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prognostic signs and recommends surgical intervention in these cases. 2,3 The treatment of these patients is frequently difficult, requiring prolonged drug therapy and in some cases, surgical intervention. I ,2,ll In our series only 6.4% of the cases resolved within the usual 15 days of clinical treatment. Aggressive surgical intervention may be necessary in the immunocompromised host if infections such as fungi or Pseudomonas arise in the paranasal sinuses. 3 In our study patients who required surgical intervention were infected by fungi or Pseudomonas. In accordance to this observation, Shibuya et al,3 suggested conservative medical therapy for sinusitis occurring in these patients, unless there was a serious infection such as mucormycosis, aspergillosis, phycomycetosis, Pseudomonas infection, or refractory sinus disease. In conclusion, treatment of sinusitis in BMT patients may be a challenge. Considerations about microbiology and antibiogram susceptibilities of this specific population should be kept in mind while dealing with such cases, in order to provide prompt and efficient treatment.
REFERENCES 1. Berlinger NT. Sinusitis in immunodeficient and immunosuppressed patients. Laryngoscope 1985;95:29-33. 2. Morrison VA, McGlave PB. Mucormycosis in BMT popUlation. Bone Marrow Transplant 1993;11:383-8. 3. Shibuya TY, Momin F, Abella E, et al. Sinus disease in the bone marrow transplant population: incidence, risk factors and complications. Otolaryngol Head Neck Surg 1995;113:705-11. 4. Pagani n, Kangarloo H, Gyepes MT, et al. Radiographic manifestations of bone marrow transplantation in children. AIR Am J Roentgenol 1979;132:883-90. 5. Ganzel TM, Brohm J, Nechtrnan CM, et al. Otolaryngology problems in cardiac transplant patients. Laryngoscope 1989;99: 158-61. 6. Teixido M, Kron TK, Plainse M. Head and neck sequelae of cardiac transplantation. Laryngoscope 1989; I 00:231-6. 7. Reyna J, Richardson JM, Mattox DE, et al. Head and neck infection after renal transplantation. JAMA 1982;247:748-54. 8. Thomas ED, Storb R, Clift RA, et al. Bone marrow transplantation. N Engl J Med 1975;292:895-902. 9. Deutsch JH, Hudgins PA, Siegel JL, et al. Paranasal sinuses of patients with acute graft-versus-host disease. AJNR Am J NeuroradioI1995;16:1287-91. 10. McGill TJ, Simpson G, Healy GP. Fulminant aspergillosis of the nose and paranasal sinuses: a new clinical entity. Laryngoscope 1980;90:748-54. II. Schubert MM, Peterson DE, Hackman R, et al. Head and neck aspergillosis in patients undergoing bone marrow transplantation. Cancer 1986;57:1092-6. 12. Berkow RL, Weisman SJ, Provisor AI, et al. Invasive aspergillosis of paranasal tissues in children with malignancies. J Pediatr 1983;103:49-53.
Otoplasty and Reconstruction of Auricular Defects
An International Course on Otoplasty and Reconstruction of Auricular Defects will be held March 21-22, 1999, at the ENT Department, Medical University of Liibeck, Liibeck, Germany. For further information, contact PD Dr Dr R. SiegertlM. Haase, Department of Otorhinolaryngology and Plastic Head and Neck Surgery, Medical University of Liibeck, Ratzeburger Allee 160, D-23538 Liibeck, Germany; phone, 49-451-5003189; fax, 49-451-500-4192; e-mail,
[email protected].