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OUTCOMES OF PULMONARY HYPERTENSION ASSOCIATED WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION
E1602 JACC March 27, 2012 Volume 59, Issue 13
Pulmonary Hypertension OUTCOMES OF PULMONARY HYPERTENSION ASSOCIATED WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 9:30 a.m.-10:30 a.m.
Session Title: Pulmonary Hypertension Prognosis/Outcomes Abstract Category: 30. Pulmonary Hypertension Presentation Number: 1131-546 Authors: Thenappan Thenappan, Sanjiv Shah, Stuart Rich, University of Chicago Medical Center, Chicago, IL, USA Background: Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly common cause of PH. The long-term survival of patients with PH-HFpEF is unknown. We performed an observational study to determine survival in patients with PHHFpEF and to compare it with patients with WHO group 1 pulmonary arterial hypertension (PAH). Methods: We included consecutive patients with PH-HFpEF (n=100) and PAH (n=558) referred to our center from 1982-2009. Vital statistics were obtained by chart review and social security death index. We used Kaplan-Meier method and Cox proportional hazard analysis to determine survival and independent predictors of mortality. Results: Patients with PH-HFpEF were older, had a higher prevalence of cardiovascular comorbidities, had worse exercise capacity and renal function. PH was less severe in PH-HFpEF patients than in PAH patients (pulmonary vascular resistance 4.8 vs. 10.9 Wood units; P<0.001). The median observation time was 7.8 yrs. The 1-, 3-, and 5-year survival for patients with PH-HFpEF was 96%, 84%, and 75% respectively. PH-HFpEF had a worse survival compared to PAH (unadjusted HR: 0.42; 95%CI 0.31-0.57; P<0.001) that was not related to age (age adjusted HR 0.68 95% CI 0.48 - 0.96; P=0.02) (Fig 1). Conclusion: The survival of patients with PH-HFpEF is worse than those with PAH despite having less severe PH.
Pulmonary Hypertension OUTCOMES OF PULMONARY HYPERTENSION ASSOCIATED WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 9:30 a.m.-10:30 a.m.
Session Title: Pulmonary Hypertension Prognosis/Outcomes Abstract Category: 30. Pulmonary Hypertension Presentation Number: 1131-546 Authors: Thenappan Thenappan, Sanjiv Shah, Stuart Rich, University of Chicago Medical Center, Chicago, IL, USA Background: Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is an increasingly common cause of PH. The long-term survival of patients with PH-HFpEF is unknown. We performed an observational study to determine survival in patients with PHHFpEF and to compare it with patients with WHO group 1 pulmonary arterial hypertension (PAH). Methods: We included consecutive patients with PH-HFpEF (n=100) and PAH (n=558) referred to our center from 1982-2009. Vital statistics were obtained by chart review and social security death index. We used Kaplan-Meier method and Cox proportional hazard analysis to determine survival and independent predictors of mortality. Results: Patients with PH-HFpEF were older, had a higher prevalence of cardiovascular comorbidities, had worse exercise capacity and renal function. PH was less severe in PH-HFpEF patients than in PAH patients (pulmonary vascular resistance 4.8 vs. 10.9 Wood units; P<0.001). The median observation time was 7.8 yrs. The 1-, 3-, and 5-year survival for patients with PH-HFpEF was 96%, 84%, and 75% respectively. PH-HFpEF had a worse survival compared to PAH (unadjusted HR: 0.42; 95%CI 0.31-0.57; P<0.001) that was not related to age (age adjusted HR 0.68 95% CI 0.48 - 0.96; P=0.02) (Fig 1). Conclusion: The survival of patients with PH-HFpEF is worse than those with PAH despite having less severe PH.