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Oxidative stress and left ventricular dysfunction following acute coronary syndrome
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Coronary heart disease 413
The predictive value of arterial stiffness for multivessel disease after acute coronary syndrome A. Chetoui ∗ , H. Benahmed , E. Allouche , L. Bezdah Cardiologie, Hôpital Charles-Nicolle Tunis, Tunis, Tunisie ∗ Corresponding author. Adresse e-mail : [email protected] (A. Chetoui)
Fig. 1 BMS: bare metal stent; DES: drug eluting stent; ISR: in-stent restenosis. https://doi.org/10.1016/j.acvdsp.2019.09.037 241
Oxidative stress and left ventricular dysfunction following acute coronary syndrome S. Charfeddine 1,∗ , Leila Abid 1 , Z. Ben Ali 1 , C. Yousfi 1 , I. Gtif 2 , R. Hammami 1 , S. Kammoun 1 1 Cardiology, Hedi Chaker University Hospital 2 Biotechnology center, Sfax, Tunisie ∗ Corresponding author. Adresse e-mail : selma [email protected] (S. Charfeddine) Introduction Cardiovascular diseases, acute coronary syndromes and heart failure account for the highest mortality rate worldwide. The major underlying mechanism driving the onset and maintenance of cardiovascular diseases is atherosclerosis. Atherosclerosis is a consequence of Oxidative stress. Purpose We aimed to analyze the influence of superoxide dismutase (SOD) and glutathion peroxidase (GPX) activities on angiographic severity and left ventricular dysfunction in the Acute Coronary Syndrome. Methods SOD and GPX activity levels were evaluated in 117 patients admitted for either ST segment elevated myocardial infarction (STEMI) or non-ST segment elevated myocardial infarction (NSTEMI). Results Lower SOD and GPX activity levels were seen in elderly and patients who presented with STEMI and high risk NSTEMI. There was no significant relation between antioxidant activity, angiographic coronary artery severity and the left ventricular systolic function at admission (SOD: 6.1 vs. 7.5 U/mg, P = 0.17; GPX: 1.27 vs. 1.31 mol/mn/mg, P = 0.79). SOD and GPX activities levels were neither significant in relation to mortality nor to survival rates up to twelve months. Conclusion We found no relationship between reduced levels of SOD and GPX activity post-acute coronary syndrome, left ventricular dysfunction and mortality up to 12-months of follow-up in this study. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2019.09.038
Introduction Acute coronary syndrome (ACS) is a primary cause of morbidity and mortality in the world. Arterial stiffness has been shown to be a predictor of cardiovascular events and mortality. Purpose To assess the association between markers of arterial stiffness and multivessel disease after ACS. Methods This prospective study was conducted from April 2017 to March 2018 in a single cardiac center. A total of 275 patients who were referred for first ACS were enrolled. Arterial stiffness was assessed by carotid to femoral pulse wave velocity (cfPWV), central pulse pressure (cPP) and augmentation index using SphygmoCor® XCEL. Results The mean age was 56.4 ± 10.6 years. Tobacco smoking and diabetes were present in 56.4% and 41.8% of patients, respectively. ST segment elevation myocardial infarction was predominant (54.5%) and 47.6% of patients had multivessel disease. This study showed that cfPWV (OR = 1.272; 95%IC [1.090;1.483]; P = 0.002) and cPP (OR = 1.071; 95%IC [1.024;1.121]; P = 0.003) were the two independent predictors of multivessel disease. The cfVOP threshold for predicting multivessel disease was 12.65 m/s (sensitivity of 48.1% and specificity of 76.4%). Conclusion Arterial stiffness measured by cfPWV and cPP may reflect the extent of coronary artery disease after ACS. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2019.09.039 632
Predicting mortality factors after a myocardial infarction R. Khalifa ∗ , I. Chamtouri , W. Jomaa , K. Ben Hamda , F. Maatouk Cardiologie, service cardiologie Monestir tunisie, Kalaa Kebira, Tunisie ∗ Corresponding author. Adresse e-mail : [email protected] (R. Khalifa) Introduction Myocardial infarction (MI) is the leading cause of death in Tunisia. Purpose We wanted to determine the predictors of mortality in the wake of an IDM to ensure better care. Methods This is a study that included 1562 patients (1221 men and 341 women) hospitalized for Acute Coronary Syndrome with ST segment elevation in the Fattouma Bourguiba Monastir Heart Hospital B ward from January 1998 to September 2015. The predictive factors for 1-month mortality of MI were studied. Results The mortality rate was estimated at 8.3%. Sex was not a predictor of mortality (7.3% vs. 12%, P = 0.055). The history of coronary artery disease or heart failure was not a predictor of death with p equal to 0.553 and 0.575, respectively. Age over 75, diabetes, hypertension, use of an inotropic agent at admission, the occurrence of a complete atrioventricular block, complicated MI of a severe rhythm disorder (ventricular tachycardia or ventricular fibrillation) and the occurrence of severe acute mitral insufficiency would be predictive of mortality with p respectively equal to 0.03; < 0.001; 0.002; < 0.001; < 0, 001; < 0.001; 0.001. The infarct territory was also a predictor of mortality: the death rate was 10.6% in the anterior MIs, 7.6% in the inferior MIs and 2.5% in the lateral MIs (P < 0.001). Conclusion The advanced age, the diabetes, the HTA, the use of an inotropic agent at the admission, the occurrence of a serious
Coronary heart disease 413
The predictive value of arterial stiffness for multivessel disease after acute coronary syndrome A. Chetoui ∗ , H. Benahmed , E. Allouche , L. Bezdah Cardiologie, Hôpital Charles-Nicolle Tunis, Tunis, Tunisie ∗ Corresponding author. Adresse e-mail : [email protected] (A. Chetoui)
Fig. 1 BMS: bare metal stent; DES: drug eluting stent; ISR: in-stent restenosis. https://doi.org/10.1016/j.acvdsp.2019.09.037 241
Oxidative stress and left ventricular dysfunction following acute coronary syndrome S. Charfeddine 1,∗ , Leila Abid 1 , Z. Ben Ali 1 , C. Yousfi 1 , I. Gtif 2 , R. Hammami 1 , S. Kammoun 1 1 Cardiology, Hedi Chaker University Hospital 2 Biotechnology center, Sfax, Tunisie ∗ Corresponding author. Adresse e-mail : selma [email protected] (S. Charfeddine) Introduction Cardiovascular diseases, acute coronary syndromes and heart failure account for the highest mortality rate worldwide. The major underlying mechanism driving the onset and maintenance of cardiovascular diseases is atherosclerosis. Atherosclerosis is a consequence of Oxidative stress. Purpose We aimed to analyze the influence of superoxide dismutase (SOD) and glutathion peroxidase (GPX) activities on angiographic severity and left ventricular dysfunction in the Acute Coronary Syndrome. Methods SOD and GPX activity levels were evaluated in 117 patients admitted for either ST segment elevated myocardial infarction (STEMI) or non-ST segment elevated myocardial infarction (NSTEMI). Results Lower SOD and GPX activity levels were seen in elderly and patients who presented with STEMI and high risk NSTEMI. There was no significant relation between antioxidant activity, angiographic coronary artery severity and the left ventricular systolic function at admission (SOD: 6.1 vs. 7.5 U/mg, P = 0.17; GPX: 1.27 vs. 1.31 mol/mn/mg, P = 0.79). SOD and GPX activities levels were neither significant in relation to mortality nor to survival rates up to twelve months. Conclusion We found no relationship between reduced levels of SOD and GPX activity post-acute coronary syndrome, left ventricular dysfunction and mortality up to 12-months of follow-up in this study. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2019.09.038
Introduction Acute coronary syndrome (ACS) is a primary cause of morbidity and mortality in the world. Arterial stiffness has been shown to be a predictor of cardiovascular events and mortality. Purpose To assess the association between markers of arterial stiffness and multivessel disease after ACS. Methods This prospective study was conducted from April 2017 to March 2018 in a single cardiac center. A total of 275 patients who were referred for first ACS were enrolled. Arterial stiffness was assessed by carotid to femoral pulse wave velocity (cfPWV), central pulse pressure (cPP) and augmentation index using SphygmoCor® XCEL. Results The mean age was 56.4 ± 10.6 years. Tobacco smoking and diabetes were present in 56.4% and 41.8% of patients, respectively. ST segment elevation myocardial infarction was predominant (54.5%) and 47.6% of patients had multivessel disease. This study showed that cfPWV (OR = 1.272; 95%IC [1.090;1.483]; P = 0.002) and cPP (OR = 1.071; 95%IC [1.024;1.121]; P = 0.003) were the two independent predictors of multivessel disease. The cfVOP threshold for predicting multivessel disease was 12.65 m/s (sensitivity of 48.1% and specificity of 76.4%). Conclusion Arterial stiffness measured by cfPWV and cPP may reflect the extent of coronary artery disease after ACS. Disclosure of interest The authors declare that they have no competing interest. https://doi.org/10.1016/j.acvdsp.2019.09.039 632
Predicting mortality factors after a myocardial infarction R. Khalifa ∗ , I. Chamtouri , W. Jomaa , K. Ben Hamda , F. Maatouk Cardiologie, service cardiologie Monestir tunisie, Kalaa Kebira, Tunisie ∗ Corresponding author. Adresse e-mail : [email protected] (R. Khalifa) Introduction Myocardial infarction (MI) is the leading cause of death in Tunisia. Purpose We wanted to determine the predictors of mortality in the wake of an IDM to ensure better care. Methods This is a study that included 1562 patients (1221 men and 341 women) hospitalized for Acute Coronary Syndrome with ST segment elevation in the Fattouma Bourguiba Monastir Heart Hospital B ward from January 1998 to September 2015. The predictive factors for 1-month mortality of MI were studied. Results The mortality rate was estimated at 8.3%. Sex was not a predictor of mortality (7.3% vs. 12%, P = 0.055). The history of coronary artery disease or heart failure was not a predictor of death with p equal to 0.553 and 0.575, respectively. Age over 75, diabetes, hypertension, use of an inotropic agent at admission, the occurrence of a complete atrioventricular block, complicated MI of a severe rhythm disorder (ventricular tachycardia or ventricular fibrillation) and the occurrence of severe acute mitral insufficiency would be predictive of mortality with p respectively equal to 0.03; < 0.001; 0.002; < 0.001; < 0, 001; < 0.001; 0.001. The infarct territory was also a predictor of mortality: the death rate was 10.6% in the anterior MIs, 7.6% in the inferior MIs and 2.5% in the lateral MIs (P < 0.001). Conclusion The advanced age, the diabetes, the HTA, the use of an inotropic agent at the admission, the occurrence of a serious