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Oral health and pancreatic cancer risk
Abstracts / Pancreatology 16 (2016) S1eS130
Abstract ID: 1586.
S115
clinical characteristics of oral health will allow a more accurate assessment of these associations.
Oral health and pancreatic cancer risk 2, Paulina Gomez-Rubio 1, Esther Molina-Montes 1, Victor M. Barbera Alfredo Carrato 3, Tatjana Crnogorac-Jurcevic 4, Enrique Domínguez~ oz 5, Antoni Farr e 6, William Greenhalf 7, Thomas Gress 8, Manuel Mun 9 €hr 12, Hidalgo , Lucas Ilzarbe 10, Christoph W. Michalski 11, Matthias Lo ~ oz-Bellvís 14, Liam Murray 15, Mirari Marquez 1, Xavier Molero 13, Luís Mun n 19, Francisco Jos e Perea 16, Aldo Scarpa 17, Linda Sharp 18, Adonina Tardo X. Real 20, Núria Malats 1 1
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Spain 2 tica Molecular, Hospital General Universitario de Laboratorio de Gene Elche, Spain 3 n y Cajal, Spain Department of Oncology, Hospital Ramo 4 Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, United Kingdom 5 Hospital Clínico Universitario de Santiago de Compostela, Spain 6 Hospital de la Santa Creu i Sant Pau, Spain 7 The Royal Liverpool University Hospital, United Kingdom 8 Department of Gastroenterology, University Hospital UKGM, Philipps University of Marburg, Germany 9 Spanish National Cancer Research Centre (CNIO), Spain 10 Hospital del Mar?Parc de Salut Mar, Spain 11 Department of Surgery, University of Heidelberg, Germany 12 Gastrocentrum, Karolinska Institutet and University Hospital, Sweden 13 Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), noma de Barcelona, CIBEREHD, Spain Universitat Auto 14 Cirugía General y del Aparato Digestivo, Hospital Universitario de Salamanca, Spain 15 Centre for Public Health, Queen's University Belfast, United Kingdom 16 Department of Surgery, 12 de Octubre University Hospital, Spain 17 ARC-Net Centre for Applied Research on Cancer; Department of Pathology and Diagnostics, University and Hospital trust of Verona, Italy 18 National Cancer Registry Ireland and Institute of Health & Society, Newcastle University, Ireland, United Kingdom 19 Instituto Universitario de Oncología del Principado de Asturias, Oviedo, and CIBER Epidemiología y Salud Pública (CIBERESP), Spain 20 Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, and Universitat Pompeu Fabra, Spain
Abstract ID: 1604. Pancreatic function as evaluated by the 13C-MTG breath test in patients after bariatric surgery o-Noia, Laura Nieto-Garcia, Julio Laura Uribarri-Gonzalez, Jos e Larin oz Iglesias-Garcia, J. Enrique Domínguez-Mun Department of Gastroenterology and Health Research Institute of Santiago (IDIS), University Hospital of Santiago, Spain Introduction: Gastric and duodenal anatomical changes secondary to bariatric surgery lead to important disturbances in the digestion/absorption process. These digestive disturbances may be evaluated by the 13 CMTG breath test. Aims: Aim of our study was to evaluate the pancreatic and digestive function after different bariatric surgical procedures Materials & methods: A prospective, cross sectional study was performed. Pancreatic function was evaluated in patients who underwent a bariatric surgical procedure by the 13 C-MTG breath test. The cumulative 13 CO2 recovery rate (CRR %), time to 13C exhalation peak and dynamic of 13 CO2 exhalation (% digestion from 0-2, 2-4 and 4-6 hours after meal) were evaluated. Data are shown as median and interquartile range and analysed by the Kruskal Wallis and U-Mann Whitney tests. Results: 94 patients were included (35 patients duodenal switch, 36 gastric bypass, 23 gastric sleeve). Pancreatic function was lower after duodenal switch CRR 29.02% ± (21.19) than after gastric bypass 43.75%±(9.02) or gastric sleeve 49.05%±(14.04) (p<0.01). 13C- exhalation peak occurred at 330min 7.13%±(4.03), 150min 9.14%±(3.96) and 105min 12.06%±(2.32) min after duodenal switch, gastric bypass and gastric sleeve, respectively. Nutrients are digested late (4-6 hours after meal) after duodenal switch, intermediate after gastric bypass (2-4 hours) and early after gastric sleeve (0-2 hours) (p<0,01). Conclusion: Significant pathophysiological changes in digestive/absorption process according to particular bariatric surgery procedure are described. Duodenal switch alters digestive process more than any other procedure. Compared to gastric bypass, gastric sleeve does not seem to affect pancreatic function significantly.
Abstract ID: 1630. Introduction: Studies suggest an association between tooth loss and periodontal disease with an increased risk of pancreatic ductal adenocarcinoma (PDAC). However, controversial results have been recently reported. In addition, the association between other oral health problems and this cancer has not yet been investigated. Aims: To explore the association between different oral health conditions and PDAC risk. Patients & methods: Detailed information about oral health was reported for 1,413 cases and 733 controls in the PanGenEU study. Associations between PDAC and halitosis, teeth sensitivity, moving teeth, periodontitis, tooth loss, and gum bleeding, inflammation, and recession were explored through multivariate logistic regression analysis. Interactions with age, sex, smoking, diabetes and asthma were evaluated. Results: Periodontitis and tooth loss were not significantly associated with PDAC risk (OR¼ 1, 95%CI 0.76-1.34; OR for >17 tooth loss¼ 0.93, 95%CI 0.63-1.37). A significant association between gum recession and PDAC was observed among asthmatics but not among non-asthmatics (OR¼ 4.56 95% CI 1.74-11.9, OR¼ 1.06 95%CI 0.83-1.34; respectively, p-value for interaction¼ 0.02). Significant effect modification was observed between having moving teeth and smoking, age, and diabetes (p< 0.03). No other significant associations or interactions were observed. Conclusion: Oral health characteristics were not significantly associated with PDAC risk in the general models. Effect modifications for some of the explored associations point to their complex relationship and highlight the importance of further inquiry in future studies. Biological and/or
Quarter century experience of pancreatic surgery in a high volume center e A SWOT analysis of 2787 consecutive pancreatic resections €us Felsenstein 1, Timm Fritz Klein 1, Uwe Pelzer 2, Hanno Riess 2, Mattha 3 1 1 Denecke , Johann Pratschke , Marcus Bahra 1 Universita €tsmedizin Berlin, Department of General, Visceral Charite and Transplantation Surgery, Germany 2 Universita €tsmedizin Berlin, Department of Hematology and Charite Oncology, Germany 3 Universita €tsmedizin Berlin, Department of Diagnostic and Charite Interventional Radiology, Germany
Introduction: Pancreatic surgery has undergone major changes over the last decades. While the complexity of indications has increased the overall surgical complications could continuously be reduced. All the more, the quality of surgery remains to be considered as one important factor for achieving long-term survival especially in patients at advanced stages of disease. Aims: The authors reviewed the surgical outcome, pathological findings and long-term follow-up in a consecutive group of 2787 patients undergoing pancreatic resections in a high volume center. Patients & methods: Between january 1990 and september 2015 an overall of 2787 patients underwent pancreatic resection at our institution. The data of all patients were recorded in a prospective database. A retrospective SWOT analysis of all relevant parameters was performed.
Abstract ID: 1586.
S115
clinical characteristics of oral health will allow a more accurate assessment of these associations.
Oral health and pancreatic cancer risk 2, Paulina Gomez-Rubio 1, Esther Molina-Montes 1, Victor M. Barbera Alfredo Carrato 3, Tatjana Crnogorac-Jurcevic 4, Enrique Domínguez~ oz 5, Antoni Farr e 6, William Greenhalf 7, Thomas Gress 8, Manuel Mun 9 €hr 12, Hidalgo , Lucas Ilzarbe 10, Christoph W. Michalski 11, Matthias Lo ~ oz-Bellvís 14, Liam Murray 15, Mirari Marquez 1, Xavier Molero 13, Luís Mun n 19, Francisco Jos e Perea 16, Aldo Scarpa 17, Linda Sharp 18, Adonina Tardo X. Real 20, Núria Malats 1 1
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Spain 2 tica Molecular, Hospital General Universitario de Laboratorio de Gene Elche, Spain 3 n y Cajal, Spain Department of Oncology, Hospital Ramo 4 Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, United Kingdom 5 Hospital Clínico Universitario de Santiago de Compostela, Spain 6 Hospital de la Santa Creu i Sant Pau, Spain 7 The Royal Liverpool University Hospital, United Kingdom 8 Department of Gastroenterology, University Hospital UKGM, Philipps University of Marburg, Germany 9 Spanish National Cancer Research Centre (CNIO), Spain 10 Hospital del Mar?Parc de Salut Mar, Spain 11 Department of Surgery, University of Heidelberg, Germany 12 Gastrocentrum, Karolinska Institutet and University Hospital, Sweden 13 Hospital Universitari Vall d’Hebron, Institut de Recerca (VHIR), noma de Barcelona, CIBEREHD, Spain Universitat Auto 14 Cirugía General y del Aparato Digestivo, Hospital Universitario de Salamanca, Spain 15 Centre for Public Health, Queen's University Belfast, United Kingdom 16 Department of Surgery, 12 de Octubre University Hospital, Spain 17 ARC-Net Centre for Applied Research on Cancer; Department of Pathology and Diagnostics, University and Hospital trust of Verona, Italy 18 National Cancer Registry Ireland and Institute of Health & Society, Newcastle University, Ireland, United Kingdom 19 Instituto Universitario de Oncología del Principado de Asturias, Oviedo, and CIBER Epidemiología y Salud Pública (CIBERESP), Spain 20 Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, and Universitat Pompeu Fabra, Spain
Abstract ID: 1604. Pancreatic function as evaluated by the 13C-MTG breath test in patients after bariatric surgery o-Noia, Laura Nieto-Garcia, Julio Laura Uribarri-Gonzalez, Jos e Larin oz Iglesias-Garcia, J. Enrique Domínguez-Mun Department of Gastroenterology and Health Research Institute of Santiago (IDIS), University Hospital of Santiago, Spain Introduction: Gastric and duodenal anatomical changes secondary to bariatric surgery lead to important disturbances in the digestion/absorption process. These digestive disturbances may be evaluated by the 13 CMTG breath test. Aims: Aim of our study was to evaluate the pancreatic and digestive function after different bariatric surgical procedures Materials & methods: A prospective, cross sectional study was performed. Pancreatic function was evaluated in patients who underwent a bariatric surgical procedure by the 13 C-MTG breath test. The cumulative 13 CO2 recovery rate (CRR %), time to 13C exhalation peak and dynamic of 13 CO2 exhalation (% digestion from 0-2, 2-4 and 4-6 hours after meal) were evaluated. Data are shown as median and interquartile range and analysed by the Kruskal Wallis and U-Mann Whitney tests. Results: 94 patients were included (35 patients duodenal switch, 36 gastric bypass, 23 gastric sleeve). Pancreatic function was lower after duodenal switch CRR 29.02% ± (21.19) than after gastric bypass 43.75%±(9.02) or gastric sleeve 49.05%±(14.04) (p<0.01). 13C- exhalation peak occurred at 330min 7.13%±(4.03), 150min 9.14%±(3.96) and 105min 12.06%±(2.32) min after duodenal switch, gastric bypass and gastric sleeve, respectively. Nutrients are digested late (4-6 hours after meal) after duodenal switch, intermediate after gastric bypass (2-4 hours) and early after gastric sleeve (0-2 hours) (p<0,01). Conclusion: Significant pathophysiological changes in digestive/absorption process according to particular bariatric surgery procedure are described. Duodenal switch alters digestive process more than any other procedure. Compared to gastric bypass, gastric sleeve does not seem to affect pancreatic function significantly.
Abstract ID: 1630. Introduction: Studies suggest an association between tooth loss and periodontal disease with an increased risk of pancreatic ductal adenocarcinoma (PDAC). However, controversial results have been recently reported. In addition, the association between other oral health problems and this cancer has not yet been investigated. Aims: To explore the association between different oral health conditions and PDAC risk. Patients & methods: Detailed information about oral health was reported for 1,413 cases and 733 controls in the PanGenEU study. Associations between PDAC and halitosis, teeth sensitivity, moving teeth, periodontitis, tooth loss, and gum bleeding, inflammation, and recession were explored through multivariate logistic regression analysis. Interactions with age, sex, smoking, diabetes and asthma were evaluated. Results: Periodontitis and tooth loss were not significantly associated with PDAC risk (OR¼ 1, 95%CI 0.76-1.34; OR for >17 tooth loss¼ 0.93, 95%CI 0.63-1.37). A significant association between gum recession and PDAC was observed among asthmatics but not among non-asthmatics (OR¼ 4.56 95% CI 1.74-11.9, OR¼ 1.06 95%CI 0.83-1.34; respectively, p-value for interaction¼ 0.02). Significant effect modification was observed between having moving teeth and smoking, age, and diabetes (p< 0.03). No other significant associations or interactions were observed. Conclusion: Oral health characteristics were not significantly associated with PDAC risk in the general models. Effect modifications for some of the explored associations point to their complex relationship and highlight the importance of further inquiry in future studies. Biological and/or
Quarter century experience of pancreatic surgery in a high volume center e A SWOT analysis of 2787 consecutive pancreatic resections €us Felsenstein 1, Timm Fritz Klein 1, Uwe Pelzer 2, Hanno Riess 2, Mattha 3 1 1 Denecke , Johann Pratschke , Marcus Bahra 1 Universita €tsmedizin Berlin, Department of General, Visceral Charite and Transplantation Surgery, Germany 2 Universita €tsmedizin Berlin, Department of Hematology and Charite Oncology, Germany 3 Universita €tsmedizin Berlin, Department of Diagnostic and Charite Interventional Radiology, Germany
Introduction: Pancreatic surgery has undergone major changes over the last decades. While the complexity of indications has increased the overall surgical complications could continuously be reduced. All the more, the quality of surgery remains to be considered as one important factor for achieving long-term survival especially in patients at advanced stages of disease. Aims: The authors reviewed the surgical outcome, pathological findings and long-term follow-up in a consecutive group of 2787 patients undergoing pancreatic resections in a high volume center. Patients & methods: Between january 1990 and september 2015 an overall of 2787 patients underwent pancreatic resection at our institution. The data of all patients were recorded in a prospective database. A retrospective SWOT analysis of all relevant parameters was performed.