- Email: [email protected]
Outcome of ovulation induction in combination with intrauterine insemination in infertile women with polycystic ovary syndrome who have conservatively treated for endometrial adenocarcinoma
are geared toward studying DRG1 protein expression and developing a mutant mouse model to study the role of this gene during early gestation. Supported by: NIH R01ES012070 and Vincent Memorial Research Funds.
P-801 EFFECT OF OVARIAN STIMULATION WITH HMG AND RECOMBINANT FSH ON THE EXPRESSION OF INTEGRINS ALPHA (3), BETA (1) IN THE RAT ENDOMETRIUM DURING THE IMPLANTATION PERIOD. F. Sendag, A. Akdogan, K. Ozbilgin, G. Giray, K. Oztekin. Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey; Ege University, Izmir, Turkey; Department of Histology and Embryology, Celal Bayar University, Manisa, Turkey. OBJECTIVE: Integrin expressions have been proposed as a means of distinguishing receptive endometrium from non-receptive in clinical practise. The aim of the present study is to investigate the effect of exogenous ovarian stimulation with human menopausal gonadotropin (hMG) and recombinant follicle stimulating hormone (rFSH) on the expression of integrins alpha(3), beta(1) in the rat endometrium during the implantation period. DESIGN: Experimental animal study. MATERIALS AND METHODS: A total of 50 female rats were stimulated with low- and high-doses of hMG (Group II and III, respectively) and lowand high-doses of rFSH (Group IV and V, respectively) prior to mating after the cycle control had achieved. The control group of animals was not injected (Group I). The expression of integrins alpha(3), beta(1) in the endometrium of the pregnant rats (n¼30) were detected by immunohistochemical methods using monoclonal antibody in the implantation period. A semiquantitative grading system (H-score) was used to compare the immunohystochemical staining intensities. Kruskal-Wallis test was used to compare the means. Post hoc comparison was performed by Mann Whitney U test. A p value <0.05 was considered significant. RESULTS: In groups stimulated with HMG and rFSH (Group II-V), the expression of alpha(3) and beta(1) integrins showed a significant decrease compared to the control group (Group I) (p<0.05). CONCLUSIONS: This study suggests that ovarian stimulation by lowand high-doses of HMG and rFSH may have a detrimental effect on endometrial receptivity possibly via decrease in expression of integrins in the endometrium during the implantation period. Supported by: None.
P-802 WITHDRAWN
P-803 WITHDRAWN
P-804 IL-18 SYSTEM INCLUDING IL-18, IL-18 BINDING PROTEIN (IL-18 BP) AND IL-18 RECEPTOR (IL-18 R) MRNA AND PROTEIN EXPRESSION IN THE IMPLANTATION SITE OF HUMAN FALLOPIAN TUBE WITH ECTOPIC GESTATION. H.-Y. Huang, C.W. Wang, S.-Y. Huang, C.-L. Lee, H.-S. Wang, Y.-K. Soong. Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan. OBJECTIVE: Interleukin-18 (IL-18) system including agonist, antagonist and receptor is one of the major cytokines involved in human endometrium during embryo implantation and might perform a defensive role against maternal immune response. Ectopic pregnancy, the implantation of a fertilized ovum outside the uterine cavity, has been increasing in number at
S378
Abstracts
a staggering pace of all pregnancies. The purpose of this study is to investigate IL-18 system expression in human fallopian tubes with ectopic gestation. DESIGN: The mRNA levels of IL-18 system in implantation site of fallopian tube were determined by PCR and real-time PCR. IL-18 system protein levels were determined with immunohistochemistry. MATERIALS AND METHODS: A total of seven paired segments of human fallopian tubes with ectopic implantation site and side portion close to ectopic gestation were collected from women undergoing laparoscopic salpingectomy for ectopic pregnancy after informed consent and Chang Gung IRB approval. Four segments of fallopian tubes from women undergoing tubal sterilization were used as control groups. Total extracted RNA was reverse transcribed and amplified by PCR using specific primers for GAPDH (94 bp), IL-18 (144 bp), IL-18 R (277bp) and IL-18BP (188 bp). Quantitative IL-18 and IL-18BP mRNA expression in human fallopian tube was determined by real-time PCR. To determine the presence of IL-18 system proteins, tissues were fixed and processed for immunohistochemical study. Data analysis was done with SPSS statistical analysis package. RESULTS: A complete IL-18 system mRNA were both expressed in fallopian tubal with ectopic implantation and normal tubes with PCR. Immunoreactive IL-18 system at the protein levels was also presented in human fallopian tubes with ectopic implantation and normal tubes. According to real-time PCR with CT value quantification and 2-DDCt method, there is a significantly higher IL-18 expression in tubal ectopic implantation was demonstrated in comparison to side portion of ectopic tubes and normal control (p<0.05). A significantly lower ratio of IL-18 antagonist to agonist in side portion of ectopic tubes is demonstrated in comparison to normal tubes (p<0.05). CONCLUSIONS: These results suggest that fallopian tube IL-18 system expression and ratio of antagonist to agonist may play a crucial role during the process of early embryonic implantation prior to uterine cavity. Supported by: In part by NSC (National Science Council, Taiwan) No. 922314-B-182-088 and CMRPG No. 350681 (both to H.Y.H).
ART-OTHER P-805 OUTCOME OF OVULATION INDUCTION IN COMBINATION WITH INTRAUTERINE INSEMINATION IN INFERTILE WOMEN WITH POLYCYSTIC OVARY SYNDROME WHO HAVE CONSERVATIVELY TREATED FOR ENDOMETRIAL ADENOCARCINOMA. C.-H. Kim, K.-H. Cheon, S.-R. Kim, S.-H. Kim, H.-D. Chae, B.-M. Kang. Obstetrics and Gynecology, University of Ulsan, Asan Medical Center, Seoul, Korea; University of Ulsan, Asan Medical Center, Seoul, Korea. OBJECTIVE: To evaluate the outcome of ovulation induction in combination with intrauterine insemination (OI/IUI) in infertile women with polycystic ovary syndrome (PCOS) who have conservatively treated for welldifferentiated endometrial adenocarcinoma. DESIGN: Observational case series study. MATERIALS AND METHODS: During 2002 to 2006, OI/IUI cycles were performed in eight infertile PCOS women with chronic anovulation after conservative treatment of endometrial adenocarcinoma. All women were selected at the Division of Gynecologic Oncology of Asan Medical Center. All patients underwent a metastatic workup to exclude myometrial invasion or extrauterine desease and were conservatively treated with high dose progestins and then referred to the Division of Reproductive Endocrinology and Infertility of Asan Medical Center. For OI, GnRH antagonist multidose protocols were used in all patients. IUI was scheduled 36-40 hours after hCG administration. RESULTS: All patients were nulliparous before OI/IUI treatment. A total of seventeen OI/IUI cycles were performed. The mean duration of OI with recombinant FSH (rFSH) was 11.42.6 days. The mean dose of rFSH required was 1025.7204.3 IU. The mean numbers of follicles > 14mm and 10-14mm and endometrial thickness on the day of hCG administration were 8.52.8, 8.54.3 and 8.21.8mm, respectively. Severe ovarian hyperstimulation syndrome (OHSS) was developed in one OI/IUI cycle (5.9%). The clinical pregnancy rates per cycle and per patient were 41.2%
Vol. 90, Suppl 1, September 2008
(7/17) and 75.0% (6/8), respectively. Six women delivered seven healthy offspring. CONCLUSIONS: OI/IUI treatment is successful in chronic anovulatory PCOS women conservatively treated for well-differentiated endometrial adenocarcinoma. Supported by: None.
P-806 PREGNANCY IN THE LATE 300 S AND 400 S – A MATTER OF GOOD COUNSELLING PRIOR TO FERTILITY THERAPY. E. V. Mocanu, A. Murphy, C. Collins. HARI Unit, Dublin, Ireland; Rotunda Hospital, Dublin, Ireland. OBJECTIVE: To establish the pregnancy outcomes in two groups of women (fertile and infertile) attending a teaching, tertiary referral maternity hospital in Dublin, Ireland. We aimed to characterise outcomes according to female age and use the findings to advise infertile couples seeking fertility therapy. DESIGN: This is a retrospective database cohort study. MATERIALS AND METHODS: We retrieved data on all women delivered at a single site (Rotunda Hospital Dublin) between the years 2001 and 2005, inclusive. Patients were divided in age groups < 35, 35 to 39 and > 40 years. The following parameters were analysed: maternal age, previous history of infertility, delivery gestation and method, outcome description, Apgar scores at 1 and 5 minutes and newborn gender. RESULTS: Of 37,115 deliveries analysed, 21% were in women over 35 years old. The average age at delivery was 29.2 years. There was no difference in the likelihood of a live-born birth between the age groups. Labour onset method was significantly related (p<0.01) to age group with induction of labour, elective and emergency caesarean section higher and the rate of spontaneous labour lower in women over 40 years. There was a significant relationship in mean birth weight (p¼0.022) and gestation at delivery between age groups. Apgar scores at 1 and 5 minutes and newborn gender were not significantly related to age differences. Of all women delivered 5% had a previous history of infertility. Women with a history of infertility were significantly more likely to have an elective or emergency caesarean section (p<0.01). Regression analysis showed that birthweight was significantly related to a previous history of infertility, induction of labour, parity and advanced maternal age. CONCLUSIONS: Women over 35 and in particular those over 40 should be counselled appropriately in relation to the risks of pregnancy for both the mother and baby. Relevant information is now available to allow quantification of risk. Premature delivery, low birth weight and operative delivery rates become significantly higher as maternal age advances. Women with a history of infertility are at a particular increased risk for all the above complications. Supported by: None.
P-807 POOR PROGNOSTIC VALUE OF EXTERNAL IVF FAILURES. C. Zonza, N. Prados, C. Caligara, P. Vime, A. Cepeda, M. Sa´nchez-Ferna´ndez. IVI Sevilla, Sevilla, Spain. OBJECTIVE: Assessment of pregnancy rates of patients with previous unsuccessful cycles in other IVF centres and prognostic value of this parameter in the outcome of the cycles in our centre. DESIGN: Retrospective study of number of cycles in our clinic and pregnancy outcome related to the number of previous unsuccessful cycles (standard IVF or ICSI). MATERIALS AND METHODS: We analysed 480 patients with previous unsuccessful IVF/ICSI cycles in other centres (no clinical pregnancy). These patients underwent 627 IVF/ICSI cycles in our setting between may 2001 to december 2007. We compared the outcome with 1993 patients with no previous record of IVF attempts in other clinic who undertook 2673 cycles in our center during the same period. Statistical analysis was performed with chi square test. RESULTS: In patients with no previous cycles, the pregnancy rate lessened gradually (p<0,001). The pregnancy rates of the successive cycles at
FERTILITY & STERILITYÒ
our setting in patients with previous cycles did not follow this trend (p¼0.71). TABLE 1. Clinical pregnancy rates depending on previous cycles
Patients with no previous cycles
Patients with previous cycles
Number of cycle
Total cycles
Pregnancy rate
Number of cycle
Total cycles
Pregnancy rate
1 2 3 R4
1993 526 124 30
51.4% 42.0% 37.9% 23.3%
1 2 R3
480 120 27
45.8% 47.5% 48.1%
We calculated the pregnancy rates of the first cycle at our clinic depending on the number of previous cycles, and found no difference among them or with the control group (first cycle of patients at our centre with no previous cycles). TABLE 2. Clinical pregnancy rate of first cycle
Number of previous cycles 0 1 2 3 4 5
Number of patients
Pregnancy rate
1993 237 148 67 20 8
51.4 % 49.8 % 38.5 % 46.3 % 50.0 % 50.0 %
CONCLUSIONS: The information of previous cycles is of great relevance in the patient anamnesis and the strategy for the following cycles. This study suggests that the number of previous failed cycles doesn’t have such a great impact in the fertility potential, as other aspects as oocyte number or embryo quality of these previous cycles. With a good selection of patients there is no impact in the pregnancy rates regarding the number of failed cycles undergone before outside our clinic. It seems that these couples resemble a different pool of patients with different prognosis. This may be related to different standards of other centres and the benefits of a strategic new start. Supported by: None.
P-808 WILLINGNESS TO PARTICIPATE IN REPRODUCTIVE RESEARCH IS STRATIFIED ALONG ETHNIC AND RACIAL DIVISIONS. J. Sandler, E. B. Johnstone, M. Hanna, S. M. Sohn, V. Y. Fujimoto. OB/GYN and Reproductive Sciences, University of California San Francisco, San Francisco, CA; University of California San Francisco, San Francisco, CA. OBJECTIVE: Racial and ethnic disparities exist in medical research participation within the United States. We sought to explore these differences at the UCSF Center for Reproductive Health (CRH) and focused on racial subcategories in order to gain a broader understanding of minority patient’s willingness to participate in medical research. DESIGN: Cross-sectional. MATERIALS AND METHODS: All patients seen at the CRH between 01/01/2007-4/30/2008 were asked if they were willing to be contacted about research. Willingness was considered as positive if a patient responded yes or maybe (after talking to their physician). Race and ethnicity were self-reported and classified per FDA guidelines, in addition to racial and ethnic sub-categorization and country of birth. Logistic regression models predicting willingness to be contacted for research were generated adjusting for age and gender. RESULTS: 969 patients completed the form; 950 women and 19 male partners. A logistic regression displayed significant differences among FDA categories, with Asians less willing to be contacted than Caucasians (OR 0.41; p <0.0005).
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P-801 EFFECT OF OVARIAN STIMULATION WITH HMG AND RECOMBINANT FSH ON THE EXPRESSION OF INTEGRINS ALPHA (3), BETA (1) IN THE RAT ENDOMETRIUM DURING THE IMPLANTATION PERIOD. F. Sendag, A. Akdogan, K. Ozbilgin, G. Giray, K. Oztekin. Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey; Ege University, Izmir, Turkey; Department of Histology and Embryology, Celal Bayar University, Manisa, Turkey. OBJECTIVE: Integrin expressions have been proposed as a means of distinguishing receptive endometrium from non-receptive in clinical practise. The aim of the present study is to investigate the effect of exogenous ovarian stimulation with human menopausal gonadotropin (hMG) and recombinant follicle stimulating hormone (rFSH) on the expression of integrins alpha(3), beta(1) in the rat endometrium during the implantation period. DESIGN: Experimental animal study. MATERIALS AND METHODS: A total of 50 female rats were stimulated with low- and high-doses of hMG (Group II and III, respectively) and lowand high-doses of rFSH (Group IV and V, respectively) prior to mating after the cycle control had achieved. The control group of animals was not injected (Group I). The expression of integrins alpha(3), beta(1) in the endometrium of the pregnant rats (n¼30) were detected by immunohistochemical methods using monoclonal antibody in the implantation period. A semiquantitative grading system (H-score) was used to compare the immunohystochemical staining intensities. Kruskal-Wallis test was used to compare the means. Post hoc comparison was performed by Mann Whitney U test. A p value <0.05 was considered significant. RESULTS: In groups stimulated with HMG and rFSH (Group II-V), the expression of alpha(3) and beta(1) integrins showed a significant decrease compared to the control group (Group I) (p<0.05). CONCLUSIONS: This study suggests that ovarian stimulation by lowand high-doses of HMG and rFSH may have a detrimental effect on endometrial receptivity possibly via decrease in expression of integrins in the endometrium during the implantation period. Supported by: None.
P-802 WITHDRAWN
P-803 WITHDRAWN
P-804 IL-18 SYSTEM INCLUDING IL-18, IL-18 BINDING PROTEIN (IL-18 BP) AND IL-18 RECEPTOR (IL-18 R) MRNA AND PROTEIN EXPRESSION IN THE IMPLANTATION SITE OF HUMAN FALLOPIAN TUBE WITH ECTOPIC GESTATION. H.-Y. Huang, C.W. Wang, S.-Y. Huang, C.-L. Lee, H.-S. Wang, Y.-K. Soong. Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kwei-Shan, Tao-Yuan, Taiwan. OBJECTIVE: Interleukin-18 (IL-18) system including agonist, antagonist and receptor is one of the major cytokines involved in human endometrium during embryo implantation and might perform a defensive role against maternal immune response. Ectopic pregnancy, the implantation of a fertilized ovum outside the uterine cavity, has been increasing in number at
S378
Abstracts
a staggering pace of all pregnancies. The purpose of this study is to investigate IL-18 system expression in human fallopian tubes with ectopic gestation. DESIGN: The mRNA levels of IL-18 system in implantation site of fallopian tube were determined by PCR and real-time PCR. IL-18 system protein levels were determined with immunohistochemistry. MATERIALS AND METHODS: A total of seven paired segments of human fallopian tubes with ectopic implantation site and side portion close to ectopic gestation were collected from women undergoing laparoscopic salpingectomy for ectopic pregnancy after informed consent and Chang Gung IRB approval. Four segments of fallopian tubes from women undergoing tubal sterilization were used as control groups. Total extracted RNA was reverse transcribed and amplified by PCR using specific primers for GAPDH (94 bp), IL-18 (144 bp), IL-18 R (277bp) and IL-18BP (188 bp). Quantitative IL-18 and IL-18BP mRNA expression in human fallopian tube was determined by real-time PCR. To determine the presence of IL-18 system proteins, tissues were fixed and processed for immunohistochemical study. Data analysis was done with SPSS statistical analysis package. RESULTS: A complete IL-18 system mRNA were both expressed in fallopian tubal with ectopic implantation and normal tubes with PCR. Immunoreactive IL-18 system at the protein levels was also presented in human fallopian tubes with ectopic implantation and normal tubes. According to real-time PCR with CT value quantification and 2-DDCt method, there is a significantly higher IL-18 expression in tubal ectopic implantation was demonstrated in comparison to side portion of ectopic tubes and normal control (p<0.05). A significantly lower ratio of IL-18 antagonist to agonist in side portion of ectopic tubes is demonstrated in comparison to normal tubes (p<0.05). CONCLUSIONS: These results suggest that fallopian tube IL-18 system expression and ratio of antagonist to agonist may play a crucial role during the process of early embryonic implantation prior to uterine cavity. Supported by: In part by NSC (National Science Council, Taiwan) No. 922314-B-182-088 and CMRPG No. 350681 (both to H.Y.H).
ART-OTHER P-805 OUTCOME OF OVULATION INDUCTION IN COMBINATION WITH INTRAUTERINE INSEMINATION IN INFERTILE WOMEN WITH POLYCYSTIC OVARY SYNDROME WHO HAVE CONSERVATIVELY TREATED FOR ENDOMETRIAL ADENOCARCINOMA. C.-H. Kim, K.-H. Cheon, S.-R. Kim, S.-H. Kim, H.-D. Chae, B.-M. Kang. Obstetrics and Gynecology, University of Ulsan, Asan Medical Center, Seoul, Korea; University of Ulsan, Asan Medical Center, Seoul, Korea. OBJECTIVE: To evaluate the outcome of ovulation induction in combination with intrauterine insemination (OI/IUI) in infertile women with polycystic ovary syndrome (PCOS) who have conservatively treated for welldifferentiated endometrial adenocarcinoma. DESIGN: Observational case series study. MATERIALS AND METHODS: During 2002 to 2006, OI/IUI cycles were performed in eight infertile PCOS women with chronic anovulation after conservative treatment of endometrial adenocarcinoma. All women were selected at the Division of Gynecologic Oncology of Asan Medical Center. All patients underwent a metastatic workup to exclude myometrial invasion or extrauterine desease and were conservatively treated with high dose progestins and then referred to the Division of Reproductive Endocrinology and Infertility of Asan Medical Center. For OI, GnRH antagonist multidose protocols were used in all patients. IUI was scheduled 36-40 hours after hCG administration. RESULTS: All patients were nulliparous before OI/IUI treatment. A total of seventeen OI/IUI cycles were performed. The mean duration of OI with recombinant FSH (rFSH) was 11.42.6 days. The mean dose of rFSH required was 1025.7204.3 IU. The mean numbers of follicles > 14mm and 10-14mm and endometrial thickness on the day of hCG administration were 8.52.8, 8.54.3 and 8.21.8mm, respectively. Severe ovarian hyperstimulation syndrome (OHSS) was developed in one OI/IUI cycle (5.9%). The clinical pregnancy rates per cycle and per patient were 41.2%
Vol. 90, Suppl 1, September 2008
(7/17) and 75.0% (6/8), respectively. Six women delivered seven healthy offspring. CONCLUSIONS: OI/IUI treatment is successful in chronic anovulatory PCOS women conservatively treated for well-differentiated endometrial adenocarcinoma. Supported by: None.
P-806 PREGNANCY IN THE LATE 300 S AND 400 S – A MATTER OF GOOD COUNSELLING PRIOR TO FERTILITY THERAPY. E. V. Mocanu, A. Murphy, C. Collins. HARI Unit, Dublin, Ireland; Rotunda Hospital, Dublin, Ireland. OBJECTIVE: To establish the pregnancy outcomes in two groups of women (fertile and infertile) attending a teaching, tertiary referral maternity hospital in Dublin, Ireland. We aimed to characterise outcomes according to female age and use the findings to advise infertile couples seeking fertility therapy. DESIGN: This is a retrospective database cohort study. MATERIALS AND METHODS: We retrieved data on all women delivered at a single site (Rotunda Hospital Dublin) between the years 2001 and 2005, inclusive. Patients were divided in age groups < 35, 35 to 39 and > 40 years. The following parameters were analysed: maternal age, previous history of infertility, delivery gestation and method, outcome description, Apgar scores at 1 and 5 minutes and newborn gender. RESULTS: Of 37,115 deliveries analysed, 21% were in women over 35 years old. The average age at delivery was 29.2 years. There was no difference in the likelihood of a live-born birth between the age groups. Labour onset method was significantly related (p<0.01) to age group with induction of labour, elective and emergency caesarean section higher and the rate of spontaneous labour lower in women over 40 years. There was a significant relationship in mean birth weight (p¼0.022) and gestation at delivery between age groups. Apgar scores at 1 and 5 minutes and newborn gender were not significantly related to age differences. Of all women delivered 5% had a previous history of infertility. Women with a history of infertility were significantly more likely to have an elective or emergency caesarean section (p<0.01). Regression analysis showed that birthweight was significantly related to a previous history of infertility, induction of labour, parity and advanced maternal age. CONCLUSIONS: Women over 35 and in particular those over 40 should be counselled appropriately in relation to the risks of pregnancy for both the mother and baby. Relevant information is now available to allow quantification of risk. Premature delivery, low birth weight and operative delivery rates become significantly higher as maternal age advances. Women with a history of infertility are at a particular increased risk for all the above complications. Supported by: None.
P-807 POOR PROGNOSTIC VALUE OF EXTERNAL IVF FAILURES. C. Zonza, N. Prados, C. Caligara, P. Vime, A. Cepeda, M. Sa´nchez-Ferna´ndez. IVI Sevilla, Sevilla, Spain. OBJECTIVE: Assessment of pregnancy rates of patients with previous unsuccessful cycles in other IVF centres and prognostic value of this parameter in the outcome of the cycles in our centre. DESIGN: Retrospective study of number of cycles in our clinic and pregnancy outcome related to the number of previous unsuccessful cycles (standard IVF or ICSI). MATERIALS AND METHODS: We analysed 480 patients with previous unsuccessful IVF/ICSI cycles in other centres (no clinical pregnancy). These patients underwent 627 IVF/ICSI cycles in our setting between may 2001 to december 2007. We compared the outcome with 1993 patients with no previous record of IVF attempts in other clinic who undertook 2673 cycles in our center during the same period. Statistical analysis was performed with chi square test. RESULTS: In patients with no previous cycles, the pregnancy rate lessened gradually (p<0,001). The pregnancy rates of the successive cycles at
FERTILITY & STERILITYÒ
our setting in patients with previous cycles did not follow this trend (p¼0.71). TABLE 1. Clinical pregnancy rates depending on previous cycles
Patients with no previous cycles
Patients with previous cycles
Number of cycle
Total cycles
Pregnancy rate
Number of cycle
Total cycles
Pregnancy rate
1 2 3 R4
1993 526 124 30
51.4% 42.0% 37.9% 23.3%
1 2 R3
480 120 27
45.8% 47.5% 48.1%
We calculated the pregnancy rates of the first cycle at our clinic depending on the number of previous cycles, and found no difference among them or with the control group (first cycle of patients at our centre with no previous cycles). TABLE 2. Clinical pregnancy rate of first cycle
Number of previous cycles 0 1 2 3 4 5
Number of patients
Pregnancy rate
1993 237 148 67 20 8
51.4 % 49.8 % 38.5 % 46.3 % 50.0 % 50.0 %
CONCLUSIONS: The information of previous cycles is of great relevance in the patient anamnesis and the strategy for the following cycles. This study suggests that the number of previous failed cycles doesn’t have such a great impact in the fertility potential, as other aspects as oocyte number or embryo quality of these previous cycles. With a good selection of patients there is no impact in the pregnancy rates regarding the number of failed cycles undergone before outside our clinic. It seems that these couples resemble a different pool of patients with different prognosis. This may be related to different standards of other centres and the benefits of a strategic new start. Supported by: None.
P-808 WILLINGNESS TO PARTICIPATE IN REPRODUCTIVE RESEARCH IS STRATIFIED ALONG ETHNIC AND RACIAL DIVISIONS. J. Sandler, E. B. Johnstone, M. Hanna, S. M. Sohn, V. Y. Fujimoto. OB/GYN and Reproductive Sciences, University of California San Francisco, San Francisco, CA; University of California San Francisco, San Francisco, CA. OBJECTIVE: Racial and ethnic disparities exist in medical research participation within the United States. We sought to explore these differences at the UCSF Center for Reproductive Health (CRH) and focused on racial subcategories in order to gain a broader understanding of minority patient’s willingness to participate in medical research. DESIGN: Cross-sectional. MATERIALS AND METHODS: All patients seen at the CRH between 01/01/2007-4/30/2008 were asked if they were willing to be contacted about research. Willingness was considered as positive if a patient responded yes or maybe (after talking to their physician). Race and ethnicity were self-reported and classified per FDA guidelines, in addition to racial and ethnic sub-categorization and country of birth. Logistic regression models predicting willingness to be contacted for research were generated adjusting for age and gender. RESULTS: 969 patients completed the form; 950 women and 19 male partners. A logistic regression displayed significant differences among FDA categories, with Asians less willing to be contacted than Caucasians (OR 0.41; p <0.0005).
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