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P-02-011 Novel tumor markers of breast cancer
P-02 Female sexual dysfunction obesity condition, even if a protective role of sexuality in chronic diseases is demonstrated in literature. For instance, the use of contraceptives seems to improve sexual health and QoL. These results have important implications in both clinical and research field, showing the need for a deeper understanding and speaking about sexuality for a comprehensive taking care. Policy of full disclosure: None P-02-009 PSYCHOLOGICAL AND SEXUAL CORRELATES OF SEXUAL ABUSE IN WOMEN WITH SEXUAL DYSFUNCTION Maseroli, E.1; Scavello, I.2; Fanni, E.2; Fambrini, M.2; Maggi, M.2; Vignozzi, L.2 1 University of Florence, Sexual Medicine and Andrology, Florence, Italy; 2 University of Florence, Florence, Italy Objective: Approximately 20% of women experience sexual abuse (SA) worldwide. SA survivors are prone to experiencing psychiatric symptoms and sexual dysfunction (SD). This study aimed to evaluate the prevalence and correlates of reported SA at different ages in a sexual medicine setting. Methods: We retrospectively studied 200 heterosexual women attending our clinic for SD. All patients completed the Middlesex Hospital Questionnaire (MHQ), Female Sexual Function Index (FSFI), Female Sexual Distress Scale (FSDS) and Body Uneasiness Test (BUT). Results: Forty-seven women (23.5%) reported SA, which occurred in childhood, adolescence and adulthood in 9% (n¼18), 7.5% (n¼15) and 7% (n¼14) of cases, respectively. SA women showed significantly higher MHQ total score (p¼0.023), free-floating anxiety (MHQ-A: p<0.0001) and phobic anxiety symptoms (p¼0.043) when compared with non-SA women. SA women also showed significantly lower FSFI Orgasm domain (p¼0.001), Satisfaction domain (p¼0.004) and Total scores (p¼0.027), and a higher FSDS total score (p¼0.003). After adjusting for age and the use of psychotropic drugs, only the difference in MHQA (F¼9.824, p¼0.002), FSFI Orgasm (F¼7.395, p¼0.007) and FSDS total scores (F¼7.208, p¼0.008) retained statistical significance. When considering BUT, SA patients showed significantly higher Global Severity Index (p¼0.021), Weight Phobia (p¼0.025), Body Image Concerns (p¼0.025), Avoidance (p¼0.042), Depersonalization (p¼0.032), Positive Symptom Total (p¼0.045) and Positive Symptom Distress Index (PSDI) scores (p¼0.022) than non-SA patients. All the differences retained statistical significance after adjusting for age, psychotropic drugs and body mass index. Significantly lower FSFI Orgasm (p¼0.009) and Satisfaction domain scores (p¼0.012) were found in patients reporting SA in adolescence when compared with SA in childhood, even after adjusting for confounders (F¼8.577, p¼0.007 and F¼7.102, p¼0,013 for Orgasm and Satisfaction, respectively). Conclusion: SA women show higher anxiety symptoms, sexual distress and body image concerns and a worse orgasm functioning when compared to non-SA women. SA has a greater negative impact on orgasm functioning and sexual satisfaction when perpetrated in adolescence than in childhood. Policy of full disclosure: None
P-02-011 NOVEL TUMOR MARKERS OF BREAST CANCER Rawat, A.1; Ganesh, N.2 1 JNCH & RC, Department of Research, Bhopal, India; 2JNCH & RC, Bhopal, India
J Sex Med 2017;14:e107ee197
e185 Objective: The objective of the present study is to look for some Novel Tumor Markers for the diagnosis of Breast Cancer and screening females having high risk of developing Breast Cancer by exploring the Anthropometric, Cytogenetic and Biochemical Technique. Methods: The study consists of three parameters for which informed consent were taken from each individual. First for the Anthropometric Analysis, “angle of triradius” (atd) of Breast Cancer patients (age group 18-70 years) along with age matched healthy control females were taken ( Harold Cummins, 1960). For the Cytogenetic Analysis, peripheral blood of the same group of individuals were subjected to lymphocyte culture by standard protocol of Moorehead et al., (1964) and chromosomal aberrations were observed by karyotype preparation. For the Biochemical Analysis, plasma samples of both the groups were studied by running them in cellulose acetate membrane in an Electrophoretic chamber (Robyt, John F, 1990) and any altered plasma protein patterns that were specific for Breast Cancer patients were observed. Results: In the Anthropometric Analysis using dermatoglyphic tool “atd” angle, Breast Cancer patients were found to be having wider angles (>42 ) than their healthy counterparts. In the Cytogenetic Analysis, Breast Cancer patients were showing a much higher frequency of numerical as well as structural aberrations than the healthy females and in the Biochemical Analysis, Breast Cancer patients (>80%) were found to be having a raised alpha 2 proteins while healthy females showed a normal range. In addition, more than 80% breast cancer females showed a gamma globulin pattern of polyclonal origin. Conclusion: These parameters in combination have a potential to be used as Tumor Markers for the diagnosis of breast cancer and these are not only cost effective but also non-invasive which makes them more accessible especially for screening females at high risk of developing Breast Cancer. Policy of full disclosure: None
P-02-012 EROTIC ART: AS A WAY TO BETTER UNDERSTAND SEXUALITY Trotta, D.1; Strepetova, T.2 1 Salerno, Italy; 2ISA, Istitut of Sexodynamics, Salerno, Italy Objective: Art Involves in many cases a sexual topics or has a sexual meaning. They want to understand if this can be useful for better understanding of human sexuality and its problems. Methods: Analysis of the erotic production of contemporary artists. Comparisons between what is expressed in sexual artworks and what we get from our work with clinical patients. We prefer to study contemporary artists than writers of the past. This is because they are close to our modern way to live sexuality and its needs and anxieties. Results: Our results are fruitful and encouraging. There is usually an emotional involvement of the viewer about the erotic motif. Sometimes with support and identification with the artwork, other times with disapproval or bewilderment for a theme considered to be of a private nature. In relation with works with explicit erotic content as well as with indirect o symbolic sexual art. There are also differences in the way men and women artists choose their erotic subjects or men and women spectators give to different sexual themes. Particularly on sentimental and aggressive topics. Conclusion: As clinicians we are continuously confronted with the difficulties our patients live their sexuality and their sexual limits even when their sexual behavior is not substantiated by sufficient biological medical causes. Like with young patients or even adults with no evidence or organic disease, risk factors and drugs use and abuse. Even if patient’s clinical investigation is essential in the comprehension of sexual issues useful observation can be also
P-02-011 NOVEL TUMOR MARKERS OF BREAST CANCER Rawat, A.1; Ganesh, N.2 1 JNCH & RC, Department of Research, Bhopal, India; 2JNCH & RC, Bhopal, India
J Sex Med 2017;14:e107ee197
e185 Objective: The objective of the present study is to look for some Novel Tumor Markers for the diagnosis of Breast Cancer and screening females having high risk of developing Breast Cancer by exploring the Anthropometric, Cytogenetic and Biochemical Technique. Methods: The study consists of three parameters for which informed consent were taken from each individual. First for the Anthropometric Analysis, “angle of triradius” (atd) of Breast Cancer patients (age group 18-70 years) along with age matched healthy control females were taken ( Harold Cummins, 1960). For the Cytogenetic Analysis, peripheral blood of the same group of individuals were subjected to lymphocyte culture by standard protocol of Moorehead et al., (1964) and chromosomal aberrations were observed by karyotype preparation. For the Biochemical Analysis, plasma samples of both the groups were studied by running them in cellulose acetate membrane in an Electrophoretic chamber (Robyt, John F, 1990) and any altered plasma protein patterns that were specific for Breast Cancer patients were observed. Results: In the Anthropometric Analysis using dermatoglyphic tool “atd” angle, Breast Cancer patients were found to be having wider angles (>42 ) than their healthy counterparts. In the Cytogenetic Analysis, Breast Cancer patients were showing a much higher frequency of numerical as well as structural aberrations than the healthy females and in the Biochemical Analysis, Breast Cancer patients (>80%) were found to be having a raised alpha 2 proteins while healthy females showed a normal range. In addition, more than 80% breast cancer females showed a gamma globulin pattern of polyclonal origin. Conclusion: These parameters in combination have a potential to be used as Tumor Markers for the diagnosis of breast cancer and these are not only cost effective but also non-invasive which makes them more accessible especially for screening females at high risk of developing Breast Cancer. Policy of full disclosure: None
P-02-012 EROTIC ART: AS A WAY TO BETTER UNDERSTAND SEXUALITY Trotta, D.1; Strepetova, T.2 1 Salerno, Italy; 2ISA, Istitut of Sexodynamics, Salerno, Italy Objective: Art Involves in many cases a sexual topics or has a sexual meaning. They want to understand if this can be useful for better understanding of human sexuality and its problems. Methods: Analysis of the erotic production of contemporary artists. Comparisons between what is expressed in sexual artworks and what we get from our work with clinical patients. We prefer to study contemporary artists than writers of the past. This is because they are close to our modern way to live sexuality and its needs and anxieties. Results: Our results are fruitful and encouraging. There is usually an emotional involvement of the viewer about the erotic motif. Sometimes with support and identification with the artwork, other times with disapproval or bewilderment for a theme considered to be of a private nature. In relation with works with explicit erotic content as well as with indirect o symbolic sexual art. There are also differences in the way men and women artists choose their erotic subjects or men and women spectators give to different sexual themes. Particularly on sentimental and aggressive topics. Conclusion: As clinicians we are continuously confronted with the difficulties our patients live their sexuality and their sexual limits even when their sexual behavior is not substantiated by sufficient biological medical causes. Like with young patients or even adults with no evidence or organic disease, risk factors and drugs use and abuse. Even if patient’s clinical investigation is essential in the comprehension of sexual issues useful observation can be also