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Oral involvement of multiple myeloma: 2 case reports
OOOO Volume 114, Number 4 radiographically showed less radiodense enamel. Histopathological evaluation showed persistence of organic matrix and SEM revealed a prismatic structure of enamel. Conclusion: The histopathological and SEM analysis showed correlation with the clinical and radiographic observations. Project: FIOUCh09-1.
ORAL INVOLVEMENT OF MULTIPLE MYELOMA: 2 CASE REPORTS Guollo A1, Silva AP1, Andrade VP2, Piragine J1, Rocha AC1, Prado JD1 - 1HOSPITAL AC CAMARGO - ESTOMATOLOGIA, 2HOSPITAL AC CAMARGO - ANATOMIA PATOLÓGICA Multiple myeloma (MM) is a multicentric bone malignancy which involves the jaw bones in 30% of the cases. The objective this report is present two cases of MM with maxillofacial involvement. Case 1: a 58-years-old male complaining of intraoral painless swelling. His medical history showed larynx plasmacytoma treated 9 years ago. Oral examination presented nodular lesion in the inferior alveolar ridge measuring 3cm, firm to palpation. On panoramic x-ray was observed a radiolucent lesion causing tooth resorption. Case 2: a 73-years-old female with MM had a swelling in maxilla. Intra-oral examination showed reddish mass with ulcerated surface, measuring 5cm. Computed tomography revealed a heterogeneous expansive lesion, involving hard palate and maxillary sinus floor. Both patients underwent incisional biopsy and histopathological examination evidenced diffuse infiltrate of well differentiated plasma cells compatible with MM. Intraoral swelling in patients with MM should be investigated due to possibility of oral manifestation of the disease.
EXTENSIVE VERRUCOUS CARCINOMA IN MAXILLA CASE REPORT Sant’Ana LN, Sant’Ana Filho M1, Rados ARV2, Martins MD1, Heitz C3, Scolari N3 - 1FACULDADE DE ODONTOLOGIA UFRGS - PATOLOGIA BUCAL, 2 FACULDADE DE ODONTOLOGIA / HOSPITAL DE CLÍNICAS DE PORTO ALEGRE - ESTOMATOLOGIA, 3 HOSPITAL SÃO LUCAS PUCRS Verrucous carcinoma is a highly differentiated variant of squamous cell carcinoma that exhibit slow growing, locally destructive behavior and rarely metastasizes. The most common sites of occurrence in oral cavity are mandibular alveolar bone crest, buccal mucosa and hard palate. A 63-years old male patient was indicated to the Maxillofacial Surgery Department with a painless lesion on the right side of the maxilla surface. The clinical examination showed an extensive exophytic white lesion with a papillary surface. The clinical diagnosis was verrucous carcinoma and an incisional biopsy was performed. The histopathological analysis confirmed the verrucous carcinoma diagnosis. The patient was referred to the head and neck medical service but disappeared without treatment.
MUTATION ANALYSIS OF THE SH3BP2 GENE IN CHERUBISM Bufalino A1, Alves DBM2, Carlos R3, Silva ARS, Lopes MA, Coletta RD, Pires FR4 - 1PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS (UNICAMP) - ORAL DIAGNOSIS, 2 PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS (UNICAMP) ORAL DIAGNOSIS, 3CENTRO CLÍNICO DE CABEZA Y CUELLO/HOSPITAL HERRERA LLERANDI, GUATEMALA
ORAL ABSTRACTS Abstracts e107 CITY, GUATEMALA - DIVISION OF ORAL AND MAXILLOFACIAL PATHOLOGY, 4SCHOOL OF DENTISTRY, STATE UNIVERSITY OF RIO DE JANEIRO (UERJ) - DEPARTMENT OF DIAGNOSIS AND SURGERY Objective: We performed sequencing analysis of the SH3BP2 gene in 8 patients with cherubism, and discussed the craniofacial and genetic features of this disease. Study design: All exons and splice junctions were sequenced using genomic DNA from oral cells. Physical, radiographic and histopathological examination was performed. Results: Sequencing analysis revealed 2 different mutations within SH3BP2, which were represented by the heterozygous missense mutations c.1505G⬎A and c.1514C⬎A. In one patient, no mutation was found. Although patients demonstrated similar clinical, radiographic and histopathological features, a wide variation in the extension and progression of the facial swelling was observed in individuals with identical gene mutation. Clinical progression even in the adulthood, growth stagnation with persistence of the lesions and complete remission of the lesions were detected in cherubism patients. Conclusion: The findings suggest that not only the genotype but also environmental and epigenetic factors might regulate the progression of the lesions in cherubism.
EXPRESSION OF PLUNC FAMILY MEMBERS IN PATIENTS WITH ORAL GRAFT-VERSUS-HOST-DISEASE: PRELIMINARY RESULTS Silva AA1, Feio PSQ, Schaira VRL2, Correa MEP, Coletta RD1, Bingle L3, Vargas PA 1 SCHOOL OF DENTISTRY OF PIRACICABA, CAMPINAS UNIVERSITY FOP/UNICAMP - DEPARTMENT OF ORAL DIAGNOSIS, ORAL PATHOLOGY SECTION, 2CAMPINAS UNIVERSITY - ORAL MEDICINE AMBULATORY, BONE MARROW TRANSPLANTATION UNIT, 3SCHOOL OF CLINICAL DENTISTRY, UNIVERSITY OF SHEFFIELD DEPARTMENT OF ORAL PATHOLOGY Background/objective: The aim of this study was to analyze the expression of PLUNC proteins, putative host-defense proteins, in patients diagnosed with oral graft-versus-host-disease (GVHD). Study design: Whole saliva from eight patients diagnosed with oral GVHD was collected. Western blotting was performed using a LPLUNC1 antibody and two SPLUNC 2 antibodies; one raised to an internal peptide (SPLUNC 2B) and another to an epitope at the c-terminus (SPLUNC 2A). Clinical data were collected from medical records. Results: PLUNC expression was found in all patients, however, there was a statistical difference in expression levels when we compared LPLUNC with SPLUNC 2A (p⫽ 0.035) and LPLUNC with SPLUNC 2B (p⫽ 0.044). Conclusion: PLUNC proteins are differentially expressed in the saliva of patients with oral GVHD. Further studies are needed to better understand the biological processes involved in PLUNC expression and the significance of the differential expression patterns.
SYPHILIS DIAGNOSIS BY ORAL MANIFESTATIONS: A CASE REPORT Nigri AP1, Ribeiro CFP1, Akra IP1, Maciel RM1 - 1UERJ Syphilis is a sexually transmitted disease, caused by a bacteria, that mimics others that are unrelated. The aim of this study is to report a case in which there were no more clinical signs
ORAL INVOLVEMENT OF MULTIPLE MYELOMA: 2 CASE REPORTS Guollo A1, Silva AP1, Andrade VP2, Piragine J1, Rocha AC1, Prado JD1 - 1HOSPITAL AC CAMARGO - ESTOMATOLOGIA, 2HOSPITAL AC CAMARGO - ANATOMIA PATOLÓGICA Multiple myeloma (MM) is a multicentric bone malignancy which involves the jaw bones in 30% of the cases. The objective this report is present two cases of MM with maxillofacial involvement. Case 1: a 58-years-old male complaining of intraoral painless swelling. His medical history showed larynx plasmacytoma treated 9 years ago. Oral examination presented nodular lesion in the inferior alveolar ridge measuring 3cm, firm to palpation. On panoramic x-ray was observed a radiolucent lesion causing tooth resorption. Case 2: a 73-years-old female with MM had a swelling in maxilla. Intra-oral examination showed reddish mass with ulcerated surface, measuring 5cm. Computed tomography revealed a heterogeneous expansive lesion, involving hard palate and maxillary sinus floor. Both patients underwent incisional biopsy and histopathological examination evidenced diffuse infiltrate of well differentiated plasma cells compatible with MM. Intraoral swelling in patients with MM should be investigated due to possibility of oral manifestation of the disease.
EXTENSIVE VERRUCOUS CARCINOMA IN MAXILLA CASE REPORT Sant’Ana LN, Sant’Ana Filho M1, Rados ARV2, Martins MD1, Heitz C3, Scolari N3 - 1FACULDADE DE ODONTOLOGIA UFRGS - PATOLOGIA BUCAL, 2 FACULDADE DE ODONTOLOGIA / HOSPITAL DE CLÍNICAS DE PORTO ALEGRE - ESTOMATOLOGIA, 3 HOSPITAL SÃO LUCAS PUCRS Verrucous carcinoma is a highly differentiated variant of squamous cell carcinoma that exhibit slow growing, locally destructive behavior and rarely metastasizes. The most common sites of occurrence in oral cavity are mandibular alveolar bone crest, buccal mucosa and hard palate. A 63-years old male patient was indicated to the Maxillofacial Surgery Department with a painless lesion on the right side of the maxilla surface. The clinical examination showed an extensive exophytic white lesion with a papillary surface. The clinical diagnosis was verrucous carcinoma and an incisional biopsy was performed. The histopathological analysis confirmed the verrucous carcinoma diagnosis. The patient was referred to the head and neck medical service but disappeared without treatment.
MUTATION ANALYSIS OF THE SH3BP2 GENE IN CHERUBISM Bufalino A1, Alves DBM2, Carlos R3, Silva ARS, Lopes MA, Coletta RD, Pires FR4 - 1PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS (UNICAMP) - ORAL DIAGNOSIS, 2 PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS (UNICAMP) ORAL DIAGNOSIS, 3CENTRO CLÍNICO DE CABEZA Y CUELLO/HOSPITAL HERRERA LLERANDI, GUATEMALA
ORAL ABSTRACTS Abstracts e107 CITY, GUATEMALA - DIVISION OF ORAL AND MAXILLOFACIAL PATHOLOGY, 4SCHOOL OF DENTISTRY, STATE UNIVERSITY OF RIO DE JANEIRO (UERJ) - DEPARTMENT OF DIAGNOSIS AND SURGERY Objective: We performed sequencing analysis of the SH3BP2 gene in 8 patients with cherubism, and discussed the craniofacial and genetic features of this disease. Study design: All exons and splice junctions were sequenced using genomic DNA from oral cells. Physical, radiographic and histopathological examination was performed. Results: Sequencing analysis revealed 2 different mutations within SH3BP2, which were represented by the heterozygous missense mutations c.1505G⬎A and c.1514C⬎A. In one patient, no mutation was found. Although patients demonstrated similar clinical, radiographic and histopathological features, a wide variation in the extension and progression of the facial swelling was observed in individuals with identical gene mutation. Clinical progression even in the adulthood, growth stagnation with persistence of the lesions and complete remission of the lesions were detected in cherubism patients. Conclusion: The findings suggest that not only the genotype but also environmental and epigenetic factors might regulate the progression of the lesions in cherubism.
EXPRESSION OF PLUNC FAMILY MEMBERS IN PATIENTS WITH ORAL GRAFT-VERSUS-HOST-DISEASE: PRELIMINARY RESULTS Silva AA1, Feio PSQ, Schaira VRL2, Correa MEP, Coletta RD1, Bingle L3, Vargas PA 1 SCHOOL OF DENTISTRY OF PIRACICABA, CAMPINAS UNIVERSITY FOP/UNICAMP - DEPARTMENT OF ORAL DIAGNOSIS, ORAL PATHOLOGY SECTION, 2CAMPINAS UNIVERSITY - ORAL MEDICINE AMBULATORY, BONE MARROW TRANSPLANTATION UNIT, 3SCHOOL OF CLINICAL DENTISTRY, UNIVERSITY OF SHEFFIELD DEPARTMENT OF ORAL PATHOLOGY Background/objective: The aim of this study was to analyze the expression of PLUNC proteins, putative host-defense proteins, in patients diagnosed with oral graft-versus-host-disease (GVHD). Study design: Whole saliva from eight patients diagnosed with oral GVHD was collected. Western blotting was performed using a LPLUNC1 antibody and two SPLUNC 2 antibodies; one raised to an internal peptide (SPLUNC 2B) and another to an epitope at the c-terminus (SPLUNC 2A). Clinical data were collected from medical records. Results: PLUNC expression was found in all patients, however, there was a statistical difference in expression levels when we compared LPLUNC with SPLUNC 2A (p⫽ 0.035) and LPLUNC with SPLUNC 2B (p⫽ 0.044). Conclusion: PLUNC proteins are differentially expressed in the saliva of patients with oral GVHD. Further studies are needed to better understand the biological processes involved in PLUNC expression and the significance of the differential expression patterns.
SYPHILIS DIAGNOSIS BY ORAL MANIFESTATIONS: A CASE REPORT Nigri AP1, Ribeiro CFP1, Akra IP1, Maciel RM1 - 1UERJ Syphilis is a sexually transmitted disease, caused by a bacteria, that mimics others that are unrelated. The aim of this study is to report a case in which there were no more clinical signs