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P-200 Prevalence of Polyvascular Disease in Patients with Coronary Artery Disease in Japanese Population
S108
Abstracts of the 17th Asian Pacific Congress of Cardiology
The mean of carotid IMT was 0.948±0.28 mm in men and 0.881±0.22 mm in women (p < 0.001). The prevalence of the MS was 31.6% in men and 45.2% in women. Mean carotid IMT increased with an increasing number of risk factors (p for trend <0.001) and carotid IMT values were 0.815 mm, 0.848 mm, 0.869 mm, 0.889 mm and 0.940 mm for 0, 1, 2, 3, 4, and 5 risk factors, respectively. After adjustment, those with more components of MS had higher odds ratios for highest quartile carotid IMT compared with those without components. Carotid IMT was increased with the increasing number of components of MS. There is a strong relationship between carotid IMT and the MS. Current findings indicate the need for prevention and control of metabolic syndrome in a population of middle-aged Koreans. P-199 Gender Disparity in the Risk Factors for Coronary Vasospasm Without Hemodynamically Significant Coronary Artery Disease 1
2
3
Ming-Yow Hung , Kuang-Hung Hsu , Ming-Jui Hung . 1 Graduate Institute of Clinical Medical Sciences, Department of Cardiology, Chang Gung University, Shuang-Ho Hospital, Taiwan, 2 Department of Health Care Management, Chang Gung University, Taiwan, 3 Section of Cardiology, Department of Medicine, Chang Gung Memorial Hospital at Keelung, Taiwan Background: To determine gender differences in the risk factors for coronary vasospasm (CV) and the effect of hypertension associated with inflammation on the prediction of CV in patients without hemodynamically significant coronary artery disease (CAD). Methods: A total of 722 patients (39% women) who underwent diagnostic coronary angiography with or without proven CV and without CAD (>50% stenosis) during an 8-year period were included. The levels of high-sensitivity C-reactive protein (hs-CRP) were analyzed in a subset of 375 patients. Results: In women, only the highest hs-CRP tertile (>3 mg/L) was independently associated with CV (odds ratio [OR]: 3.21; 95% confidence interval [CI]: 1.28 8.07), while hypertension was negatively associated with CV (OR: 0.42; 95% CI: 0.19 0.94). In men, age (>58 years) and the highest hsCRP tertile were independently associated with CV, with the highest tertile being the most significant factor (OR: 2.88; 95% CI: 1.35 6.18). In the presence of hypertension, the OR (95% CI) for CV in the highest hs-CRP tertile declined from 6.01 (1.45 24.88) to 1.48 (0.48 4.51) in men and from 6.35 (1.96 20.56) to 2.69 (1.00 7.21) in women. Conclusions: We found gender disparity in the risk factors for developing CV and a negative association between hypertension and CV development in both genders. This study also demonstrated a negative interaction between hypertension and hs-CRP in patients with CV. P-200 Prevalence of Polyvascular Disease in Patients with Coronary Artery Disease in Japanese Population Masanori Taniwaki, Shuzou Tanimoto, Kengo Tanabe, Shunsuke Sasaki, Shuji Ohtsuki, Sen Yachi, Masataka Nakano, Satoru Kishi, Teruhiko Imamura, Kazuhiro Mutoh, Yoshifumi Nakajima, Satoru Shimizu, Hiroyoshi Nakajima, Kazuhiro Hara. Department of Cardiology, Mitsui Memorial Hospital, Japan Background and Purpose: Prevalence of polyvascular disease, including carotid artery stenosis (CAS), renal artery stenosis (RAS) and arteriosclerosis obliterans (ASO), in
patients with coronary artery disease (CAD) has not been elucidated in Japanese population. Methods: The study populations consisted of 193 consecutive patients who underwent coronary angiography because of suspicion of CAD. All patients underwent carotid and renal artery ultrasonography, and ankle brachial index (ABI) before coronary angiography. Results: Coronary anigiography revealed 126 patients (65.3%) had CAD. The prevalence rate of polyvascular disease in patients with CAD was 31.2%. Conclusion: Although the number of patients with PAD has been considered to be low in Japanese population, the prevalence rate of polyvascular disease with patients with CAD is high in the present study. P-201 Relation Between Functional Exercise Capacity and Functional Stenosis with Patients of Stable Angina with Moderate Coronary Stenosis Tomoko Hirose1 , Shinichiro Tanaka1 , Toshiyuki Noda1 , Tomonori Segawa1 , Reiko Matsuoka1 , Shintaro Abe1 , Yoshiaki Goto1 , Takashi Katou1 , Shunichiro Warita1 , Tai Kojima1 , Takeshi Hirose1 , Makoto Iwama1 , Koji Ono1 , Haruki Takahashi1 , Taro Minagawa2 , Sachiro Watanabe1 . 1 Department of Cardiology, Gifu Prefectural General Medical Center, Japan, 2 Gifu Cardiovascular Institution, Japan Purpose: Stable angina patients with significant coronary stenosis are known to have low exercise capacity. But some patients can have higher exercise capacity. Coronary pressure-derived fractional flow reserve (FFR) is functional index of coronary stenosis. We hypothesized that there are some relevance between functional exercise capacity and functional stenosis, and assessed those with pressure wire and cardiopulmonary exercise test (CPX). Method: The subjects were fifteen male (65.8±8.9years old) of stable angina with lesion estimated 75%-stenosis visually by coronary angiography. Eligible patients received CPX, and were measured peak oxygen uptake (PeakVO2: ml/kg/min) and oxygen uptake at anaerobic threshold (AT: ml/kg/min). We assessed the relation between FFR and values of CPX. Result: Lesions were localized eight in left anterior descending artery, five in left circumflex, and two in right coronary artery. %diameter stenosis (%DS) was 65.8±8.9% by quantitative coronary angiography. FFR was 0.84±0.66. PeakVO2 was 17.1±3.2, and AT was 11.1±2.0. Significant correlation was not observed between %DS and FFR (r = 0.12). There are no entirely correlation between %DS and PeakVO2 (r = 0.05), and between %DS and AT (r = 0.01). The correlation coefficient between FFR and PeakVO2 was r = 0.53 (p < 0.05), between FFR and AT was r = 0.54 (p < 0.05): which have positive correlations. Conclusion: In this study, PeakVO2 and AT have some correlation to FFR. Functional exercise capacity with patients of stable angina could be affected by functionally stenosis rather than angiographic stenosis.
Abstracts of the 17th Asian Pacific Congress of Cardiology
The mean of carotid IMT was 0.948±0.28 mm in men and 0.881±0.22 mm in women (p < 0.001). The prevalence of the MS was 31.6% in men and 45.2% in women. Mean carotid IMT increased with an increasing number of risk factors (p for trend <0.001) and carotid IMT values were 0.815 mm, 0.848 mm, 0.869 mm, 0.889 mm and 0.940 mm for 0, 1, 2, 3, 4, and 5 risk factors, respectively. After adjustment, those with more components of MS had higher odds ratios for highest quartile carotid IMT compared with those without components. Carotid IMT was increased with the increasing number of components of MS. There is a strong relationship between carotid IMT and the MS. Current findings indicate the need for prevention and control of metabolic syndrome in a population of middle-aged Koreans. P-199 Gender Disparity in the Risk Factors for Coronary Vasospasm Without Hemodynamically Significant Coronary Artery Disease 1
2
3
Ming-Yow Hung , Kuang-Hung Hsu , Ming-Jui Hung . 1 Graduate Institute of Clinical Medical Sciences, Department of Cardiology, Chang Gung University, Shuang-Ho Hospital, Taiwan, 2 Department of Health Care Management, Chang Gung University, Taiwan, 3 Section of Cardiology, Department of Medicine, Chang Gung Memorial Hospital at Keelung, Taiwan Background: To determine gender differences in the risk factors for coronary vasospasm (CV) and the effect of hypertension associated with inflammation on the prediction of CV in patients without hemodynamically significant coronary artery disease (CAD). Methods: A total of 722 patients (39% women) who underwent diagnostic coronary angiography with or without proven CV and without CAD (>50% stenosis) during an 8-year period were included. The levels of high-sensitivity C-reactive protein (hs-CRP) were analyzed in a subset of 375 patients. Results: In women, only the highest hs-CRP tertile (>3 mg/L) was independently associated with CV (odds ratio [OR]: 3.21; 95% confidence interval [CI]: 1.28 8.07), while hypertension was negatively associated with CV (OR: 0.42; 95% CI: 0.19 0.94). In men, age (>58 years) and the highest hsCRP tertile were independently associated with CV, with the highest tertile being the most significant factor (OR: 2.88; 95% CI: 1.35 6.18). In the presence of hypertension, the OR (95% CI) for CV in the highest hs-CRP tertile declined from 6.01 (1.45 24.88) to 1.48 (0.48 4.51) in men and from 6.35 (1.96 20.56) to 2.69 (1.00 7.21) in women. Conclusions: We found gender disparity in the risk factors for developing CV and a negative association between hypertension and CV development in both genders. This study also demonstrated a negative interaction between hypertension and hs-CRP in patients with CV. P-200 Prevalence of Polyvascular Disease in Patients with Coronary Artery Disease in Japanese Population Masanori Taniwaki, Shuzou Tanimoto, Kengo Tanabe, Shunsuke Sasaki, Shuji Ohtsuki, Sen Yachi, Masataka Nakano, Satoru Kishi, Teruhiko Imamura, Kazuhiro Mutoh, Yoshifumi Nakajima, Satoru Shimizu, Hiroyoshi Nakajima, Kazuhiro Hara. Department of Cardiology, Mitsui Memorial Hospital, Japan Background and Purpose: Prevalence of polyvascular disease, including carotid artery stenosis (CAS), renal artery stenosis (RAS) and arteriosclerosis obliterans (ASO), in
patients with coronary artery disease (CAD) has not been elucidated in Japanese population. Methods: The study populations consisted of 193 consecutive patients who underwent coronary angiography because of suspicion of CAD. All patients underwent carotid and renal artery ultrasonography, and ankle brachial index (ABI) before coronary angiography. Results: Coronary anigiography revealed 126 patients (65.3%) had CAD. The prevalence rate of polyvascular disease in patients with CAD was 31.2%. Conclusion: Although the number of patients with PAD has been considered to be low in Japanese population, the prevalence rate of polyvascular disease with patients with CAD is high in the present study. P-201 Relation Between Functional Exercise Capacity and Functional Stenosis with Patients of Stable Angina with Moderate Coronary Stenosis Tomoko Hirose1 , Shinichiro Tanaka1 , Toshiyuki Noda1 , Tomonori Segawa1 , Reiko Matsuoka1 , Shintaro Abe1 , Yoshiaki Goto1 , Takashi Katou1 , Shunichiro Warita1 , Tai Kojima1 , Takeshi Hirose1 , Makoto Iwama1 , Koji Ono1 , Haruki Takahashi1 , Taro Minagawa2 , Sachiro Watanabe1 . 1 Department of Cardiology, Gifu Prefectural General Medical Center, Japan, 2 Gifu Cardiovascular Institution, Japan Purpose: Stable angina patients with significant coronary stenosis are known to have low exercise capacity. But some patients can have higher exercise capacity. Coronary pressure-derived fractional flow reserve (FFR) is functional index of coronary stenosis. We hypothesized that there are some relevance between functional exercise capacity and functional stenosis, and assessed those with pressure wire and cardiopulmonary exercise test (CPX). Method: The subjects were fifteen male (65.8±8.9years old) of stable angina with lesion estimated 75%-stenosis visually by coronary angiography. Eligible patients received CPX, and were measured peak oxygen uptake (PeakVO2: ml/kg/min) and oxygen uptake at anaerobic threshold (AT: ml/kg/min). We assessed the relation between FFR and values of CPX. Result: Lesions were localized eight in left anterior descending artery, five in left circumflex, and two in right coronary artery. %diameter stenosis (%DS) was 65.8±8.9% by quantitative coronary angiography. FFR was 0.84±0.66. PeakVO2 was 17.1±3.2, and AT was 11.1±2.0. Significant correlation was not observed between %DS and FFR (r = 0.12). There are no entirely correlation between %DS and PeakVO2 (r = 0.05), and between %DS and AT (r = 0.01). The correlation coefficient between FFR and PeakVO2 was r = 0.53 (p < 0.05), between FFR and AT was r = 0.54 (p < 0.05): which have positive correlations. Conclusion: In this study, PeakVO2 and AT have some correlation to FFR. Functional exercise capacity with patients of stable angina could be affected by functionally stenosis rather than angiographic stenosis.