to decrease fat mass in aged rats. We therefore hypothesized that in malnourished elderly people in whom muscle anabolism is diminished, Cit could stimulate muscle protein synthesis and increase muscle mass. Methods: This prospective randomized multicenter study enrolled 29 elderly malnourished patients in inpatient rehabilitation units. All were given an oral dose of 10 g of Cit or an equimolair mixture of 6 non-essential amino acids (NEAAs), as isonitrogenous placebo, for 21 days. The patients were evaluated at D1 and D21 for body composition: whole body lean mass (LM), appendicular skeletal muscle mass (ASMM), fat mass (FM) (X-ray absorptiometry). Results: 24 patients completed the study. Changes in body composition in the whole population (WP) and in women (W) are given in the table. LM and ASMM were significantly increased at D21 as compared with D1 in the Cit group and FM was significantly decreased in the Cit group in women. ASMM mass and FM changes were significantly different between the 2 groups in women. Women
Whole population NEAA, n = 13
Cit, n = 11
NEAA, n = 10
Cit, n = 8
LM (%) 1.72 [ 0.07; 3.94] 2.33 [0.26; 12.06]a 1.63 [ 0.07; 3.94] 5.52 [0.57; 12.67]a ASMM (%) 1.42 [ 1.07; 6.30] 5.40 [1.76; 11.32]a 2.10 [ 0.60; 6.20] 9.60 [5.40; 15.60]a,b 3.52 [ 3.27; 5.60] 8.82 FM (%) 2.01 [ 3.27; 5.60] 4.73 [ 12.35; 1.47] [ 14.62; 4.46]a,c Values are median; quartiles [Q1; Q3] of the relative percent change (D21 D1)/D1. a p < 0.05 signed-rank Wilcoxon test for paired samples (D21 vs D1). b p = 0.03, c p < 0.01 Wilcoxon test for unpaired samples (Cit vs NEAA).