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ORAL ASPERGILLOSIS DIAGNOSIS IN ONCOHEMATOLOGIC PATIENTS: CASE SERIES
OOOO Volume 129, Number 1 and inflammatory myofibroblastic sarcoma-1. We herein present a series of 22 cases of oral sarcomas diagnosed at a single diagnostic center, thus contributing regional data to the few series reported in the literature. A distinctive feature of the present series is the high prevalence of Kaposi sarcoma, which in all cases was associated with HHV-8.
MEDICINAL PLANTS FOR PREVENTION AND TREATMENT OF ACTINIC CHEILITIS: A CASE SERIES. JOSE FERREIRA MENEZES FILHO, THEURE SALES E SILVA, ANELISE RIBEIRO PEIXOTO DE ALENCAR, DEBORAH ABUCHAIM DE MENEZES, VIVIANE SIQUEIRA, ANA CAROLYNE TROVO COSTA and, ANA LUCIA ROSELINO RIBEIRO Actinic cheilitis is a potentially malignant inflammatory labial pathology. It usually affects the lower lip in white patients between 40 and 80 years of age, with a history of long and continuous sun exposure, as seen in the reported cases. In this work, the classification proposed by Silva et al. (2006) was used to classify the lesions as mild (first case), moderate (second case), or severe (third case). It is important to emphasize the importance of clinical diagnosis, since it allows prevention and treatment, before a possible progression to carcinoma. The treatment of first choice in all cases was the topical use of a compounding preparation (50% aloe vera gel and 5% calendula) with the aim of acting as a moisturizer, an emollient, and an anti-inflammatory agent, thereby increasing vascularization and oxygenation, as well as initiating the repair of collagen and healing of the lesions.
PLASMABLASTIC LYMPHOMA OF THE ORAL CAVITY: A CASE SERIES. CARLA ISABELLY RODRIGUES-FERNANDES, MARCIO AJUDARTE LOPES, OSLEI PAES DE ALMEIDA, ^ ALAN ROGER SANTOS-SILVA, HELDER ANTONIO REBELO PONTES, LUCAS LACERDA DE SOUZA and, FELIPE PAIVA FONSECA This study described the clinical and histopathologic data of 6 cases diagnosed as oral plasmablastic lymphoma (PBL) retrieved from the files of 2 Brazilian oral pathology services from 2000 to 2018. The mean age at presentation was 41.5 years, with a male predominance of 2:1. Involved sites were the palate, maxillary mucosa, and mandibular mucosa. All cases presented as a combination of illdefined swellings and ulcers, with pain or bleeding. Histopathologic features revealed the proliferation of large cells, with round to ovoid eccentric nuclei, and peripheral nucleoli, as well as plasmablastic cells with prominent nucleoli. The cases were positive for CD138 and plasma cell, negative for CD20, and presented with a high proliferative index (>90%). All cases were positive for Epstein-Barr virus-encoded small ribonucleic acids (EBER). Treatment included chemotherapy associated with highly active antiretroviral therapy (HAART). Radiotherapy was performed in 1 case and HAART only was applied in 1 case. Currently, 4 patients remain alive.
ORAL ASPERGILLOSIS DIAGNOSIS IN ONCOHEMATOLOGIC PATIENTS: CASE SERIES. LARA MARIA ALENCAR RAMOS INNOCENTINI, TATIANE CRISTINA FERRARI, HILTON MARCOS ALVES RICZ, LUIZ CARLOS CONTI DE FREITAS, ALFREDO RIBEIRO-SILVA, BELINDA PINTO e and, LEANDRO DORIGAN DE MACEDO SIMOES
ABSTRACTS
e25
We report a series of 12 cases of oral aspergillosis with an age range from 21 to 63 years (mean, 42 y), 7 women, 5 men, whose underlying diseases were acute myeloid leukemia (n = 9) and chronic myeloid leukemia in blastic crisis (n = 3). Primary sites and symptoms were: 2 cases in the nasal cavity presenting as rhinorrhea and fever, 5 cases in the paranasal sinus (2 with pain, 1 with fever and 2 with pain and fever), and 5 cases in the oral mucosa who presented only with pain. All cases localized in paranasal sinuses were detected by computed tomography while in the nasal cavity; however, none were detected by imaging when localized to the oral mucosa. Galactomannan (GM) was positive only when fever was present. Histopathology (HP) and culture were all positive for Aspergillus sp., however HP diagnosis was within 48 hours. In conclusion, GM was not effective for localized lesions without systemic repercussion and histopathologic examination is strongly recommended for early aspergillosis diagnosis.
ORAL CANCER: WHAT HAVE WE LEARNED IN 30 YEARS? A FEW REFLECTIONS CONSIDERING A CASE SERIES. BERNARDO VENEGAS, DANIEL DROGUETT, MARCELO SANCHEZ, SONIA VASQUEZ, BERNARDITA FUENTES, WENDY DONOSO and, CESAR RIVERA After 30 years working in the field of oral pathology with strong emphasis in oral cancer diagnosis, teaching, and research, several thoughts come to mind about lessons obtained from patients and their sufferings. Undoubtedly, scientific and clinical aspects, including etiology, risk factors, genetic and epigenetic disorders, psychoneuroimmunology, and diagnostic and therapeutic methods constitute specific knowledge obtained during the process. Nevertheless, other essential lessons like the strong impact to the patient, the patient’s family, health team, and the whole society; together with the necessary respect to the patient’s decisions and the consequences of late diagnosis and misdiagnosis; turn out to be the fundamental knowledge that comes to lead the behavior toward the assisting activity in the field. In this paper, several cases of head and neck squamous cell carcinoma have been selected to analyze the importance of the fundamental considerations necessary to keep in mind when treating patients with this disease.
ENAMEL HYPOPLASIA IN PATIENTS WITH RENAL TRANSPLANT: REPORT OF AN ORAL TUMA, REHABILITATION. MARINA MAUES NEZ-AGUILERA e JUAN FERNANDO ORDO and, MARINA GALLOTTINI Enamel hypoplasia is a developmental defect of enamel often found in people with renal disease, probably due to hypocalcemia and elevated levels of serum phosphate and fluoride during amelogenesis. A 14-year-old boy, white, with diagnosis of nephropathic cystinosis since 3 years of age and undergoing renal transplant at 11 years of age, with a chief complaint of "severe aesthetic issues" of the teeth. We observed generalized enamel hypoplasia and grade 1 gingival hyperplasia. We performed gingivoplasty using high-power diode laser and made direct resin facets from the right to the left premolars, upper and lower. Direct restorations with composite resin restored the harmony, function, and aesthetics, besides being low cost and fast to perform. The negative impact of generalized enamel hypoplasia on patients’ self-esteem underscores the importance of dental rehabilitation treatment.
MEDICINAL PLANTS FOR PREVENTION AND TREATMENT OF ACTINIC CHEILITIS: A CASE SERIES. JOSE FERREIRA MENEZES FILHO, THEURE SALES E SILVA, ANELISE RIBEIRO PEIXOTO DE ALENCAR, DEBORAH ABUCHAIM DE MENEZES, VIVIANE SIQUEIRA, ANA CAROLYNE TROVO COSTA and, ANA LUCIA ROSELINO RIBEIRO Actinic cheilitis is a potentially malignant inflammatory labial pathology. It usually affects the lower lip in white patients between 40 and 80 years of age, with a history of long and continuous sun exposure, as seen in the reported cases. In this work, the classification proposed by Silva et al. (2006) was used to classify the lesions as mild (first case), moderate (second case), or severe (third case). It is important to emphasize the importance of clinical diagnosis, since it allows prevention and treatment, before a possible progression to carcinoma. The treatment of first choice in all cases was the topical use of a compounding preparation (50% aloe vera gel and 5% calendula) with the aim of acting as a moisturizer, an emollient, and an anti-inflammatory agent, thereby increasing vascularization and oxygenation, as well as initiating the repair of collagen and healing of the lesions.
PLASMABLASTIC LYMPHOMA OF THE ORAL CAVITY: A CASE SERIES. CARLA ISABELLY RODRIGUES-FERNANDES, MARCIO AJUDARTE LOPES, OSLEI PAES DE ALMEIDA, ^ ALAN ROGER SANTOS-SILVA, HELDER ANTONIO REBELO PONTES, LUCAS LACERDA DE SOUZA and, FELIPE PAIVA FONSECA This study described the clinical and histopathologic data of 6 cases diagnosed as oral plasmablastic lymphoma (PBL) retrieved from the files of 2 Brazilian oral pathology services from 2000 to 2018. The mean age at presentation was 41.5 years, with a male predominance of 2:1. Involved sites were the palate, maxillary mucosa, and mandibular mucosa. All cases presented as a combination of illdefined swellings and ulcers, with pain or bleeding. Histopathologic features revealed the proliferation of large cells, with round to ovoid eccentric nuclei, and peripheral nucleoli, as well as plasmablastic cells with prominent nucleoli. The cases were positive for CD138 and plasma cell, negative for CD20, and presented with a high proliferative index (>90%). All cases were positive for Epstein-Barr virus-encoded small ribonucleic acids (EBER). Treatment included chemotherapy associated with highly active antiretroviral therapy (HAART). Radiotherapy was performed in 1 case and HAART only was applied in 1 case. Currently, 4 patients remain alive.
ORAL ASPERGILLOSIS DIAGNOSIS IN ONCOHEMATOLOGIC PATIENTS: CASE SERIES. LARA MARIA ALENCAR RAMOS INNOCENTINI, TATIANE CRISTINA FERRARI, HILTON MARCOS ALVES RICZ, LUIZ CARLOS CONTI DE FREITAS, ALFREDO RIBEIRO-SILVA, BELINDA PINTO e and, LEANDRO DORIGAN DE MACEDO SIMOES
ABSTRACTS
e25
We report a series of 12 cases of oral aspergillosis with an age range from 21 to 63 years (mean, 42 y), 7 women, 5 men, whose underlying diseases were acute myeloid leukemia (n = 9) and chronic myeloid leukemia in blastic crisis (n = 3). Primary sites and symptoms were: 2 cases in the nasal cavity presenting as rhinorrhea and fever, 5 cases in the paranasal sinus (2 with pain, 1 with fever and 2 with pain and fever), and 5 cases in the oral mucosa who presented only with pain. All cases localized in paranasal sinuses were detected by computed tomography while in the nasal cavity; however, none were detected by imaging when localized to the oral mucosa. Galactomannan (GM) was positive only when fever was present. Histopathology (HP) and culture were all positive for Aspergillus sp., however HP diagnosis was within 48 hours. In conclusion, GM was not effective for localized lesions without systemic repercussion and histopathologic examination is strongly recommended for early aspergillosis diagnosis.
ORAL CANCER: WHAT HAVE WE LEARNED IN 30 YEARS? A FEW REFLECTIONS CONSIDERING A CASE SERIES. BERNARDO VENEGAS, DANIEL DROGUETT, MARCELO SANCHEZ, SONIA VASQUEZ, BERNARDITA FUENTES, WENDY DONOSO and, CESAR RIVERA After 30 years working in the field of oral pathology with strong emphasis in oral cancer diagnosis, teaching, and research, several thoughts come to mind about lessons obtained from patients and their sufferings. Undoubtedly, scientific and clinical aspects, including etiology, risk factors, genetic and epigenetic disorders, psychoneuroimmunology, and diagnostic and therapeutic methods constitute specific knowledge obtained during the process. Nevertheless, other essential lessons like the strong impact to the patient, the patient’s family, health team, and the whole society; together with the necessary respect to the patient’s decisions and the consequences of late diagnosis and misdiagnosis; turn out to be the fundamental knowledge that comes to lead the behavior toward the assisting activity in the field. In this paper, several cases of head and neck squamous cell carcinoma have been selected to analyze the importance of the fundamental considerations necessary to keep in mind when treating patients with this disease.
ENAMEL HYPOPLASIA IN PATIENTS WITH RENAL TRANSPLANT: REPORT OF AN ORAL TUMA, REHABILITATION. MARINA MAUES NEZ-AGUILERA e JUAN FERNANDO ORDO and, MARINA GALLOTTINI Enamel hypoplasia is a developmental defect of enamel often found in people with renal disease, probably due to hypocalcemia and elevated levels of serum phosphate and fluoride during amelogenesis. A 14-year-old boy, white, with diagnosis of nephropathic cystinosis since 3 years of age and undergoing renal transplant at 11 years of age, with a chief complaint of "severe aesthetic issues" of the teeth. We observed generalized enamel hypoplasia and grade 1 gingival hyperplasia. We performed gingivoplasty using high-power diode laser and made direct resin facets from the right to the left premolars, upper and lower. Direct restorations with composite resin restored the harmony, function, and aesthetics, besides being low cost and fast to perform. The negative impact of generalized enamel hypoplasia on patients’ self-esteem underscores the importance of dental rehabilitation treatment.