- Email: [email protected]
P 102 Domain-specific effects of transcranial random noise stimulation (tRNS) on auditory feature processing
Abstracts / Clinical Neurophysiology 128 (2017) e305–e412
Fig. 1.
Materials and methods: Measurements were executed on a head phantom containing brain metabolites (NAA, Cr, Cho, mI, Glu). Spectra were analyzed by LCModel using basic data sets simulated by VeSPA-Simulation. Graphic results were plotted by Matlabprocedures. Results: The influence of confounding factors for CSImeasurements could be quantified. Software routines are given for graphical representation of B0- and B1-inhomogeneities. Furthermore, the influence of digitalization on the PSF (point spread function) for the measured phantom was reduced by a correction matrix.
See Fig. 1
doi:10.1016/j.clinph.2017.06.177
e379
auditory feature processing. Considering the hemispheric specialization of the auditory system in analyzing theses features we hypothesized that a site-specific tRNS application leads to domain-specific changes in auditory features processing. In concrete, tRNS over the left auditory cortex (lAC) was hypothesized to affect the temporal domain while tRNS over the right auditory cortex (rAC) was assumed to modulate the spectral domain. Finally, we investigated whether tRNS over bilateral auditory cortex (bAC) leads to a modulation of both dimensions. Methods: On four days 18 healthy, right-handed adults received 30 min. tRNS at an intensity of 1.5 mA either over the lAC, over the rAC, over bAC or sham stimulation while continuous EEG was recorded. The task consisted of the detection of a deviant tone in a sequence of three sine wave tones. While the duration of all tones and the pitch of the standard tones was kept stable, the inter-tone interval (temporal information) and the frequency in that the deviant tone differed from the standard tones (spectral information) was modulated. Results: In result, we found that tRNS applied over the lAC and over bAC inferred with task performance. This effect was specifically modulated by the inter-tone interval between the tone triplets but not by the frequency of the deviant tone. On the electrophysiological level, this finding was paralleled by feature-specific brain response patterns in the alpha and the lower gamma band. Discussion: Our findings demonstrate the functional relevance of the lAC in processing temporal features. Most importantly, we proved tRNS as a valid technique to modulate basic auditory perception. The current results stress the need for further investigations on the effect of tRNS in the auditory domain. Systematically assessing the most effective stimulation parameters provides the basis for the clinical application of tRNS in the context of speech and language disorders. References Goswami U. A temporal sampling framework for developmental dyslexia. Trends Cognit Sci 2011;15(1):3–10. doi:10.1016/j.tics.2010.10.001. Walton JP. Timing is everything: temporal processing deficits in the aged auditory brainstem. Hear Res 2010;264(1–2):63–9. doi:10.1016/j.heares.2010.03.002. Rosen S. Temporal information in speech: acoustic, auditory and linguistic aspects. Philos Trans R Soc Lond. Ser B, Biol Sci 1992;336(1278):367–73. doi:10.1098/ rstb.1992.0070. doi:10.1016/j.clinph.2017.06.178
Poster P 102 Domain-specific effects of transcranial random noise stimulation (tRNS) on auditory feature processing—K. Rufener *, M. Keute, J. Kauk, H.J. Heinze, T. Zaehle (Otto-von-Guericke Universität, Magdeburg, Germany) ⇑
Corresponding author.
Theoretical background: Decoding acoustic speech signals requires to parse the acoustic stream into linguistically meaningful units, and to extract stress and prosody. Accordingly, the temporal and spectral resolution of the auditory cortex is essential in successful speech processing (Rosen, 1992). The reduced acuity in discriminating these features is considered as key factor in dyslexia (Goswami, 2011) but is also a consequence of normal aging (Walton, 2010). Transcranial random noise stimulation (tRNS), a non-invasive brain stimulation technique that applies weak currents at multiple frequencies, is assumed to modulate the excitability of neural assemblies and, in consequence, the reactivity of cortical structures. However, the effect of tRNS on the auditory system is yet unclear. The present study aimed to fill this gap by investigating the impact of tRNS on basic
Poster P 103 Aggressiveness of martial artists correlates with reduced temporal pole gray matter concentration—S. Breitschuh 1,2,*, M. Schöne 1,2, L. Tozzi 1, J. Kaufmann 3, H. Strumpf 3, D. Fenker 1, T. Frodl 1, B. Bogerts 1,2, K. Schiltz 1,4 (1 Universitätsklinikum Magdeburg, Klinik für Psychiatrie und Psychotherapie, Magdeburg, Germany, 2 Salus-Institut, Magdeburg, Germany, 3 Universitätsklinikum Magdeburg, Klinik für Neurologie, Magdeburg, Germany, 4 Klinik für Psychiatrie und Psychotherapie der Ludwig-Maximilians-Universität München, Abteilung für Forensische Psychiatrie, München, Germany) ⇑ Corresponding author at: Universitätsklinikum Magdeburg, Klinik für Psychiatrie und Psychotherapie, Magdeburg, Germany.
Theoretical background: Perception and practice of violence have, aside from reactive components, also hedonistic aspects that are associated with positive arousal (appetitive aggression). Earlier studies have predominantly investigated the etiology of aggressive
Fig. 1.
Materials and methods: Measurements were executed on a head phantom containing brain metabolites (NAA, Cr, Cho, mI, Glu). Spectra were analyzed by LCModel using basic data sets simulated by VeSPA-Simulation. Graphic results were plotted by Matlabprocedures. Results: The influence of confounding factors for CSImeasurements could be quantified. Software routines are given for graphical representation of B0- and B1-inhomogeneities. Furthermore, the influence of digitalization on the PSF (point spread function) for the measured phantom was reduced by a correction matrix.
See Fig. 1
doi:10.1016/j.clinph.2017.06.177
e379
auditory feature processing. Considering the hemispheric specialization of the auditory system in analyzing theses features we hypothesized that a site-specific tRNS application leads to domain-specific changes in auditory features processing. In concrete, tRNS over the left auditory cortex (lAC) was hypothesized to affect the temporal domain while tRNS over the right auditory cortex (rAC) was assumed to modulate the spectral domain. Finally, we investigated whether tRNS over bilateral auditory cortex (bAC) leads to a modulation of both dimensions. Methods: On four days 18 healthy, right-handed adults received 30 min. tRNS at an intensity of 1.5 mA either over the lAC, over the rAC, over bAC or sham stimulation while continuous EEG was recorded. The task consisted of the detection of a deviant tone in a sequence of three sine wave tones. While the duration of all tones and the pitch of the standard tones was kept stable, the inter-tone interval (temporal information) and the frequency in that the deviant tone differed from the standard tones (spectral information) was modulated. Results: In result, we found that tRNS applied over the lAC and over bAC inferred with task performance. This effect was specifically modulated by the inter-tone interval between the tone triplets but not by the frequency of the deviant tone. On the electrophysiological level, this finding was paralleled by feature-specific brain response patterns in the alpha and the lower gamma band. Discussion: Our findings demonstrate the functional relevance of the lAC in processing temporal features. Most importantly, we proved tRNS as a valid technique to modulate basic auditory perception. The current results stress the need for further investigations on the effect of tRNS in the auditory domain. Systematically assessing the most effective stimulation parameters provides the basis for the clinical application of tRNS in the context of speech and language disorders. References Goswami U. A temporal sampling framework for developmental dyslexia. Trends Cognit Sci 2011;15(1):3–10. doi:10.1016/j.tics.2010.10.001. Walton JP. Timing is everything: temporal processing deficits in the aged auditory brainstem. Hear Res 2010;264(1–2):63–9. doi:10.1016/j.heares.2010.03.002. Rosen S. Temporal information in speech: acoustic, auditory and linguistic aspects. Philos Trans R Soc Lond. Ser B, Biol Sci 1992;336(1278):367–73. doi:10.1098/ rstb.1992.0070. doi:10.1016/j.clinph.2017.06.178
Poster P 102 Domain-specific effects of transcranial random noise stimulation (tRNS) on auditory feature processing—K. Rufener *, M. Keute, J. Kauk, H.J. Heinze, T. Zaehle (Otto-von-Guericke Universität, Magdeburg, Germany) ⇑
Corresponding author.
Theoretical background: Decoding acoustic speech signals requires to parse the acoustic stream into linguistically meaningful units, and to extract stress and prosody. Accordingly, the temporal and spectral resolution of the auditory cortex is essential in successful speech processing (Rosen, 1992). The reduced acuity in discriminating these features is considered as key factor in dyslexia (Goswami, 2011) but is also a consequence of normal aging (Walton, 2010). Transcranial random noise stimulation (tRNS), a non-invasive brain stimulation technique that applies weak currents at multiple frequencies, is assumed to modulate the excitability of neural assemblies and, in consequence, the reactivity of cortical structures. However, the effect of tRNS on the auditory system is yet unclear. The present study aimed to fill this gap by investigating the impact of tRNS on basic
Poster P 103 Aggressiveness of martial artists correlates with reduced temporal pole gray matter concentration—S. Breitschuh 1,2,*, M. Schöne 1,2, L. Tozzi 1, J. Kaufmann 3, H. Strumpf 3, D. Fenker 1, T. Frodl 1, B. Bogerts 1,2, K. Schiltz 1,4 (1 Universitätsklinikum Magdeburg, Klinik für Psychiatrie und Psychotherapie, Magdeburg, Germany, 2 Salus-Institut, Magdeburg, Germany, 3 Universitätsklinikum Magdeburg, Klinik für Neurologie, Magdeburg, Germany, 4 Klinik für Psychiatrie und Psychotherapie der Ludwig-Maximilians-Universität München, Abteilung für Forensische Psychiatrie, München, Germany) ⇑ Corresponding author at: Universitätsklinikum Magdeburg, Klinik für Psychiatrie und Psychotherapie, Magdeburg, Germany.
Theoretical background: Perception and practice of violence have, aside from reactive components, also hedonistic aspects that are associated with positive arousal (appetitive aggression). Earlier studies have predominantly investigated the etiology of aggressive