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Oral manifestations of Crohn's disease
Quarterly
261
Dental Review
dent. After observation over 48 hours, his fractures were reduced and immobilized. Two weeks later it was noted that the periorbital haematoma was still present, the left eye was now proptosed and the pupil dilated and non-reacting. He had an ophthalmoplegia, could only ‘count fingers’ with the left eye and had a buzzing in his head, which was also audible on auscultation. Following a left carotid angiogram which confirmed the presence of a carotid-cavernous sinus fistula, the intra-sinus part of the carotid artery was obliterated by muscle embolism, and ligation of the left common carotid was performed. A left tarsorrhapy was performed. When the sutures were removed 3 days later the proptosis was much reduced. By 3 months the patient’s vision was fully restored. G. R. Seward
responses. The different serum antibodies are listed and their suggested roles clearly explained. Other phenomena such as the immune complex and immediate hypersensitivity are discussed in relation to their mechanisms and role in periapical disease. The causes of depressed immunological responses are described. A classified review of studies examining the immunological aspects of endodontic disease is presented. Those pertinent to periapical pathology are expanded in a separate section, and the paper concludes with comments on immunologically based prevention and treatment. J. Cunningham
BASU M. K.
In military personnel, exposure to sunlight seems to be the single most important factor in the development of cancer of the skin and the lip. Actinic blocking agents would be desirable for troops subjected to exposure to sunlight and for individuals who sunburn easily. Andrew Richardson
Oral manifestationsof Crohn’s disaasa, Dent Abstr. 22 (1977) 165. Lymphocytes from patients with Crohn’s disease release a migration inhibition factor when they are exposed to certain extracts of En terobacterium coli. It has been proposed that only in genetically predisposed individuals does the interaction of enterobacterial agents and sensitized lymphocytes cause the latter to release biological mediators, with subsequent inflammation of the tissues of the bowel wall. The author advances the hypothesis that a similar interaction between sensitized lymphocytes and antigens to E. co/i and Klebsiella 0 may account for the development of oral lesions in patients with Crohn’s disease. Andrew Richardson MORSE
0. R.
Immunologic aspects of pulpal-periapical disaasa, Oral Surg. 43 (1977) 436-451. Pulpal and periapical disease brought about by a variety of causes may produce inflammatory and immunological responses which may enhance tissue destruction. This article discusses the immunological aspects of pulpal and periapical disease. The mechanisms of immunological reactions are described, including serum- and cell-mediated
PAYNE
T. F.
The lip-protect 22 (1977) 108.
WORTHINGTON
or oaglect?,
Dent.
Abstr.
P.
The benign lymphoepithelial salivary glands, J. Max. fat. 81-86.
lesions of the Surg, 5 (1977)
A white man aged 61 complained of a painless enlargement of the left sublingual gland. The right submandibular gland was also enlarged and a large calculus was present. He had none of the clinical components of the sicca syndrome and autoantibody tests were negative. The calculus was removed end the left sublingual gland biopsied. The biopsy showed the features of benign lymphoepithelial lesions. The sublingual gland obstructed the submandibular duct, and both were subsequently excised together with the lingual nerve which was involved in the mass. Benign lymphoepithelial lesions of the sublingual gland and submandibular obstructive changes were found. At followup at 2 years the right sublingual gland was enlarged and a diffuse mass was present on the left side. The lesion on the right side proved to be benign but the left was a lymphosarcoma. Despite megavoltage radio-
261
Dental Review
dent. After observation over 48 hours, his fractures were reduced and immobilized. Two weeks later it was noted that the periorbital haematoma was still present, the left eye was now proptosed and the pupil dilated and non-reacting. He had an ophthalmoplegia, could only ‘count fingers’ with the left eye and had a buzzing in his head, which was also audible on auscultation. Following a left carotid angiogram which confirmed the presence of a carotid-cavernous sinus fistula, the intra-sinus part of the carotid artery was obliterated by muscle embolism, and ligation of the left common carotid was performed. A left tarsorrhapy was performed. When the sutures were removed 3 days later the proptosis was much reduced. By 3 months the patient’s vision was fully restored. G. R. Seward
responses. The different serum antibodies are listed and their suggested roles clearly explained. Other phenomena such as the immune complex and immediate hypersensitivity are discussed in relation to their mechanisms and role in periapical disease. The causes of depressed immunological responses are described. A classified review of studies examining the immunological aspects of endodontic disease is presented. Those pertinent to periapical pathology are expanded in a separate section, and the paper concludes with comments on immunologically based prevention and treatment. J. Cunningham
BASU M. K.
In military personnel, exposure to sunlight seems to be the single most important factor in the development of cancer of the skin and the lip. Actinic blocking agents would be desirable for troops subjected to exposure to sunlight and for individuals who sunburn easily. Andrew Richardson
Oral manifestationsof Crohn’s disaasa, Dent Abstr. 22 (1977) 165. Lymphocytes from patients with Crohn’s disease release a migration inhibition factor when they are exposed to certain extracts of En terobacterium coli. It has been proposed that only in genetically predisposed individuals does the interaction of enterobacterial agents and sensitized lymphocytes cause the latter to release biological mediators, with subsequent inflammation of the tissues of the bowel wall. The author advances the hypothesis that a similar interaction between sensitized lymphocytes and antigens to E. co/i and Klebsiella 0 may account for the development of oral lesions in patients with Crohn’s disease. Andrew Richardson MORSE
0. R.
Immunologic aspects of pulpal-periapical disaasa, Oral Surg. 43 (1977) 436-451. Pulpal and periapical disease brought about by a variety of causes may produce inflammatory and immunological responses which may enhance tissue destruction. This article discusses the immunological aspects of pulpal and periapical disease. The mechanisms of immunological reactions are described, including serum- and cell-mediated
PAYNE
T. F.
The lip-protect 22 (1977) 108.
WORTHINGTON
or oaglect?,
Dent.
Abstr.
P.
The benign lymphoepithelial salivary glands, J. Max. fat. 81-86.
lesions of the Surg, 5 (1977)
A white man aged 61 complained of a painless enlargement of the left sublingual gland. The right submandibular gland was also enlarged and a large calculus was present. He had none of the clinical components of the sicca syndrome and autoantibody tests were negative. The calculus was removed end the left sublingual gland biopsied. The biopsy showed the features of benign lymphoepithelial lesions. The sublingual gland obstructed the submandibular duct, and both were subsequently excised together with the lingual nerve which was involved in the mass. Benign lymphoepithelial lesions of the sublingual gland and submandibular obstructive changes were found. At followup at 2 years the right sublingual gland was enlarged and a diffuse mass was present on the left side. The lesion on the right side proved to be benign but the left was a lymphosarcoma. Despite megavoltage radio-